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said in several interviews that the book is one of his favourites and influenced him a lot; "I love it because it shows science in action ― not like a textbook ― it shows people struggling with ambiguity and wrestling with all sorts of difficulty, and it’s very entertaining. For a while I would read
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noted Weiner's "keen sense of history: of traditions, connectedness, and chains of influence" that resulted in a "beautifully crafted study". She observed "the scientist's empathy for the 'timeless', 'fruitless', and 'dunce' mutants that are deficient in time, love, and memory. We discover that fruit
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wrote that the science in the book is "for the most part, accurate and clearly explained" and noted that "it is remarkable how much intellectual history has been spanned in Benzer's career". But, in his opinion "it never really attempts a critical evaluation of what fruitflies have contributed to our
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The book is focused on three of the most specific types of mutants found during this period: "'Time' mutants that have an altered circadian clock, 'Love' mutants that are unable to perform the fly's intricate courtship behavior properly, and 'Memory' mutants that are unable to learn or remember."
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The book received mostly positive reviews, with critics noting its scientific accuracy and that it is about a "fascinating history". Reviews by the biologists, noted that Weiner "never really attempts a critical evaluation of what fruitflies have contributed to our understanding of behavior", and
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mostly positively, but criticized the portrayal of Max Delbrück in the book; "I don’t think Weiner quite captured the essence of Delbrück; his immense intellect, his unique personality, his moral integrity, and his almost magical influence on people who came into contact with him." One more flaw
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noted that while Benzer's work is highly influential in genetics "Benzer is little more than a footnote in most textbooks. Due to the highly private life he led, his unusual dusk to dawn working hours, and his tendency to keep to the fringes of scientific research, Benzer's story has long gone
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Benzer studied time, love and memory in fruit flies to see how genes govern behavior. Fruit flies wake up at dawn and go to sleep at night even when they are in a sealed room and never see the sun. Fruit flies also have elaborate courtship rituals and mating behavior: love. And surprisingly,
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flies can learn, and we see scientists grappling with the questions of what free will might mean – and whether it matters." Additionally, she remarked on "the allusions to philosophy, literature, and popular culture" that "are much richer than in most history of science writing".
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wrote that Weiner is good in "explaining the science with you-are-there descriptions of lab life and personalities" and "telling anecdotes that reveal the humor, quirks, frustration, anger, and rewards of being a scientist". The
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isolated by countercurrent distribution", he showed "that one can treat a fly as an 'atom of behavior' and profoundly change its behavior by introducing single-gene mutations". Benzer worked with flies from 1967 to 1980.
328:"points the way and provides the conceptual framework for the study of clocks in other organisms", but, in comparison, it contributed less into fields of learning and memory. Despite these points, Jan called
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geneticists succeeded in isolating 'atoms of behavior', as Benzer once hoped? For Weiner's three core examples—time, love and memory—I would answer no, not yet, and a tentative yes." Historian of biology
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noted that the book is about a "fascinating history", but stated that "in the second half of the book we almost lose sight of Benzer and we sometimes lose Weiner's narrative thread as well".
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events in a gene. When this field of study became more popular, Benzer abandoned it and started to work on a completely new area; that was very characteristic of Benzer throughout his career.
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model was correct, "then each gene is not a mathematical point but a linear segment, and that crossing-over should be able to occur within a gene." Benzer spent the next 10 years studying the
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Benzer was interested by how different the personalities of his two daughters were. As the environment was the same, he reasoned that the cause should be in the genes. He chose
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highlighted in the review is Weiner's treatment of the three titular mutations as "parallel and equal stories"; in Jan's view the work on
181:. After the course Benzer decided to change his career and became a biologist. For the next several years he worked with DelbrĂĽck and his
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of phage mutants, as it was found to be very suitable and "an extraordinarily sensitive and simple assay" for detection of rare
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experiments have proved that flies can learn, for example, how to avoid electric shocks. That is, they have memory.
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criticized the portrayal of Max DelbrĂĽck in the book; however, all the critics were very positive in their reviews.
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unheralded." The review praised the book for unfolding the story of Benzer's life and work.
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received several reviews in peer-reviewed journals. Charles
Jennings in his 1999 review for
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Time, Love, Memory: A Great
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Seymour Benzer in his office at
Caltech in 1974 with a big model of
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was thought to be an indivisible entity; Benzer realized that if
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506:Jennings, Charles (July 1999). "Flies by night".
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410:References
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