1267:
multi-factorial cause and shall not necessarily been seen a side effect of AVP solely. The presence of septic shock and a history of peripheral arterial occlusive disease are independent risk factors for the development of ISL. In the last decade, in early hyperdynamic septic shock, the administration of high-dose AVP as a single agent proved to fail to increase mean arterial pressure in the first hour but maintains it above 70mmHg in two-thirds of patients at 48h. AVP decreases NE exposure, has no effect on the PrCO(2) - PaCO(2 )difference, and improves renal function and SOFA score. This led to development of a large trial to see theeffect of arginin vasopressin as add-on to norepinephrine in septic shock. It could be shown, if giving vasopressin in early stage of septic shock (norepinephrin < 15 microgramm/min and lactate < 1.4 mmol/L) there is a statistically significant interaction between vasopressin and corticosteroids. The combination of low-dose vasopressin and corticosteroids was associated with decreased 28 and 90 days mortality and organ dysfunction compared with norepinephrine and corticosteroids.
1344:
are lower than what would be expected in this clinical setting. Though low endogenous vasopressin concentrations in and of themselves do not cause hemodynamic instability, neonates and children recovering from cardiac surgery who develop hemodynamic instability and have low endogenous vasopressin concentrations are optimal candidates for this surgery. Unfortunately, measurement of endogenous vasopressin concentration is time-consuming and cumbersome, and not practical for bedside application. Copeptin, a more stable and easily measured product of pro-AVP processing, may be a means of identifying patients with low endogenous vasopressin concentrations. Further research is needed. Also, systemic corticosteroids have been shown to suppress endogenous vasopressin production and release. Neonates and children recovering from cardiac surgery who are receiving systemic corticosteroid therapy may also be optimal candidates for vasopressin therapy should hemodynamic instability be present.
1289:
during resuscitation attempts after induced cardiac arrest. Also contributing to the idea that vasopressors may be useful treatments in cardiac arrest are studies performed in the early to mid 1990s that found significantly higher levels of endogenous serum vasopressin in adults after successful resuscitation from out-of-hospital cardiac arrest compared to those who did not live. Results of animal models have supported the use of either vasopressin or epinephrine in cardiac arrest resuscitation attempts, showing improved coronary perfusion pressure and overall improvement in short-term survival as well as neurological outcomes.
1019:) to increase the blood pressure while sparing the use of catecholamines. These argipressins have much shorter elimination half-life (around 20 minutes) than synthetic non-arginine vasopresines with much longer elimination half-life of many hours. Further, argipressins act on V1a, V1b, and V2 receptors which consequently lead to higher eGFR and lower vascular resistance in the lungs. A number of injectable arginine vasopressins are in clinical use in the United States and the European Union. Pitressin among others, is a
854:
831:
985:
InChI=1S/C46H65N15O12S2 /c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1
152:
1331:
ROSC and survival to hospital discharge with this combination treatment; unfortunately, those patients that survived to hospital discharge had overall poor outcomes and many sustained permanent, severe neurological damage. A more recently published clinical trial out of
Singapore has shown similar results, finding combination treatment to only improve the rate of survival to hospital admission, especially in the
933:
143:
1165:
32:
1257:
124:
3464:
1343:
Vasopressin is used in managing hemodynamic instability in newborns and older children recovering from cardiac surgery. There is evidence that some children recovering from cardiac surgery have relative vasopressin deficiency, such that their endogenous plasma concentrations of arginine vasopressin
1330:
There is no current evidence of significant survival benefit with improved neurological outcomes in patients given combinations of both epinephrine and vasopressin during cardiac arrest. A systematic review from 2008 did, however, find one study that showed a statistically significant improvement in
1305:
as epinephrine does. Thus, vasopressin is theorized to be of increased benefit over epinephrine in cardiac arrest due to its properties of not increasing myocardial and cerebral oxygen demands. This idea has led to the advent of several studies searching for the presence of a clinical difference in
2268:
Gueugniaud PY, David JS, Chanzy E, Hubert H, Dubien PY, Mauriaucourt P, Bragança C, Billères X, Clotteau-Lambert MP, Fuster P, Thiercelin D, Debaty G, Ricard-Hibon A, Roux P, Espesson C, Querellou E, Ducros L, Ecollan P, Halbout L, Savary D, Guillaumée F, Maupoint R, Capelle P, Bracq C, Dreyfus P,
1288:
Modern interest in vasopressors as a treatment for cardiac arrest stem mostly from canine studies performed in the 1960s by anesthesiologists Dr. John W. Pearson and Dr. Joseph
Stafford Redding in which they demonstrated improved outcomes with the use of adjunct intracardiac epinephrine injection
1266:
Efficacy of vasopressin on systemic hemodynamics in catecholamine-resistant septic and postcardiotomy shock have been studied and published first in 2001 Later, the group concluded the ischemic skin lesions (ISL) developed in patients with catecholamine-resistant vasodilatory shock have
2172:
Stiell IG, Hébert PC, Wells GA, Vandemheen KL, Tang AS, Higginson LA, Dreyer JF, Clement C, Battram E, Watpool I, Mason S, Klassen T, Weitzman BN (July 2001). "Vasopressin versus epinephrine for inhospital cardiac arrest: a randomised controlled trial".
2349:
Ong ME, Tiah L, Leong BS, Tan EC, Ong VY, Tan EA, Poh BY, Pek PP, Chen Y (August 2012). "A randomised, double-blind, multi-centre trial comparing vasopressin and adrenaline in patients with cardiac arrest presenting to or in the
Emergency Department".
1626:
Dünser MW, Mayr AJ, Tür A, Pajk W, Barbara F, Knotzer H, Ulmer H, Hasibeder WR (May 2003). "Ischemic skin lesions as a complication of continuous vasopressin infusion in catecholamine-resistant vasodilatory shock: incidence and risk factors". primary.
1765:
Russell JA, Walley KR, Gordon AC, Cooper DJ, Hébert PC, Singer J, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ (March 2009). "Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock". primary.
1275:
The
Surviving Sepsis Campaign guidelines recommend the very early management of the sepsis focusing on the hour-1 bundle. This includes use of Vasopressin 0.03 units/minute as add-on to norepinephrine (NE) with intent of either raising the
2479:
Mastropietro CW, Mahan M, Valentine KM, Clark JA, Hines PC, Walters HL, Delius RE, Sarnaik AP, Rossi NF (December 2012). "Copeptin as a marker of relative arginine vasopressin deficiency after pediatric cardiac surgery".
2721:
2313:
Sillberg VA, Perry JJ, Stiell IG, Wells GA (December 2008). "Is the combination of vasopressin and epinephrine superior to repeated doses of epinephrine alone in the treatment of cardiac arrest-a systematic review".
1306:
benefit of these two treatment choices. Initial small studies demonstrated improved outcomes with vasopressin in comparison to epinephrine. However, subsequent studies have not all been in agreement. Several
2137:
Callaway CW, Hostler D, Doshi AA, Pinchalk M, Roth RN, Lubin J, Newman DH, Kelly LJ (November 2006). "Usefulness of vasopressin administered with epinephrine during out-of-hospital cardiac arrest".
506:
2431:
Mastropietro CW, Rossi NF, Clark JA, Chen H, Walters H, Delius R, Lieh-Lai M, Sarnaik AP (October 2010). "Relative deficiency of arginine vasopressin in children after cardiopulmonary bypass".
2714:
2566:
Davalos MC, Barrett R, Seshadri S, Walters HL, Delius RE, Zidan M, Mastropietro CW (March 2013). "Hyponatremia during arginine vasopressin therapy in children following cardiac surgery".
2385:
Mastropietro CW, Clark JA, Delius RE, Walters HL, Sarnaik AP (September 2008). "Arginine vasopressin to manage hypoxemic infants after stage I palliation of single ventricle lesions".
290:
2707:
350:
1175:
42:
1819:
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. (Surviving Sepsis
Campaign Guidelines Committee including the Pediatric Subgroup) (February 2013).
3494:
1932:
Lindner KH, Strohmenger HU, Ensinger H, Hetzel WD, Ahnefeld FW, Georgieff M (October 1992). "Stress hormone response during and after cardiopulmonary resuscitation".
1820:
2523:
Mastropietro CW, Davalos MC, Seshadri S, Walters HL, Delius RE (June 2013). "Clinical response to arginine vasopressin therapy after paediatric cardiac surgery".
1670:
Lauzier F, Lévy B, Lamarre P, Lesur O (November 2006). "Vasopressin or norepinephrine in early hyperdynamic septic shock: a randomized clinical trial". primary.
236:
1713:
Russell JA, Walley KR, Singer J, Gordon AC, Hébert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D (February 2008).
957:
1512:
2069:
Williamson K, Breed M, Alibertis K, Brady WJ (February 2012). "The impact of the code drugs: cardioactive medications in cardiac arrest resuscitation".
2614:
Mastropietro CW, Miletic K, Chen H, Rossi NF (December 2014). "Effect of corticosteroids on arginine vasopressin after pediatric cardiac surgery".
393:
3504:
2269:
Nouguier P, Gache A, Meurisse C, Boulanger B, Lae C, Metzger J, Raphael V, Beruben A, Wenzel V, Guinhouya C, Vilhelm C, Marret E (July 2008).
1579:"The effects of vasopressin on systemic hemodynamics in catecholamine-resistant septic and postcardiotomy shock: a retrospective analysis"
2649:
Palm C, Pistrosch F, Herbrig K, Gross P (July 2006). "Vasopressin antagonists as aquaretic agents for the treatment of hyponatremia".
1236:
103:
1475:
1311:
977:
286:
1208:
75:
3132:
2988:
1558:
Baum S, Nusbaum M, Tumen HJ (1970). "The control of gastrointestinal hemorrhage by selective mesenteric infusion of pitressin".
3489:
3236:
2941:
1359:
1353:
965:
c1ccc(cc1)C2C(=O)N(C(=O)N(C(=O)N(CSSC(C(=O)N(C(=O)N2)Cc3ccc(cc3)O)N)C(=O)N4CCC4C(=O)N(CCCN=C(N)N)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
608:
491:
254:
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82:
3454:
1859:
1506:
1307:
1222:
730:
89:
1183:
273:
50:
1093:
Vasopressin is used to manage anti-diuretic hormone deficiency. It has off-label uses and is used in the treatment of
810:
1204:
71:
1194:
1179:
61:
46:
1416:
1094:
1500:
1322:
completed in 2005 that found no evidence of a significant difference with vasopressin in five studied outcomes.
1112:
is used in conditions featuring low vasopressin secretion, as well as for control of bleeding (in some forms of
679:
1821:"Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012"
1108:
Vasopressin agonists are used therapeutically in various conditions, and its long-acting synthetic analogue
1098:
420:
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408:
338:
327:
2809:
849:
3484:
1775:
1277:
1113:
550:
427:
342:
1101:
and ventricular defibrillation. Vasopressin is used to treat diabetes insipidus related to low levels of
799:
3499:
2021:
Aung K, Htay T (January 2005). "Vasopressin for cardiac arrest: a systematic review and meta-analysis".
1302:
670:
2979:
2734:
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577:
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1229:
96:
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1714:
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2250:
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1914:
1851:
1801:
1695:
1652:
1608:
1129:
1082:
1036:
1024:
389:
301:
3369:
3364:
3320:
2921:
2916:
2871:
2821:
2789:
2769:
2759:
1534:
3389:
3206:
3077:
3057:
2906:
2901:
2881:
2699:
2221:"A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation"
3408:
3384:
3379:
3374:
3340:
3226:
3122:
2745:
2730:
2666:
2631:
2583:
2540:
2497:
2448:
2402:
2367:
2331:
2292:
2242:
2190:
2154:
2116:
2086:
2038:
1998:
1949:
1906:
1843:
1793:
1747:
1687:
1644:
1600:
1335:
of patients with longer "collapse to emergency department" arrival times of 15 to 45 minutes.
1332:
1315:
532:
519:
434:
218:
3191:
779:
3335:
3117:
3112:
3097:
2959:
2841:
2658:
2623:
2575:
2532:
2489:
2440:
2394:
2359:
2323:
2282:
2232:
2182:
2146:
2078:
2030:
1988:
1980:
1941:
1896:
1835:
1785:
1737:
1729:
1679:
1636:
1590:
866:
719:
542:
384:
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739:
634:
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2779:
1125:
1044:
560:
469:
2688:
2363:
2327:
853:
830:
3440:
3399:
2964:
1640:
1148:
1016:
151:
2186:
1993:
1968:
3478:
3436:
1945:
1901:
1884:
1595:
1578:
1319:
1140:
1117:
1008:
842:
375:
2595:
2552:
2509:
2460:
2414:
2271:"Vasopressin and epinephrine vs. epinephrine alone in cardiopulmonary resuscitation"
2254:
2219:
Wenzel V, Krismer AC, Arntz HR, Sitter H, Stadlbauer KH, Lindner KH (January 2004).
2202:
2050:
1918:
1855:
1699:
1656:
1612:
3280:
3250:
3166:
3146:
3022:
1969:"Release of endogenous vasopressors during and after cardiopulmonary resuscitation"
1805:
1577:
Dünser MW, Mayr AJ, Ulmer H, Ritsch N, Knotzer H, Pajk W, et al. (July 2001).
1390:
1367:
1136:
1121:
1109:
1055:
1004:
659:
450:
363:
358:
246:
142:
2150:
1310:
have been unable to reproduce positive results with vasopressin treatment in both
2662:
2579:
2444:
2398:
1839:
1789:
3432:
3285:
3270:
3255:
3196:
3171:
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3002:
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20:
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3359:
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3300:
3201:
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2034:
1683:
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1020:
905:
710:
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3290:
3265:
3176:
3156:
3082:
3032:
3007:
2969:
2954:
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2896:
2891:
2876:
2866:
2814:
2784:
1447:
1063:
590:
240:
134:
2670:
2635:
2587:
2544:
2501:
2452:
2406:
2371:
2335:
2296:
2246:
2194:
2158:
2120:
2090:
2042:
1910:
1847:
1797:
1751:
1742:
1691:
1648:
1604:
2287:
2270:
2002:
1953:
1715:"Vasopressin versus norepinephrine infusion in patients with septic shock"
3275:
3102:
3042:
2936:
2854:
2831:
2794:
2237:
2220:
1984:
1733:
1144:
1071:
1012:
690:
462:
268:
699:
3404:
3260:
3186:
3072:
2826:
1280:
or decreasing the norepinephrine dosage (i.e. de-catecholaminization).
1193:
if you can. Unsourced or poorly sourced material may be challenged and
1059:
944:
645:
441:
60:
if you can. Unsourced or poorly sourced material may be challenged and
3092:
1075:
1048:
790:
570:
479:
1967:
Lindner KH, Haak T, Keller A, Bothner U, Lurie KG (February 1996).
759:
19:
This article is about the medication. For the natural peptide, see
932:
923:
770:
566:
475:
1421:
National
Institute of Diabetes and Digestive and Kidney Diseases
1039:, which causes increased and diluted urine. It is used to treat
750:
513:
2703:
1139:
patients not responding to fluid resuscitation or infusions of
1007:
patients not responding to fluid resuscitation or infusions of
526:
280:
263:
1158:
1135:
Vasopressin infusions are also used as second line therapy in
25:
815:
2107:
Lee SW (August 2011). "Drugs in resuscitation: an update".
1301:
differ in that vasopressin does not have direct effects on
500:
312:
196:
184:
178:
223:
Vasostrict (USA), Reverpleg (FR), Empressin (GER), others
202:
1128:
in certain conditions. Use of vasopressin analogues for
1314:(ROSC) and survival to hospital discharge, including a
1190:
57:
3452:
1385:
1383:
205:
199:
181:
172:
2609:
2607:
2605:
2474:
2472:
2470:
2426:
2424:
1155:
Catecholamine refractory hypotension in septic shock
193:
190:
175:
3422:
3349:
3235:
3131:
2987:
2978:
2744:
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921:
904:
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841:
809:
789:
769:
749:
729:
709:
689:
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644:
624:
599:
589:
576:
559:
549:
541:
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456:
440:
407:
399:
382:
374:
349:
326:
300:
253:
235:
227:
217:
187:
163:
158:
1120:) and in extreme cases of bedwetting by children.
1326:Vasopressin and epinephrine vs. epinephrine alone
1885:"The Role of Epinephrine in Cardiac Resuscition"
658:
1362:is an agent that interferes with action at the
633:
2214:
2212:
1189:Please review the contents of the section and
285:
56:Please review the contents of the article and
2715:
2064:
2062:
2060:
8:
1297:Although both vasopressors, vasopressin and
1047:. Vasopressin is a hormone that affects the
272:
133:
2308:
2306:
2132:
2130:
2071:Emergency Medicine Clinics of North America
616:1-{carbonyl}-L-p rolyl-L-arginylglycinamide
2984:
2722:
2708:
2700:
852:
829:
718:
3495:Drugs acting on the genito-urinary system
2286:
2236:
1992:
1900:
1779:
1741:
1594:
1271:2018 Surviving Sepsis Campaign Guidelines
738:
3459:
2016:
2014:
2012:
1883:Pearson JW, Redding JS (Sep–Oct 1963).
1501:"Competitive Generic Therapy Approvals"
1442:
1440:
1438:
1379:
1366:. They can be used in the treatment of
1023:most commonly used in the treatment of
982:
962:
825:
698:
613:
394:Paraventricular nucleus of hypothalamus
2102:
2100:
1470:
1468:
843:
132:
798:
778:
245:
7:
2695:. U.S. National Library of Medicine.
1339:Surgery for congenital heart disease
362:
2364:10.1016/j.resuscitation.2012.02.005
2328:10.1016/j.resuscitation.2008.07.020
2275:The New England Journal of Medicine
2225:The New England Journal of Medicine
1722:The New England Journal of Medicine
758:
649:
2139:The American Journal of Cardiology
1641:10.1097/01.CCM.0000059722.94182.79
1391:"Vasopressin Use During Pregnancy"
1124:and related analogues are used as
14:
1515:from the original on 29 June 2023
1312:return of spontaneous circulation
1043:following some surgeries, and in
231:arginine vasopressin; argipressin
3462:
2651:The American Journal of Medicine
2568:Pediatric Critical Care Medicine
2387:Pediatric Critical Care Medicine
1946:10.1097/00000542-199210000-00008
1902:10.1213/00000539-196309000-00022
1596:10.1097/00000539-200107000-00003
1255:
1163:
883:
877:
168:
150:
141:
122:
30:
1476:"Vasopressin (Injection Route)"
1360:vasopressin receptor antagonist
1354:Vasopressin receptor antagonist
1348:Vasopressin receptor inhibition
990:Key:KBZOIRJILGZLEJ-LGYYRGKSSA-N
1191:add the appropriate references
1105:. It is available as Pressyn.
895:
889:
871:
58:add the appropriate references
1:
3505:Vasopressin receptor agonists
2187:10.1016/S0140-6736(01)05328-4
2151:10.1016/j.amjcard.2006.06.022
2023:Archives of Internal Medicine
1205:"Vasopressin" medication
72:"Vasopressin" medication
2663:10.1016/j.amjmed.2006.05.014
2580:10.1097/pcc.0b013e3182720473
2445:10.1097/ccm.0b013e3181eed91d
2399:10.1097/pcc.0b013e3181849ce0
1840:10.1097/CCM.0b013e31827e83af
1790:10.1097/CCM.0b013e3181961ace
1507:Food and Drug Administration
1308:randomized controlled trials
1035:such as that resulting from
1293:Vasopressin vs. epinephrine
1176:reliable medical references
43:reliable medical references
3521:
2628:10.1016/j.jcrc.2014.07.007
1540:. F.A. Davis Company. 2017
1351:
861:Chemical and physical data
18:
3291:Vasotocin (argiprestocin)
3286:Vasopressin (argipressin)
3177:Vasotocin (argiprestocin)
3172:Vasopressin (argipressin)
3033:Vasotocin (argiprestocin)
3028:Vasopressin (argipressin)
2815:Vasotocin (argiprestocin)
2537:10.1017/S1047951112000996
2494:10.1007/s00134-012-2731-9
2109:Singapore Medical Journal
2083:10.1016/j.emc.2011.09.008
2035:10.1001/archinte.165.1.17
1684:10.1007/s00134-006-0378-0
1182:or relies too heavily on
1095:gastrointestinal bleeding
1054:Side effects may include
1003:infusions are in use for
973:
953:
604:
149:
140:
49:or relies too heavily on
2616:Journal of Critical Care
1889:Anesthesia and Analgesia
1583:Anesthesia and Analgesia
1051:and reduces urine flow.
2693:Drug Information Portal
2525:Cardiology in the Young
2482:Intensive Care Medicine
1672:Intensive Care Medicine
1448:"Pitressin (Injection)"
1099:ventricular tachycardia
1045:stomach roentgenography
3490:Antihypotensive agents
3207:ORG-52186 (SCH-740935)
2929:Catabolism inhibitors:
2433:Critical Care Medicine
1828:Critical Care Medicine
1768:Critical Care Medicine
1629:Critical Care Medicine
1278:mean arterial pressure
1114:von Willebrand disease
2657:(7 Suppl 1): S87–92.
2288:10.1056/NEJMoa0706873
1364:vasopressin receptors
1303:cardiac contractility
1081:It is available as a
565:Predominantly in the
474:Predominantly in the
2735:vasopressin receptor
2238:10.1056/NEJMoa025431
1985:10.1136/hrt.75.2.145
1734:10.1056/NEJMoa067373
1417:"Diabetes Insipidus"
1103:antidiuretic hormone
1041:abdominal distension
2937:Bestatin (ubenimex)
1132:commenced in 1970.
522:(Prescription only)
509:(Prescription only)
137:
1130:esophageal varices
1083:generic medication
1037:diabetes insipidus
1025:frequent urination
390:Supraoptic nucleus
3450:
3449:
3430:Carrier proteins:
3418:
3417:
3409:lithium carbonate
3397:Other inhibitors:
2949:
2805:PF-06655075 (PF1)
1397:. 22 January 2020
1333:subgroup analysis
1316:systematic review
1264:
1263:
1240:
998:
997:
949:1.6±0.1 g/cm
934:Interactive image
811:CompTox Dashboard
530:
517:
504:
316:
283:
266:
131:
130:
107:
16:Chemical compound
3512:
3467:
3466:
3465:
3458:
2985:
2960:o-Phenanthroline
2947:
2724:
2717:
2710:
2701:
2696:
2675:
2674:
2646:
2640:
2639:
2611:
2600:
2599:
2563:
2557:
2556:
2520:
2514:
2513:
2476:
2465:
2464:
2428:
2419:
2418:
2382:
2376:
2375:
2346:
2340:
2339:
2310:
2301:
2300:
2290:
2265:
2259:
2258:
2240:
2216:
2207:
2206:
2169:
2163:
2162:
2134:
2125:
2124:
2104:
2095:
2094:
2066:
2055:
2054:
2018:
2007:
2006:
1996:
1964:
1958:
1957:
1929:
1923:
1922:
1904:
1880:
1874:
1873:
1871:
1870:
1864:
1858:. Archived from
1825:
1816:
1810:
1809:
1783:
1762:
1756:
1755:
1745:
1719:
1710:
1704:
1703:
1667:
1661:
1660:
1623:
1617:
1616:
1598:
1574:
1568:
1567:
1560:Gastroenterology
1555:
1549:
1548:
1546:
1545:
1539:
1531:
1525:
1524:
1522:
1520:
1511:. 29 June 2023.
1497:
1491:
1490:
1488:
1486:
1472:
1463:
1462:
1460:
1458:
1444:
1433:
1432:
1430:
1428:
1413:
1407:
1406:
1404:
1402:
1387:
1259:
1258:
1250:
1247:
1241:
1239:
1198:
1167:
1166:
1159:
1126:vasoconstrictors
1029:increased thirst
936:
916:
914:
897:
891:
885:
879:
873:
856:
845:
834:
833:
819:
817:
802:
782:
762:
742:
722:
702:
682:
662:
652:
651:
637:
581:
528:
525:
515:
512:
502:
499:
366:
314:
311:
293:
282:
279:
276:
265:
262:
249:
212:
211:
208:
207:
204:
201:
198:
195:
192:
189:
186:
183:
180:
177:
174:
154:
145:
138:
136:
126:
125:
117:
114:
108:
106:
65:
34:
33:
26:
3520:
3519:
3515:
3514:
3513:
3511:
3510:
3509:
3475:
3474:
3473:
3463:
3461:
3453:
3451:
3446:
3414:
3345:
3240:
3231:
3136:
3127:
2992:
2974:
2780:Lipo-oxytocin-1
2740:
2728:
2687:
2684:
2679:
2678:
2648:
2647:
2643:
2613:
2612:
2603:
2565:
2564:
2560:
2522:
2521:
2517:
2488:(12): 2047–54.
2478:
2477:
2468:
2430:
2429:
2422:
2384:
2383:
2379:
2348:
2347:
2343:
2312:
2311:
2304:
2267:
2266:
2262:
2218:
2217:
2210:
2181:(9276): 105–9.
2171:
2170:
2166:
2145:(10): 1316–21.
2136:
2135:
2128:
2106:
2105:
2098:
2068:
2067:
2058:
2020:
2019:
2010:
1966:
1965:
1961:
1931:
1930:
1926:
1882:
1881:
1877:
1868:
1866:
1862:
1823:
1818:
1817:
1813:
1781:10.1.1.325.6984
1764:
1763:
1759:
1717:
1712:
1711:
1707:
1669:
1668:
1664:
1625:
1624:
1620:
1576:
1575:
1571:
1557:
1556:
1552:
1543:
1541:
1537:
1533:
1532:
1528:
1518:
1516:
1499:
1498:
1494:
1484:
1482:
1474:
1473:
1466:
1456:
1454:
1446:
1445:
1436:
1426:
1424:
1415:
1414:
1410:
1400:
1398:
1389:
1388:
1381:
1376:
1356:
1350:
1341:
1328:
1295:
1286:
1273:
1260:
1256:
1251:
1245:
1242:
1199:
1188:
1184:primary sources
1168:
1164:
1157:
1091:
994:
991:
986:
981:
980:
969:
966:
961:
960:
939:
912:
910:
900:
894:
888:
882:
876:
837:
813:
805:
785:
765:
745:
725:
705:
685:
665:
648:
640:
620:
617:
612:
611:
579:
551:Protein binding
543:Pharmacokinetic
537:
431:
424:
417:
370:
329:
322:
303:
296:
171:
167:
127:
123:
118:
112:
109:
66:
55:
51:primary sources
35:
31:
24:
17:
12:
11:
5:
3518:
3516:
3508:
3507:
3502:
3497:
3492:
3487:
3477:
3476:
3472:
3471:
3448:
3447:
3445:
3444:
3426:
3424:
3420:
3419:
3416:
3415:
3413:
3412:
3402:
3400:Demeclocycline
3393:
3392:
3387:
3382:
3377:
3372:
3367:
3362:
3353:
3351:
3347:
3346:
3344:
3343:
3338:
3333:
3328:
3323:
3318:
3313:
3308:
3303:
3294:
3293:
3288:
3283:
3278:
3273:
3268:
3263:
3258:
3253:
3244:
3242:
3238:
3233:
3232:
3230:
3229:
3220:
3219:
3214:
3209:
3204:
3199:
3194:
3189:
3180:
3179:
3174:
3169:
3164:
3159:
3154:
3149:
3140:
3138:
3134:
3129:
3128:
3126:
3125:
3120:
3115:
3110:
3105:
3100:
3095:
3090:
3085:
3080:
3075:
3070:
3065:
3060:
3055:
3050:
3045:
3036:
3035:
3030:
3025:
3020:
3015:
3010:
3005:
2996:
2994:
2990:
2982:
2976:
2975:
2973:
2972:
2967:
2965:Phosphoramidon
2962:
2957:
2952:
2944:
2939:
2934:
2925:
2924:
2919:
2914:
2909:
2904:
2899:
2894:
2889:
2884:
2879:
2874:
2869:
2857:
2845:
2844:
2839:
2834:
2829:
2824:
2812:
2807:
2802:
2797:
2792:
2787:
2782:
2777:
2772:
2767:
2762:
2750:
2748:
2742:
2741:
2729:
2727:
2726:
2719:
2712:
2704:
2698:
2697:
2683:
2682:External links
2680:
2677:
2676:
2641:
2601:
2558:
2515:
2466:
2439:(10): 2052–8.
2420:
2377:
2341:
2302:
2260:
2208:
2164:
2126:
2115:(8): 596–602.
2096:
2056:
2008:
1959:
1934:Anesthesiology
1924:
1895:(5): 599–606.
1875:
1834:(2): 580–637.
1811:
1757:
1705:
1678:(11): 1782–9.
1662:
1618:
1569:
1550:
1526:
1492:
1480:mayoclinic.org
1464:
1434:
1423:. October 2015
1408:
1378:
1377:
1375:
1372:
1352:Main article:
1349:
1346:
1340:
1337:
1327:
1324:
1294:
1291:
1285:
1284:Cardiac arrest
1282:
1272:
1269:
1262:
1261:
1254:
1252:
1246:September 2018
1171:
1169:
1162:
1156:
1153:
1149:norepinephrine
1141:catecholamines
1090:
1087:
1017:norepinephrine
1009:catecholamines
996:
995:
993:
992:
989:
987:
984:
976:
975:
974:
971:
970:
968:
967:
964:
956:
955:
954:
951:
950:
947:
941:
940:
938:
937:
929:
927:
919:
918:
908:
902:
901:
898:
892:
886:
880:
874:
869:
863:
862:
858:
857:
847:
839:
838:
836:
835:
822:
820:
807:
806:
804:
803:
795:
793:
787:
786:
784:
783:
775:
773:
767:
766:
764:
763:
755:
753:
747:
746:
744:
743:
735:
733:
727:
726:
724:
723:
715:
713:
707:
706:
704:
703:
695:
693:
687:
686:
684:
683:
675:
673:
667:
666:
664:
663:
655:
653:
642:
641:
639:
638:
630:
628:
622:
621:
619:
618:
615:
607:
606:
605:
602:
601:
597:
596:
593:
587:
586:
583:
574:
573:
563:
557:
556:
553:
547:
546:
539:
538:
536:
535:
523:
510:
496:
494:
488:
487:
483:
482:
472:
466:
465:
460:
454:
453:
444:
438:
437:
429:
422:
415:
411:
405:
404:
401:
400:Target tissues
397:
396:
387:
380:
379:
372:
371:
369:
368:
355:
353:
347:
346:
332:
330:administration
324:
323:
321:
320:
318:
308:
306:
298:
297:
295:
294:
277:
259:
257:
251:
250:
243:
233:
232:
229:
225:
224:
221:
215:
214:
165:
161:
160:
156:
155:
147:
146:
129:
128:
121:
119:
38:
36:
29:
15:
13:
10:
9:
6:
4:
3:
2:
3517:
3506:
3503:
3501:
3498:
3496:
3493:
3491:
3488:
3486:
3485:Antidiuretics
3483:
3482:
3480:
3470:
3460:
3456:
3442:
3438:
3434:
3431:
3428:
3427:
3425:
3421:
3410:
3406:
3403:
3401:
3398:
3395:
3394:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3355:
3354:
3352:
3348:
3342:
3339:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3296:
3295:
3292:
3289:
3287:
3284:
3282:
3279:
3277:
3274:
3272:
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3246:
3245:
3243:
3241:
3234:
3228:
3225:
3222:
3221:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3190:
3188:
3185:
3182:
3181:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3158:
3155:
3153:
3150:
3148:
3145:
3142:
3141:
3139:
3137:
3130:
3124:
3121:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3101:
3099:
3096:
3094:
3091:
3089:
3086:
3084:
3081:
3079:
3076:
3074:
3071:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3038:
3037:
3034:
3031:
3029:
3026:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3004:
3001:
2998:
2997:
2995:
2993:
2986:
2983:
2981:
2977:
2971:
2968:
2966:
2963:
2961:
2958:
2956:
2953:
2951:
2945:
2943:
2940:
2938:
2935:
2933:
2930:
2927:
2926:
2923:
2920:
2918:
2915:
2913:
2910:
2908:
2905:
2903:
2900:
2898:
2895:
2893:
2890:
2888:
2885:
2883:
2880:
2878:
2875:
2873:
2870:
2868:
2865:
2861:
2860:Tocinoic acid
2858:
2856:
2853:
2850:
2847:
2846:
2843:
2840:
2838:
2835:
2833:
2830:
2828:
2825:
2823:
2820:
2816:
2813:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2791:
2788:
2786:
2783:
2781:
2778:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2758:
2755:
2752:
2751:
2749:
2747:
2743:
2739:
2736:
2732:
2725:
2720:
2718:
2713:
2711:
2706:
2705:
2702:
2694:
2690:
2689:"Vasopressin"
2686:
2685:
2681:
2672:
2668:
2664:
2660:
2656:
2652:
2645:
2642:
2637:
2633:
2629:
2625:
2621:
2617:
2610:
2608:
2606:
2602:
2597:
2593:
2589:
2585:
2581:
2577:
2573:
2569:
2562:
2559:
2554:
2550:
2546:
2542:
2538:
2534:
2531:(3): 387–93.
2530:
2526:
2519:
2516:
2511:
2507:
2503:
2499:
2495:
2491:
2487:
2483:
2475:
2473:
2471:
2467:
2462:
2458:
2454:
2450:
2446:
2442:
2438:
2434:
2427:
2425:
2421:
2416:
2412:
2408:
2404:
2400:
2396:
2393:(5): 506–10.
2392:
2388:
2381:
2378:
2373:
2369:
2365:
2361:
2358:(8): 953–60.
2357:
2353:
2352:Resuscitation
2345:
2342:
2337:
2333:
2329:
2325:
2321:
2317:
2316:Resuscitation
2309:
2307:
2303:
2298:
2294:
2289:
2284:
2280:
2276:
2272:
2264:
2261:
2256:
2252:
2248:
2244:
2239:
2234:
2231:(2): 105–13.
2230:
2226:
2222:
2215:
2213:
2209:
2204:
2200:
2196:
2192:
2188:
2184:
2180:
2176:
2168:
2165:
2160:
2156:
2152:
2148:
2144:
2140:
2133:
2131:
2127:
2122:
2118:
2114:
2110:
2103:
2101:
2097:
2092:
2088:
2084:
2080:
2076:
2072:
2065:
2063:
2061:
2057:
2052:
2048:
2044:
2040:
2036:
2032:
2028:
2024:
2017:
2015:
2013:
2009:
2004:
2000:
1995:
1990:
1986:
1982:
1979:(2): 145–50.
1978:
1974:
1970:
1963:
1960:
1955:
1951:
1947:
1943:
1939:
1935:
1928:
1925:
1920:
1916:
1912:
1908:
1903:
1898:
1894:
1890:
1886:
1879:
1876:
1865:on 2018-04-03
1861:
1857:
1853:
1849:
1845:
1841:
1837:
1833:
1829:
1822:
1815:
1812:
1807:
1803:
1799:
1795:
1791:
1787:
1782:
1777:
1773:
1769:
1761:
1758:
1753:
1749:
1744:
1743:10044/1/19375
1739:
1735:
1731:
1728:(9): 877–87.
1727:
1723:
1716:
1709:
1706:
1701:
1697:
1693:
1689:
1685:
1681:
1677:
1673:
1666:
1663:
1658:
1654:
1650:
1646:
1642:
1638:
1635:(5): 1394–8.
1634:
1630:
1622:
1619:
1614:
1610:
1606:
1602:
1597:
1592:
1588:
1584:
1580:
1573:
1570:
1565:
1561:
1554:
1551:
1536:
1535:"Vasopressin"
1530:
1527:
1514:
1510:
1508:
1502:
1496:
1493:
1481:
1477:
1471:
1469:
1465:
1453:
1449:
1443:
1441:
1439:
1435:
1422:
1418:
1412:
1409:
1396:
1392:
1386:
1384:
1380:
1373:
1371:
1369:
1365:
1361:
1355:
1347:
1345:
1338:
1336:
1334:
1325:
1323:
1321:
1320:meta-analysis
1317:
1313:
1309:
1304:
1300:
1292:
1290:
1283:
1281:
1279:
1270:
1268:
1253:
1249:
1238:
1235:
1231:
1228:
1224:
1221:
1217:
1214:
1210:
1207: –
1206:
1202:
1201:Find sources:
1196:
1192:
1186:
1185:
1181:
1177:
1172:This section
1170:
1161:
1160:
1154:
1152:
1150:
1146:
1142:
1138:
1133:
1131:
1127:
1123:
1119:
1118:haemophilia A
1115:
1111:
1106:
1104:
1100:
1096:
1088:
1086:
1084:
1079:
1077:
1073:
1069:
1065:
1061:
1057:
1052:
1050:
1046:
1042:
1038:
1034:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
1002:
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848:
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844:ECHA InfoCard
840:
832:
828:
827:DTXSID0048349
824:
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164:Pronunciation
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159:Clinical data
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74: –
73:
69:
68:Find sources:
63:
59:
53:
52:
48:
44:
39:This article
37:
28:
27:
22:
3500:Nonapeptides
3429:
3396:
3357:Antagonists:
3356:
3306:JNJ-17079166
3298:Antagonists:
3297:
3281:Terlipressin
3251:Desmopressin
3247:
3223:
3217:TASP-0390325
3212:TASP-0233278
3184:Antagonists:
3183:
3167:Terlipressin
3147:Desmopressin
3143:
3068:JNJ-17308616
3063:JNJ-17079166
3040:Antagonists:
3039:
3023:Terlipressin
2999:
2928:
2864:Non-peptide:
2863:
2851:
2849:Antagonists:
2848:
2819:Non-peptide:
2818:
2756:
2753:
2692:
2654:
2650:
2644:
2622:(6): 982–6.
2619:
2615:
2574:(3): 290–7.
2571:
2567:
2561:
2528:
2524:
2518:
2485:
2481:
2436:
2432:
2390:
2386:
2380:
2355:
2351:
2344:
2322:(3): 380–6.
2319:
2315:
2281:(1): 21–30.
2278:
2274:
2263:
2228:
2224:
2178:
2174:
2167:
2142:
2138:
2112:
2108:
2077:(1): 65–75.
2074:
2070:
2029:(1): 17–24.
2026:
2022:
1976:
1972:
1962:
1940:(4): 662–8.
1937:
1933:
1927:
1892:
1888:
1878:
1867:. Retrieved
1860:the original
1831:
1827:
1814:
1774:(3): 811–8.
1771:
1767:
1760:
1725:
1721:
1708:
1675:
1671:
1665:
1632:
1628:
1621:
1586:
1582:
1572:
1563:
1559:
1553:
1542:. Retrieved
1529:
1517:. Retrieved
1504:
1495:
1483:. Retrieved
1479:
1455:. Retrieved
1451:
1425:. Retrieved
1420:
1411:
1399:. Retrieved
1394:
1368:hyponatremia
1357:
1342:
1329:
1296:
1287:
1274:
1265:
1243:
1233:
1226:
1219:
1212:
1200:
1180:verification
1173:
1137:septic shock
1134:
1122:Terlipressin
1116:and in mild
1110:desmopressin
1107:
1092:
1089:Medical uses
1080:
1056:stomach ache
1053:
1005:septic shock
1000:
999:
800:ChEMBL373742
578:Elimination
492:Legal status
486:Legal status
451:Desmopressin
343:subcutaneous
255:License data
110:
100:
93:
86:
79:
67:
47:verification
40:
3433:Neurophysin
3271:Ornipressin
3256:Felypressin
3197:Brezivaptan
3162:Ornipressin
3152:Felypressin
3088:Relcovaptan
3018:Selepressin
3013:Ornipressin
3003:Felypressin
2980:Vasopressin
2950:-Methionine
2800:PF-06478939
2775:Demoxytocin
1720:. primary.
1589:(1): 7–13.
1581:. primary.
1401:7 September
1299:epinephrine
1174:needs more
1033:dehydration
1001:Vasopressin
917: g·mol
850:100.003.669
600:Identifiers
458:Antagonists
447:Felypressin
403:System-wide
335:Intravenous
291:Vasopressin
274:Vasopressin
228:Other names
219:Trade names
135:Vasopressin
41:needs more
21:Vasopressin
3479:Categories
3370:RWJ-339489
3365:Ribuvaptan
3360:Balovaptan
3326:Satavaptan
3321:RWJ-351647
3316:Mozavaptan
3311:Lixivaptan
3301:Conivaptan
3202:Nelivaptan
3108:WAY-267464
3053:Conivaptan
3048:Balovaptan
2922:WAY-162720
2917:SSR-126768
2872:Cligosiban
2837:WAY-267464
2790:Nacartocin
2770:Cargutocin
2765:Carbetocin
2760:Aspartocin
2738:modulators
1869:2018-09-11
1544:2017-03-13
1374:References
1216:newspapers
1068:flatulence
1021:medication
922:3D model (
906:Molar mass
780:CHEBI:9937
740:Y87Y826H08
711:ChemSpider
671:IUPHAR/BPS
635:11000-17-2
626:CAS Number
609:IUPAC name
561:Metabolism
470:Metabolism
83:newspapers
3390:YM-222546
3331:Tolvaptan
3266:Lypressin
3248:Agonists:
3157:Lypressin
3144:Agonists:
3083:PF-184563
3078:LY-307174
3058:FR-218944
3008:Lypressin
3000:Agonists:
2970:Puromycin
2955:Leupeptin
2932:Amastatin
2912:Retosiban
2907:Nolasiban
2902:L-372,662
2897:L-371,257
2892:L-368,899
2882:Erlosiban
2877:Epelsiban
2867:Barusiban
2785:Merotocin
2754:Agonists:
1776:CiteSeerX
1452:Drugs.com
1395:Drugs.com
1064:pale skin
591:Excretion
580:half-life
463:Diuretics
409:Receptors
328:Routes of
302:Pregnancy
247:Monograph
241:Drugs.com
113:June 2017
3469:Medicine
3385:VMAX-382
3380:VMAX-372
3375:VMAX-367
3350:Unsorted
3341:YM-35471
3276:TC OT 39
3227:TASP-699
3224:Ligands:
3123:YM-35471
3103:TC OT 39
3043:Atosiban
2855:Atosiban
2852:Peptide:
2832:TC OT 39
2795:Oxytocin
2757:Peptide:
2746:Oxytocin
2731:Oxytocin
2671:16843091
2636:25092616
2596:35061631
2588:23392370
2553:26088566
2545:22805534
2510:23426960
2502:23093248
2461:46667831
2453:20683257
2415:30271090
2407:18679141
2372:22353644
2336:18951676
2297:18596271
2255:33578302
2247:14711909
2203:31444934
2195:11463411
2159:17134621
2121:21879219
2091:22107975
2051:42028060
2043:15642869
1919:45444406
1911:14061643
1856:34855187
1848:23353941
1798:19237882
1752:18305265
1700:25452934
1692:17019548
1657:11514445
1649:12771608
1613:41265162
1605:11429329
1513:Archived
1145:dopamine
1072:headache
1013:dopamine
691:DrugBank
442:Agonists
351:ATC code
317: B2
304:category
269:DailyMed
3405:Lithium
3261:LIT-001
3192:ABT-558
3187:ABT-436
3073:LIT-001
2827:LIT-001
2003:8673752
1954:1329579
1806:8267590
1519:29 June
1485:26 June
1457:26 June
1230:scholar
1195:removed
1143:(e.g.,
1060:vertigo
1049:kidneys
1011:(e.g.,
945:Density
867:Formula
700:DB00067
646:PubChem
571:kidneys
480:kidneys
385:tissues
383:Source
367:)
361: (
359:H01BA01
289::
271::
97:scholar
62:removed
3455:Portal
3423:Others
3336:YM-471
3118:YM-471
3113:YM-218
3098:SRX251
3093:SRX246
2842:WJ0679
2669:
2634:
2594:
2586:
2551:
2543:
2508:
2500:
2459:
2451:
2413:
2405:
2370:
2334:
2295:
2253:
2245:
2201:
2193:
2175:Lancet
2157:
2119:
2089:
2049:
2041:
2001:
1994:484250
1991:
1952:
1917:
1909:
1854:
1846:
1804:
1796:
1778:
1750:
1698:
1690:
1655:
1647:
1611:
1603:
1566:: 926.
1427:28 May
1232:
1225:
1218:
1211:
1203:
1076:tremor
1031:, and
958:SMILES
791:ChEMBL
760:D00101
720:559126
660:644077
533:℞-only
531:
518:
505:
341:(IM),
337:(IV),
284:
267:
213:
99:
92:
85:
78:
70:
2887:IX-01
2592:S2CID
2549:S2CID
2506:S2CID
2457:S2CID
2411:S2CID
2251:S2CID
2199:S2CID
2047:S2CID
1973:Heart
1915:S2CID
1863:(PDF)
1852:S2CID
1824:(PDF)
1802:S2CID
1718:(PDF)
1696:S2CID
1653:S2CID
1609:S2CID
1538:(PDF)
1509:(FDA)
1505:U.S.
1237:JSTOR
1223:books
1074:, or
978:InChI
924:JSmol
771:ChEBI
595:Urine
567:liver
476:liver
104:JSTOR
90:books
2942:EDTA
2810:TGOT
2733:and
2667:PMID
2632:PMID
2584:PMID
2541:PMID
2498:PMID
2449:PMID
2403:PMID
2368:PMID
2332:PMID
2293:PMID
2243:PMID
2191:PMID
2155:PMID
2117:PMID
2087:PMID
2039:PMID
1999:PMID
1950:PMID
1907:PMID
1844:PMID
1794:PMID
1748:PMID
1688:PMID
1645:PMID
1601:PMID
1521:2023
1487:2017
1459:2017
1429:2017
1403:2020
1318:and
1209:news
1178:for
751:KEGG
731:UNII
680:2168
569:and
545:data
478:and
435:OXTR
378:data
345:(SC)
237:AHFS
76:news
45:for
2822:CA7
2659:doi
2655:119
2624:doi
2576:doi
2533:doi
2490:doi
2441:doi
2395:doi
2360:doi
2324:doi
2283:doi
2279:359
2233:doi
2229:350
2183:doi
2179:358
2147:doi
2079:doi
2031:doi
2027:165
1989:PMC
1981:doi
1942:doi
1897:doi
1836:doi
1786:doi
1738:hdl
1730:doi
1726:358
1680:doi
1637:doi
1591:doi
1151:).
1147:or
1015:or
915:.24
913:084
816:EPA
650:CID
520:POM
364:WHO
287:FDA
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3441:II
3439:,
3135:1B
2991:1A
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