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376:, I did include electron crystallography on the top line; the cryo-EM on the 2nd line was intended to be real-space microscopy, a la Keiichi Namba, Eva Nogales or Wah Chiu, those 5-10 Å structures of viruses and whatnot. I like the old-fashioned low-resolution methods, so I would kind of mourn their loss ;), but I'm open to other ideas.
491:. It's been a good mental exercise to refine all of our understandings, but sometimes there's been more heat than light, and hardly anyone seems to cite scientific references. I confess, I feel the temptation to do the same: "See, this 5-eyed worm says that I'm awesome, so you all should go along with whatever I say." ;)
425:- if there's a link in the middle of the bottom navigation row, it doesn't align properly in the center of the template using the "each set of links gets its own table column" method. You seem more knowledgeable about formatting than I am (I'm terminally hopeless at anything to do with GUIness) - I've copied them into
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As an aside, might we want to clone this template to make a "Protein interaction domains" template? If you count up the common modular protein-protein, protein-DNA and protein-sugar interaction domains (no enzymes!), there's probably enough to fill out a good-sized template box. The protein-protein
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My bias is to use "Protein folds" and keep the definition structural rather than partly functional. Even variant
Rossman folds can do things other than bind nucleotides, for example, so maintaining a functional definition might be difficult. Also, if a common function were required, we'd have to find
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I wondered about the inclusion of secondary structures but thought there might be some use in keeping all the "protein stuff" together. Would it be too huge to list secondary structures, supersecondary structures, and folds/domains under three separate headers on the same template? I think it might
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also seems a bit overcategorized to me. Maybe split it into general methods of study and actual structure determination (ie, segregate things like HD exchange and light scattering from atomic-resolution methods like crystallography). Also cryo-EM isn't necessarily only medium resolution - electron
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I like the linked-templates idea a lot; it would make this stuff a lot more navigable. I did make a minor formatting change to the arrows. I think the primary structure one is a little long right now, especially with the two or three other navboxes at the bottom of most of the amino acid articles.
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Harvest time? Wow. I don't know what you're harvesting but it sounds yummy all the same. I think secondary structure looks good, though there might be some ambiguity eventually separating "supersecondary" from "motif" from "fold". I'm trying to fix a minor formatting issue that come up in
239:) or is it defined by having both a common structure and function (say, ATP-binding)? If the former (i.e., if our definition is purely structural), would it make sense to relabel the template as "Protein folds"? Just a stray thought,
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No light at the photon article? That's not a good sign. And five-eyed worms are always authoritative on who is awesome and who isn't. You can't tell from the fossils but one of those eyes is specialized for awesomeness detection.
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I'm concerned, however, by some elements in the template that are not structural domains, in the sense that they do not fold cooperatively as a unit, e.g., the alpha helix. I started a new template
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Secondary structure looks good to me. I guess what we really need for the tertiary structure case is a better article on electron crystallography. Other than that everything looks great.
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be too big for lower resolutions, so the current separation works. Maybe there's a good way to provide a standard link from one template to the main article of the other.
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The formatted versions in my userspace do exactly what I was trying to do, so I've put those versions into the main templates. Did I mention that you're awesome?
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if you want to take a look without poking the real template. Do you know of a way to force the columns to evenly distribute without breaking word wrap?
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type of page (unless I've just missed it?) but if it did exist it could contain basic data, including possible modifications, all in one place.
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to cover some of those (please add some more!), but I didn't want to delete the entries here until we reach consensus.
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could go on the structure determination pages listed there; is that OK with you? Oops, gotta run to the stove,
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Maybe it would be easier to list "N-linked", "O-linked", and "other" modifications? I'm surprised there isn't a
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Knowledge (XXG). If you would like to participate, please visit the project page, where you can join
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More generally, I'm wondering about our definition of "domain". Does it mean a protein
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article at the moment. Any opinions on splitting the article vs narrowing the template?
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The cat's doing better at staying off the computer but my couch is taking a beating :)
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somewhere else to put things like beta propellers that don't really have one.
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Normally, I get awkward and self-conscious when people say kind things about
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I agree, it seems very sensible to unite the various topologies under
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crystallography is awesome with 2D arrays of membrane proteins.
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And did I mention that you rock, too? Infinite praise loop! ;)
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399:— oops! I also added the amino-acid propensities to
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WikiProject
Molecular and Cellular Biology articles
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299:Hoping all's well with you and kitty,
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