Knowledge

VK2809

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163: 29: 432: 339:
Zhou, Jin; Waskowicz, Lauren R.; Lim, Andrea; Liao, Xiao-Hui; Lian, Brian; Masamune, Hiroko; Refetoff, Samuel; Tran, Brian; Koeberl, Dwight D.; Yen, Paul M. (1 August 2019).
402: 300:"Thyromimetics as emerging therapeutic agents for nonalcoholic steatohepatitis: rationale for the development of resmetirom (MGL-3196)" 422: 253: 57: 427: 412: 249: 122: 142: 273: 245: 341:"A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia" 158: 82: 407: 378: 360: 321: 417: 368: 352: 311: 179: 91: 241: 131: 162: 373: 340: 73:)-4-(3-Chlorophenyl)-2-methyl}-3,5-dimethylphenoxy)methyl]-1,3,2λ-dioxaphosphinan-2-one 396: 234: 316: 299: 212: 364: 325: 382: 356: 102: 111: 237: 20: 433:
Experimental drugs developed for non-alcoholic fatty liver disease
28: 147: 211: 178: 173: 141: 121: 101: 81: 48: 40: 35: 90: 8: 19: 161: 27: 372: 315: 248:in a phase II trial for the treatment of 130: 304:Expert Opinion on Investigational Drugs 265: 240:whose active form is selective for the 157: 110: 62: 403:Thyroid hormone receptor beta agonists 18: 7: 252:and is also being investigated for 298:Alkhouri, Naim (1 February 2020). 244:isoform. It is being developed by 205: 14: 254:glycogen storage disease type Ia 196: 190: 199: 184: 1: 317:10.1080/13543784.2020.1708899 250:nonalcoholic steatohepatitis 449: 174:Chemical and physical data 53: 26: 423:3-Chlorophenyl compounds 357:10.1089/thy.2019.0007 428:Isopropyl compounds 413:Dioxaphosphorinanes 278:Viking Therapeutics 246:Viking Therapeutics 229:(formerly known as 23: 224: 223: 143:CompTox Dashboard 16:Chemical compound 440: 387: 386: 376: 351:(8): 1158–1167. 336: 330: 329: 319: 295: 289: 288: 286: 284: 270: 219: 207: 201: 198: 192: 186: 166: 165: 151: 149: 134: 114: 94: 44:VK-2809; MB07811 31: 24: 22: 448: 447: 443: 442: 441: 439: 438: 437: 393: 392: 391: 390: 338: 337: 333: 297: 296: 292: 282: 280: 272: 271: 267: 262: 217: 204: 195: 189: 169: 159:DTXSID501005783 145: 137: 117: 97: 77: 74: 61: 60: 17: 12: 11: 5: 446: 444: 436: 435: 430: 425: 420: 415: 410: 405: 395: 394: 389: 388: 331: 290: 264: 263: 261: 258: 222: 221: 215: 209: 208: 202: 193: 187: 182: 176: 175: 171: 170: 168: 167: 154: 152: 139: 138: 136: 135: 127: 125: 119: 118: 116: 115: 107: 105: 99: 98: 96: 95: 87: 85: 79: 78: 76: 75: 64: 56: 55: 54: 51: 50: 46: 45: 42: 38: 37: 33: 32: 15: 13: 10: 9: 6: 4: 3: 2: 445: 434: 431: 429: 426: 424: 421: 419: 416: 414: 411: 409: 406: 404: 401: 400: 398: 384: 380: 375: 370: 366: 362: 358: 354: 350: 346: 342: 335: 332: 327: 323: 318: 313: 310:(2): 99–101. 309: 305: 301: 294: 291: 279: 275: 269: 266: 259: 257: 255: 251: 247: 243: 239: 236: 232: 228: 216: 214: 210: 183: 181: 177: 172: 164: 160: 156: 155: 153: 144: 140: 133: 129: 128: 126: 124: 120: 113: 109: 108: 106: 104: 100: 93: 89: 88: 86: 84: 80: 72: 68: 63: 59: 52: 47: 43: 39: 36:Clinical data 34: 30: 25: 348: 344: 334: 307: 303: 293: 283:15 September 281:. Retrieved 277: 268: 235:thyromimetic 230: 226: 225: 70: 66: 220: g·mol 92:852948-13-1 49:Identifiers 41:Other names 397:Categories 260:References 213:Molar mass 132:3Z11398FNQ 83:CAS Number 58:IUPAC name 365:1050-7256 326:1354-3784 408:Prodrugs 383:31337282 274:"VK2809" 103:DrugBank 418:Phenols 374:6707038 345:Thyroid 238:prodrug 233:) is a 231:MB07811 180:Formula 112:DB15137 381:  371:  363:  324:  227:VK2809 218:514.98 21:VK2809 242:THR-β 379:PMID 361:ISSN 322:ISSN 285:2023 123:UNII 369:PMC 353:doi 312:doi 148:EPA 399:: 377:. 367:. 359:. 349:29 347:. 343:. 320:. 308:29 306:. 302:. 276:. 256:. 197:Cl 194:32 188:28 69:,4 65:(2 385:. 355:: 328:. 314:: 287:. 206:P 203:5 200:O 191:H 185:C 150:) 146:( 71:S 67:R

Index


IUPAC name
CAS Number
852948-13-1
DrugBank
DB15137
UNII
3Z11398FNQ
CompTox Dashboard
DTXSID501005783
Edit this at Wikidata
Formula
Molar mass
thyromimetic
prodrug
THR-β
Viking Therapeutics
nonalcoholic steatohepatitis
glycogen storage disease type Ia
"VK2809"
"Thyromimetics as emerging therapeutic agents for nonalcoholic steatohepatitis: rationale for the development of resmetirom (MGL-3196)"
doi
10.1080/13543784.2020.1708899
ISSN
1354-3784
"A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia"
doi
10.1089/thy.2019.0007
ISSN
1050-7256

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