30:
1205:
20:
40:
109:(Brilinta) is often listed with thienopyridine inhibitors and has similar indications for use but is not a thienopyridine. It is a cyclo-pentyltriazolo-pyrimidine that is distinct from the mechanism of the thienopyridines in that it reversibly (rather than irreversibly) inhibits the
177:
Depta, Jeremiah P.; Bhatt, Deepak L. (2008-01-01). "Aspirin and platelet adenosine diphosphate receptor antagonists in acute coronary syndromes and percutaneous coronary intervention: role in therapy and strategies to overcome resistance".
1278:
1254:
1047:
285:
377:
1161:
532:
72:
They are used in the management of peripheral artery disease, as well as the prevention of coronary stent thrombosis and strokes.
328:
1142:
550:
523:
263:
477:
1247:
278:
761:
1178:
852:
572:
138:"P2Y12 Receptor Inhibitors in Acute Coronary Syndromes: From the Research Laboratory to the Clinic and Vice Versa"
934:
908:
900:
1273:
1240:
271:
1166:
515:
439:
1043:
1105:
684:
639:
1212:
495:
229:
786:
211:
95:
948:
351:
346:
29:
1030:
801:
791:
781:
776:
771:
746:
319:
306:
298:
249:
203:
195:
159:
1004:
835:
796:
766:
241:
232:, Bates ER, Bass TA (August 2008). "Clinical profile of prasugrel, a novel thienopyridine".
187:
149:
1204:
808:
1224:
1220:
1172:
699:
294:
1267:
1129:
1099:
689:
674:
669:
630:
302:
64:
activity. They have a significant role in the management of cardiovascular disease.
215:
1119:
1089:
1067:
1062:
1035:
984:
963:
813:
752:
708:
585:
528:
467:
462:
443:
341:
310:
53:
989:
917:
886:
818:
719:
713:
703:
606:
400:
390:
89:
81:
33:
23:
1094:
1011:
994:
979:
958:
943:
938:
881:
866:
840:
830:
825:
679:
648:
580:
560:
538:
427:
411:
407:
356:
245:
106:
199:
1082:
1077:
1057:
1052:
999:
953:
927:
922:
871:
729:
652:
616:
590:
555:
543:
505:
500:
490:
452:
422:
417:
395:
361:
336:
85:
43:
253:
207:
163:
876:
861:
694:
665:
656:
644:
611:
457:
61:
19:
1147:
1137:
1114:
912:
741:
485:
191:
154:
137:
39:
1109:
1216:
371:
110:
57:
38:
28:
18:
1016:
267:
1228:
1128:
1029:
972:
899:
851:
740:
728:
638:
629:
599:
571:
514:
476:
438:
370:
327:
318:
1248:
279:
131:
129:
8:
1255:
1241:
737:
635:
324:
286:
272:
264:
153:
98:was actually a predecessor to this work.
1279:Blood and blood forming organ drug stubs
180:American Journal of Cardiovascular Drugs
125:
52:are a class of selective, irreversible
7:
1201:
1199:
14:
1203:
901:Direct thrombin (IIa) inhibitors
329:Glycoprotein IIb/IIIa inhibitors
524:Thromboxane synthase inhibitors
136:Alexopoulos, Dimitrios (2014).
60:inhibitors used for their anti-
1:
80:Drugs in this class include:
1227:. You can help Knowledge by
762:Low-molecular-weight heparin
573:Phosphodiesterase inhibitors
486:Acetylsalicylic acid/Aspirin
16:Class of chemical compounds
1295:
1198:
1156:
734:(with some II inhibition)
246:10.1016/j.ahj.2008.06.005
1215:article relating to the
1044:Plasminogen activators
516:Thromboxane inhibitors
440:Prostaglandin analogue
46:
36:
26:
1106:serine endopeptidases
640:Vitamin K antagonists
42:
32:
22:
1221:blood forming organs
853:Direct Xa inhibitors
685:Ethyl biscoumacetate
551:Receptor antagonists
496:Carbasalate calcium
240:(2 Suppl): S16–22.
1183:Never to phase III
1031:Thrombolytic drugs
747:glycosaminoglycans
320:Antiplatelet drugs
307:antiplatelet drugs
192:10.1007/BF03256587
47:
37:
27:
1236:
1235:
1193:
1192:
1025:
1024:
895:
894:
625:
624:
155:10.1159/000357399
1286:
1257:
1250:
1243:
1207:
1200:
1005:Drotrecogin alfa
985:Antithrombin III
836:Dermatan sulfate
809:Oligosaccharides
738:
636:
372:ADP receptor/P2Y
325:
288:
281:
274:
265:
258:
257:
226:
220:
219:
174:
168:
167:
157:
133:
1294:
1293:
1289:
1288:
1287:
1285:
1284:
1283:
1274:Thienopyridines
1264:
1263:
1262:
1261:
1196:
1194:
1189:
1188:
1173:Clinical trials
1152:
1124:
1034:
1021:
968:
891:
847:
750:
745:
733:
724:
700:1,3-Indandiones
642:
621:
595:
567:
510:
472:
434:
386:Thienopyridines
375:
366:
314:
295:Antithrombotics
292:
262:
261:
228:
227:
223:
176:
175:
171:
135:
134:
127:
122:
114:
104:
88:(Effient), and
78:
70:
50:Thienopyridines
17:
12:
11:
5:
1292:
1290:
1282:
1281:
1276:
1266:
1265:
1260:
1259:
1252:
1245:
1237:
1234:
1233:
1208:
1191:
1190:
1187:
1186:
1185:
1184:
1181:
1170:
1164:
1158:
1157:
1154:
1153:
1151:
1150:
1145:
1140:
1134:
1132:
1126:
1125:
1123:
1122:
1117:
1112:
1102:
1097:
1092:
1087:
1086:
1085:
1080:
1072:
1071:
1070:
1065:
1060:
1055:
1040:
1038:
1027:
1026:
1023:
1022:
1020:
1019:
1014:
1009:
1008:
1007:
997:
992:
987:
982:
976:
974:
970:
969:
967:
966:
961:
956:
951:
946:
941:
932:
931:
930:
925:
920:
905:
903:
897:
896:
893:
892:
890:
889:
884:
879:
874:
869:
864:
858:
856:
849:
848:
846:
845:
844:
843:
838:
833:
823:
822:
821:
816:
806:
805:
804:
799:
794:
789:
784:
779:
774:
769:
758:
756:
735:
726:
725:
723:
722:
716:
711:
706:
697:
692:
687:
682:
677:
672:
662:
660:
633:
631:Anticoagulants
627:
626:
623:
622:
620:
619:
614:
609:
603:
601:
597:
596:
594:
593:
588:
583:
577:
575:
569:
568:
566:
565:
564:
563:
558:
548:
547:
546:
541:
536:
520:
518:
512:
511:
509:
508:
503:
498:
493:
488:
482:
480:
478:COX inhibitors
474:
473:
471:
470:
465:
460:
455:
449:
447:
436:
435:
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432:
431:
430:
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403:
398:
393:
382:
380:
373:
368:
367:
365:
364:
359:
354:
349:
344:
339:
333:
331:
322:
316:
315:
303:anticoagulants
293:
291:
290:
283:
276:
268:
260:
259:
221:
169:
148:(4): 211–219.
124:
123:
121:
118:
112:
103:
100:
77:
74:
69:
66:
15:
13:
10:
9:
6:
4:
3:
2:
1291:
1280:
1277:
1275:
1272:
1271:
1269:
1258:
1253:
1251:
1246:
1244:
1239:
1238:
1232:
1230:
1226:
1222:
1218:
1214:
1209:
1206:
1202:
1197:
1182:
1180:
1177:
1176:
1174:
1171:
1168:
1165:
1163:
1160:
1159:
1155:
1149:
1146:
1144:
1141:
1139:
1136:
1135:
1133:
1131:
1130:Non-medicinal
1127:
1121:
1118:
1116:
1113:
1111:
1107:
1103:
1101:
1100:Streptokinase
1098:
1096:
1093:
1091:
1088:
1084:
1081:
1079:
1076:
1075:
1073:
1069:
1066:
1064:
1061:
1059:
1056:
1054:
1051:
1050:
1049:
1045:
1042:
1041:
1039:
1037:
1036:fibrinolytics
1032:
1028:
1018:
1015:
1013:
1010:
1006:
1003:
1002:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
978:
977:
975:
971:
965:
962:
960:
957:
955:
952:
950:
947:
945:
942:
940:
936:
933:
929:
926:
924:
921:
919:
916:
915:
914:
910:
907:
906:
904:
902:
898:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
859:
857:
854:
850:
842:
839:
837:
834:
832:
829:
828:
827:
824:
820:
817:
815:
812:
811:
810:
807:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
764:
763:
760:
759:
757:
754:
748:
743:
739:
736:
731:
727:
721:
717:
715:
712:
710:
707:
705:
701:
698:
696:
693:
691:
690:Phenprocoumon
688:
686:
683:
681:
678:
676:
675:Coumatetralyl
673:
671:
670:Acenocoumarol
667:
664:
663:
661:
658:
654:
650:
646:
641:
637:
634:
632:
628:
618:
615:
613:
610:
608:
605:
604:
602:
598:
592:
589:
587:
584:
582:
579:
578:
576:
574:
570:
562:
559:
557:
554:
553:
552:
549:
545:
542:
540:
537:
534:
530:
527:
526:
525:
522:
521:
519:
517:
513:
507:
504:
502:
499:
497:
494:
492:
489:
487:
484:
483:
481:
479:
475:
469:
466:
464:
461:
459:
456:
454:
451:
450:
448:
445:
441:
437:
429:
426:
424:
421:
419:
416:
415:
413:
409:
406:
402:
399:
397:
394:
392:
389:
388:
387:
384:
383:
381:
379:
376:
369:
363:
360:
358:
355:
353:
350:
348:
345:
343:
340:
338:
335:
334:
332:
330:
326:
323:
321:
317:
312:
308:
304:
300:
299:thrombolytics
296:
289:
284:
282:
277:
275:
270:
269:
266:
255:
251:
247:
243:
239:
235:
231:
230:Angiolillo DJ
225:
222:
217:
213:
209:
205:
201:
197:
193:
189:
186:(2): 91–112.
185:
181:
173:
170:
165:
161:
156:
151:
147:
143:
139:
132:
130:
126:
119:
117:
115:
108:
101:
99:
97:
93:
91:
87:
83:
75:
73:
68:Clinical Uses
67:
65:
63:
59:
55:
51:
45:
41:
35:
31:
25:
21:
1229:expanding it
1210:
1195:
1120:Fibrinolysin
1090:Anistreplase
1068:Desmoteplase
1063:Tenecteplase
964:Ximelagatran
814:Fondaparinux
753:antithrombin
709:Diphenadione
586:Dipyridamole
529:Dipyridamole
468:Treprostinil
463:Prostacyclin
385:
342:Eptifibatide
237:
233:
224:
183:
179:
172:
145:
141:
105:
102:Alternatives
94:
79:
71:
54:ADP receptor
49:
48:
1169:from market
990:Defibrotide
918:Bivalirudin
887:Rivaroxaban
826:Heparinoids
819:Idraparinux
720:Tioclomarol
714:Phenindione
704:Clorindione
607:Cloricromen
401:Ticlopidine
391:Clopidogrel
234:Am. Heart J
90:ticlopidine
82:clopidogrel
34:Clopidogrel
24:Ticlopidine
1268:Categories
1095:Monteplase
1012:Ramatroban
995:Nafamostat
980:Abelacimab
959:Melagatran
944:Dabigatran
939:Argatroban
882:Otamixaban
867:Betrixaban
855:("xabans")
841:Sulodexide
831:Danaparoid
802:Tinzaparin
792:Parnaparin
787:Nadroparin
782:Enoxaparin
777:Dalteparin
772:Certoparin
732:inhibitors
680:Dicoumarol
581:Cilostazol
561:Terutroban
539:Picotamide
428:Ticagrelor
412:nucleoside
408:Nucleotide
378:inhibitors
357:Sibrafiban
142:Cardiology
120:References
116:receptor.
107:Ticagrelor
96:Tinoridine
92:(Ticlid).
84:(Plavix),
1179:Phase III
1167:Withdrawn
1083:Urokinase
1078:Saruplase
1058:Reteplase
1053:Alteplase
1000:Protein C
954:Inogatran
949:Efegatran
935:Univalent
928:Lepirudin
923:Desirudin
872:Darexaban
797:Reviparin
767:Bemiparin
730:Factor Xa
666:Coumarins
643:(inhibit
617:Vorapaxar
591:Triflusal
556:Terbogrel
544:Terbogrel
533:+ aspirin
506:Triflusal
501:Indobufen
491:Aloxiprin
453:Beraprost
423:Elinogrel
418:Cangrelor
396:Prasugrel
362:Tirofiban
352:Roxifiban
347:Orbofiban
337:Abciximab
200:1175-3277
86:prasugrel
44:Prasugrel
909:Bivalent
877:Edoxaban
862:Apixaban
695:Warfarin
612:Ditazole
458:Iloprost
414:analogs
254:18657682
216:34689805
208:18422393
164:24458006
76:Examples
62:platelet
1148:Oxalate
1138:Citrate
1115:Brinase
913:Hirudin
742:Heparin
718:Other:
1162:WHO-EM
1110:Ancrod
1104:Other
751:(bind
744:group/
252:
214:
206:
198:
162:
1223:is a
1217:blood
1211:This
1048:r-tPA
973:Other
600:Other
212:S2CID
58:P2Y12
1225:stub
1219:and
1213:drug
1143:EDTA
1074:UPA
1017:REG1
444:PGI2
305:and
250:PMID
204:PMID
196:ISSN
160:PMID
649:VII
311:B01
309:) (
242:doi
238:156
188:doi
150:doi
146:127
111:P2Y
1270::
1175::
1108::
1046::
937::
911::
702::
668::
655:,
653:IX
651:,
647:,
645:II
374:12
301:,
248:.
236:.
210:.
202:.
194:.
182:.
158:.
144:.
140:.
128:^
113:12
1256:e
1249:t
1242:v
1231:.
1033:/
755:)
749:/
659:)
657:X
535:)
531:(
446:)
442:(
410:/
313:)
297:(
287:e
280:t
273:v
256:.
244::
218:.
190::
184:8
166:.
152::
56:/
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