1521:(HLA) system results in a reduction of immune resistance to bacteria that are carried into the bronchioles by the airstream. The HLA system contains a large number of genes, and there is not yet clear evidence for which ones are responsible, but several candidates have been identified. The implicated HLA variants occur most commonly among Japanese, followed by Koreans, followed by other East Asian populations. The disease occurs slightly more often in males, and is not age-related. It was first recognized to be a distinct disease in the early 1960s, and was formally named "diffuse panbronchiolitis" in 1969.
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The term "diffuse" refers to lesions that appear throughout both lungs, while "panbronchiolitis" refers to inflammation found in all layers of the respiratory bronchioles; these describe the common pathology for the disease. DPB causes severe inflammation of the respiratory bronchioles (the section
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about this and was then told "Not a mistake; I felt those edits were counterproductive, and the src you used had a broken doi and didn't appear to be secondary." Actually the source had primary data (the small study I mentioned of azithromycin, since you'd mentioned it) but I was also using it for
1092:"A report of the ACCP-ATS Joint Committee on Pulmonary Nomenclature in 1975 recommended that a more specific term, such as chronic obstructive bronchitis or chronic obstructive emphysema, be used whenever possible, and a term such as COPD, which represents a group of diseases, should be used less."
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As usual, I took it upon myself to just go crazy tweaking this article in my own idiosyncratic way. If you don't like it, please feel free to roll me back. I have some concerns about repetitiveness and organization that I did not act upon, but congrats and thanks to the major contributors for all
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It's only a draft and there's no doubt that it would need quite a bit of editing. The question at this point is whether it goes enough in the right direction to be worth placing in the article so it can be edited there, or whether it is better to continue to work with the existing lead. I don't
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I've been doing a terminology paper on COPD, and I must conclude that characterizing DPB as "a type of chronic obstructive pulmonary disease", or even talking about "a type of" COPD seems to grossly misrepresent current understanding of COPD (while mildly excusable given this is about DPB, it is
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I have simplified the lead, specifically by condensing all mention of HLA and its haplotypes into the word "genes". But I'd prefer to leave the rest as is; the average adult can read and grasp an encyclopedic entry, and I stand by my prose in that regard. ;) But do allow me to edit the lead if
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Rcej, you reverted wholesale a significantly large good-faith edit along with a procedural bot edit, using the summary "ce" and you tagged the edit as "minor". That is particularly poor form. Your reversion was neither a copyedit nor minor. If you truly believe that the information added was
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Thank you, Rcej. I have edited the new text a little. The reference (Li, "Effect of
Azithromycin on Patients with Diffuse Panbronchiolitis: Retrospective Study of 51 Cases") is a primary source, although the information added isn't from the "primary part" of the source. In my opinion, this
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That's not what I mean at all!! I just don't like the idea of writing down to our readers in what, in my opinion, reads like less than an encyclopedic style of writing. Patronage and 'dumming down' is not how we inform the
Knowledge audience. I apologize how I came across, though :)
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I believe that the use of erythromycin as an anti-inflammatory macrolide is a little outdated. The frequency of treatment with erythromycin (four times a day) and its side-effect profile (mainly gastro-intestinal) have caused it to be replaced by azithromycin & clarithromycin.
1421:, small tubes that carry air into the lungs. The most common symptoms are wheezing, shortness of breath, enlargement of the bronchiolar passages, and a severe cough with large amounts of sputum. The disease is difficult to cure, but daily treatment with antibiotics such as
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We however should have an image in the lead. And half of that CT IMO is the best image at this point. If you mean that someone allowed
Knowledge to only use the CT img in the diagnosis section this can not be done. Anyway I do not see a good reason not to have it in both
1125:, hopefully s/he can address it quickly. I'm also happy to help, and of course others are welcome to make whatever corrections are necessary. Is there a time frame you're expecting to have this fixed by before bringing to GAR or straight delisting?
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Rcej, thank you for removing the offending picture. Regarding Doc James' suggestion for an alternative image, I agree that the left half (section a) of the CT would be appropriate. The full CT (i.e. both sides) can remain in the "Diagnosis" section.
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Respectfully, the above reads more like a high school essay than what an adult would expect to read in a good encyclopedia. Are not relative proficiency of prose and its associated confidence collateral elements of a featured article? :)
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Here is a draft that tries to make the essential information a bit more accessible. Experience has taught me that it is a bad idea to make such large changes directly, so I place it here for consideration.
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secondary information; in any case there should be no problem, as I was citing authors' major conclusions, not reinterpreting snippets of primary data. But if you want to fix it, do it yourself - I'm
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Also the diagram under the disease box is a little strange. Not sure why it is so significant to belong in the lead. None of the other FAs I have worked on give an image of a body system in the lead.
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The solution to a broken doi is not to delete all the text as well as the reference. The appropriate action would have been to either fix the doi or replace it with another unique code such as pmid.
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I think there's enough in both the signs & symptoms section and the diagnosis subsection that each could stand on their own. You might consider putting
Diagnosis before Treatment per
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with this article. I'm going to go work on something copyrighted instead. If you can't defeat the evil empire or its agents, might as well ask for your boots of spanish leather.
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We should have an image in the lead and half of the CT one works well. Also the diagram of the respiratory system pertains to pathophysiology. Not sure why it is in the lead.
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still unacceptable on a global level). The only papers actually referring to DPB as a COPD date back some 10 years, and their basis is the following (from Homma et al. 1983,
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Impairment of the human leukocyte antigen (HLA) system results in a reduction of immune resistance to bacteria that are carried into the bronchioles by the airstream.
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This is NOT current terminology and I challenge anybody to find a recent work that treats COPD as a spectrum. At best there are discussions whether to include
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inappropriate, the best course of action would have been to move the contentious text to the talk page and invite the editor (Wnt) to discuss the matter.
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DPB is not a purely genetic disease. HLA B54 certainly is a strong risk factor, but it is not the only one. Environmental factors also contribute.
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Which basically means that it is more important to impress readers than to inform them. Not an unusual reaction, unfortunately. Oh well.
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Susceptibility to DPB results from alterations to genes that play important roles in the immune system. Specifically, impairment of the
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information is likely to be available in a purely secondary source. It would be preferable to use a secondary source if possible.
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has been shown to ease symptoms and increase survival time to 10 years or more. If left untreated, the disease progresses to
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Yeah, this is a serious concern, and a bad oversight on my part. Thanks for catching it, Circeus. I'm leaving a note for
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Great, thanks for working on this Rcej. This article seems to call it a "chronic inflammatory airway disease":
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of the bronchioles involved in gas exchange), and nodule-like lesions in respiratory and terminal bronchioles.
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editor, so most likely they'll have plenty time before I get off my ass to do anything about it XD
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to Wnt's enquiry. You were rude, dismissive and did not acknowledge any wrong-doing on your part.
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on
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Hmm. This can likely be resolved by a ce. In the article, though, I did not assert beyond
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While those actions could be interpreted as mistakes on your part, I am dismayed to see
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1617:"Tubes" sounds like a medical device – I suggest "small airway passages in the lungs".
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In the absence of any further comment, I have edited the text, adding a new reference.
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think it would be proper to do anything major before Rcej has a chance to weigh in.
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Perhaps put "small tubes that carry air into the lungs" in parentheses?
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1654:" Is that really true? Is HLA B54 an "impairment of the HLA system"?
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for
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Chronic sinusitis is actually the most common feature.
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Featured articles that have appeared on the main page
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797:: Participate in Japan-related deletion discussions.
603:. Current time in Japan: 08:41, September 29, 2024 (
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clinical publications about evidence-based medicine
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348:This article has not yet received a rating on the
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159:A fact from this article appeared on Knowledge's
1326:I can neither excuse nor explain my behavior; I
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1787:Thank you :) My best to you too!
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1415:bronchiolitis
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1306:your reaction
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1049:Dx before Rx?
1048:
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1036:
1031:
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1021:
1016:
1015:TRIP database
1012:
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971:Ideal sources
969:
966:
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924:Asia articles
911:
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834:
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513:(assessed as
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167:Did you know?
162:
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55:
51:
50:
46:
42:
38:
37:
32:
28:
25:
22:
18:
17:
2042:
2030:
1998:
1980:
1979:
1970:
1966:
1945:
1926:
1921:my agreement
1888:
1864:
1863:
1854:
1829:
1825:
1817:
1798:
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1788:
1765:
1742:
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1732:
1714:
1710:
1696:
1692:
1657:
1651:
1649:
1635:
1631:
1601:
1597:
1575:gas exchange
1567:inflammation
1543:lung disease
1524:
1506:
1487:
1486:
1477:
1444:
1443:
1434:
1423:erythromycin
1410:
1404:
1376:
1358:
1341:
1340:
1331:
1311:
1280:
1269:
1249:
1244:
1241:Erythromycin
1185:, 1998; nor
1177:
1156:
1152:
1151:I've been a
1097:
1095:
1079:
1052:
1044:
1033:
1027:
1018:
1005:
999:
988:
984:
974:
970:
939:
899:
830:
818:
809:
808:Create some
800:
792:
784:
776:
771:Vinland Saga
770:
763:
750:
743:
736:
735:
727:
713:
705:
651:
613:
593:project page
581:
575:
569:Japan portal
508:
486:
454:
440:
367:
309:
266:WikiProjects
230:
192:
190:lung disease
187:inflammatory
181:
174:May 14, 2008
172:
164:
140:
121:
102:
45:please do so
34:
26:
1619:Graham Colm
1419:bronchioles
893:Asia portal
773:(TV series)
707:Peer review
589:participate
402:Pulmonology
219:East Asians
123:Peer review
2061:Categories
1915:Rcej, per
1551:antibiotic
1004:(limit to
599:, and see
184:idiopathic
171:column on
36:identified
2033:this edit
1999:Doc James
1889:Doc James
1830:Doc James
1571:pathology
1276:User:Rcej
1123:User:Rcej
1055:WP:MEDMOS
1017:provides
998:provides
820:translate
161:Main Page
2037:WP:MEDRS
2009:contribs
1976:(Robert)
1899:contribs
1860:(Robert)
1840:contribs
1794:(Robert)
1738:(Robert)
1678:Looie496
1559:wheezing
1526:Looie496
1483:(Robert)
1463:Looie496
1440:(Robert)
1337:(Robert)
1219:18990961
1212:19118228
745:Pictures
738:Articles
462:Medicine
397:Medicine
290:Genetics
256:FA-class
199:Japanese
147:Promoted
128:Reviewed
1882:places.
1224:delldot
1190:9927368
1183:9731015
1161:Circéus
1128:delldot
1106:Circéus
1086:6848335
1060:delldot
942:on the
755:: None
748:: None
741:: None
681:history
654:on the
618:Refresh
489:on the
207:Chinese
163:in the
87:Process
1583:Sasata
1547:sputum
1098:asthma
996:PubMed
832:Assess
718:: None
710:: None
262:scale.
217:among
203:Korean
109:Listed
90:Result
2013:email
1903:email
1844:email
817:Help
752:Lists
691:purge
686:watch
627:Japan
609:Reiwa
583:Japan
538:Japan
29:is a
2005:talk
1983:talk
1973:Rcej
1967:Done
1919:and
1895:talk
1867:talk
1857:Rcej
1836:talk
1801:talk
1791:Rcej
1772:talk
1745:talk
1735:Rcej
1682:talk
1623:talk
1587:talk
1530:talk
1490:talk
1480:Rcej
1467:talk
1447:talk
1437:Rcej
1344:talk
1334:Rcej
1289:talk
1281:done
1216:PMID
1209:PMID
1198:talk
1194:Rcej
1187:PMID
1180:PMID
1165:talk
1157:lazy
1153:slow
1110:talk
1083:PMID
1076:COPD
1032:and
1013:The
915:Asia
906:Asia
862:Asia
783:Add
676:edit
211:Thai
209:and
84:Date
2043:Axl
1946:Axl
1927:Axl
1715:Axl
1697:Axl
1658:Axl
1636:Axl
1602:Axl
1377:Axl
1359:Axl
1312:Axl
1285:Wnt
1250:Axl
1221:.
1035:CDC
934:Mid
646:Mid
611:6)
605:JST
481:Mid
344:???
2063::
2039:.
2015:)
2011:·
2007:·
1978:–
1905:)
1901:·
1897:·
1862:–
1846:)
1842:·
1838:·
1796:–
1774:)
1740:–
1684:)
1625:)
1589:)
1581:.
1577:,
1573:,
1569:,
1565:,
1561:,
1557:,
1549:,
1545:,
1532:)
1485:–
1469:)
1442:–
1339:–
1291:)
1230:∇.
1200:)
1167:)
1134:∇.
1112:)
1066:∇.
775:,
768::
730:–
607:,
517:).
400::
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288::
205:,
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1951:¤
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614:(
493:.
459:.
352:.
268::
221:?
177:.
169:"
165:"
47:.
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