129:
473:). New subgroups can be added to experiment with a different dosing regimen as long as the previous subgroup did not experience SAEs. There are variations in the vaccination order that can be used for different studies. For example, the first subgroup could complete the entire regimen before the second subgroup starts or the second can begin before the first ends as long as SAEs were not detected. The vaccination schedule will vary depending on the nature of the drug (i.e. the need for a booster or several doses over the course of short time period). Escalation studies are ideal for minimizing risks for SAEs that could occur with less controlled and divided protocols.
3740:
27:
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119:
3752:
923:, Piotr, Eric K. France, Frank Destefano, Steven B. Black, Henry Shinefield, Joel I. Ward, Emily J. Chang et al. "Population-based study of rotavirus vaccination and intussusception." The Pediatric infectious disease journal 20, no. 4 (2001): 410-416.] The rotavirus vaccine originated in 1998 and was withdrawn in 1999.
4134:
469:
increasing the drug dosage or frequency. The first level of an escalation study usually has two or three groups of around 10 healthy volunteers. Each subgroup receives the same vaccine dose, which is the expected lowest dose necessary to invoke an immune response (the main goal in a vaccine – to create
518:
trials are typically monitor stages that collect information continuously on vaccine usage, adverse effects, and long-term immunity after the vaccine is licensed and marketed. Harmful effects, such as increased risk of liver failure or heart attacks, discovered by Phase IV trials may result in a drug
468:
One typical version of Phase I studies in vaccines involves an escalation study, which is used in mainly medicinal research trials. The drug is introduced into a small cohort of healthy volunteers. Vaccine escalation studies aim to minimize chances of serious adverse effects (SAE) by slowly
489:
and toxicity results from Phase I in a small cohort of healthy volunteers. Phase II will consist of more healthy volunteers in the vaccine target population (~ hundreds of people) to determine reactions in a more diverse set of humans and test different schedules.
502:
trials continue to monitor toxicity, immunogenicity, and SAEs on a much larger scale. The vaccine must be shown to be safe and effective in natural disease conditions before being submitted for approval and then general production. In the United States, the
3550:
3957:
417:
The Phase I study consists of introducing the vaccine candidate to assess its safety in healthy people. A vaccine Phase I trial involves normal healthy subjects, each tested with either the candidate vaccine or a
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612:
37:
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2099:
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Some vaccine trials may take months or years to complete, depending on the time required for the subjects to react to the vaccine and develop the required
3998:
4685:
4651:
3585:
942:
409:; however, in vaccine studies it is essential to understand toxic effects at all possible dosage levels and the interactions with the immune system.
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A vaccine candidate drug is first identified through preclinical evaluations that could involve high throughput screening and selecting the proper
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2437:
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653:
919:
Penina Haber, MPH; Frank DeStefano, MD, MPH; Fredrick J. Angulo, DVM, PhD; et al, Guillain-Barré Syndrome
Following Influenza Vaccination, 2004,
4711:
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as a part of vaccine preclinical protocol in hopes to more accurately determine drug reactions in humans. Understanding vaccine safety and the
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1292:
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2019:
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544:
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of the vaccine are also noted, and these contribute to the decision on whether to advance the candidate vaccine to a Phase II trial.
3658:
3184:
2767:
2085:
1431:
4787:
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3892:
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1998:
973:
639:
Neurovirulence Test of Types 1, 2 or 3 Live attenuated
Poliomyelitis vaccines (Oral) in Transgenic Mice susceptible to Poliovirus
3943:
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3000:
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2060:
515:
499:
482:
450:
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production, on health outcomes (such as illness due to the targeted infection or to another infection). Following the
371:
680:"Models of Phase 1 vaccine trials: optimization of trial design to minimize risks of multiple serious adverse events"
77:
370:
This is also the stage in which the drug candidate may be first tested in laboratory animals prior to moving to the
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1022:
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423:
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56:
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462:
458:
306:
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3149:
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2315:
2263:
2143:
1602:
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1562:
1557:
84:
4135:
Departments of Labor, Health and Human
Services, and Education, and Related Agencies Appropriations Act, 2008
4539:
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2403:
2361:
2339:
2309:
2209:
2153:
2136:
2048:
1981:
1962:
1758:
1730:
1692:
1687:
1667:
1195:
364:
3219:
2512:
2270:
367:
stages are necessary to determine the immunogenicity potential and safety profile for a vaccine candidate.
4330:
4149:
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1958:
957:
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270:
137:
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2240:
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2148:
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2024:
1858:
1853:
1309:
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1165:
430:-containing cocktail, or an established vaccine (which might be intended to protect against a different
275:
194:
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4833:
4185:
4169:
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3325:
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1907:
1848:
1639:
1282:
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1111:
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1012:
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299:
280:
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respectively. Thus, the fourth phase of clinical trials is used to ensure long-term vaccine safety.
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1986:
1953:
1932:
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265:
232:
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152:
747:"Biologics License Applications (BLA) Process (Biologics) – Vaccine Product Approval Process"
4752:
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of the observed differences in the outcomes between the treatment and control groups.
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237:
217:
855:
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After the administration of the vaccine or placebo, the researchers collect data on
401:, are necessary components of the preclinical stage. Other drug trials focus on the
378:
have been first tested for adverse effects and immunogenicity in monkeys as well as
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3711:
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2014:
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179:
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2700:
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2413:
1976:
1547:
1420:
989:
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133:
906:
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703:
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383:
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981:
346:
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184:
141:
55:
if you can. Unsourced or poorly sourced material may be challenged and
519:
being no longer sold, or restricted to certain uses; examples include
4262:
3263:
1840:
1825:
1116:
605:"How are Vaccines Made? Vaccine Development, Testing, and Regulation"
434:). The primary observation is for detection of safety (absence of an
838:
821:
679:
3425:
1835:
1720:
1326:
1260:
127:
3780:
4165:
Biodefense and
Pandemic Vaccine and Drug Development Act of 2005
3357:
2608:
1135:
642:. Standard Operating Procedure. World Health Organization. 2015.
3916:
3784:
2612:
2081:
946:
921:
https://jamanetwork.com/journals/jama/fullarticle/199859Kramarz
20:
3551:
Committee on the
Environment, Public Health and Food Safety
939:
Information regarding preventative vaccine research studies
575:. Statistics for biology and health. New York: Springer.
52:
820:
Faich, Gerald A.; Moseley, Richard H. (October 2001).
773:"Rofecoxib (Vioxx) voluntarily withdrawn from market"
875:
Current
Controlled Trials in Cardiovascular Medicine
4740:
4698:
4471:
4425:
4354:
4301:
4272:
4214:
4178:
4120:
4012:
3981:
3950:
3864:
3816:
3669:
3628:
3515:
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3441:
3366:
3282:
3210:
3115:
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2503:
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2402:
2376:
2338:
2308:
2299:
2225:
2172:
2119:
2007:
1946:
1878:
1769:
1741:
1708:
1382:
1213:
1206:
1125:
1053:
1005:
4145:Countermeasures Injury Compensation Program (CICP)
871:"Withdrawal of cerivastatin from the world market"
656:. US Food and Drug Administration. 30 January 2018
4803:Shoulder injury related to vaccine administration
4129:Cedillo v. Secretary of Health and Human Services
1993:Cedillo v. Secretary of Health and Human Services
4515:Association of American Physicians and Surgeons
4319:Joint Committee on Vaccination and Immunisation
745:Research, Center for Biologics Evaluation and.
4309:National Immunization Technical Advisory Group
389:Recent scientific advances have helped to use
51:Please review the contents of the article and
3928:
3796:
2624:
2093:
958:
720:Bloom, Barry R.; Lambert, Paul-Henri (2003).
611:. The College of Physicians of Philadelphia.
507:(FDA) is responsible for approving vaccines.
307:
8:
4525:Children's Medical Safety Research Institute
4495:Children's Medical Safety Research Institute
4314:Advisory Committee on Immunization Practices
4140:National Vaccine Injury Compensation Program
632:
630:
132:Volunteer participating in phase 3 trial of
4535:New Jersey Coalition for Vaccination Choice
4500:New Jersey Coalition for Vaccination Choice
822:"Troglitazone (Rezulin) and hepatic injury"
4686:Warnings About Vaccination Expectations NZ
4661:
4652:National League for Liberty in Vaccination
4637:
4603:
4564:
4475:
4093:
3935:
3921:
3913:
3902:
3868:
3803:
3789:
3781:
3586:Centers for Disease Control and Prevention
3512:
2631:
2617:
2609:
2305:
2100:
2086:
2078:
1210:
965:
951:
943:
314:
300:
147:
3546:Centre for Disease Prevention and Control
3536:Center for Disease Control and Prevention
896:
886:
837:
796:
334:that aims at establishing the safety and
2392:Preventable fraction among the unexposed
2388:Attributable fraction for the population
4082:Measles resurgence in the United States
3883:1990–1991 Philadelphia measles outbreak
3591:Health departments in the United States
2396:Preventable fraction for the population
2384:Attributable fraction among the exposed
869:Furberg, Curt D; Pitt, Bertram (2001).
556:
159:
4712:Vaccine Adverse Event Reporting System
4346:Northern Rivers Vaccination Supporters
3596:Council on Education for Public Health
573:Design and analysis of vaccine studies
531:(Vioxx). Further examples include the
4160:National Childhood Vaccine Injury Act
3654:Professional degrees of public health
3561:Ministry of Health and Family Welfare
615:from the original on 10 December 2022
7:
4618:Australian Vaccination-risks Network
3751:
3644:Bachelor of Science in Public Health
2559:Correlation does not imply causation
2475:Animal testing on non-human primates
826:Pharmacoepidemiology and Drug Safety
777:Canadian Medical Association Journal
715:
713:
673:
671:
4793:Anti-vaccinationism in chiropractic
4530:National Vaccine Information Center
4510:Anti-Vaccination Society of America
4336:Strategic Advisory Group of Experts
4108:Mumps outbreaks in the 21st century
3763:
2912:Workers' right to access the toilet
2753:Human right to water and sanitation
3841:Oral polio vaccine AIDS hypothesis
3831:Blood-injection-injury type phobia
2020:Eradication of infectious diseases
1777:Androvax (androstenedione albumin)
654:"Vaccine product approval process"
523:(brand names Baycol and Lipobay),
14:
3185:Commercial determinants of health
1610:Respiratory syncytial virus (RSV)
571:; Struchiner, Claudio J. (2010).
4788:Alternative vaccination schedule
4579:National Anti-Vaccination League
3958:Democratic Republic of the Congo
3893:2018 Madagascar measles outbreak
3762:
3750:
3739:
3738:
2768:National public health institute
1999:Alternative vaccination schedule
974:Artificial induction of immunity
117:
25:
4773:2000 Simpsonwood CDC conference
4505:Informed Consent Action Network
3982:1,000 to 10,000 confirmed cases
3165:Open-source healthcare software
2907:Sociology of health and illness
771:Sibbald, B. (26 October 2004).
4768:Vaccine-induced seropositivity
4628:Informed Medical Options Party
4545:The Autism Community in Action
3526:Caribbean Public Health Agency
3338:Sexually transmitted infection
3235:Statistical hypothesis testing
2996:Occupational safety and health
2897:Sexual and reproductive health
2810:Occupational safety and health
2442:Pre- and post-test probability
2164:Patient and public involvement
1831:Ovandrotone albumin (Fecundin)
539:, which increased the risk of
349:to invoke an immune response.
53:add the appropriate references
1:
4206:Vaccine Information Statement
3888:2013 Swansea measles epidemic
3180:Social determinants of health
1367:Group B streptococcal disease
1186:Vaccines for Children Program
696:10.1016/j.vaccine.2004.10.048
374:trials. Vaccines such as the
3240:Analysis of variance (ANOVA)
3001:Human factors and ergonomics
2569:Sex as a biological variable
505:Food and Drug Administration
342:prior to it being licensed.
4594:Pioneer Club (women's club)
4555:World Chiropractic Alliance
4326:Patient safety organization
4244:Melanie's Marvelous Measles
3944:2019–2020 measles outbreaks
3421:Good manufacturing practice
3225:Randomized controlled trial
2533:Intention-to-treat analysis
2505:Analysis of clinical trials
2434:Specificity and sensitivity
2188:Randomized controlled trial
38:reliable medical references
4860:
4783:Vaccine-associated sarcoma
4717:Number needed to vaccinate
4676:Stop Mandatory Vaccination
4623:Church of Conscious Living
3951:>10,000 confirmed cases
3491:Theory of planned behavior
3416:Good agricultural practice
3321:Public health surveillance
3213:epidemiological statistics
2857:Public health intervention
678:Saul, Allan (April 2005).
457:is performed to gauge the
4671:
4664:
4647:
4640:
4613:
4606:
4574:
4567:
4550:Texans for Vaccine Choice
4520:Children's Health Defense
4485:
4478:
4472:Anti-vaxxer organizations
4426:Anti-vaxxer personalities
4179:Vaccine safety procedures
4103:
4096:
4078:
4013:<1,000 confirmed cases
3912:
3905:
3878:
3871:
3734:
3613:World Toilet Organization
3608:World Health Organization
3175:Public health informatics
2882:Right to rest and leisure
2711:Globalization and disease
2577:
2542:Interpretation of results
2275:Nested case–control study
2038:
422:" treatment, typically a
44:or relies too heavily on
4758:Vaccination and religion
4480:United States of America
3659:Schools of public health
3451:Diffusion of innovations
3150:Health impact assessment
2862:Public health laboratory
2758:Management of depression
2144:Academic clinical trials
1362:Clostridioides difficile
459:statistical significance
397:to the vaccine, such as
4540:Palmetto Family Council
4201:Vaccine Safety Datalink
3846:Thiomersal and vaccines
3722:Social hygiene movement
3649:Doctor of Public Health
3481:Social cognitive theory
3283:Infectious and epidemic
3065:Fecal–oral transmission
2362:Relative risk reduction
2210:Adaptive clinical trial
2154:Evidence-based medicine
2137:Adaptive clinical trial
1620:Tick-borne encephalitis
937:Vaccine Research Center
541:Guillain-Barré syndrome
365:Preclinical development
144:, West Java, Indonesia.
4331:Brighton Collaboration
4150:Vaccine Damage Payment
3836:MMR vaccine and autism
3717:Germ theory of disease
3496:Transtheoretical model
2350:Number needed to treat
2030:List of vaccine topics
1030:Mathematical modelling
565:Halloran, M. Elizabeth
395:immunological response
271:Vaccine misinformation
145:
138:Padjadjaran University
4844:Design of experiments
4778:Vaccine adverse event
4732:Immunization registry
4681:Vaccine Choice Canada
4443:Robert F. Kennedy Jr.
4341:Immunization Alliance
4285:Dengvaxia controversy
3601:Public Health Service
3486:Social norms approach
3476:PRECEDE–PROCEED model
2922:Preventive healthcare
2815:Pharmaceutical policy
2664:Chief Medical Officer
2354:Number needed to harm
2241:Cross-sectional study
2193:Scientific experiment
2149:Clinical study design
2025:Vaccinate Your Family
1476:Japanese encephalitis
276:Anti-vaccine activism
228:Measles/Mumps/Rubella
195:COVID-19 vaccine card
131:
4186:Vaccine vial monitor
4170:Operation Warp Speed
3677:Sara Josephine Baker
3576:Public Health Agency
3461:Health communication
3326:Disease surveillance
3292:Asymptomatic carrier
3274:Statistical software
2962:Preventive nutrition
2790:Medical anthropology
2679:Environmental health
2320:Cumulative incidence
1908:John Franklin Enders
789:10.1503/cmaj.1041606
281:Vaccine line jumping
4589:Humanitarian League
3851:Vaccines and autism
3687:Carl Rogers Darnall
3682:Samuel Jay Crumbine
3456:Health belief model
3309:Notifiable diseases
3245:Regression analysis
3080:Waterborne diseases
2669:Cultural competence
2227:Observational study
2159:Real world evidence
2113:experimental design
1094:Virus-like particle
1018:Vaccine ingredients
888:10.1186/cvm-2-5-205
609:History of Vaccines
569:Longini, Ira M. Jr.
169:General information
4727:Yellow Card Scheme
4463:Ethan Lindenberger
4433:Taylor Winterstein
4417:Michael Pichichero
4402:H. Vasken Aposhian
4155:Vaccination policy
3865:Disease resurgence
3285:disease prevention
3220:Case–control study
2892:Security of person
2741:Health care reform
2513:Risk–benefit ratio
2480:First-in-man study
2430:Case fatality rate
2271:Case–control study
2245:Longitudinal study
2065:Never to phase III
1864:Hexavalent vaccine
1678:Epstein–Barr virus
1573:Oxford–AstraZeneca
1266:NmVac4-A/C/Y/W-135
724:. Academic Press.
481:The transition to
440:an immune response
438:) and evidence of
391:transgenic animals
380:non-human primates
376:oral polio vaccine
286:Vaccine resistance
146:
4839:Clinical research
4816:
4815:
4694:
4693:
4660:
4659:
4636:
4635:
4602:
4601:
4563:
4562:
4215:Anti-vaxxer media
4116:
4115:
4092:
4091:
4088:
4087:
4040:Pacific Northwest
3901:
3900:
3856:Vaccines and SIDS
3818:Vaccine hesitancy
3778:
3777:
3730:
3729:
3640:Higher education
3471:Positive deviance
3466:Health psychology
3442:Health behavioral
3369:safety management
3343:Social distancing
3117:Population health
3097:Smoking cessation
3045:Pharmacovigilance
3016:Injury prevention
2984:Infection control
2902:Social psychology
2852:Prisoners' rights
2795:Medical sociology
2763:Public health law
2659:Biological hazard
2606:
2605:
2554:Survivorship bias
2518:Systematic review
2485:Multicenter trial
2448:
2447:
2438:Likelihood-ratios
2410:Clinical endpoint
2378:Population impact
2332:Period prevalence
2109:Clinical research
2075:
2074:
1987:Vaccines and SIDS
1874:
1873:
1648:Hepatitis A and B
1624:Varicella zoster
1086:Subunit/component
731:978-0-12-107258-2
690:(23): 3068–3075.
582:978-0-387-40313-7
537:rotavirus vaccine
533:swine flu vaccine
360:Preclinical stage
324:
323:
266:Vaccine hesitancy
126:
125:
102:
4851:
4753:Vaccine shedding
4748:Vaccine efficacy
4662:
4638:
4604:
4584:Homeopathy Plus!
4565:
4476:
4453:Andrew Wakefield
4293:MMR autism fraud
4237:Hear the Silence
4230:The Greater Good
4094:
3937:
3930:
3923:
3914:
3903:
3869:
3805:
3798:
3791:
3782:
3766:
3765:
3754:
3753:
3742:
3741:
3636:Health education
3513:
3367:Food hygiene and
3348:Tropical disease
3160:Infant mortality
3135:Community health
3011:Controlled Drugs
2947:Health promotion
2877:Right to housing
2721:Health economics
2633:
2626:
2619:
2610:
2453:Trial/test types
2328:Point prevalence
2306:
2249:Ecological study
2232:EBM II-2 to II-3
2203:Open-label trial
2198:Blind experiment
2174:Controlled study
2102:
2095:
2088:
2079:
1966:MMR autism fraud
1913:Maurice Hilleman
1898:Hilary Koprowski
1211:
967:
960:
953:
944:
924:
917:
911:
910:
900:
890:
866:
860:
859:
841:
817:
811:
810:
800:
783:(9): 1027–1028.
768:
762:
761:
759:
757:
742:
736:
735:
722:The Vaccine Book
717:
708:
707:
675:
666:
665:
663:
661:
650:
644:
643:
634:
625:
624:
622:
620:
601:
595:
594:
561:
455:statistical test
453:, the specified
407:pharmacokinetics
403:pharmacodynamics
316:
309:
302:
148:
121:
120:
112:
109:
103:
101:
60:
29:
28:
21:
4859:
4858:
4854:
4853:
4852:
4850:
4849:
4848:
4819:
4818:
4817:
4812:
4736:
4690:
4667:
4656:
4643:
4632:
4609:
4598:
4570:
4559:
4481:
4467:
4438:Jeanette Wilson
4421:
4377:Frank DeStefano
4350:
4297:
4268:
4223:Deadly Immunity
4210:
4174:
4112:
4099:
4084:
4074:
4058:(113 suspected)
4008:
3977:
3964:, 7,018 deaths)
3946:
3941:
3908:
3897:
3874:
3860:
3812:
3809:
3779:
3774:
3726:
3697:Margaret Sanger
3665:
3624:
3508:
3506:
3500:
3443:
3437:
3409:Safety scandals
3368:
3362:
3284:
3278:
3212:
3206:
3202:Social medicine
3195:Race and health
3130:Child mortality
3111:
3070:Open defecation
2952:Human nutrition
2942:Family planning
2930:Behavior change
2916:
2872:Right to health
2785:Maternal health
2775:Health politics
2726:Health literacy
2642:
2637:
2607:
2602:
2573:
2537:
2499:
2444:
2398:
2372:
2346:Risk difference
2334:
2295:
2229:
2221:
2176:
2168:
2132:Trial protocols
2115:
2106:
2076:
2071:
2070:
2055:Clinical trials
2034:
2003:
1942:
1918:Stanley Plotkin
1880:
1870:
1782:Cancer vaccines
1765:
1759:Schistosomiasis
1737:
1731:Trypanosomiasis
1704:
1668:Cytomegalovirus
1578:Pfizer–BioNTech
1378:
1202:
1151:Vaccine wastage
1121:
1049:
1001:
971:
933:
928:
927:
918:
914:
868:
867:
863:
839:10.1002/pds.652
819:
818:
814:
770:
769:
765:
755:
753:
744:
743:
739:
732:
719:
718:
711:
677:
676:
669:
659:
657:
652:
651:
647:
636:
635:
628:
618:
616:
603:
602:
598:
583:
563:
562:
558:
553:
545:intussusception
513:
496:
479:
415:
362:
320:
291:
290:
256:
248:
247:
208:
200:
199:
170:
122:
118:
113:
107:
104:
67:"Vaccine trial"
61:
50:
46:primary sources
30:
26:
17:
12:
11:
5:
4857:
4855:
4847:
4846:
4841:
4836:
4831:
4821:
4820:
4814:
4813:
4811:
4810:
4805:
4800:
4795:
4790:
4785:
4780:
4775:
4770:
4765:
4763:Marker vaccine
4760:
4755:
4750:
4744:
4742:
4738:
4737:
4735:
4734:
4729:
4724:
4719:
4714:
4708:
4706:
4696:
4695:
4692:
4691:
4689:
4688:
4683:
4678:
4672:
4669:
4668:
4665:
4658:
4657:
4655:
4654:
4648:
4645:
4644:
4641:
4634:
4633:
4631:
4630:
4625:
4620:
4614:
4611:
4610:
4607:
4600:
4599:
4597:
4596:
4591:
4586:
4581:
4575:
4572:
4571:
4569:United Kingdom
4568:
4561:
4560:
4558:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4490:Learn The Risk
4486:
4483:
4482:
4479:
4473:
4469:
4468:
4466:
4465:
4460:
4458:Jenny McCarthy
4455:
4450:
4448:Joseph Mercola
4445:
4440:
4435:
4429:
4427:
4423:
4422:
4420:
4419:
4414:
4409:
4404:
4399:
4394:
4389:
4384:
4379:
4374:
4369:
4364:
4358:
4356:
4352:
4351:
4349:
4348:
4343:
4338:
4333:
4328:
4323:
4322:
4321:
4316:
4305:
4303:
4299:
4298:
4296:
4295:
4287:
4282:
4276:
4274:
4270:
4269:
4267:
4266:
4259:
4252:
4247:
4240:
4233:
4226:
4218:
4216:
4212:
4211:
4209:
4208:
4203:
4198:
4193:
4188:
4182:
4180:
4176:
4175:
4173:
4172:
4167:
4162:
4157:
4152:
4147:
4142:
4137:
4132:
4124:
4122:
4118:
4117:
4114:
4113:
4111:
4110:
4104:
4101:
4100:
4097:
4090:
4089:
4086:
4085:
4079:
4076:
4075:
4073:
4072:
4060:
4047:
4037:
4027:
4016:
4014:
4010:
4009:
4007:
4006:
3996:
3985:
3983:
3979:
3978:
3976:
3975:
3965:
3954:
3952:
3948:
3947:
3942:
3940:
3939:
3932:
3925:
3917:
3910:
3909:
3906:
3899:
3898:
3896:
3895:
3890:
3885:
3879:
3876:
3875:
3872:
3866:
3862:
3861:
3859:
3858:
3853:
3848:
3843:
3838:
3833:
3828:
3822:
3820:
3814:
3813:
3811:Vaccine safety
3810:
3808:
3807:
3800:
3793:
3785:
3776:
3775:
3773:
3772:
3760:
3748:
3735:
3732:
3731:
3728:
3727:
3725:
3724:
3719:
3714:
3709:
3704:
3699:
3694:
3689:
3684:
3679:
3673:
3671:
3667:
3666:
3664:
3663:
3662:
3661:
3656:
3651:
3646:
3638:
3632:
3630:
3626:
3625:
3623:
3622:
3615:
3610:
3605:
3604:
3603:
3598:
3593:
3588:
3580:
3579:
3578:
3573:
3565:
3564:
3563:
3555:
3554:
3553:
3548:
3540:
3539:
3538:
3530:
3529:
3528:
3519:
3517:
3510:
3505:Organizations,
3502:
3501:
3499:
3498:
3493:
3488:
3483:
3478:
3473:
3468:
3463:
3458:
3453:
3447:
3445:
3439:
3438:
3436:
3435:
3434:
3433:
3428:
3418:
3413:
3412:
3411:
3406:
3401:
3396:
3391:
3386:
3381:
3372:
3370:
3364:
3363:
3361:
3360:
3355:
3350:
3345:
3340:
3335:
3330:
3329:
3328:
3318:
3317:
3316:
3306:
3305:
3304:
3294:
3288:
3286:
3280:
3279:
3277:
3276:
3271:
3270:
3269:
3261:
3252:
3247:
3242:
3232:
3227:
3222:
3216:
3214:
3211:Biological and
3208:
3207:
3205:
3204:
3199:
3198:
3197:
3192:
3187:
3177:
3172:
3170:Multimorbidity
3167:
3162:
3157:
3152:
3147:
3142:
3137:
3132:
3127:
3121:
3119:
3113:
3112:
3110:
3109:
3107:Vector control
3104:
3099:
3094:
3092:School hygiene
3089:
3088:
3087:
3082:
3077:
3075:Sanitary sewer
3072:
3067:
3062:
3052:
3047:
3042:
3041:
3040:
3033:Patient safety
3030:
3029:
3028:
3023:
3018:
3013:
3008:
3003:
2993:
2992:
2991:
2986:
2981:
2976:
2966:
2965:
2964:
2959:
2949:
2944:
2939:
2938:
2937:
2926:
2924:
2918:
2917:
2915:
2914:
2909:
2904:
2899:
2894:
2889:
2884:
2879:
2874:
2869:
2864:
2859:
2854:
2849:
2848:
2847:
2842:
2837:
2832:
2827:
2817:
2812:
2807:
2797:
2792:
2787:
2782:
2777:
2772:
2771:
2770:
2765:
2755:
2750:
2745:
2744:
2743:
2738:
2728:
2723:
2718:
2716:Harm reduction
2713:
2708:
2703:
2698:
2697:
2696:
2691:
2681:
2676:
2671:
2666:
2661:
2656:
2650:
2648:
2644:
2643:
2638:
2636:
2635:
2628:
2621:
2613:
2604:
2603:
2601:
2600:
2597:List of topics
2593:
2586:
2578:
2575:
2574:
2572:
2571:
2566:
2561:
2556:
2551:
2549:Selection bias
2545:
2543:
2539:
2538:
2536:
2535:
2530:
2525:
2520:
2515:
2509:
2507:
2501:
2500:
2498:
2497:
2492:
2487:
2482:
2477:
2472:
2470:Animal testing
2467:
2462:
2456:
2454:
2450:
2449:
2446:
2445:
2422:Mortality rate
2408:
2406:
2400:
2399:
2382:
2380:
2374:
2373:
2344:
2342:
2336:
2335:
2314:
2312:
2303:
2297:
2296:
2294:
2293:
2288:
2283:
2278:
2268:
2267:
2266:
2261:
2251:
2237:
2235:
2223:
2222:
2220:
2219:
2218:
2217:
2215:Platform trial
2207:
2206:
2205:
2200:
2195:
2184:
2182:
2170:
2169:
2167:
2166:
2161:
2156:
2151:
2146:
2141:
2140:
2139:
2134:
2127:Clinical trial
2123:
2121:
2117:
2116:
2107:
2105:
2104:
2097:
2090:
2082:
2073:
2072:
2069:
2068:
2067:
2066:
2063:
2052:
2046:
2040:
2039:
2036:
2035:
2033:
2032:
2027:
2022:
2017:
2011:
2009:
2005:
2004:
2002:
2001:
1996:
1989:
1984:
1979:
1974:
1969:
1956:
1950:
1948:
1944:
1943:
1941:
1940:
1935:
1933:Katalin KarikĂł
1930:
1925:
1920:
1915:
1910:
1905:
1900:
1895:
1890:
1884:
1882:
1876:
1875:
1872:
1871:
1869:
1868:
1867:
1866:
1861:
1856:
1851:
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1828:
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1816:
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1809:
1799:
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1725:
1724:
1723:
1712:
1710:
1706:
1705:
1703:
1702:
1701:
1700:
1695:
1690:
1688:Herpes simplex
1685:
1680:
1675:
1670:
1662:
1661:
1660:
1655:
1650:
1642:
1637:
1636:
1635:
1630:
1622:
1617:
1612:
1607:
1606:
1605:
1600:
1595:
1590:
1588:Sinopharm BIBP
1585:
1580:
1575:
1570:
1565:
1560:
1555:
1550:
1545:
1540:
1538:Bharat Biotech
1535:
1525:
1520:
1515:
1510:
1509:
1508:
1503:
1493:
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1203:
1201:
1200:
1199:
1198:
1193:
1188:
1183:
1178:
1170:
1169:
1168:
1166:Vaccine injury
1163:
1158:
1153:
1148:
1143:
1138:
1129:
1127:
1126:Administration
1123:
1122:
1120:
1119:
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1109:
1100:
1083:
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1009:
1007:
1003:
1002:
972:
970:
969:
962:
955:
947:
941:
940:
932:
931:External links
929:
926:
925:
912:
881:(5): 205–207.
861:
832:(6): 537–547.
812:
763:
737:
730:
709:
667:
645:
626:
596:
581:
555:
554:
552:
549:
527:(Rezulin) and
512:
509:
495:
492:
485:relies on the
478:
475:
451:trial protocol
414:
411:
361:
358:
332:clinical trial
322:
321:
319:
318:
311:
304:
296:
293:
292:
289:
288:
283:
278:
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261:Vaccine equity
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108:September 2020
33:
31:
24:
16:Clinical trial
15:
13:
10:
9:
6:
4:
3:
2:
4856:
4845:
4842:
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4809:
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4804:
4801:
4799:
4798:CEASE therapy
4796:
4794:
4791:
4789:
4786:
4784:
4781:
4779:
4776:
4774:
4771:
4769:
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4454:
4451:
4449:
4446:
4444:
4441:
4439:
4436:
4434:
4431:
4430:
4428:
4424:
4418:
4415:
4413:
4410:
4408:
4405:
4403:
4400:
4398:
4395:
4393:
4390:
4388:
4387:Jeffrey Brent
4385:
4383:
4380:
4378:
4375:
4373:
4372:Riko Muranaka
4370:
4368:
4365:
4363:
4360:
4359:
4357:
4353:
4347:
4344:
4342:
4339:
4337:
4334:
4332:
4329:
4327:
4324:
4320:
4317:
4315:
4312:
4311:
4310:
4307:
4306:
4304:
4302:Organizations
4300:
4294:
4292:
4288:
4286:
4283:
4281:
4278:
4277:
4275:
4273:Controversies
4271:
4265:
4264:
4260:
4258:
4257:
4253:
4251:
4248:
4246:
4245:
4241:
4239:
4238:
4234:
4232:
4231:
4227:
4224:
4220:
4219:
4217:
4213:
4207:
4204:
4202:
4199:
4197:
4196:Vaccine trial
4194:
4192:
4189:
4187:
4184:
4183:
4181:
4177:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4146:
4143:
4141:
4138:
4136:
4133:
4131:
4130:
4126:
4125:
4123:
4119:
4109:
4106:
4105:
4102:
4095:
4083:
4077:
4070:
4066:
4065:
4061:
4059:
4056:, 15 deaths)
4055:
4051:
4048:
4045:
4041:
4038:
4035:
4031:
4028:
4025:
4021:
4018:
4017:
4015:
4011:
4004:
4000:
3997:
3994:
3990:
3987:
3986:
3984:
3980:
3974:, 415 deaths)
3973:
3969:
3966:
3963:
3959:
3956:
3955:
3953:
3949:
3945:
3938:
3933:
3931:
3926:
3924:
3919:
3918:
3915:
3911:
3904:
3894:
3891:
3889:
3886:
3884:
3881:
3880:
3877:
3870:
3867:
3863:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3823:
3821:
3819:
3815:
3806:
3801:
3799:
3794:
3792:
3787:
3786:
3783:
3771:
3770:
3761:
3759:
3758:
3749:
3747:
3746:
3737:
3736:
3733:
3723:
3720:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3693:
3692:Joseph Lister
3690:
3688:
3685:
3683:
3680:
3678:
3675:
3674:
3672:
3668:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3641:
3639:
3637:
3634:
3633:
3631:
3627:
3620:
3616:
3614:
3611:
3609:
3606:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3583:
3581:
3577:
3574:
3572:
3571:Health Canada
3569:
3568:
3566:
3562:
3559:
3558:
3556:
3552:
3549:
3547:
3544:
3543:
3541:
3537:
3534:
3533:
3531:
3527:
3524:
3523:
3521:
3520:
3518:
3516:Organizations
3514:
3511:
3503:
3497:
3494:
3492:
3489:
3487:
3484:
3482:
3479:
3477:
3474:
3472:
3469:
3467:
3464:
3462:
3459:
3457:
3454:
3452:
3449:
3448:
3446:
3440:
3432:
3429:
3427:
3424:
3423:
3422:
3419:
3417:
3414:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3376:
3374:
3373:
3371:
3365:
3359:
3356:
3354:
3353:Vaccine trial
3351:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3327:
3324:
3323:
3322:
3319:
3315:
3312:
3311:
3310:
3307:
3303:
3300:
3299:
3298:
3295:
3293:
3290:
3289:
3287:
3281:
3275:
3272:
3268:
3266:
3262:
3260:
3258:
3253:
3251:
3248:
3246:
3243:
3241:
3238:
3237:
3236:
3233:
3231:
3230:Relative risk
3228:
3226:
3223:
3221:
3218:
3217:
3215:
3209:
3203:
3200:
3196:
3193:
3191:
3190:Health equity
3188:
3186:
3183:
3182:
3181:
3178:
3176:
3173:
3171:
3168:
3166:
3163:
3161:
3158:
3156:
3155:Health system
3153:
3151:
3148:
3146:
3145:Global health
3143:
3141:
3138:
3136:
3133:
3131:
3128:
3126:
3125:Biostatistics
3123:
3122:
3120:
3118:
3114:
3108:
3105:
3103:
3100:
3098:
3095:
3093:
3090:
3086:
3083:
3081:
3078:
3076:
3073:
3071:
3068:
3066:
3063:
3061:
3058:
3057:
3056:
3053:
3051:
3048:
3046:
3043:
3039:
3036:
3035:
3034:
3031:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3007:
3004:
3002:
2999:
2998:
2997:
2994:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2972:
2971:
2970:
2967:
2963:
2960:
2958:
2955:
2954:
2953:
2950:
2948:
2945:
2943:
2940:
2936:
2933:
2932:
2931:
2928:
2927:
2925:
2923:
2919:
2913:
2910:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2890:
2888:
2885:
2883:
2880:
2878:
2875:
2873:
2870:
2868:
2867:Right to food
2865:
2863:
2860:
2858:
2855:
2853:
2850:
2846:
2843:
2841:
2838:
2836:
2833:
2831:
2828:
2826:
2823:
2822:
2821:
2818:
2816:
2813:
2811:
2808:
2805:
2801:
2800:Mental health
2798:
2796:
2793:
2791:
2788:
2786:
2783:
2781:
2778:
2776:
2773:
2769:
2766:
2764:
2761:
2760:
2759:
2756:
2754:
2751:
2749:
2748:Housing First
2746:
2742:
2739:
2737:
2736:Health system
2734:
2733:
2732:
2731:Health policy
2729:
2727:
2724:
2722:
2719:
2717:
2714:
2712:
2709:
2707:
2704:
2702:
2699:
2695:
2692:
2690:
2687:
2686:
2685:
2682:
2680:
2677:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2651:
2649:
2645:
2641:
2640:Public health
2634:
2629:
2627:
2622:
2620:
2615:
2614:
2611:
2599:
2598:
2594:
2592:
2591:
2587:
2585:
2584:
2580:
2579:
2576:
2570:
2567:
2565:
2562:
2560:
2557:
2555:
2552:
2550:
2547:
2546:
2544:
2540:
2534:
2531:
2529:
2528:Meta-analysis
2526:
2524:
2521:
2519:
2516:
2514:
2511:
2510:
2508:
2506:
2502:
2496:
2495:Vaccine trial
2493:
2491:
2490:Seeding trial
2488:
2486:
2483:
2481:
2478:
2476:
2473:
2471:
2468:
2466:
2463:
2461:
2458:
2457:
2455:
2451:
2443:
2439:
2435:
2431:
2427:
2423:
2419:
2415:
2411:
2407:
2405:
2401:
2397:
2393:
2389:
2385:
2381:
2379:
2375:
2371:
2367:
2363:
2359:
2355:
2351:
2347:
2343:
2341:
2337:
2333:
2329:
2325:
2321:
2317:
2313:
2311:
2307:
2304:
2302:
2298:
2292:
2289:
2287:
2284:
2282:
2279:
2276:
2272:
2269:
2265:
2262:
2260:
2259:Retrospective
2257:
2256:
2255:
2252:
2250:
2246:
2242:
2239:
2238:
2236:
2233:
2228:
2224:
2216:
2213:
2212:
2211:
2208:
2204:
2201:
2199:
2196:
2194:
2191:
2190:
2189:
2186:
2185:
2183:
2180:
2179:EBM I to II-1
2175:
2171:
2165:
2162:
2160:
2157:
2155:
2152:
2150:
2147:
2145:
2142:
2138:
2135:
2133:
2130:
2129:
2128:
2125:
2124:
2122:
2118:
2114:
2110:
2103:
2098:
2096:
2091:
2089:
2084:
2083:
2080:
2064:
2062:
2059:
2058:
2056:
2053:
2050:
2047:
2045:
2042:
2041:
2037:
2031:
2028:
2026:
2023:
2021:
2018:
2016:
2013:
2012:
2010:
2006:
2000:
1997:
1995:
1994:
1990:
1988:
1985:
1983:
1980:
1978:
1975:
1973:
1970:
1967:
1965:
1960:
1957:
1955:
1952:
1951:
1949:
1945:
1939:
1938:Drew Weissman
1936:
1934:
1931:
1929:
1926:
1924:
1923:H. Fred Clark
1921:
1919:
1916:
1914:
1911:
1909:
1906:
1904:
1901:
1899:
1896:
1894:
1893:Louis Pasteur
1891:
1889:
1888:Edward Jenner
1886:
1885:
1883:
1877:
1865:
1862:
1860:
1859:DTwP-HepB-Hib
1857:
1855:
1854:DTaP-IPV-HepB
1852:
1850:
1847:
1846:
1845:combination:
1844:
1842:
1839:
1837:
1834:
1832:
1829:
1827:
1824:
1820:
1817:
1813:
1810:
1808:
1805:
1804:
1803:
1800:
1798:
1795:
1793:
1790:
1788:
1785:
1784:
1783:
1780:
1778:
1775:
1774:
1772:
1768:
1760:
1757:
1755:
1752:
1751:
1749:
1748:
1746:
1744:
1743:Helminthiasis
1740:
1732:
1729:
1728:
1726:
1722:
1719:
1718:
1717:
1714:
1713:
1711:
1707:
1699:
1696:
1694:
1691:
1689:
1686:
1684:
1681:
1679:
1676:
1674:
1671:
1669:
1666:
1665:
1663:
1659:
1656:
1654:
1651:
1649:
1646:
1645:
1644:combination:
1643:
1641:
1638:
1634:
1631:
1629:
1626:
1625:
1623:
1621:
1618:
1616:
1613:
1611:
1608:
1604:
1601:
1599:
1596:
1594:
1591:
1589:
1586:
1584:
1581:
1579:
1576:
1574:
1571:
1569:
1566:
1564:
1561:
1559:
1556:
1554:
1551:
1549:
1546:
1544:
1541:
1539:
1536:
1534:
1531:
1530:
1529:
1526:
1524:
1521:
1519:
1516:
1514:
1511:
1507:
1504:
1502:
1499:
1498:
1497:
1494:
1492:
1489:
1487:
1484:
1482:
1479:
1477:
1474:
1470:
1467:
1465:
1462:
1461:
1460:
1457:
1455:
1452:
1450:
1447:
1445:
1442:
1440:
1437:
1433:
1430:
1428:
1425:
1422:
1418:
1415:
1414:
1413:
1410:
1406:
1403:
1402:
1401:
1398:
1396:
1393:
1391:
1388:
1387:
1385:
1381:
1373:
1370:
1368:
1365:
1363:
1360:
1359:
1357:
1353:
1350:
1348:
1347:DPT/DTwP/DTaP
1345:
1344:
1343:combination:
1342:
1340:
1337:
1333:
1330:
1328:
1325:
1324:
1323:
1320:
1316:
1313:
1312:
1311:
1308:
1306:
1303:
1301:
1298:
1294:
1291:
1289:
1286:
1285:
1284:
1281:
1279:
1276:
1274:
1271:
1267:
1264:
1262:
1259:
1258:
1257:
1256:Meningococcus
1254:
1252:
1249:
1247:
1246:Leptospirosis
1244:
1242:
1239:
1237:
1234:
1232:
1229:
1227:
1224:
1222:
1219:
1218:
1216:
1212:
1209:
1205:
1197:
1194:
1192:
1189:
1187:
1184:
1182:
1181:Vaccine court
1179:
1177:
1174:
1173:
1171:
1167:
1164:
1162:
1159:
1157:
1154:
1152:
1149:
1147:
1144:
1142:
1139:
1137:
1136:GAVI Alliance
1134:
1133:
1131:
1130:
1128:
1124:
1118:
1115:
1113:
1110:
1108:
1104:
1101:
1099:
1095:
1091:
1087:
1084:
1080:
1077:
1075:
1072:
1071:
1069:
1067:
1064:
1062:
1059:
1058:
1056:
1052:
1046:
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1024:
1021:
1020:
1019:
1016:
1014:
1011:
1010:
1008:
1004:
999:
995:
991:
987:
983:
979:
975:
968:
963:
961:
956:
954:
949:
948:
945:
938:
935:
934:
930:
922:
916:
913:
908:
904:
899:
894:
889:
884:
880:
876:
872:
865:
862:
857:
853:
849:
845:
840:
835:
831:
827:
823:
816:
813:
808:
804:
799:
794:
790:
786:
782:
778:
774:
767:
764:
752:
748:
741:
738:
733:
727:
723:
716:
714:
710:
705:
701:
697:
693:
689:
685:
681:
674:
672:
668:
655:
649:
646:
641:
640:
633:
631:
627:
614:
610:
606:
600:
597:
592:
588:
584:
578:
574:
570:
566:
560:
557:
550:
548:
546:
542:
538:
534:
530:
526:
522:
517:
510:
508:
506:
501:
493:
491:
488:
484:
476:
474:
472:
466:
464:
460:
456:
452:
448:
443:
441:
437:
436:adverse event
433:
429:
425:
421:
412:
410:
408:
404:
400:
396:
392:
387:
385:
381:
377:
373:
368:
366:
359:
357:
355:
350:
348:
343:
341:
337:
333:
329:
328:vaccine trial
317:
312:
310:
305:
303:
298:
297:
295:
294:
287:
284:
282:
279:
277:
274:
272:
269:
267:
264:
262:
259:
258:
252:
251:
244:
241:
239:
236:
234:
231:
229:
226:
224:
221:
219:
216:
214:
211:
210:
204:
203:
196:
193:
191:
190:Vaccine trial
188:
186:
183:
181:
178:
176:
173:
172:
166:
165:
162:
158:
154:
150:
149:
143:
139:
135:
130:
115:
111:
100:
97:
93:
90:
86:
83:
79:
76:
72:
69: –
68:
64:
63:Find sources:
58:
54:
48:
47:
43:
39:
34:This article
32:
23:
22:
19:
4808:Turbo cancer
4704:surveillance
4700:Epidemiology
4392:Richard Deth
4382:David Baskin
4290:
4261:
4254:
4250:Natural News
4242:
4235:
4228:
4195:
4127:
4068:
4062:
4057:
4053:
4043:
4033:
4023:
4002:
3995:, 83 deaths)
3992:
3971:
3961:
3767:
3755:
3743:
3712:Radium Girls
3707:Typhoid Mary
3394:Microbiology
3352:
3264:
3256:
3140:Epidemiology
3038:Organization
2989:Oral hygiene
2979:Hand washing
2957:Healthy diet
2887:Right to sit
2780:Labor rights
2595:
2588:
2581:
2494:
2370:Hazard ratio
2254:Cohort study
2015:Epidemiology
1991:
1963:
1849:DTaP-IPV/Hib
1640:Yellow fever
1553:EpiVacCorona
1310:Tuberculosis
1283:Pneumococcal
1251:Lyme disease
1079:Heterologous
1044:
978:Immunization
915:
878:
874:
864:
829:
825:
815:
780:
776:
766:
754:. Retrieved
750:
740:
721:
687:
683:
660:25 September
658:. Retrieved
648:
638:
617:. Retrieved
608:
599:
572:
559:
525:troglitazone
521:cerivastatin
514:
497:
480:
467:
463:Side effects
444:
416:
388:
369:
363:
351:
344:
327:
325:
189:
105:
95:
88:
81:
74:
62:
42:verification
35:
18:
4834:Vaccination
4412:Mady Hornig
4367:Neal Halsey
4005:, 2 deaths)
3999:New Zealand
3968:Philippines
3873:Before 2019
3826:Chemophobia
3769:WikiProject
3509:and history
3389:Engineering
3102:Vaccination
2974:Food safety
2564:Null result
2523:Replication
2418:Infectivity
2340:Association
2291:Case report
2281:Case series
2264:Prospective
2051:from market
1947:Controversy
1881:researchers
1797:Hepatitis B
1683:Hepatitis C
1628:Chicken pox
1454:Hepatitis E
1449:Hepatitis B
1444:Hepatitis A
1395:Chikungunya
1372:Shigellosis
1226:Brucellosis
1112:Therapeutic
1066:Inactivated
1006:Development
994:Inoculation
986:Vaccination
756:15 November
751:www.fda.gov
619:12 December
498:Similarly.
487:immunogenic
223:Chicken pox
175:Vaccination
161:Vaccination
36:needs more
4823:Categories
4722:STEP Study
4407:Boyd Haley
4397:Mark Geier
4362:Paul Offit
4355:Scientists
4191:Cold chain
3522:Caribbean
3399:Processing
3333:Quarantine
3255:Student's
3055:Sanitation
2689:History of
2366:Odds ratio
2358:Risk ratio
2324:Prevalence
2310:Occurrence
2286:Case study
1982:Thiomersal
1928:Paul Offit
1903:Jonas Salk
1879:Inventors/
1750:research:
1727:research:
1664:research:
1593:Skycovione
1583:Sanofi–GSK
1528:SARS-CoV-2
1439:Hantavirus
1405:rVSV-ZEBOV
1390:Adenovirus
1358:research:
1236:Diphtheria
1074:Attenuated
551:References
543:(GBS) and
354:antibodies
180:Vaccinator
78:newspapers
4608:Australia
4280:Pandemrix
4256:Plandemic
4080:Related:
4064:Freewinds
4050:Kuala Koh
3702:John Snow
3629:Education
3619:Full list
3507:education
3431:ISO 22000
3384:Chemistry
3297:Epidemics
3250:ROC curve
3060:Emergency
2840:Radiation
2820:Pollution
2804:Ministers
2701:Euthenics
2426:Morbidity
2414:Virulence
2316:Incidence
2061:Phase III
2049:Withdrawn
1977:Pox party
1787:ALVAC-CEA
1709:Protozoan
1598:Sputnik V
1548:CoronaVac
1518:Rotavirus
1421:Pandemrix
1273:Pertussis
1214:Bacterial
1098:Synthetic
1061:Conjugate
1013:Adjuvants
990:Infection
529:rofecoxib
500:Phase III
494:Phase III
233:Influenza
134:CoronaVac
4829:Virology
4030:New York
3745:Category
3444:sciences
3379:Additive
3050:Safe sex
3021:Medicine
2935:Theories
2706:Genomics
2684:Eugenics
2674:Deviance
2654:Auxology
2590:Glossary
2583:Category
2460:In vitro
2301:Measures
2120:Overview
1819:Prostvac
1812:Gardasil
1807:Cervarix
1754:Hookworm
1633:Shingles
1615:Smallpox
1533:Corbevax
1469:Gardasil
1464:Cervarix
1207:Vaccines
1161:Schedule
1132:Global:
1040:Timeline
982:Vaccines
907:11806796
856:37579770
848:11828837
807:15505253
704:15811654
613:Archived
535:and the
516:Phase IV
511:Phase IV
483:Phase II
477:Phase II
471:immunity
447:antibody
432:pathogen
428:adjuvant
399:toxicity
384:lab mice
336:efficacy
243:COVID-19
213:Smallpox
207:Vaccines
153:a series
151:Part of
3962:380,766
3757:Commons
3670:History
3567:Canada
3542:Europe
3026:Nursing
3006:Hygiene
2969:Hygiene
2694:Liberal
2647:General
2465:In vivo
2008:Related
1954:General
1716:Malaria
1603:Valneva
1568:Novavax
1563:Moderna
1558:Janssen
1543:CanSino
1523:Rubella
1481:Measles
1352:Td/Tdap
1322:Typhoid
1305:Tetanus
1300:Q fever
1231:Cholera
1221:Anthrax
1090:Peptide
1054:Classes
1035:Storage
684:Vaccine
591:2572061
424:placebo
420:control
413:Phase I
372:Phase I
347:antigen
340:vaccine
185:Vaccine
142:Bandung
92:scholar
57:removed
4741:Others
4666:Others
4642:France
4291:Lancet
4263:Vaxxed
4098:Others
3972:31,056
3557:India
3532:China
3404:Safety
3085:Worker
2044:WHO-EM
1964:Lancet
1841:TA-NIC
1826:NicVAX
1673:Dengue
1513:Rabies
1339:Typhus
1278:Plague
1156:Policy
1117:Toxoid
1045:Trials
905:
895:
854:
846:
805:
798:526313
795:
728:
702:
589:
579:
426:or an
255:Issues
94:
87:
80:
73:
65:
4121:Legal
4020:Tonga
4003:2,194
3993:5,700
3989:Samoa
3582:U.S.
3426:HACCP
3375:Food
3267:-test
3259:-test
2845:Light
2830:Water
2404:Other
1972:NCVIA
1836:TA-CD
1770:Other
1721:RTS,S
1501:Sabin
1496:Polio
1491:Mumps
1400:Ebola
1383:Viral
1332:ViCPS
1327:Ty21a
1261:MeNZB
1191:VAERS
1141:NITAG
1070:Live
898:59524
852:S2CID
338:of a
330:is a
238:Ebola
218:Polio
99:JSTOR
85:books
4702:and
3907:2019
3358:WASH
3314:List
3302:List
2835:Soil
2243:vs.
2111:and
1698:Zika
1658:MMRV
1506:Salk
1486:Mpox
1432:LAIV
1427:H5N1
1417:H1N1
1293:PPSV
1176:ACIP
1172:US:
1146:SAGE
1107:mRNA
1023:list
903:PMID
844:PMID
803:PMID
758:2015
726:ISBN
700:PMID
662:2020
621:2022
577:ISBN
405:and
382:and
71:news
40:for
4034:423
4024:612
2825:Air
1959:MMR
1802:HPV
1792:BCG
1693:HIV
1653:MMR
1459:HPV
1412:Flu
1315:BCG
1288:PCV
1241:Hib
1196:VSD
1103:DNA
998:J07
893:PMC
883:doi
834:doi
793:PMC
785:doi
781:171
692:doi
136:in
4825::
4054:43
4044:73
2440:,
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