Knowledge (XXG) talk:WikiProject Pharmacology/Archive 7

2566:. But a key issue is somehow getting all that text source data from NCBI to be accessible to Knowledge (XXG). So far, Knowledge (XXG) seems to have been very wary of directly importing data from outside sources, which means a local copy of a great deal of information is needed. I had hoped to avoid putting it on a single-language project, but the approach Wikidata takes seems cumbersome. The script I have still takes quite a few parameters to produce readable output, so it isn't really fully automatic anyway, and maybe gene-by-gene cutting and pasting here is sometimes worth it, but at some point I think we could do better. 1137: 512:, investigating the safety and efficacy of afatinib in patients with mBC. In total, an estimated 1020 patients will be enrolled into the LUX-Breast clinical trials in more than 300 locations in more than 30 countries. The LUX-Head & Neck 1 and LUX-Head & Neck 2 Phase III trials, initiated in January 2012 and October 2011 respectively are evaluating afatinib in patients with metastatic and recurrent HNSCC, and in patients with locally advanced disease, respectively. 3435: 1445:"tests on rats showed that at all doses, the drug rapidly causes cancers in a multitude of organs, including the liver, bladder, stomach, skin, thyroid, tongue, testes, ovaries and womb." Somehow our article failed to mention that GSK abandoned their research on it in 2006 and painted a pretty rosy picture instead. I've quickly made it more NPOV, but could someone with more experience with these things take a look and prune any sources which don't meet 31: 3232: 3033: 5349:

internet (the group's website no longer exists), the goal of this group seems to have been to "support those seeking compensation for injuries caused by fluoroquinolones" and it seems likely that the editor himself was involved in litigation against one of the manufacturers. I was wondering if someone could fill me in on the history here and whether there are now policies in place regarding this sort of situation.

780:) a note who might be interacting with some of these folks over the next month or two (the course runs until April 10). I gave them a rundown on some of the common mistakes students make as part of these projects, e.g. assuming that one's edits have to stay up in order for them to be useful as a grade (which I've seen a number of times). I am confident they will be able to avoid most of these common pitfalls. 2206:

work on those prototypes (which look great to me BTW)? I certainly don't want to get in the way if you're already on it. Otherwise, I'm happy to join forces. Right now, we're trying to pick a small ecosystem of articles (one or two diseases, plus all related genes and drugs/compounds) that we can use for prototyping using all the various resources. I'll post here when we start moving forward... Cheers,

893:. The current text contains a few inaccuracies and I wanted to suggest a few more additions as well. To do this though I would think that there would need to be a consensus in favour, so I would like to propose that someone from this WikiProject Pharmacology group or another interested editor review the suggestions and reply and/or accept and implement, if possible. The suggestion is below for review. 5377:, i.e., everything in or articles should have high-quality sources. Case reports, animal studies etc. are insufficient for claiming adverse effects of a drug, just as they are insufficient for claiming effectiveness. Dealing with people who have an agenda to push (be it the addition or removal of adverse effects) is difficult to neigh-impossible, unfortunately. In theory, there is of course 3242: 1209:

mechanism of caffeine electro-oxidation, involves four electrons and four protons. In this more complicated process, the first step is a two electron, two proton oxidation of the C- 8 to N-9 bond to give the substituted uric acid (c), followed by an immediate two electron and two proton electro-oxidation to the 4,5-diol analogue of uric acid (d), which rapidly fragments.

4068:, and add yourself in the "active" section. But really all it comes down to is editing pages you want to edit within the subject matter. I see from your user talk page that you are already in touch with the Teahouse, and that's the ideal way to get advice about editing. (Please also feel free to ask me on my user talk page if you ever have any questions.) By watchlisting 5194: 3763: 4774:). It's a broad field and – a bird in the hand is worth two in the bush – I found it easier to begin with a more restricted task. I chose the term "GPCR oligomer" as a working title and it was envisaged that the article once might be integrated into a broader framework (oligomer → multimer, GPCR → receptor/target protein in general). -- 2521:. (Those prototypes are important for us to get continued funding to support our contributions here.) Once we decide all the great information that can be harvested from reliable sources and displayed in these infoboxes, I'm sure we can work out the technical details of how to make it happen (relying heavily on Wikidata). Cheers, 4886:

the benefit appears to be little to none in those with mild or moderate depression.", but one, representing a single side of the argument, has been presented. NPOV states "Avoid stating seriously contested assertions as facts". I'd say the intro to this article is as good of an example of that as can be found in Knowledge (XXG).

2823:. Articles are typically reviewed for two weeks. If substantial concerns are not addressed during the review period, the article will be moved to the Featured Article Removal Candidates list for a further period, where editors may declare "Keep" or "Delist" the article's featured status. The instructions for the review process are 3705: 2535:

Hi Andrew! I already visited the Molecular Biology task force page a couple of times to update the tables. I also looked at the new infoboxes and they look really great. We should stay in touch on the MB task force page. If you think of any queries that should be included in the infobox we can try to

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When PotatoBot created the trade name redirects, quite a number of errors in Drugbank turned up. If I remember correctly, they have names of combination drugs in the Brand names section (although, meanwhile, there is a separate Brand mixtures section, so maybe that's fixed). I also caught a number of

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School of Medicine for a few months now about a wiki editing pilot project. I just spoke with the students (a total of 8, so it should be quite manageable) about editing the ins and outs of editing wikipedia a bit. It is part of a course on pharmacology, and the "prompt" they were given had something

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Thanks for your willingness to contribute! Another suggestion: Keep in mind that Knowledge (XXG) is for a general audience, not for medical professionals. Most people won't get as far as the word "cancer" in the first sentence of your suggestion, they'll probably give up on ErbB, malignancies, or one

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The WiR will receive a stipend of up to $ 6,500 USD/£4,000 for the initial six month term, which will be paid in two instalments at the beginning and middle of the term. In addition, the WiR will be funded to attend and present a session at the 22nd Cochrane Colloquium in Hyderabad, India, 21st-25th

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Cochrane is structured as a network of groups located throughout the world to which people contribute in different ways, but primarily as authors of Cochrane Systematic Reviews. The WiR will work remotely from their chosen location and will interact with a number of groups and their contributors via

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The position is open to anyone who can meet these criteria but may be particularly suited to students or recent graduates looking to expand their skills and experience, or those who work part-time in another job. Candidates should have an excellent level of written and spoken English, although those

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A few years ago the AMA had recommended against prescribing generic levothyroxine due to dosage fluxuations. I was told this by many doctors over the last decade. As a patient, I can't find any information online about the current status of this controversy and neither my doctor, nor my pharmacist

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agonists, respectively, because that's basically what they are and how they work. Lumping these in with cathinones and hallucinogenic amphetamines/designer-psychostimulants/bath-salts is just bad categorizing. This is a fairly well-established category in the literature, so we should really update

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I've also been catching up on the past discussions that Boghog linked for connecting genes and diseases. Definitely lots of relevant thoughts there. In addition to the PDB and Drugbank as resources, we've also just started looking into PubChem data as well. Boghog, were you planning on continuing

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Thanks for the clarification. On taking a look at figure 3A, this does indeed seem to refer to the bromine compound as epimerox, which as you say, is different from the chlorine compound in the description. I agree with you that that's really frustrating. Is there anyone here with suitable knowledge

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for the revision containing this infobox. I'm not a chemist, but I'm a bit perplexed as to why the molecule in the infobox seems to be different from the molecule given in the systematic name taken from the article: particularly the presence of bromine instead of chlorine, which even I can spot from

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policy and therefore have an internal policy to engage with the Knowledge (XXG) communities first about certain content suggestions. Only when patient safety is at risk, would we edit an article ourselves but always give a reasoning for this via the Talk pages. And thank you for the resource tip – I

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I was also interested to see in the history of these articles that all of the fluoroquinolone articles seem to have been re-written in 2009 and then mostly dominated for 2 years by an editor who self-described as the head of the "Fluoroquinolone Toxicity Research Foundation". Digging around on the

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article over the last few weeks and would appreciate any commentary on what else needs to be done there, particularly with respect to content. I'm planning to take a run at the other fluoroquinolones over the next few months and it would be good to have a feedback on cipro article before working on

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I have no background or technical knowledge of pharmacology, so I can't act on my evaluation of this article, but I thought I would draw this to this team's attention. After all, Lexapro/escitalopram is one of the most commonly prescribed anti-depressants, so I would imagine this page gets quite a

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Receptor heteromers as well as biased signal transduction are becoming increasingly important in pharmacology and in drug development. I think it would be good to have corresponding categories and I put this thought up for discussion. – What is the best naming? Anything to consider for embedding it

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This submission needs extensive editing. The main problem I have with this article is that it is essentially a repackaging by Nicholas Bodor of soft drug and targeted drug delivery approaches with a specific terminology that has not been widely used by independent third party sources. Amazingly

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I'm not entirely familiar with the identifier verification system, so I was wondering if anyone from this wikiproject would be able to validate the links in this article, as they seem to go to the correct place. I intend to nominate the article for FA status very soon, and I have a feeling a bunch

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Another question... any idea on the appropriate title for amphetamine blends known in the US as "Adderall"? The INN would be listing out each ingredient. "non proprietary name" listed on Shire's page is "Mixed salts of a single-entity amphetamine product". Either of these are too long to be used as

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the wiki page on pheniramine shows that it is pregnancy catagary "A" drug, but does not specify is it US FDA catagory or a Australian catagory. A search on web shows the drug to be catagorized by US FDA as catagory "C". I request any competant doctor / pharmacist to look into the matter and correct

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Hm. Aren't these just some random unrelated mechanisms? Oxidation of paracetamol, hydrolysis of Aspirin, oxidation of caffeine. Why are they in one image, and how are they related to the effects of Aspirin (as they have been placed in that section of the Aspirin article)? There also seem to be some

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Hello. Thanks for your quick feedback. Good suggestion to not hyperlink words every time, will remember this. The asthma study is not referenced any longer as Olodaterol is not further developed for the indication asthma. With your proposal to add the entire suggested text, to avoid COI, we ask the

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The ErbB Family is frequently dysregulated in cancer cells; overexpression of ErbB receptors can lead to the development of a variety of solid tumours and is associated with poor prognosis and advanced-stage cancers. Over-activation of these receptors triggers intracellular signalling cascades that

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Is rxwiki.com a sufficiently reliable source for Knowledge (XXG)'s pharmacology/medical articles? The website appears to be crowd-sourced, but it also claims to be "written, edited, and reviewed exclusively by licensed pharmacists". I have noticed quite a few editors who do nothing but add content

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I think one can make that argument Doc, and that there is some good supporting evidence. But is it the overwhelmingly dominant thought among psychiatry experts? There are a whole slew of articles on both sides around the assertion "When both published and unpublished trials are taken into account

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The structure in the chembox is what is shown in the first reference, figure 3A. That being said, the name listed in the synthesis is indeed different (minorly so) from the figure. As a chemist this frustrates me a lot; chemical accuracy is my currency. I suppose it's best to just table the issue.

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Afatinib has also shown clinical efficacy in EGFR M+ second-line NSCLC (LUX-Lung 2 Phase II trial) and is being investigated in later lines of treatment (LUX-Lung 1 and 5). LUX-Lung 6, the sister trial to LUX-Lung 3, is investigating afatinib as a first-line treatment in EGFR M+ NSCLC patients in

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Afatinib, an irreversible ErbB Family Blocker, inhibits signal transduction of all kinase receptors from the ErbB Family, blocking key pathways involved in cell growth and division. Since ErbB Family signalling can be initiated by a variety of homo- and heterodimers, a combined inhibition of more

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I would like to propose an update to the current article for afatinib. The current text, as a whole, is out of date and it contains many inaccuracies, so in a sense, a major re-write is suggested. To do this though I would think that there would need to be a consensus in favour, so I would like to

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It's basically a summary of the medicinal chemistry of a series of syntheses. It's not clear to me that the compounds actually have any pharmacologic usages, beyond some trivial structure-activity relationships. For that reason, I'm inclined to support page deletion. But first, I'd like to see if

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As for drug articles containing biased stuff by special interests groups, this is a serious issue. I am actually surprised that pharmaceutical companies have not already tried to improve their brand protection on Knowledge (XXG). It should be possible to be a declared drug company representative

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is there for a reason and deserves close reading. I've been seeing a lot of pitchfork-wielding opposition to primary sources lately, and while I'm sure everyone has the best interests of the encyclopedia in mind, our policies and guidelines do note (quite rightly) that they can be acceptable and

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status, a few sentences on side effects, contraindications and interactions would be appropriate when this information is available. Regarding asthma: I'd find it nice to retain that information ("... was also investigated for the treatment of asthma, but these studies were discontinued " or the

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Yang JCH et al. LUX-lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations. Oral Presentation at 48th Annual Meeting of the American Society of

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The LUX-Lung clinical trial programme is investigating afatinib in a number of clinical settings with advanced NSCLC. One of the pivotal trials in this programme is LUX-Lung 3, a global, multicentre, randomised, open-label, Phase III trial, studying afatinib in EGFR M+ NSCLC patients who had not

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The WiR will be expected to work flexibly at different times of their day to suit their schedule and to help support Cochrane groups throughout the world (some work in the evenings is likely to be required). The exact number of hours per week will be agreed with the successful candidate, but is

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I gave it a quick look, and I wonder whether we should suggest to the editor who has been working on it that it become a part of an existing page (not sure which one), instead of being a page on its own. It's not clear to me that it really is a single free-standing topic on its own. But I'm not

2245:"brand names" that were actually chemical names and some genuine errors (brands that contained different substances altogether). I gave up fixing the redirects, there are too many of them. So unless someone can convince me the data quality has significantly improved, I won't run that task again. 4736:

Part of the problem is that the GPCR and nuclear receptor fields have developed slightly different terminology to describe equivalent behavior. The question is whether we should have two sets of parallel articles or try to merge them. I am leaning towards merging leaving appropriate redirects

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Hi Doc James! If your interested in what data should go into the infoboxes then you could make a task force page on Wikidata and assemble a list of things that should be included. I can help out with any Wikidata specific problems (or I can set up a basic page with existing properties). In the

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The oxidation products for are N-acetyl-p-quinone imine for acetaminophen, which involve two proton and two electron transfer, and 3,6-dioxocyclohexa-1,4-dienecarboxylate (a) or 5,6- dioxocyclohexa-1,3-dienecarboxylate (b) for aspirin, which involves two electron and one proton transfers . The

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is an independent medical nonprofit organization consisting of over 28,000 volunteers in more than 100 countries. The collaboration was formed to organize medical scholarship in a systematic way in the interests of evidence-based research. The group conducts systematic reviews of randomized

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The WiR will report to, and be guided by, Cochrane’s Head of Communications & External Affairs, and a Senior Editor of The Cochrane Library. They will also interact regularly with other members of Cochrane’s senior management team and representatives of its publishing partner for

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I certainly think there is legitimacy to reasoned arguments questioning the efficacy and safety of many drugs, including this one. But compared to many other wiki articles about similar drugs, the current article does not seem objective to me, and seems to strongly push an agenda.

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As it stands it appears that they will be looking for either stubs to build out that are related to the clinical vignette that is their initial prompt; they might instead/also work on rewriting part of an article that is jargon-laden or otherwise confusing to adhere more closely to

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for a standalone page. It's probably just a matter of someone wanting to do the work of creating it. Personally, I think that would be a better outcome than simply expanding the infobox, but I doubt that anyone at this end would object to putting an infobox in that page section.

2473:. 5 properties (excluding very generic things like "named after" and "image") are available already. I have 7 pretty straightforward strings lined up for creation. The only help we currently need is an occasional visit and maybe a comment to one of the proposed properties. -- 166:

propose that someone from this WikiProject Pharmacology group or another interested editor review the suggestions and reply and/or accept and implement, if possible – or – if I can implement only some edits, that would be feasible as well. The suggestion is below for review.

2094:). This turned out to be more complicated than I originally thought. Many drugs, particularly older but still important ones display polypharmacology. Listing all the targets for a particular drug could become rather messy. But maybe we should again consider this. 3833:

I just went through and deleted every reference to "trace amines" and non-designer and non-cathinone "amphetamines" that I could find in associated reuptake inhibitor or releasing agent pages. These two groups could just as well be called endogenous and exogenous

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What the evidence states if of primary importance. Usage does not always match the evidence. Usage should be discussed in the society and culture section. And if there is data dealing with the discrepancy between usage and evidence should also be discussed there.

5381:, telling the editor about or quality criteria, discussing the matter with them, and ultimately blocking them. But blocks seldom occur of there is no blatant vandalism, so the effect often is endless discussion (as was the case with the editor you mentioned). 139:

was assessed as a "B" by Project Pharmacology, there has been heavy editing of the article, particularly related to the claimed safety of cannabis; There is currently a POV tag and there are active discussions and editing. Additional comments are welcome.

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After the success of the gene pages, the idea of expanding to other biomedical topics has been suggested several times by other scientists I’ve talked to. The set of drugs and compounds that are relevant to human diseases is one natural area. Clearly,

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currently has a redirect to its plant name - the page's infobox is just a box with its binomial name and a picture. I assume its a wikiproject plants format, but given that it's a pretty well researched drug (interesting neuropharmacology - it's a

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1. Bouyssou T, Casarosa P, Naline E, et al. Pharmacological characterization of olodaterol, a novel inhaled beta2-adrenoceptor agonist exerting a 24-hour-long duration of action in preclinical models. J Pharmacol Exp Ther. 2010 Jul; 334(1): 53-62

444:. There are a variety of mechanisms leading to constitutive activation of this signal-transduction pathway, including receptor mutation (e.g. EGFR mutation in lung cancer), receptor overexpression (e.g. HER2 overexpression in breast cancer) or 1468:

I've gone through both pages, and hopefully I've helped with that issue. There are still a lot of primary sources (not review articles) that are cited. That didn't seem to me to be a problem, but other editors might want to double-check that.

4613:"Biased Ligands" is synonymous to "functionally selective ligands" and refers to the articles "Functional selectivity" and "Ligand (biochemistry)". "Receptor heteromers" refer to "Heteromer" and "GPCR oligomer". Emerging examples are 4755:

I would appreciate to have a superordinate article in the long run and I suppose Boghog is, at the present, the only one who could manage it. Indeed, I am not familiar with nuclear receptors. One has to consider that transporters

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is adding a section titled "Spectrum of Bacterial Susceptibility and Resistance" to many antibiotic articles. I don't know if this is relevant information for those articles or not, so I thought I would ask here. It looks like

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Yes, that makes sense. Perhaps the new material could be generalized, so that it would not be exclusively toxicology, or perhaps it could just be made a long page section, with future edits to add a parallel pharmacology section.

2338:. The short summary is that it is probably time for this project to also build a presence on Wikidata. Properties are already created and we need all the expertise we can get. I can help out with any Wikidata related questions. -- 287:

and forget to come back. Try to start simple and give technical details later, as in "Afatinib is a drug under investigation for the treatment of various types of cancer that are driven by mutations of a family of proteins called

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policy you should not edit the article yourself. There are a few issues with the text below. One is that the references are not very well formatted and the second is that many of the sources are primary rather than secondary. Per

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our content accordingly - especially because literally no one (at least in the past 5 years in relevant secondary sources on these) has called amph/meth that term. Edit:I forgot to link the only pubmed source on this topic:

4133:? I'd say that, at least for UK readers, it's a pretty important topic, but the article is a mess. (Consider this a note to self as much as anything; I'm on a school computer, and have three minutes until roll call starts!) 1811: 4089:

Thanks for the tips. I'll add myself to the list, grab a ubx, and get stuck in. One thing I've noticed is the squiffy grammar in a handful of pharmaceutical articles. Would it just be retentive of me to go editing them?

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Ou, S-H L. Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): A better mousetrap? A review of the clinical evidence. Critical Reviews in Oncology / Hematology 2012,

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2140:: Let me get caught up on those past discussions. Though taking a cue from the Gene Wiki pages, we could have a show/hide section of the template when the list gets too long. Also, we are starting to work with the 998:

6. van Noord JA, Korducki L, Hamilton AL and Koker P. Four Weeks Once Daily Treatment with BI 1744 CL, a Novel Long-Acting ß2-Agonist, is Effective in COPD Patients. Am. J. Respir. Crit. Care Med. 2009; 179: A6183.

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folks, so we could also categorize that data over there and figure out how/if to display it on the Knowledge (XXG) page later. (I should have mentioned that Wikidata figures prominently in all the bot work we're

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Hey, even if it is a toxic metabolite, does it matter? It is truth. Truth can be even bad. M I rite? I am telling again. The third step was a mistake on my part (one double bond in the main reaction is missing)

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Annual Meeting 2012 and a further analysis was presented at ESMO 2012 (European Society for Medical Oncology). Data from this trial formed the basis of submission of afatinib for marketing authorisation to the

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I am glad to contribute! Based upon the feedback above, please see below for the updated suggestion. I have included more secondary resources and edited the introduction text as well. Looking forward to further

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That is indeed the Australian category. Pheniramine is pregnancy category C in the U.S., although I don't think any systemic formulations are available anymore. I have amended the drugbox accordingly. Thanks,

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Hey thnx for pointing out the reaction on line 3. I made the reaction from the original article (I am the first author of that article) colored for wikipedia and forgot to put a double bond. Thank you again.

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Is there any chance of getting machine-readable lists? I'm manually updating the drugboxes once a year, and still haven't finished checking the boxes for missing codes, so doing this by bot would be of great

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4. Joos G, Aumann JL, Coeck C, et al. ATS 2012 Abstract: Comparison of 24-Hour FEV1 Profile for Once-Daily versus Twice-Daily Treatment with Olodaterol, A Novel Long-Acting ß2-Agonist, in Patients with COPD.

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to me since all the content is being referenced to company web pages at toku-e.com. It will probably continue since it seems that he is going through all the articles alphabetically and he is only on C.

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Do you mean attention specifically to the pharmacology content of the page? I don't see any obvious problems, but I might be missing something. I think the current events are mentioned on the page, and at

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is already serving a very valuable role here tracking links to external databases and providing lots of relevant data. Relative to what already exists, I can see a few possible ways we might contribute:

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LUX-Lung 6: A Randomized, Open-label, Phase III Study of BIBW 2992 Versus Chemotherapy as First-line Treatment for Patients With Stage IIIB or IV Adenocarcinoma of the Lung Harbouring an EGFR Activating

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Afatinib (trade name under discussion) is a drug currently under investigation for the treatment of various types of cancer that are driven by mutations and overexpression of a family of proteins called

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I would prefer non-moving ones in the articles, I always find them very distracting when reading an article. However it would be nice to have a link to the animated version in the caption in that case.

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talk page, you can find out whenever there is something that has been brought to the attention of the WikiProject where you and other editors might want to help out. By the way, I like your username! --

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LUX-Lung 5: Afatinib Plus Weekly Paclitaxel Versus Investigator's Choice of Single Agent Chemotherapy Following Afatinib Monotherapy in Non-small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib

2134:: The INN list seems like an excellent starting point. I'd been thinking of the more research-oriented sites (PubChem, ChemSpider, Chembl, etc.), but the INN list seems a great alternative/complement. 2283:

to keep an eye out for those issues. On the ATC issue, I'm hoping (naively?) that we can find a machine-readable list, and if so, we'd be happy to take over maintenance of that property... Cheers,

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We would appreciate any feedback, thoughts, and suggestions on whether this community thinks our involvement would be useful and productive. (Note, we’ve also started a very similar discussion with

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Sequist L. V. et al. LUX-Lung 3: Symptom and health-related quality of life results from a randomized phase III study in 1st-line advanced NSCLC patients harbouring EGFR mutations. ESMO 2012 Congress

3471: 2584:). And you're absolutely right that the data deposition is cumbersome at the moment. We should stay in touch and try to work out how something like that could be stored independent of its source. -- 5045:- MEDRS review) which is prescribed in some countries for depression, shouldn't this be a drugbox? What's normally done when a topic has multiple associated wikiprojects with different infoboxes? 5187: 5151: 2903: 2076:

templates. The last edit by this bot was a year ago. Hopefully this bot will resume operation at some point, but regardless, any proposal for drugbox data maintenance should be coordinated with

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for key information on human genes. In cases where a gene page already existed, we just added/updated the template. When they didn’t exist before, we auto-created stubs. Now, we maintain a

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3. Bouyssou T, Hoenke C, Rudolf K, et al. Discovery of olodaterol, a novel inhaled b2-adrenoceptor agonist with a 24 h bronchodilatory efficacy Bioorg Med Chem Lett 2010; 20 (4), 1410-1414

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discusses animated images and has recommendations on how to do them. Please remember also that not all users have fast machines, broadband connections, large screens, and modern browsers.

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3. van der Molena T, Cazzola M. Beyond lung function in COPD management: effectiveness of LABA/LAMA combination therapy on patient-centred outcomes Prim Care Respir J 2012; 21(1): 101-108

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2. Cazzola M, Molimard M. The scientific rationale for combining long-acting β2-agonists and muscarinic antagonists in COPD Pulmonary Pharmacology & Therapeutics. 2010; 23 (4):257-267

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Hi Wnt! I think that you're idea is great, but that you are a little ahead of Wikidata. Wikidata is still far behind what WolframAlpha can do in terms of dynamic content generation (e.g.

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Sorry for the late reply -- was out of town for a week. Great point on Wikidata of course, so thanks for including those links. We've starting thinking about the Wikidata model behind

1754:'s first and only edit here, so they may be struggling with the infobox syntax and conventions -- I know I am. Can someone knowledgeable take a look at this and check it out, please? -- 2816: 2180:

including target, transporter, carrier, and enzyme information plus a lot more for each drug. Perhaps the redirects could also be updated then as I think that was a one-time job. --

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5. van Noord JA, Smeets JJ, Drenth BM, et al. 24-hour Bronchodilation following a single dose of the novel β(2)-agonist olodaterol in COPD. Pulm Pharmacol Ther. 2011; 24(6): 666-72

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anyone else in this project feels that this is something on its way to clinical use, because that could be something I'm unaware of, that could make it notable for our purposes. --

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It has been over a year since I last worked on the prototype (I obviously ran out of steam ;-). In any case, I am happy to join forces Andrew and resume work on a prototype (this

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article has content that might be of interest to WP Pharmacology, because of the spiders venom and a specific antivenom injection. Medical pages on this genus of spiders include

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I'm not saying we should issue more blocks (this could drive inexperienced editors away), but it is sometimes difficult to find a balanced stance towards "difficult" editors. --

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page. Much of the article is not about Escitalopram per se, but seems to be a thinly-veiled argument about how anti-depressants are ineffective and can cause permanent damage.

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By the way pubmed health is also a good source. They contain lists of brand names. I am wondering if we should get a bot to add this somewhere? It should also be in Wikidata.

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I see that the existing page has a section about the medicinal use, but you raise an interesting point. It seems to me that the pharmacological formulation easily satisfies

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Thank you! Drugbank is definitely on our list of resources, and maintaining the redirects is definitely something we can add to the scope of our bot. (I also just invited

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Because of the ongoing edit warring, I have protected the page. Any additional assistance from the regulars here to help resolve this efficiently would be appreciated. --

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the title. I have it titled as "amphetamine salts combo" which is how it is named by pharmacies/industry, but a few editors expressed concerns that "combo" is too informal.

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That's my understanding too, but did read the guideline for naming of drugs on Knowledge (XXG)? "The article title and the first name to mention in the lead should be the

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I am wondering if there is any clinical significance? Ie What do these mechanisms mean to someone reading the article? Is this how these meds are metabolised? Eliminated?

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in the "Today's articles for improvement" section for one week, beginning today. Everyone is encouraged to collaborate to improve the article. Thanks, and happy editing!

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LUX-Lung 8: A Phase III Trial of Afatinib (BIBW 2992) Versus Erlotinib for the Treatment of Squamous Cell Lung Cancer After at Least One Prior Platinum Based Chemotherapy

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Would be helpful to have definitions of solvent vs. cosolvent. Also derivations of equations would make for a nice complete story. Does anyone have this info off hand?

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Sometimes a still image is enough, sometimes it is hard to understand something without animation. And is it possible to insert a link on animated image in drugbox?

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The LUX-Lung, LUX-Breast and LUX-Head & Neck clinical trial programmes are investigating afatinib in a number of clinical settings within these disease areas.

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2. Casarosa P, Kollak I, Kiechle T, et al. Functional and Biochemical Rationales for the 24-Hour-Long Duration of Action of Olodaterol. JPET 2011; 337: 600–609

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Solca, F. et al. Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker. J Pharmacol Exp Ther 2012, 343(2)

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Ah ok, got it. So, there's no need to provide much information about SSRIs, since they are just products of marketing based on poor evidence. Carry on, then.

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I have a strong preference for the second one (rotation only about one axis) since it is easier to view and it is much less distracting. However I agree with

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like) for historical reasons. That's precisely the kind of information you don't find in package inserts or drugs.com, but only on Knowledge (XXG) :-) Cheers,

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seeking fair treatment of a product within the constraints of Knowledge (XXG) policy (although "paid editing" seems very much frowned upon for COI reasons).

3675:) - combining it with the former mechanism of action section and updating the content from 2 recent reviews. I'd appreciate it if someone familiar with the 2414: 1483:

I've noticed that an IP editor has started a thread about this at the dispute resolution noticeboard, not that they really have much of a valid complaint. --

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has initiated two trials aimed at comparing afatinib head-to-head with targeted treatment agents. LUX-Lung 7 is a Phase IIb trial evaluating afatinib versus

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As someone seeking information about this drug, I did not feel I could consider this page a reasonably reliable or objective place to begin my research.

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I need feedback on my tentative plan for which sections to move and which sections to copy to that article, which will also need to be renamed. Regards,

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would be a logical place to merge this article. On the other hand, the amount of material in this new submission would overwhelm the existing article.

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Have had a look at the article and commented on the Talk page. There are at least two claims still in the text that should be removed immediately IMHO.

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The first line shows the creation of a toxic metabolite of paracetamol, the second an inactivation step of Aspirin, and I don't know about the third. --

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Wieduwilt, M.J. et al. The epidermal growth factor receptor family: biology driving targeted therapeutics. Cellular and Molecular Life Sciences 2008, 65

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Wikiproject Pharmacology expert members first for their review and for their help with adding in what they see as appropriate for Knowledge (XXG). --

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LUX-Lung 7: A Phase IIb Trial of Afatinib(BIBW2992) Versus Gefitinib for the Treatment of 1st Line EGFR Mutation Positive Adenocarcinoma of the Lung

1054:

What about the asthma study mentioned in the present version of the article? Is this indication still in the pipeline, or has it been discontinued?

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to do with methamphetamine, or perhaps other sympathomimetics or indications for same. And FWIW, I have also spoken a bit with Lane Rasberry and

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for drugs, it advises to use the INN name if available. The INN for amphetamine is amfetamine, however I think that is unconventional. This

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find a way to implement that into our data structure. There was also recently this request to generate pictures out of raw data from GenPept (

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Given the size of this change, I've temporarily reverted my deletions pending discussion - but I did expand the agonist category last night.

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and is willing to flesh out this stub, it would be greatly appreciated. This compound will probably be all over the news in the coming days.

917: 752: 474: 951:(NDA) for olodaterol provide substantial evidence of safety and efficacy to support the approval of olodaterol as a once-daily maintenance 5186:

I'm not sure how much longer this nomination will be open, but if anyone else is interested in providing feedback/taking a position on the

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Clauson, KA.; Polen, HH.; Boulos, MN.; Dzenowagis, JH. (2008). "Scope, completeness, and accuracy of drug information in Knowledge (XXG)".

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Yes SSRIs have been very effectively marketed on very poor quality evidence. The best available independent sources raise these concerns.

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have its own page, or should it be a section in amfetamine/amphetamine? What should it be named? Dexamfetamine or dextroamphetamine?

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However, I have to confess that at the moment, I'm selfishly most interested in designing the new and expanded template prototypes at

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Such categories should have the same names as the articles explaining the concepts (only in the plural). Regrettably, we don't even

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Just finished some excellent discussions regarding how to improve these drug boxes. One would be to add these overview from the EMA

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article suggestion below. Looking forward to feedback on the entire suggestion or on individual suggested edits as well. Thanks! --

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1. Cazzola M, Calzetta L, Matera MG. β2-adrenoceptor agonists: current and future direction Br J Pharmacol. 2011; 163(1): 4–17.

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I also like this idea. Probably easier than diseases not already covered as there are fairly well defined lists of medications.

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5. Ford PA, Russell REK, and Barnes PJ. ICS and COPD: Time to clear the air. Int J Chron Obstruct Pulmon Dis. 2009; 4: 289–290.

620: 5011:) 15:02, 1 December 2013 (UTC) You may find a wealth of information on the FDA web site or by including "FDA" in your search. 4149:

Is there more recent data on the scope, completeness, or accuracy of drug information in Knowledge (XXG) than this 2008 study?

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An active Knowledge (XXG) editor, a Wikipedian in good standing, for at least 1 year and with 1,000 edits (more is preferable)

4520:. I would like to know if the Wiki article on individual species of venomous spiders are within the scope of WP Pharmacology. 2086:

Adding wiki links to related genes and diseases: I had previously proposed adding target/MoA information to the drugbox (see

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In an effort to centralize the discussion with all interested parties and actually work on tangible prototypes, I've created

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as a first-line treatment in EGFR M+ NSCLC patients. LUX-Lung 8 is a Phase III trial evaluating afatinib head-to-head versus

4770:) and ion channels also can multimerize and, in addition, the range of these proteins are supposed to do so across classes ( 3630:

I've made another, more complicated proposal to split or copy and merge the socio-cultural and historical components of the

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to upload content to Wikidata. So I hope all of that will be highly complementary to your Medicine Task force work (and to

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I'm surprised that wasn't spotted by the reviewers. I wonder if the authors have published anything else on the subject? --

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As far as I am aware, spelling with an "f" is indeed very unconventional, for any of them. Let's stay with "ph", please! --

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PubChem also contains errors. Notably, all polymers are listed as monomers (including molecular mass, InChI, SMILES etc.).

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BIBW 2992 and BSC Versus Placebo and BSC in Non-small Cell Lung Cancer Patients Failing Erlotinib or Gefitinib (LUX-LUNG 1)

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in the "other names" section says that it refers to racemic form and must be named using this name for European products.

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since I am not aware of any general review articles that covers both biased GPCR and nuclear receptor ligands. Thoughts?

3216: 3124: 940:.1-6 Olodaterol is being evaluated as a once-daily inhalation product administered in the Respimat Soft Mist Inhaler.4-6 4914: 4848: 4708: 4656: 2447: 2399: 2371: 2042: 2013: 1774: 1291: 1192: 1160: 1090: 944: 901: 791:

Most of them, as of right now, do not have WP accounts, but should be making them soon. If you see them around, say Hi!

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This dual PPAR α/γ agonist is the first glitazar to be approved. Just in case somebody has time to write an article. --

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That all sounds great, thanks for the initiative! At the moment, I can only add a couple of thoughts to the discussion:

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I've left a note on the talk page of the editor who created the draft page, telling them about the discussion here. --

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Reid, A. et al. 2007. Dual inhibition of ErbB1 (EGFR/HER1) and ErbB2 (HER2/neu). European Journal of Cancer 2007 43(3)

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I can see no POV problems in your suggestion; it looks perfectly neutral. If you intend to expand the article beyond

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knows. The levothyroxine article should describe this problem, how standards have changed, and the current status.

4866: 4823: 4130: 3502: 2518: 2315: 2027: 38: 3734:. I manually verified that the links with red checks (KEGG, ChEBI, and ChEMBL) were all OK, and then updated the 2511: 1005:

7. Hollis A. Panel Overwhelmingly Supports Boehringer COPD Drug Striverdi. FDA News/Drug Industry Daily 1/30/2013

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We want to learn more about you and see how we can best give you an opportunity to work with Cochrane. Signup!

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Normanno, N. et al. The ErbB receptors and their ligands in cancer: an overview. Current Drug Targets 2005, 6(3)

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we MUCH prefer secondary sources. If you want to adjust you suggestion to comply with this that would be great.

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email and online. Cochrane will provide a selection of online collaboration tools to facilitate communication.

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Cochrane is a fantastic organization which published systematic reviews about medical treatments and efficacy.

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If you have problems with Knowledge (XXG)'s citation system, I can do it for you when you have added your text.

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http://ajrccm.atsjournals.org/cgi/reprint/179/1_MeetingAbstracts/A6183?sid=998dc07a-878a-4098-9654-153a94e60f04

988:

http://ajrccm.atsjournals.org/cgi/reprint/185/1_MeetingAbstracts/A2930?sid=0fb45a56-8e92-42dc-b8b7-13b9725c56f6

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of the mentioned article shows the dichloro/furan compound, but I'd prefer a second and independent source. --

5008: 3467: 1815: 1362: 676: 665: 5022: 4461: 3559: 2911: 1877: 1770: 1751: 1606: 1581: 1534: 1416: 1380: 1086: 947:(FDA) Pulmonary-Allergy Drugs Advisory Committee (PADAC) recommended that the clinical data included in the 897: 866: 737: 5014: 4943: 3495: 3153: 1529:

There appears to be some resolution happening now that the discussion has gone through several iterations.

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the names and formulae. Clicking the "verify" button also gives what seem to me to be peculiar results.

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received prior therapy (first-line). Positive results from this registration trial were presented at the

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A science and/or healthcare enthusiast, preferably with a background as either a student or professional

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please? It seems to be the product of a problematic sock, but it may have a little useful content. TIA.

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I am unfortunately not qualified to join your team, but I thought I would direct your attention to the

3270: 788:. The consensus was that they would try and sandbox everything before putting it in an actual article. 113: 5257:

A teacher, helping Cochrane contributors to properly and successfully navigate and use Knowledge (XXG)

4296:. I can stop it by hitting ESC, but it really should be still by default until a reader activates it. 116:.) Is this appropriate? Is it possibly some kind of promotion? Or is it helpful and constructive? 5389: 5128: 5070: 4980: 4951: 4947: 4731:

Receptor heteromer ligand – heterodimer selective ligand, we don't yet have an article on this topic.

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Hello, and welcome to Knowledge (XXG)! If you want to make your membership "formal", you can go to

3968:"International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature" 3529: 2526: 2358:. They come in many different languages and thus could be an improvement for many different wikis. 2324: 2288: 2211: 2155: 1986: 1855: 1832:

Oops, overlooked that the two structures also differ in furan vs. thiophene. Fig. 7 in the section

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controlled trials of health-care interventions, which it then publishes in the Cochrane Library.

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Actually, the script to generate the pictures is what I have (at least in a rudimentary way - see

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Pharmacology is my main area of interest, layperson as I am. May I join you, and how may I help?

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Doing a Google Scholar search for "JZ-IV-10 clinical trials" doesn't show anything of interest:

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A passionate individual, both about Knowledge (XXG)’s mission and Cochrane's approach and goals

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4. Barnes PJ. Inhaled corticosteroids in COPD: a controversy. Respiration. 2010; 80(2): 89-95.

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By way of disclosure I have previously done some work on these articles as a registered user.

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Hello. I agree, there is no doubt, that this one is too fast. But these ones have less speed:

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An ambassador, capable of interacting between Knowledge (XXG)'s community and Cochrane groups

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than one ErbB Family member may provide a more successful blockade of ErbB Family signaling.

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are all red links. Maybe you have got the knowledge and time to start on these articles? --

4544: 4426:

Marina, none of the above comments say not to use animation, but rather do it differently.

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Knowledge (XXG):Redirects for discussion/Log/2013 February 12#1,25-dihydroxyergocalciferol

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A remote facilitator, adept with email, scheduling, online meetings, and conference calls

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and also a prolonged discussion on the talk page. I would appreciate some further input.

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I haven't even read past the abstract. So, no. I'm assuming nothing about that study. --

3024:

The Knowledge (XXG) Library now offering accounts from Cochrane Collaboration (sign up!)

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has several problems that I feel compromise its status as Featured Article. Please read

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A collaborator, comfortable working in and among a distributed network of professionals

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Wiki Project Med Foundation is helping to coordinate the search for great candidates.

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Hi everyone, I recently rewrote a large chunk of this article's pharmacology section (

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Thanks for your initiative, please go ahead and add your text! Just some minor points:

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Since I'd prefer to avoid a potential wait of 6–9 weeks for my FA-nom to close, I'd

1940:

I run an academic research group, and one of our current projects is to develop the

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You don't have to link words every time, just link the first occurrence (e.g. COPD).

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Re: the username - thank you! It makes me smile to be complimented on such a thing.

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Wikipedia_talk:WikiProject_Medicine#Proposal_to_create.2Fmaintain_disease_infoboxes

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under development for treating patients with chronic obstructive pulmonary disease

3265:. (Individual access would otherwise cost between $ 300 and $ 800 per account). 4314: 3863:

in a minute, but I could probably use some help setting up an analogous page for

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Categories "Biased Ligands", "Receptor heteromer ligands", "Receptor heteromers"

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we currently do not have a Knowledge (XXG) article on the more basic concept of

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Looking forward to the community feedback and thanks for your time with this, --

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Afatinib is currently being investigated for ErbB-driven malignancies including

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If you wish to start a new discussion or revive an old one, please do so on the

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Just a reminder that Cochrane is taking signups for a Wikipedian in Residence:

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The discussion is pretty spread out, but I made a comment about Wikidata here:

1893:; and obviously they are not about the pharmacology of the compound as such. -- 5042: 4630: 4618: 4536: 4513: 4270: 3506: 3009:

A request for comment has been made at the above link. Your input is welcome.

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for my two cents. If these problems are not addressed, I will take it to FAR.

2110:

Great ideas, thank you both. Just to summarize those points and a few ideas:

1034: 1022: 993: 980: 968: 890: 437: 5093:. It could do with some work, perhaps removing references from books such as 4273:

rather distracting from the text, but I don't want to discourage the author (

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confident in that assessment, so I'm asking here what other editors think. --

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Maguire JJ, Parker WA, Foord SM, Bonner TI, Neubig RR, Davenport AP (2009).

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Proposal to rename "Amphetamine mixed salts (medication)" back to "Adderall"

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There may be more. If people could take a look at them it would be helpful.

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http://www.fdanews.com/newsletter/article?articleId=152790&issueId=16510

937: 502: 498: 441: 5089:, which relies heavily on pharamacological concepts, but doesn't adhere to 4767: 4760: 4675: 4173: 4047: 3999: 3931: 3843: 2737:, and (2) this WikiProject to reconsider that sentence of the guideline. -- 2256: 4488:

submission needs to be shortened and an article on soft drugs be created.

3983: 2319:. We'd welcome your input and continued involvement over there! Cheers, 4145:

Scope, completeness, and accuracy of drug information in Knowledge (XXG).

3387: 3291: 2844: 2567: 2544:. You might also be interested in something like that for the infobox. -- 2541: 2432: 1968:

Identifying a “comprehensive” list of notable compounds for stub creation

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the original version of the graphic with the second one provided above.

4277:) if this is only my personal perception. What do other people think? -- 3850:, some of which have lists of ligands, but these are what I've cited in 3060: 1720:. Any idea which is the current (and preferably non-commercial) name? -- 852:

A cursory PubMed/Google Books search doesn't yield much work on 1,25(OH)

229:

Thank you for the quick feedback. We understand and want to respect the

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You are presuming that the Clauson article was methodologically sound.

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Hello~ I'm interested in pharmacology. May I join, and how may I help?

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Naming conventions and if each isomer should have its own article page

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that speak more than one language are particularly welcome to apply.

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Should this be a redirect to something? It has virtually no content.

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overrides that. So you don't need to use IAR, since UCN is policy --

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meantime everyone is invited to vote on already proposed properties:

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Systematically determining, adding, and maintaining the data mappings

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behind. However one problem of merging is that this might represent

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Would anyone like to help me expand and clean up the article on the

3449:, which is within this project's scope, has been selected as one of 2866:

I started it as a stub. It could certainly use some expansion. --

632:

Dr. Li Reviews Afatinib Data From the LUX-Lung 3 Trial. OncLive 2013

493:

To further explore the potential of afatinib as an NSCLC treatment,

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Thank you Cochrane! If you are an active medical editor, come and

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Providing wikilinks to related genes and diseases (with references)

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Being a top concern in America right now, it needs some attention!

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European Medicines Agency, Medicines under evaluation. January 2013

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referenced to this website. (For example, here are two from today:

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I would like to propose a small update to the current article for

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that keeps these infoboxes up to date with the source databases.

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useful within the bounds of editorial judgment and common sense.

505:

in second-line treatment of squamous cell carcinoma of the lung.

5000:

http://thyroid.about.com/od/thyroiddrugstreatments/a/oct2006.htm

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I also think this is a worthwhile proposal. A couple of notes:

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Date stamp for the archiving bot: 08:43, 15 February 2013 (UTC)

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Thanks for your work! I'll try to have a look when time allows.

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marks in the drugbox won't help my cause in the review process.

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build a bot dealing with the medication templates a while ago.

1810:, along with fluoro-, methoxy- and other derivatives have been 5421:

Blocks should be applied in those who won't play by the rules.

3027: 2124:. And of course, we've had many productive interactions with 2026:

We have a fairly exhaustive list of INN names by the WHO here

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errors -- eg., the third line shows 3 identical structures. --

730:

Knowledge (XXG):WikiProject Council/Proposals/Medicinal botany

728:

FYI, a wikiproject on medicinal botany has been proposed, see

508:

The LUX-Breast clinical trial programme consists of three key

357:

Hi everyone. I just wanted to check back for feedback on this

25: 5138:

Requesting a FAC review on a high-importance WP:PHARM article

2882:

Will be good to know that it won't end up like muraglitazar.

1638:

I've found quite a few other articles with similar problems:

587:

Hanahan, D. et al. The Hallmarks of Cancer. Cell 2000, 100(1)

565:

Hanahan, D. et al. The Hallmarks of Cancer. Cell 2000, 100(1)

3433: 2988:

I see that the page has been accepted into the mainspace. --

2661:

A few questions on style convention on pharmacology pages.

4704:

We have a lot of overlapping articles here. To summarize:

4476:(also known as antedrugs). We do at least have articles on 4292:

The speed's a bit overwhelming, and it doesn't really meet

3679:

receptor could give this section a quick review. Regards,

2819:. Please join the discussion on whether this article meets 1981:

on the idea of expanding disease topics as well.) Cheers,

837:. Creating the article would be preferable, of course... -- 5154:. Any/all constructive feedback or criticism is welcome! 5402:

Someone who makes biased edits should be challenged with

3730:

The instructions for verifying drugbox data may be found

3390:, since it really is just a neologism – could it include 3241: 4990:

Update needed on current status of generic levothyroxine

975:

http://jpet.aspetjournals.org/content/337/3/600.full.pdf

186:

Great we will look at it at some point in time. Per the

4971:

I know this is nitpicking, but there's a discussion on

3743: 3735: 3565: 3553: 3052: 2280: 1743: 1145: 1140:

Reaction mechanism of paracetamol, aspirin and caffeine

4659:

the later of which have been around for quite awhile.

2659:

I have been working on pages related to amphetamines.

886:

WikiProject Pharmacology group and all other editors,

162:

WikiProject Pharmacology group and all other editors,

4066:

Knowledge (XXG):WikiProject Pharmacology/Participants

924:. It is being developed as a once-daily maintenance 760:

about this in the past, it's just now getting going.

1944:

project. Basically, we helped to create/maintain a

1041:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722868/

1017:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085864/

5302:likely to be in the region of 7-12 hours per week. 4796:

Escitalopram (Lexapro) page seems very biased to me

3520:

Spectrum of Bacterial Susceptibility and Resistance

2224:could be used as a starting point for discussion). 1750:I also note that adding this infobox appears to be 1029:

http://www.thepcrj.org/journ/vol21/21_1_101_108.pdf

955:treatment for airflow obstruction in patients with 610:

Clinical Oncology (ASCO) 2012. Abstract no: LBA7500

486:(FDA)for treatment of patients with EGFR M+ NSCLC. 5121:Template:Did you know nominations/Nitrovasodilator 4105:. There's plenty of unmet need for copyediting. -- 2733:My reaction is that this is a good reason for (1) 2500:d:Wikidata:Molecular_Biology_task_force/Properties 928:treatment of airflow obstruction in patients with 860:. I wonder if there's enough for a decent stub... 283:of the other technical terms; or they'll click on 252:Here is some more advice about formatting content 4998:Most recent information I can find is from 2006. 4935:More information needed for "Binding Coefficient" 3856:I cited this the most with this to support it. 3386:Thanks for finding that. I made it a redirect to 3343:Hearing no opposing opinions, I've put it up for 3263:free, full-access accounts to 100 medical editors 2674:So, should we title it amfetamine? Also, should 1451:Acadesine#5-Aminoimidazole-4-carboxamide_riboside 4539:are within our scope but not those on syndroms ( 4535:I'd say articles on venomous substances such as 3426:One of your project's articles has been featured 2434:as there is much overlap between the two groups 4725:) which is in turn a special case of a protein 5244:The Wikipedian in Residence would ideally be: 2906:is of relevance to this WikiProject. Regards, 2083:Stub creation: good idea that I fully support. 2066:had been maintaining the chemical data within 490:Asia (China, Republic of Korea and Thailand). 3202:Help disambiguate authors of scholarly papers 18:Knowledge (XXG) talk:WikiProject Pharmacology 8: 5224:Cochrane Wikipedian in Residence Application 3846:There's more MEDRS and non-MEDRS sources on 3149:The Knowledge (XXG) Library Bookshelf (meta) 169:Looking forward to the community feedback,-- 5123:. Still begs a bit of expansion, though. -- 4818:Thanks for your work and contributions. — 3634:article to the recently split content from 1035:http://www.ncbi.nlm.nih.gov/pubmed/20501985 1023:http://www.ncbi.nlm.nih.gov/pubmed/20381630 994:http://www.ncbi.nlm.nih.gov/pubmed/21839850 981:http://www.ncbi.nlm.nih.gov/pubmed/20096576 969:http://www.ncbi.nlm.nih.gov/pubmed/20371707 482:(EMA) and a New Drug Application to the US 4921:) (if I write on your page reply on mine) 4855:) (if I write on your page reply on mine) 4340:, the graphic should be still by default. 3821: 3640:Amphetamine: History, Society, and Culture 3619:Amphetamine: History, Society, and Culture 3425: 2582:http://www.wolframalpha.com/input/?i=foxp2 2454:) (if I write on your page reply on mine) 2431:We should join it with these efforts here 2406:) (if I write on your page reply on mine) 2378:) (if I write on your page reply on mine) 2279:Hmmm, great caveats, thanks! I've made a 2049:) (if I write on your page reply on mine) 2020:) (if I write on your page reply on mine) 1936:Proposal to create/maintain drug infoboxes 1298:) (if I write on your page reply on mine) 1199:) (if I write on your page reply on mine) 1167:) (if I write on your page reply on mine) 751:I have been in talks with some faculty at 276:) (if I write on your page reply on mine) 215:) (if I write on your page reply on mine) 5081:Another fringe article with odd citations 4671:heterodimers was discovered in 2001 (see 4026:CS1 maint: multiple names: authors list ( 3990: 3922: 3626:Knowledge (XXG) talk:WikiProject Medicine 2469:I started mapping of the drug infobox at 1563:I disagree. It still needs more eyes. -- 4973:Talk:Meclizine#Title needs to be changed 2506:student this summer working on updating 2128:so I look forward to continuing those... 1718:User talk:Anypodetos#Nanofitin / Affitin 1147:. Not sure about copyright and utility. 4975:which is the correct INN. Any ideas? -- 4587:articles on that as far as I can tell: 4378:Special:Contributions/MarinaVladivostok 4321:. Which of the two variants is better? 3890: 3261:Cochrane has generously agreed to give 2164:One more suggestion for a data source: 1595:By the way, may I remind everyone that 1176:Uploader is the same as the author per 523: 4190: 4179: 4016: 4005: 3948: 3937: 3713:(Also posted to the chem wikiproject) 44:Do not edit the contents of this page. 4651:"Biased Ligands" are synonymous with 3859:I'm about to add a bunch of pages to 3207:Be a Knowledge (XXG) Visiting Scholar 2116:: We will definitely coordinate with 1708:I've received a request to re-rename 1352:pheniramine pregancy catagary A or C? 918:long acting beta-adrenoceptor agonist 475:American Society of Clinical Oncology 432:ultimately cause uncontrolled tumour 7: 5191: 5190:, more input is always appreciated. 2768:That's a very good point. Thanks! -- 2172:to redirect trade names to INN's by 1643:Growth hormone releasing hexapeptide 882:Update to current Olodaterol Article 5146:appreciate it if a few people from 3644:Talk:Methamphetamine#Split sections 2613:has been nominated for deletion -- 1742:has just had an infobox added. See 1449:? There many also be problems with 3642:. The talk page discussion is at 2176:. All their data is available for 24: 5150:would provide their input on the 4635:D1-D2 Dopamine receptor heteromer 2564:Template:ImportProtein/Src (gene) 916:Olodaterol is an investigational 5192: 3916:10.1111/j.1471-4159.2010.07109.x 3761: 3703: 3452:Today's articles for improvement 3240: 3230: 3031: 763:I just wanted to drop everyone ( 397:Epidermal growth factor receptor 29: 5414:path (if not collaborating) or 4682:folks a little longer than the 4568:into the category tree? etc. -- 4452:Anyone interested in reviewing 3459:to appear on Knowledge (XXG)'s 3169:Knowledge (XXG) Loves Libraries 2512:d:Wikidata:Chemistry_task_force 399:(ErbB1) mutation positive (M+) 4686:people to figure this out ;-) 4257:20:35, 29 September 2013 (UTC) 4235:19:56, 29 September 2013 (UTC) 4219:03:02, 29 September 2013 (UTC) 4140:07:38, 11 September 2013 (UTC) 3689:21:39, 21 September 2013 (UTC) 3659:05:40, 16 September 2013 (UTC) 2471:d:Wikidata:Medicine_task_force 2242:Possible errors in data bases: 1: 5436:15:26, 31 December 2013 (UTC) 5394:13:40, 31 December 2013 (UTC) 5365:13:03, 31 December 2013 (UTC) 5331:18:58, 16 December 2013 (UTC) 5182:12:33, 13 December 2013 (UTC) 4985:07:53, 20 November 2013 (UTC) 4960:13:57, 18 November 2013 (UTC) 4896:23:41, 28 December 2013 (UTC) 4871:01:14, 19 November 2013 (UTC) 4857:05:20, 13 November 2013 (UTC) 4828:02:52, 13 November 2013 (UTC) 4657:selective receptor modulators 4115:22:59, 5 September 2013 (UTC) 4097:07:32, 5 September 2013 (UTC) 4082:20:49, 4 September 2013 (UTC) 4059:07:32, 4 September 2013 (UTC) 3871:page where these came from). 3597:Missing topics about Pharmacy 3290:Could someone have a look at 1814:. Which of those was used in 1785:who could help with this? -- 1340:19:41, 21 February 2013 (UTC) 1314:19:36, 21 February 2013 (UTC) 1300:19:18, 21 February 2013 (UTC) 1269:14:44, 21 February 2013 (UTC) 1242:14:18, 21 February 2013 (UTC) 1225:06:28, 21 February 2013 (UTC) 1201:01:17, 21 February 2013 (UTC) 1169:00:46, 21 February 2013 (UTC) 1144:A new diagram was added here 1122:18:09, 21 February 2013 (UTC) 1095:15:43, 21 February 2013 (UTC) 1072:17:12, 18 February 2013 (UTC) 906:16:43, 18 February 2013 (UTC) 876:14:36, 12 February 2013 (UTC) 847:10:28, 12 February 2013 (UTC) 459:Non-small-cell lung carcinoma 401:Non-small-cell lung carcinoma 371:08:43, 15 February 2013 (UTC) 155:Update to current article on 5233:Knowledge (XXG):COCHRANE/WIR 5219:20:04, 15 January 2014 (UTC) 5133:21:54, 8 December 2013 (UTC) 5107:10:38, 7 December 2013 (UTC) 5085:I came across this article: 5075:16:53, 4 December 2013 (UTC) 5055:01:48, 4 December 2013 (UTC) 5043:monoamine reuptake inhibitor 5027:00:10, 4 December 2013 (UTC) 4923:12:47, 2 February 2014 (UTC) 4784:13:21, 3 November 2013 (UTC) 4751:20:01, 2 November 2013 (UTC) 4723:nuclear receptor heterodimer 4709:selective receptor modulator 4696:16:14, 2 November 2013 (UTC) 4647:15:45, 2 November 2013 (UTC) 4609:08:55, 2 November 2013 (UTC) 4578:22:17, 1 November 2013 (UTC) 4557:11:25, 24 October 2013 (UTC) 4530:16:31, 23 October 2013 (UTC) 4498:05:49, 16 October 2013 (UTC) 4466:02:37, 16 October 2013 (UTC) 4442:04:06, 16 October 2013 (UTC) 4421:07:48, 15 October 2013 (UTC) 4406:08:00, 14 October 2013 (UTC) 4390:16:43, 12 October 2013 (UTC) 4368:06:05, 12 October 2013 (UTC) 4350:05:58, 12 October 2013 (UTC) 4331:03:33, 12 October 2013 (UTC) 4308:00:51, 12 October 2013 (UTC) 4287:18:51, 11 October 2013 (UTC) 4265:Moving ball-and-stick images 3881:23:02, 4 December 2013 (UTC) 3817:15:31, 5 December 2013 (UTC) 3780:05:55, 14 October 2013 (UTC) 3756:05:32, 14 October 2013 (UTC) 3725:02:00, 14 October 2013 (UTC) 3120:Find Your Local Library tips 3061:Get free access to research! 2817:featured article review here 1408:10.1126/scitranslmed.3005029 945:Food and Drug Administration 943:On January 29 2013 the U.S. 827:1,25-dihydroxyergocalciferol 819:01:13, 9 February 2013 (UTC) 804:00:55, 9 February 2013 (UTC) 742:08:14, 2 February 2013 (UTC) 724:WikiProject Medicinal botany 484:Food and Drug Administration 407:(ErbB2) positive metastatic 335:13:11, 30 January 2013 (UTC) 302:17:37, 28 January 2013 (UTC) 278:15:17, 28 January 2013 (UTC) 248:14:34, 28 January 2013 (UTC) 217:12:36, 25 January 2013 (UTC) 179:08:13, 25 January 2013 (UTC) 150:16:13, 14 January 2013 (UTC) 126:20:53, 10 January 2013 (UTC) 3609:11:08, 29 August 2013 (UTC) 3586:21:33, 15 August 2013 (UTC) 3515:06:43, 15 August 2013 (UTC) 3501:Please consider commenting 3472:00:06, 12 August 2013 (UTC) 3068:Research tools and services 3042:The Knowledge (XXG) Library 1497:An edit war has started on 1062:Cheers, and happy editing, 5454: 4547:, nor those on species. -- 4486:retrometabolic drug design 4376:: There's a lot more, see 4131:British National Formulary 3474:on behalf of the TAFI team 3188:Get free access to sources 3154:Universities and Libraries 2519:User:ProteinBoxBot/Phase_3 2316:User:ProteinBoxBot/Phase_3 1903:23:14, 18 April 2013 (UTC) 1883:11:21, 18 April 2013 (UTC) 1860:09:49, 17 April 2013 (UTC) 1846:20:19, 16 April 2013 (UTC) 1828:19:57, 16 April 2013 (UTC) 1795:19:23, 16 April 2013 (UTC) 1779:18:10, 16 April 2013 (UTC) 1764:17:07, 16 April 2013 (UTC) 1730:09:46, 10 April 2013 (UTC) 1699:11:46, 27 March 2013 (UTC) 1668:13:51, 28 March 2013 (UTC) 1525:12:52, 29 March 2013 (UTC) 1511:05:28, 29 March 2013 (UTC) 1493:00:20, 29 March 2013 (UTC) 1479:22:47, 26 March 2013 (UTC) 1463:22:21, 26 March 2013 (UTC) 1443:according to New Scientist 1426:21:46, 20 March 2013 (UTC) 1390:19:14, 19 March 2013 (UTC) 1367:18:18, 19 March 2013 (UTC) 5340:I've been working on the 4593:Receptor heteromer ligand 3746:the links as OK. Cheers. 3738:, which in turn prompted 3617:content split/merge with 3420:21:01, 21 July 2013 (UTC) 3381:05:49, 21 July 2013 (UTC) 3357:18:46, 28 June 2013 (UTC) 3339:18:11, 27 June 2013 (UTC) 3322:18:00, 27 June 2013 (UTC) 3306:03:26, 27 June 2013 (UTC) 3281:19:39, 16 June 2013 (UTC) 3019:13:07, 16 June 2013 (UTC) 2998:22:07, 13 June 2013 (UTC) 2821:featured article criteria 1917:is under discussion, see 1891:Incidents involving ricin 1616:17:28, 1 April 2013 (UTC) 1591:17:25, 1 April 2013 (UTC) 1571:16:46, 1 April 2013 (UTC) 1539:15:18, 1 April 2013 (UTC) 480:European Medicines Agency 238:and respond soon again.-- 5410:and eventually down the 5336:Fluoroquinolone articles 3792:page/cat to replace the 3673:Amphetamine#Pharmacology 3666:Amphetamine#Pharmacology 3174:Wikidata source metadata 2979:21:46, 6 June 2013 (UTC) 2965:21:42, 6 June 2013 (UTC) 2950:21:37, 6 June 2013 (UTC) 2932:21:27, 6 June 2013 (UTC) 2916:19:32, 6 June 2013 (UTC) 2893:19:38, 6 June 2013 (UTC) 2876:15:29, 6 June 2013 (UTC) 2861:14:46, 6 June 2013 (UTC) 2835:04:13, 27 May 2013 (UTC) 2802:20:43, 22 May 2013 (UTC) 2778:19:25, 24 May 2013 (UTC) 2764:05:51, 24 May 2013 (UTC) 2747:21:03, 22 May 2013 (UTC) 2729:20:43, 22 May 2013 (UTC) 2703:20:36, 22 May 2013 (UTC) 2688:20:33, 22 May 2013 (UTC) 2647:07:27, 22 May 2013 (UTC) 2623:07:11, 22 May 2013 (UTC) 2594:15:28, 5 June 2013 (UTC) 2576:15:03, 5 June 2013 (UTC) 2554:06:57, 5 June 2013 (UTC) 2531:00:55, 5 June 2013 (UTC) 2483:10:08, 4 June 2013 (UTC) 2456:17:23, 31 May 2013 (UTC) 2427:15:55, 31 May 2013 (UTC) 2408:02:50, 31 May 2013 (UTC) 2380:02:31, 31 May 2013 (UTC) 2348:18:57, 26 May 2013 (UTC) 2329:19:34, 20 May 2013 (UTC) 2293:19:34, 20 May 2013 (UTC) 2275:07:23, 18 May 2013 (UTC) 2234:04:34, 17 May 2013 (UTC) 2216:01:01, 17 May 2013 (UTC) 2202:to join the discussion.) 2190:11:01, 14 May 2013 (UTC) 2160:06:32, 14 May 2013 (UTC) 2104:05:33, 14 May 2013 (UTC) 2051:01:27, 14 May 2013 (UTC) 2022:01:17, 14 May 2013 (UTC) 1991:22:04, 13 May 2013 (UTC) 1931:03:08, 12 May 2013 (UTC) 1716:. For pros and cons see 1402:If anyone has access to 4967:Meclizine or meclozine? 4717:Receptor heteromer – a 4663:which is selective for 4319:Ticagrelor-D09017-1.gif 4101:Not at all! Go for it! 3861:Category:TAAR1 agonists 3697:verified drugbox fields 2637:Talk:Bupropion#Problems 1752:User:Imanorganicchemist 395:. The cancers include 4713:functionally selective 4653:functional selectivity 4482:targeted drug delivery 4354:I took the liberty of 4275:User:MarinaVladivostok 3438: 3254:Cochrane Collaboration 3110:Free newspaper sources 2611:file:Pethidine3Dan.gif 1834:Supporting Information 1818:is anyones guess... -- 1634:Other similar articles 1441:is used in doping and 1141: 5033:St Johns wort drugbox 4315:Ticagrelor-D09017.gif 3984:10.1124/pr.109.001107 3796:page/cat for certain 3437: 3366:Respiratory stimulant 3212:Teach Library Interns 3125:Find Your Source tips 2502:, and we will have a 1139: 42:of past discussions. 5373:The basic policy id 5291:The Cochrane Library 5152:amphetamine FAC page 4678:). It just took the 3826:Collapse by Seppi333 3217:Become a Coordinator 3135:Citation tools guide 3090:Free Resource Guides 3085:Discover open access 2560:Module:ImportProtein 2150:More soon! Cheers, 1977:WikiProject Medicine 1431:More eyes needed at 949:new drug application 495:Boehringer Ingelheim 467:head and neck cancer 461:(NSCLC,) metastatic 440:, and inhibition of 413:head and neck cancer 234:will look into this 5095:The tao of medicine 4543:), which belong to 4269:I find images like 3715:Thanks in advance, 3591:Missing topics page 3237:Support Open Access 3130:How to find sources 1704:Nanofitin / Affitin 1687:Talk:PPAR modulator 1012:Secondary sources: 465:(mBC) and squamous 423:Mechanism of action 411:(mBC) and squamous 5315:Applying to be WIR 4707:Biased ligand – a 4597:Receptor heteromer 4189:Unknown parameter 4015:Unknown parameter 3947:Unknown parameter 3898:Miller GM (2011). 3736:Pharmacology/Index 3638:, which is now at 3484:Fluorodeoxyglucose 3455:. The article was 3439: 2665:naming convenition 2508:User:ProteinBoxBot 2415:medicine proposals 2058:Data maintenance: 1879:Bob the WikipediaN 1771:Imanorganicchemist 1142: 1087:Christoph Hallmann 934:chronic bronchitis 898:Christoph Hallmann 768: 453:Development status 434:cell proliferation 5433: 5156:(Cross-posted on 5115:nominated for DYK 5017:comment added by 4963: 4946:comment added by 4701: 4440: 4413:MarinaVladivostok 4323:MarinaVladivostok 4306: 4232: 4167:10.1345/aph.1L474 4041: 4040: 3867:(to parallel the 3664:Large rewrite of 3480: 3479: 3468:Theo's Little Bot 3443:Please note that 3304: 3250: 3249: 3195:Books & Bytes 3075:Resource Exchange 3056: 2890: 2811:I have nominated 2676:dextroamphetamine 2606:Pethidine3Dan.gif 1614: 1589: 1424: 1388: 1343: 1326:comment added by 1272: 1255:comment added by 1215:comment added by 874: 811:UseTheCommandLine 809:---Updated links 796:UseTheCommandLine 764: 114:User:66.90.153.55 100: 99: 54: 53: 48:current talk page 5445: 5431: 5311:September 2014. 5206: 5202: 5197: 5196: 5195: 5169: 5165: 5113:Nitrovasodilator 5029: 4962: 4940: 4907: 4863:StrangeAttractor 4841: 4820:StrangeAttractor 4699: 4684:nuclear receptor 4438: 4434: 4304: 4300: 4230: 4198: 4192: 4187: 4185: 4177: 4155:Ann Pharmacother 4138: 4095: 4057: 4032: 4031: 4024: 4018: 4013: 4011: 4003: 3994: 3963: 3957: 3956: 3950: 3945: 3943: 3935: 3926: 3895: 3822: 3769: 3765: 3764: 3710: 3707: 3706: 3624:(Also posted on 3569: 3542:deleted contribs 3430: 3429: 3400:anticholinergics 3396:sympathomimetics 3302: 3298: 3244: 3234: 3063: 3046: 3045: 3035: 3028: 2888: 2832: 2830:Ten Pound Hammer 2644: 2642:Ten Pound Hammer 2497: 2491: 2440: 2392: 2364: 2138:Polypharmacology 2075: 2069: 2035: 2006: 1958:Template:Drugbox 1880: 1604: 1579: 1569: 1568: 1414: 1378: 1342: 1320: 1284: 1271: 1249: 1227: 1185: 1153: 864: 713: 708: 702: 697: 691: 685: 679: 674: 668: 663: 657: 651: 645: 640: 634: 629: 623: 618: 612: 606: 600: 595: 589: 584: 578: 573: 567: 562: 556: 551: 545: 539: 533: 528: 448:overexpression. 436:, migration and 292:. ..." Cheers -- 262: 201: 81: 56: 55: 33: 32: 26: 5453: 5452: 5448: 5447: 5446: 5444: 5443: 5442: 5338: 5321:WP:COCHRANE/WIR 5226: 5204: 5200: 5193: 5188:amphetamine FAC 5167: 5163: 5140: 5117: 5083: 5035: 5012: 4992: 4969: 4941: 4937: 4903: 4837: 4798: 4565: 4506: 4450: 4436: 4302: 4267: 4188: 4178: 4161:(12): 1814–21. 4152: 4147: 4134: 4127: 4091: 4053: 4050: 4042: 4037: 4036: 4035: 4025: 4014: 4004: 3965: 3964: 3960: 3946: 3936: 3897: 3896: 3892: 3869:releasing agent 3827: 3805: 3794:releasing agent 3762: 3760: 3708: 3704: 3699: 3669: 3632:methamphetamine 3622: 3615:Methamphetamine 3595:I have updated 3593: 3527: 3522: 3499: 3488:Fludeoxyglucose 3475: 3428: 3392:bronchodilators 3369: 3300: 3288: 3246: 3245: 3227: 3226: 3222:Learn about TWL 3178: 3139: 3115:Online archives 3100:Journal Sources 3059: 3039: 3026: 3007: 2904:This submission 2901: 2849: 2828: 2809: 2657: 2640: 2630: 2608: 2495: 2493:GNF Protein box 2489: 2436: 2388: 2360: 2196:User:Anypodetos 2170:a few years ago 2073: 2067: 2031: 2002: 1938: 1911: 1878: 1874: 1803:Both compounds 1737: 1706: 1683: 1636: 1566: 1564: 1436: 1400: 1354: 1321: 1280: 1250: 1210: 1181: 1149: 1134: 884: 859: 855: 831: 749: 726: 718: 717: 716: 709: 705: 698: 694: 686: 682: 675: 671: 664: 660: 652: 648: 641: 637: 630: 626: 619: 615: 607: 603: 596: 592: 585: 581: 574: 570: 563: 559: 552: 548: 540: 536: 529: 525: 510:clinical trials 258: 197: 160: 137:Cannabis (drug) 133: 131:Cannabis Safety 105: 77: 30: 22: 21: 20: 12: 11: 5: 5451: 5449: 5441: 5440: 5439: 5438: 5422: 5419: 5397: 5396: 5382: 5371: 5337: 5334: 5317: 5316: 5308: 5307: 5299: 5298: 5286: 5285: 5277: 5276: 5268: 5267: 5264: 5261: 5258: 5255: 5252: 5249: 5225: 5222: 5155: 5139: 5136: 5116: 5110: 5082: 5079: 5078: 5077: 5038:St John's wort 5034: 5031: 4991: 4988: 4968: 4965: 4936: 4933: 4932: 4931: 4930: 4929: 4928: 4927: 4926: 4925: 4878: 4877: 4876: 4875: 4874: 4873: 4815:few visitors. 4797: 4794: 4793: 4792: 4791: 4790: 4789: 4788: 4787: 4786: 4734: 4733: 4732: 4729: 4715: 4702: 4564: 4561: 4560: 4559: 4510:Redback spider 4505: 4504:Redback spider 4502: 4501: 4500: 4484:. I think the 4449: 4448:AfC submission 4446: 4445: 4444: 4409: 4408: 4371: 4370: 4352: 4311: 4310: 4266: 4263: 4262: 4261: 4260: 4259: 4146: 4143: 4126: 4123: 4122: 4121: 4120: 4119: 4118: 4117: 4087: 4049: 4046: 4044: 4039: 4038: 4034: 4033: 3972:Pharmacol. Rev 3958: 3910:(2): 164–176. 3889: 3888: 3884: 3855: 3829: 3828: 3825: 3820: 3804: 3790:TAAR1 agonists 3786: 3785: 3784: 3783: 3782: 3770:for the help! 3714: 3712: 3698: 3692: 3668: 3662: 3629: 3621: 3612: 3592: 3589: 3521: 3518: 3498: 3481: 3478: 3477: 3465: 3464: 3442: 3427: 3424: 3423: 3422: 3368: 3363: 3362: 3361: 3360: 3359: 3324: 3287: 3284: 3248: 3247: 3229: 3228: 3225: 3224: 3219: 3214: 3209: 3204: 3199: 3190: 3184: 3177: 3176: 3171: 3166: 3161: 3156: 3151: 3145: 3138: 3137: 3132: 3127: 3122: 3117: 3112: 3107: 3105:Bibliographies 3102: 3097: 3092: 3087: 3082: 3080:Reference Desk 3077: 3071: 3065: 3057: 3038: 3036: 3025: 3022: 3006: 3001: 2986: 2985: 2984: 2983: 2982: 2981: 2967: 2938:mode of action 2900: 2899:AfC submission 2897: 2896: 2895: 2879: 2878: 2848: 2838: 2808: 2805: 2789: 2788: 2787: 2786: 2785: 2784: 2783: 2782: 2781: 2780: 2706: 2705: 2673: 2672: 2662: 2660: 2656: 2653: 2651: 2629: 2626: 2607: 2604: 2603: 2602: 2601: 2600: 2599: 2598: 2597: 2596: 2562:, for example 2515: 2467: 2466: 2465: 2464: 2463: 2462: 2461: 2460: 2459: 2458: 2332: 2331: 2311: 2310: 2309: 2308: 2307: 2306: 2305: 2304: 2303: 2302: 2301: 2300: 2299: 2298: 2297: 2296: 2295: 2263: 2249: 2246: 2239: 2203: 2200:User:PotatoBot 2174:User:PotatoBot 2168:data was used 2148: 2147: 2146: 2135: 2132:Compound lists 2129: 2114:Other accounts 2107: 2106: 2084: 2081: 1973: 1972: 1969: 1966: 1937: 1934: 1910: 1907: 1906: 1905: 1873: 1868: 1867: 1866: 1865: 1864: 1863: 1862: 1830: 1798: 1797: 1736: 1733: 1705: 1702: 1682: 1675:PPAR modulator 1671: 1656: 1655: 1650: 1645: 1635: 1632: 1631: 1630: 1629: 1628: 1627: 1626: 1625: 1624: 1623: 1622: 1621: 1620: 1619: 1618: 1593: 1550: 1549: 1548: 1547: 1546: 1545: 1544: 1543: 1542: 1541: 1435: 1429: 1399: 1394: 1393: 1392: 1357:the catagory. 1353: 1350: 1349: 1348: 1347: 1346: 1345: 1344: 1316: 1245: 1244: 1217:128.143.68.217 1206: 1205: 1204: 1203: 1133: 1130: 1129: 1128: 1127: 1126: 1125: 1124: 1100: 1099: 1098: 1097: 1075: 1074: 1059: 1058: 1055: 1052: 1048: 1047: 1011: 962: 953:bronchodilator 926:bronchodilator 910: 883: 880: 879: 878: 857: 853: 830: 823: 822: 821: 748: 745: 725: 722: 715: 714: 703: 692: 680: 669: 658: 646: 635: 624: 613: 601: 590: 579: 568: 557: 546: 534: 522: 521: 517: 451: 421: 384: 382: 381: 380: 379: 378: 377: 376: 375: 374: 373: 346: 345: 344: 343: 342: 341: 340: 339: 338: 337: 313: 312: 311: 310: 309: 308: 307: 306: 305: 304: 222: 221: 220: 219: 159: 153: 132: 129: 104: 101: 98: 97: 92: 87: 82: 75: 70: 65: 62: 52: 51: 34: 23: 15: 14: 13: 10: 9: 6: 4: 3: 2: 5450: 5437: 5434: 5428: 5423: 5420: 5417: 5413: 5409: 5405: 5401: 5400: 5399: 5398: 5395: 5391: 5387: 5383: 5380: 5376: 5372: 5369: 5368: 5367: 5366: 5362: 5358: 5353: 5350: 5346: 5343: 5342:ciprofloxacin 5335: 5333: 5332: 5329: 5324: 5322: 5314: 5313: 5312: 5305: 5304: 5303: 5297:Working hours 5296: 5295: 5294: 5292: 5283: 5282: 5281: 5274: 5273: 5272: 5265: 5262: 5259: 5256: 5253: 5250: 5247: 5246: 5245: 5242: 5239: 5236: 5234: 5229: 5223: 5221: 5220: 5216: 5215: 5209: 5208: 5207: 5189: 5184: 5183: 5179: 5178: 5172: 5171: 5170: 5159: 5153: 5149: 5145: 5137: 5135: 5134: 5130: 5126: 5122: 5114: 5111: 5109: 5108: 5104: 5100: 5096: 5092: 5088: 5080: 5076: 5072: 5068: 5063: 5059: 5058: 5057: 5056: 5052: 5048: 5044: 5039: 5032: 5030: 5028: 5024: 5020: 5019:152.133.7.192 5016: 5010: 5006: 5005:98.221.153.47 5002: 5001: 4996: 4989: 4987: 4986: 4982: 4978: 4974: 4966: 4964: 4961: 4957: 4953: 4949: 4945: 4934: 4924: 4920: 4916: 4912: 4908: 4906: 4899: 4898: 4897: 4893: 4889: 4884: 4883: 4882: 4881: 4880: 4879: 4872: 4868: 4864: 4860: 4859: 4858: 4854: 4850: 4846: 4842: 4840: 4834: 4833: 4832: 4831: 4830: 4829: 4825: 4821: 4816: 4812: 4809: 4805: 4803: 4795: 4785: 4781: 4777: 4773: 4769: 4766: 4762: 4759: 4754: 4753: 4752: 4748: 4744: 4740: 4735: 4730: 4728: 4724: 4720: 4719:GPCR oligomer 4716: 4714: 4710: 4706: 4705: 4703: 4697: 4693: 4689: 4685: 4681: 4677: 4674: 4670: 4666: 4662: 4658: 4654: 4650: 4649: 4648: 4644: 4640: 4636: 4632: 4628: 4624: 4620: 4616: 4612: 4611: 4610: 4606: 4602: 4598: 4594: 4590: 4589:Biased ligand 4586: 4582: 4581: 4580: 4579: 4575: 4571: 4562: 4558: 4554: 4550: 4546: 4542: 4538: 4534: 4533: 4532: 4531: 4527: 4523: 4519: 4515: 4511: 4503: 4499: 4495: 4491: 4487: 4483: 4479: 4475: 4470: 4469: 4468: 4467: 4463: 4459: 4458:FoCuSandLeArN 4455: 4447: 4443: 4439: 4433: 4429: 4425: 4424: 4423: 4422: 4418: 4414: 4407: 4403: 4399: 4394: 4393: 4392: 4391: 4387: 4383: 4379: 4375: 4369: 4365: 4361: 4357: 4353: 4351: 4347: 4343: 4339: 4335: 4334: 4333: 4332: 4328: 4324: 4320: 4316: 4309: 4305: 4299: 4295: 4291: 4290: 4289: 4288: 4284: 4280: 4276: 4272: 4264: 4258: 4254: 4250: 4246: 4242: 4238: 4237: 4236: 4233: 4227: 4223: 4222: 4221: 4220: 4216: 4212: 4208: 4204: 4199: 4196: 4183: 4175: 4172: 4168: 4164: 4160: 4156: 4150: 4144: 4142: 4141: 4137: 4132: 4124: 4116: 4112: 4108: 4104: 4100: 4099: 4098: 4094: 4088: 4085: 4084: 4083: 4079: 4075: 4071: 4067: 4063: 4062: 4061: 4060: 4056: 4045: 4029: 4022: 4009: 4001: 3998: 3993: 3989: 3985: 3981: 3977: 3973: 3969: 3962: 3959: 3954: 3941: 3933: 3930: 3925: 3921: 3917: 3913: 3909: 3905: 3901: 3894: 3891: 3887: 3883: 3882: 3878: 3874: 3870: 3866: 3865:TAAR1 agonist 3862: 3857: 3853: 3849: 3845: 3842: 3837: 3831: 3830: 3824: 3823: 3819: 3818: 3814: 3810: 3803: 3799: 3795: 3791: 3787: 3781: 3777: 3773: 3768: 3759: 3758: 3757: 3753: 3749: 3745: 3741: 3737: 3733: 3729: 3728: 3727: 3726: 3722: 3718: 3696: 3693: 3691: 3690: 3686: 3682: 3678: 3674: 3667: 3663: 3661: 3660: 3656: 3652: 3647: 3645: 3641: 3637: 3633: 3627: 3620: 3616: 3613: 3611: 3610: 3606: 3602: 3598: 3590: 3588: 3587: 3583: 3579: 3574: 3567: 3564: 3561: 3558: 3555: 3552: 3549: 3546: 3543: 3540: 3537: 3534: 3531: 3526: 3519: 3517: 3516: 3512: 3508: 3504: 3497: 3496:WP:COMMONNAME 3493: 3489: 3485: 3482: 3476: 3473: 3469: 3466:Delivered by 3462: 3458: 3454: 3453: 3448: 3447: 3436: 3432: 3431: 3421: 3417: 3413: 3409: 3405: 3401: 3397: 3393: 3389: 3385: 3384: 3383: 3382: 3378: 3374: 3367: 3364: 3358: 3354: 3350: 3346: 3342: 3341: 3340: 3336: 3332: 3328: 3325: 3323: 3319: 3315: 3310: 3309: 3308: 3307: 3303: 3297: 3293: 3285: 3283: 3282: 3279: 3274: 3273: 3272: 3266: 3264: 3259: 3256: 3255: 3243: 3238: 3233: 3223: 3220: 3218: 3215: 3213: 3210: 3208: 3205: 3203: 3200: 3198: 3196: 3191: 3189: 3186: 3185: 3183: 3182: 3175: 3172: 3170: 3167: 3165: 3162: 3160: 3157: 3155: 3152: 3150: 3147: 3146: 3144: 3143: 3136: 3133: 3131: 3128: 3126: 3123: 3121: 3118: 3116: 3113: 3111: 3108: 3106: 3103: 3101: 3098: 3096: 3093: 3091: 3088: 3086: 3083: 3081: 3078: 3076: 3073: 3072: 3070: 3069: 3064: 3062: 3054: 3050: 3044: 3043: 3037: 3034: 3030: 3029: 3023: 3021: 3020: 3016: 3012: 3005: 3002: 3000: 2999: 2995: 2991: 2980: 2976: 2972: 2968: 2966: 2962: 2958: 2953: 2952: 2951: 2947: 2943: 2939: 2935: 2934: 2933: 2929: 2925: 2920: 2919: 2918: 2917: 2913: 2909: 2908:FoCuSandLeArN 2905: 2898: 2894: 2891: 2885: 2881: 2880: 2877: 2873: 2869: 2865: 2864: 2863: 2862: 2858: 2854: 2847:) in the news 2846: 2842: 2839: 2837: 2836: 2831: 2826: 2822: 2818: 2814: 2806: 2804: 2803: 2799: 2795: 2779: 2775: 2771: 2767: 2766: 2765: 2761: 2757: 2753: 2750: 2749: 2748: 2744: 2740: 2736: 2732: 2731: 2730: 2726: 2722: 2718: 2715:of the drug" 2714: 2710: 2709: 2708: 2707: 2704: 2700: 2696: 2692: 2691: 2690: 2689: 2685: 2681: 2677: 2670: 2666: 2654: 2652: 2649: 2648: 2643: 2638: 2634: 2627: 2625: 2624: 2620: 2616: 2612: 2605: 2595: 2591: 2587: 2583: 2579: 2578: 2577: 2573: 2569: 2565: 2561: 2557: 2556: 2555: 2551: 2547: 2543: 2539: 2534: 2533: 2532: 2528: 2524: 2520: 2516: 2513: 2509: 2505: 2501: 2494: 2487: 2486: 2485: 2484: 2480: 2476: 2472: 2457: 2453: 2449: 2445: 2441: 2439: 2433: 2430: 2429: 2428: 2424: 2420: 2416: 2411: 2410: 2409: 2405: 2401: 2397: 2393: 2391: 2386: 2383: 2382: 2381: 2377: 2373: 2369: 2365: 2363: 2357: 2354: 2353: 2352: 2351: 2350: 2349: 2345: 2341: 2337: 2330: 2326: 2322: 2318: 2317: 2312: 2294: 2290: 2286: 2282: 2278: 2277: 2276: 2272: 2268: 2264: 2260: 2258: 2254: 2250: 2247: 2243: 2240: 2237: 2236: 2235: 2231: 2227: 2223: 2219: 2218: 2217: 2213: 2209: 2204: 2201: 2198:who operates 2197: 2193: 2192: 2191: 2187: 2183: 2179: 2175: 2171: 2167: 2163: 2162: 2161: 2157: 2153: 2149: 2143: 2139: 2136: 2133: 2130: 2127: 2123: 2122:User:CheMoBot 2119: 2118:User:Beetstra 2115: 2112: 2111: 2109: 2108: 2105: 2101: 2097: 2093: 2089: 2085: 2082: 2079: 2078:User:Beetstra 2072: 2065: 2064:User:Beetstra 2061: 2060:User:CheMoBot 2057: 2056: 2054: 2053: 2052: 2048: 2044: 2040: 2036: 2034: 2028: 2025: 2024: 2023: 2019: 2015: 2011: 2007: 2005: 1999: 1995: 1994: 1993: 1992: 1988: 1984: 1980: 1978: 1970: 1967: 1964: 1963: 1962: 1959: 1953: 1951: 1947: 1943: 1935: 1933: 1932: 1928: 1924: 1920: 1916: 1913:The usage of 1908: 1904: 1900: 1896: 1892: 1887: 1886: 1885: 1884: 1881: 1872: 1869: 1861: 1857: 1853: 1849: 1848: 1847: 1843: 1839: 1835: 1831: 1829: 1825: 1821: 1817: 1813: 1809: 1808: 1805: 1802: 1801: 1800: 1799: 1796: 1792: 1788: 1783: 1782: 1781: 1780: 1776: 1772: 1766: 1765: 1761: 1757: 1753: 1748: 1745: 1741: 1734: 1732: 1731: 1727: 1723: 1719: 1715: 1711: 1703: 1701: 1700: 1696: 1692: 1688: 1680: 1676: 1672: 1670: 1669: 1665: 1661: 1654: 1651: 1649: 1646: 1644: 1641: 1640: 1639: 1633: 1617: 1612: 1608: 1603: 1602:Fvasconcellos 1598: 1594: 1592: 1587: 1583: 1578: 1577:Fvasconcellos 1574: 1573: 1572: 1562: 1561: 1560: 1559: 1558: 1557: 1556: 1555: 1554: 1553: 1552: 1551: 1540: 1536: 1532: 1531:Foamyslippers 1528: 1527: 1526: 1522: 1518: 1514: 1513: 1512: 1508: 1504: 1500: 1496: 1495: 1494: 1490: 1486: 1482: 1481: 1480: 1476: 1472: 1467: 1466: 1465: 1464: 1460: 1456: 1452: 1448: 1444: 1440: 1434: 1430: 1428: 1427: 1422: 1418: 1413: 1412:Fvasconcellos 1409: 1405: 1398: 1395: 1391: 1386: 1382: 1377: 1376:Fvasconcellos 1372: 1371: 1370: 1368: 1364: 1360: 1359:49.202.33.171 1351: 1341: 1337: 1333: 1329: 1325: 1317: 1315: 1311: 1307: 1303: 1302: 1301: 1297: 1293: 1289: 1285: 1283: 1277: 1276: 1275: 1274: 1273: 1270: 1266: 1262: 1258: 1254: 1243: 1239: 1235: 1230: 1229: 1228: 1226: 1222: 1218: 1214: 1202: 1198: 1194: 1190: 1186: 1184: 1179: 1175: 1174: 1173: 1172: 1171: 1170: 1166: 1162: 1158: 1154: 1152: 1146: 1138: 1131: 1123: 1119: 1115: 1110: 1106: 1105: 1104: 1103: 1102: 1101: 1096: 1092: 1088: 1084: 1079: 1078: 1077: 1076: 1073: 1069: 1065: 1061: 1060: 1056: 1053: 1050: 1049: 1045: 1044: 1043: 1042: 1037: 1036: 1031: 1030: 1025: 1024: 1019: 1018: 1013: 1009: 1008: 1003: 1002: 996: 995: 990: 989: 983: 982: 977: 976: 971: 970: 964: 960: 958: 954: 950: 946: 941: 939: 935: 931: 927: 923: 919: 914: 913: 908: 907: 903: 899: 894: 892: 887: 881: 877: 872: 868: 863: 862:Fvasconcellos 851: 850: 849: 848: 844: 840: 836: 828: 824: 820: 816: 812: 808: 807: 806: 805: 801: 797: 792: 789: 787: 781: 779: 775: 771: 767: 761: 759: 754: 746: 744: 743: 739: 735: 734:65.92.180.137 731: 723: 721: 712: 707: 704: 701: 696: 693: 690: 684: 681: 678: 673: 670: 667: 662: 659: 656: 650: 647: 644: 639: 636: 633: 628: 625: 622: 617: 614: 611: 605: 602: 599: 594: 591: 588: 583: 580: 577: 572: 569: 566: 561: 558: 555: 550: 547: 544: 538: 535: 532: 527: 524: 520: 516: 513: 511: 506: 504: 500: 496: 491: 487: 485: 481: 476: 470: 468: 464: 463:Breast cancer 460: 455: 454: 449: 447: 443: 439: 435: 429: 425: 424: 419: 416: 414: 410: 409:breast cancer 406: 402: 398: 394: 388: 387: 372: 368: 364: 360: 356: 355: 354: 353: 352: 351: 350: 349: 348: 347: 336: 332: 328: 323: 322: 321: 320: 319: 318: 317: 316: 315: 314: 303: 299: 295: 291: 286: 281: 280: 279: 275: 271: 267: 263: 261: 255: 251: 250: 249: 245: 241: 237: 232: 228: 227: 226: 225: 224: 223: 218: 214: 210: 206: 202: 200: 194: 189: 185: 184: 183: 182: 181: 180: 176: 172: 167: 163: 158: 154: 152: 151: 147: 143: 138: 130: 128: 127: 123: 119: 115: 111: 102: 96: 93: 91: 88: 86: 83: 80: 76: 74: 71: 69: 66: 63: 61: 58: 57: 49: 45: 41: 40: 35: 28: 27: 19: 5357:98.155.21.76 5354: 5351: 5347: 5345:the others. 5339: 5325: 5318: 5309: 5306:Remuneration 5300: 5290: 5287: 5278: 5269: 5243: 5240: 5237: 5230: 5228:Hey folks, 5227: 5213: 5203: 5199: 5185: 5176: 5166: 5162: 5143: 5141: 5118: 5094: 5084: 5036: 5013:— Preceding 5003: 4997: 4993: 4970: 4942:— Preceding 4938: 4904: 4888:98.155.21.76 4838: 4817: 4813: 4810: 4806: 4802:Escitalopram 4799: 4584: 4566: 4541:latrodectism 4518:Latrodectism 4507: 4451: 4410: 4373: 4372: 4312: 4268: 4241:Anthonyhcole 4203:Anthonyhcole 4200: 4182:cite journal 4158: 4154: 4151: 4148: 4136:hollyperidol 4128: 4093:hollyperidol 4069: 4055:hollyperidol 4051: 4043: 4008:cite journal 3975: 3971: 3961: 3940:cite journal 3907: 3904:J. Neurochem 3903: 3893: 3885: 3860: 3858: 3832: 3806: 3802:trace amines 3798:amphetamines 3766: 3700: 3670: 3648: 3623: 3594: 3562: 3556: 3550: 3544: 3538: 3532: 3523: 3500: 3450: 3444: 3440: 3370: 3289: 3275: 3268: 3267: 3262: 3260: 3252: 3251: 3236: 3194: 3181:Get involved 3180: 3179: 3141: 3140: 3095:Book Sources 3067: 3066: 3058: 3040: 3008: 2987: 2902: 2850: 2841:Saroglitazar 2829: 2810: 2790: 2756:65.94.76.126 2658: 2650: 2641: 2631: 2615:65.94.76.126 2609: 2468: 2437: 2389: 2361: 2333: 2313: 2281:special note 2257:ATCvet lists 2251: 2241: 2137: 2131: 2113: 2032: 2003: 1974: 1954: 1939: 1923:65.94.76.126 1912: 1875: 1833: 1806: 1767: 1749: 1738: 1707: 1684: 1679:PPAR agonist 1657: 1637: 1437: 1401: 1369:viral Patel 1355: 1322:— Preceding 1281: 1251:— Preceding 1246: 1211:— Preceding 1207: 1182: 1150: 1143: 1132:New diagrams 1083:148.188.1.60 1038: 1032: 1026: 1020: 1014: 1010: 1004: 997: 991: 984: 978: 972: 965: 963:References: 961: 942: 915: 911: 909: 895: 888: 885: 832: 829:for deletion 793: 790: 782: 762: 750: 747:OHSU Project 727: 719: 706: 695: 683: 672: 661: 649: 638: 627: 616: 604: 593: 582: 571: 560: 549: 537: 526: 518: 515:References: 514: 507: 492: 488: 471: 456: 452: 450: 430: 426: 422: 420: 417: 389: 385: 383: 363:Sagschneider 327:Sagschneider 259: 240:Sagschneider 198: 171:Sagschneider 168: 164: 161: 134: 106: 78: 43: 37: 4727:heterodimer 4432:LeadSongDog 4338:LeadSongDog 4298:LeadSongDog 4125:BNF article 3852:amphetamine 3695:Amphetamine 3636:Amphetamine 3296:LeadSongDog 2794:Cantaloupe2 2721:Cantaloupe2 2680:Cantaloupe2 2126:User:Boghog 1998:User:Boghog 1919:talk:Mortar 912:Suggestion: 325:feedback.-- 110:User:Kc2749 36:This is an 5386:ἀνυπόδητος 5125:ἀνυπόδητος 5067:Tryptofish 4977:ἀνυπόδητος 4948:Erinmcasey 4631:SKF-83,959 4619:ergotamine 4601:ἀνυπόδητος 4549:ἀνυπόδητος 4537:latrotoxin 4514:Latrotoxin 4474:soft drugs 4456:? 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