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Wolff–Parkinson–White syndrome

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activity at a significantly higher rate than the AV node. For instance, in the example above, if an individual had an atrial rate of 300 beats per minute, the accessory bundle may conduct all the electrical impulses from the atria to the ventricles, causing the ventricles to contract at 300 beats per minute. Extremely rapid heart rates such as this may result in hemodynamic instability or
331:. It affects between 0.1 and 0.3% in the population. The risk of death in those without symptoms is about 0.5% per year in children and 0.1% per year in adults. In some cases, non-invasive monitoring may help to more carefully risk stratify patients into a lower risk category. In those without symptoms ongoing observation may be reasonable. In those with WPW complicated by 711:
ACC/AHA/HRS guidelines recommend beta-blockers or calcium channel blockers as second-line agents, electric cardioversion is reserved for refractory arrhythmias. However, if there is any doubt about the diagnosis of orthodromic AVRT or if aberrant conduction leading to a wide complex QRS is observed, it may be prudent to manage as undifferentiated wide complex tachycardia.
558: 65: 633: 525: 459:), the AV node limits the number of signals conducted to the ventricles. For example, if the atria are electrically activated at 300 beats per minute, half those electrical impulses may be blocked by the AV node, so that the ventricles are stimulated at only 150 beats per minute – resulting in a 657:
laboratory. This is an invasive but generally low-risk procedure during which the atria are stimulated to try to induce tachycardia. If a tachycardia involving the accessory pathway can be triggered, the cardiologist can then assess how rapidly the accessory pathway is able to conduct. The faster it
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Other methods of risk stratification include observing the ventricular rate during spontaneous atrial fibrillation on a 12-lead ECG. RR intervals of less than 250 ms suggest a higher risk pathway. During exercise testing, abrupt loss of pre-excitation as heart rate increases also suggest a lower
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It is unclear whether invasive risk stratification (with PES) is necessary in the asymptomatic individual. While some groups advocate PES for risk stratification in all individuals under 35 years old, others only offer it to individuals who have history suggestive of a tachydysrhythmia, since the
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In individuals with WPW, electrical activity that is initiated in the SA node travels through the accessory pathway, as well as through the AV node to activate the ventricles via both pathways. Since the accessory pathway does not have the impulse slowing properties of the AV node, the electrical
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In case of type A pre-excitation (left atrioventricular connections), a positive R wave is seen in V1 ("positive delta") on the precordial leads of the electrocardiogram, while in type B pre-excitation (right atrioventricular connections), a predominantly negative delta wave is seen in lead V1
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between the atria and ventricles that is present in a small percentage (between 0.1 and 0.3%) of the general population. This pathway may communicate between the left atrium and the left ventricle, in which case it is termed a "type A pre-excitation", or between the right atrium and the right
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Individuals with WPW have an accessory pathway that communicates between the atria and the ventricles, in addition to the AV node. This accessory pathway is known as the bundle of Kent. This accessory pathway does not share the rate-slowing properties of the AV node and may conduct electrical
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and has high success rate in the hands of an experienced electrophysiologist. Findings from 1994 indicate success rates of as high as 95% in people treated with radiofrequency catheter ablation for WPW. If radiofrequency catheter ablation is successfully performed, the condition is generally
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WPW is commonly diagnosed on the basis of the electrocardiogram in an asymptomatic individual. In this case, it is manifested as a delta wave, which is a slurred upstroke in the QRS complex that is associated with a short PR interval. The short PR interval and slurring of the QRS complex are
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WPW pattern with hemodynamically stability and orthodromic AVRT leading to a regular narrow complex tachycardia may be managed similarly to other regular narrow complex supraventricular tachycardias: first with vagal maneuvers followed by a trial of adenosine (first-line therapy). The 2015
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WPW carries a small risk of sudden death, presumably due to rapidly conducted atrial fibrillation causing ventricular fibrillation. While the overall risk is approximately 2.4 per 1000 person years, the risk in an individual is dependent on the properties of the accessory pathway causing
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to stabilize their heart rate. Procainamide and cardioversion are accepted treatments for conversion of tachycardia found with WPW. Amiodarone in atrial fibrillation with WPW, is linked to ventricular fibrillation, and thus may be worse than procainamide.
590:, the ECG characteristics of WPW are a short PR interval (less than 120 milliseconds in duration), widened QRS complex (greater than 120 milliseconds in duration) with slurred upstroke of the QRS complex, and secondary repolarization changes (reflected in 1755:"2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society" 2698: 2683: 568:
demonstrating characteristic findings in Wolff–Parkinson–White syndrome. A characteristic delta wave (above the blue bar), a short PR interval (red bar) of 80 ms, and a long QRS complex (blue bar plus green bar) at 120 ms are
746:. They can exacerbate the syndrome by blocking the heart's normal electrical pathway (therefore favoring 1:1 atrial to ventricle conduction through the pre-excitation pathway, potentially leading to unstable ventricular arrhythmias). 3911: 661:
High-risk features that may be present during PES include an effective refractory period of the accessory pathway less than 250 ms, multiple pathways, septal location of pathway, and inducibility of supraventricular tachycardia
3904: 666:, atrial fibrillation). Individuals with any of these high-risk features are generally considered at increased risk for SCD or symptomatic tachycardia, and should be treated accordingly (i.e.: catheter ablation). 1276:"2019 ESC Guidelines for the management of patients with supraventricular tachycardiaThe Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC)" 602:
impulse first activates the ventricles via the accessory pathway, and immediately afterwards via the AV node. This gives the short PR interval and slurred upstroke of the QRS complex known as the delta wave.
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The AV node serves an important function as a "gatekeeper", limiting the electrical activity that reaches the ventricles. In situations where the atria generate excessively rapid electrical activity (such as
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A higher risk accessory pathway may be suggested by a history of syncope, but risk stratification is best performed by assessing how frequently a pathway can conduct impulse to the ventricles, usually via
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risk pathway. However, this approach is hampered by the normal improvement in AV node conduction during exercise which can also mask pre-excitation despite ongoing conduction down the accessory pathway.
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that bypasses the AV node. The AV node is capable of slowing the rate of conduction of electrical impulses to the ventricles, whereas the bundle of Kent lacks this capability. When an
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People with WPW may have more than one accessory pathway – in some cases, as many as eight abnormal pathways have been found. This has been seen in individuals with
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Rosner MH, Brady WJ, Kefer MP, Martin ML (November 1999). "Electrocardiography in the patient with the Wolff-Parkinson-White syndrome: diagnostic and initial therapeutic issues".
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Mashima Y, Kigasawa K, Hasegawa H, Tani M, Oguchi Y (December 1996). "High incidence of pre-excitation syndrome in Japanese families with Leber's hereditary optic neuropathy".
790:(1890–1952) became the first to describe the condition later called Wolff–Parkinson–White syndrome. Alfred M. Wedd (1887–1967) was the next to describe the condition in 1921. 463:
of 150 beats per minute. Another important property of the AV node is that it slows down individual electrical impulses. This is manifested on the electrocardiogram as the
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ventricle, in which case it is termed a "type B pre-excitation" in old, currently abandoned classification. Problems arise when this pathway creates an
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Fengler BT, Brady WJ, Plautz CU (June 2007). "Atrial fibrillation in the Wolff-Parkinson-White syndrome: ECG recognition and treatment in the ED".
758:. Two main types of catheter ablation include radiofrequency ablation with heat or cryoablation with cold energy. This procedure is performed by 270: 4049: 2382: 4703: 4382: 2867: 1637: 663: 617: 984: 2660: 2464: 2218:
Wolff L, Parkinson J, White PD (1930). "Bundle-branch block with short P-R interval in healthy young people prone to paroxysmal tachyardia".
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The cause of WPW is typically unknown and is likely due to a combination of chance and genetic factors. A small number of cases are due to a
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reflective of the impulse making it to the ventricles early (via the accessory pathway) without the usual delay experienced in the AV node.
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considered cured. Recurrence rates are typically less than 5% after a successful ablation. Some patients, such as the ones with underlying
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Kent AF (1914). "A conducting path between the right auricle and the external wall of the right ventricle in the heart of the mammal".
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If a person with WPW experiences episodes of atrial fibrillation, the ECG shows a rapid polymorphic wide-complex tachycardia (without
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Wedd AM (1921). "Paroxysmal tachycardia, with reference to nomotropic tachycardia and the role of the extrinsic cardiac nerves".
879: 328: 184: 3391: 3172: 935: 583:). This combination of atrial fibrillation and WPW is considered dangerous, and most antiarrhythmic drugs are contraindicated. 2584: 1096:"Asymptomatic Wolff-Parkinson-White syndrome: incidental ECG diagnosis and a review of literature regarding current treatment" 4034: 3933: 3467: 3462: 3386: 862: 699: 309: 3186: 2363: 2309: 4238: 4186: 4104: 3813: 3689: 3618: 3450: 798: 683: 348: 4456: 4054: 2495: 4480: 4434: 4262: 3808: 3601: 3584: 3517: 3437: 2816: 468: 380: 3651: 2277: 1569:"A randomized study of prophylactic catheter ablation in asymptomatic patients with the Wolff-Parkinson-White syndrome" 4693: 4277: 3096: 759: 726:
AV node blockers should be avoided in atrial fibrillation and atrial flutter with WPW or history of it; this includes
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can conduct, the higher the likelihood the accessory pathway can conduct fast enough to trigger a lethal tachycardia.
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WPW syndrome may be monitored or treated with either medications or an ablation (destroying the tissues) such as with
4362: 4271: 3985: 1435:"A population study of the natural history of Wolff-Parkinson-White syndrome in Olmsted County, Minnesota, 1953-1989" 391: 3633: 3121: 3106: 1653:"The natural history of Wolff-Parkinson-White syndrome in 228 military aviators: a long-term follow-up of 22 years" 4320: 4214: 3408: 383:. WPW is also associated with a very small risk of sudden death due to more dangerous heart rhythm disturbances. 4588: 4149: 3942: 3711: 3376: 3303: 3030: 1017: 840: 654: 363:
People with WPW are usually asymptomatic when not having a fast heart rate. However, individuals may experience
98: 4334: 3896: 3661: 4644: 4044: 4018: 3950: 3835: 3591: 3381: 3278: 3259: 3089: 2862: 2724: 2413: 909: 780: 492: 416: 408: 2606: 1610:"Survey of current practice of pediatric electrophysiologists for asymptomatic Wolff-Parkinson-White syndrome" 1836:"Challenging the superiority of amiodarone for rate control in Wolff-Parkinson-White and atrial fibrillation" 1224:"Challenging the superiority of amiodarone for rate control in Wolff-Parkinson-White and atrial fibrillation" 4698: 4422: 4369: 4175: 3868: 3842: 3830: 3818: 3803: 3537: 3479: 3283: 3264: 2916: 2856: 2809: 739: 650: 321: 117: 72:
A characteristic "delta wave" (arrow) seen in a person with Wolff–Parkinson–White syndrome. Note the short
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Brugada J, Katritsis DG, Arbelo E, Arribas F, Bax JJ, Blomström-Lundqvist C, et al. (February 2020).
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Pappone C, Santinelli V, Manguso F, Augello G, Santinelli O, Vicedomini G, et al. (November 2003).
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Pappone C, Lamberti F, Santomauro M, Stabile G, De Simone A, Turco P, et al. (December 1993). "".
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WPW pattern, Ventricular pre-excitation with arrhythmia, auriculoventricular accessory pathway syndrome
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Zachariah JP, Walsh EP, Triedman JK, Berul CI, Cecchin F, Alexander ME, Bevilacqua LM (January 2013).
3717: 3245: 3226: 3126: 3037: 2980: 764: 610: 130: 1609: 3722: 3579: 3574: 3497: 3401: 3371: 3330: 2956: 2873: 2702: 2162:"A case in which the vagus influenced the form of the ventricular complex of the electrocardiogram" 976: 787: 637: 579: 488: 452: 332: 250: 106: 2650: 50: 4504: 4374: 4135: 4030: 3960: 3825: 3623: 3445: 3396: 3021: 2968: 2878: 1863: 1549: 1350: 1251: 903: 542: 376: 289: 258: 110: 93: 2554: 1433:
Munger TM, Packer DL, Hammill SC, Feldman BJ, Bailey KR, Ballard DJ, et al. (March 1993).
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Kim SS, Knight BP (May 2017). "Long term risk of Wolff-Parkinson-White pattern and syndrome".
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electrical connection is made via the bundle of Kent, tachydysrhythmias may therefore result.
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Gollob MH (January 2008). "Modulating phenotypic expression of the PRKAG2 cardiac syndrome".
4582: 4499: 4396: 4291: 4200: 3858: 3750: 3643: 3339: 2227: 2200: 2173: 2113: 2105: 2064: 2056: 2015: 1948: 1942: 1890: 1847: 1766: 1664: 1621: 1580: 1533: 1446: 1377: 1334: 1297: 1287: 1235: 1161: 1115: 1107: 1065: 266: 180: 241:. About 60% of people with the electrical problem developed symptoms, which may include an 4494: 4461: 4388: 4099: 3955: 3880: 3272: 3253: 3240: 3047: 2926: 1691: 1403:
Sorbo MD, Buja GF, Miorelli M, Nistri S, Perrone C, Manca S, et al. (June 1995). "".
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Page RL, Joglar JA, Caldwell MA, Calkins H, Conti JB, Deal BJ, et al. (April 2016).
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The definitive treatment of WPW is the destruction of the abnormal electrical pathway by
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Josephson's clinical cardiac electrophysiology : techniques and interpretations
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Campbell RM, Strieper MJ, Frias PA, Collins KK, Van Hare GF, Dubin AM (March 2003).
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People with atrial fibrillation and rapid ventricular response may be treated with
587: 424: 340: 246: 102: 2045:"Multiple accessory pathways in the young: the impact of structural heart disease" 2004:"Radiofrequency catheter ablation in patients with Wolff-Parkinson-White syndrome" 805:(1886–1973) are credited with the definitive description of the disorder in 1930. 403: 2801: 2729: 2310:"Heart Surgery, Foot Injuries, a Demotion to Backup—Max Duggan Overcame Them All" 2245: 1771: 1754: 4445: 4253: 3730: 3628: 3418: 3335: 3317: 3143: 3116: 3067: 3008: 2759: 2367: 1798: 846: 794: 695: 476: 472: 464: 440: 431:(AV) node. After a brief delay at the AV node, the stimulus travels through the 364: 344: 317: 242: 169: 165: 73: 2778: 2740: 1894: 1292: 1275: 4563: 3758: 3308: 2784: 2692: 2060: 1851: 1239: 1199:. University of Wisconsin Hospitals and Clinics. 29 March 2019. Archived from 1165: 922: 830: 818: 791: 715: 670:
incidence of sudden cardiac death is so low (less than 0.6% in some reports).
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protocol, people with WPW who are experiencing rapid abnormal heart rhythms (
312:. The diagnosis of WPW occurs with a combination of palpitations and when an 4549: 4009: 2770: 2661:
Wolff-Parkinson-White Syndrome Clinic, The University of Wisconsin - Madison
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Abnormal heart rhythm due to faulty electrical connections in the heart
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Fitzsimmons PJ, McWhirter PD, Peterson DW, Kruyer WB (September 2001).
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Without symptoms 0.5% (children), 0.1% (adults) risk of death per year
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Bhatia A, Sra J, Akhtar M (March 2016). "Preexcitation Syndromes".
4356: 4342: 4328: 4285: 4180: 4143: 4129: 4115: 631: 556: 523: 460: 402: 390: 222: 2607:"New Jersey Devils' Rupp has been in teammate Tallackson's shoes" 2364:"By The Way, in conversation with Jeff Garlin podcast episode #5" 2094:"Researches on the Structure and Function of the Mammalian Heart" 779:
The bundle of Kent is eponymously named for British physiologist
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if they are demonstrating severe signs or symptoms (for example,
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Conduction through the accessory pathway results in a delta wave.
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Simonian SM, Lotfipour S, Wall C, Langdorf MI (October 2010).
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Simonian SM, Lotfipour S, Wall C, Langdorf MI (October 2010).
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Deficiencies of intracellular signaling peptides and proteins
487:. In some cases, the combination of an accessory pathway and 616:
Wolff–Parkinson–White syndrome is sometimes associated with
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Electrical activity in the normal human heart begins when a
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at the apex of the heart, then finally to the ventricular
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through the conduction system of the normal human heart
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to the left and right bundle branches and then to the
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welterweight fighter, turned analyst and commentator
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of an individual with Wolff–Parkinson–White syndrome
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The underlying mechanism involves an 4674:intracellular signaling peptides and proteins 3912: 2817: 2002:Thakur RK, Klein GJ, Yee R (September 1994). 1797:Chhabra L, Goyal A, Benham MD (August 2022). 1428: 1426: 8: 2547:"Texas A&M defense gets the full Monty" 2465:"Jessie J Shares Battle With Heart Disease" 2439:Events and Medals, Biographical Information 1792: 1790: 1187: 1185: 1183: 536:The bundle of Kent is an abnormal extra or 495:, a leading cause of sudden cardiac death. 4258: 4014: 3938: 3919: 3905: 3897: 3433: 3313: 3153: 3134:Arrhythmogenic right ventricular dysplasia 3004: 2846: 2824: 2810: 2802: 2666: 2655:United States National Library of Medicine 1883:The American Journal of Emergency Medicine 1829: 1827: 1370:The American Journal of Emergency Medicine 1012: 1010: 1008: 1006: 1004: 1002: 971: 343:may be used. 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Associated Press. 2007-04-10. 1799:"Wolff Parkinson White Syndrome" 1640:from the original on 2011-01-30. 1405:Giornale Italiano di Cardiologia 1018:"Wolff-Parkinson-White syndrome" 977:"Wolff-Parkinson-White syndrome" 586:When an individual is in normal 561:One beat from a rhythm strip in 329:radiofrequency catheter ablation 185:radiofrequency catheter ablation 4645:PRKCSH Polycystic liver disease 3173:Subacute bacterial endocarditis 2619:from the original on 2008-12-05 2587:from the original on 2007-10-13 2527:from the original on 2009-01-11 2258:from the original on 2012-11-05 1840:Internal and Emergency Medicine 1702:from the original on 2010-10-10 1228:Internal and Emergency Medicine 1094:Liu A, Pusalkar P (June 2011). 1070:10.1016/j.cpcardiol.2015.11.002 936:Re-entry ventricular arrhythmia 871:, New Zealand Olympic canoeist. 4631:Wolff–Parkinson–White syndrome 4035:Pseudopseudohypoparathyroidism 3934:GTP-binding protein regulators 2790:Wolff–Parkinson–White syndrome 2651:Wolff-Parkinson-White syndrome 2641:Wolff–Parkinson–White syndrome 2463:Annie D. (November 21, 2014). 2276:Hedegaard E (19 August 2010). 2110:10.1113/jphysiol.1893.sp000451 1058:Current Problems in Cardiology 528:Graphic representation of the 395:Graphic representation of the 310:hypokalemic periodic paralysis 211:Wolff–Parkinson–White syndrome 36:Wolff–Parkinson–White syndrome 18:Wolff-Parkinson-White Syndrome 1: 4704:Syndromes affecting the heart 4239:Cardiofaciocutaneous syndrome 4187:Chylomicron retention disease 3690:Pulseless electrical activity 3619:Multifocal atrial tachycardia 3493:Catecholaminergic polymorphic 2381:Werner B (October 15, 2016). 2232:10.1016/S0002-8703(30)90086-5 2193:Archives of Internal Medicine 2166:Archives of Internal Medicine 1690:Kenyon J (24 November 2014). 1382:10.1016/S0735-6757(99)90167-5 4481:X-linked myotubular myopathy 2469:International Business Times 2406:"Dan Hardy "has wolf heart"" 1772:10.1161/CIR.0000000000000311 760:cardiac electrophysiologists 538:accessory conduction pathway 397:electrical conduction system 381:supraventricular tachycardia 4278:X-linked agammaglobulinemia 4122:Charcot–Marie–Tooth disease 2545:Cessna R (8 October 2004). 498:WPW may be associated with 4720: 3981:Marinesco–Sjögren syndrome 3634:Wandering atrial pacemaker 3181:non-infective endocarditis 3122:Endocardial fibroelastosis 2336:"Courageous dog all heart" 1944:Emergency Medicine Q&A 1895:10.1016/j.ajem.2006.10.017 906:, American football player 833:, American football player 4669: 4589:Neurofibromatosis type II 4423:Pseudohypoaldosteronism 2 4150:Griscelli syndrome type 2 3943:GTPase-activating protein 3712:hexaxial reference system 3657:Jervell and Lange-Nielsen 3187:Libman–Sacks endocarditis 2649:Genetics Home Reference: 2575:Robinson J (2007-05-24). 2404:O'Regan JJ (2013-03-22). 2098:The Journal of Physiology 2061:10.1016/j.ahj.2012.10.025 1852:10.1007/s11739-010-0385-6 1240:10.1007/s11739-010-0385-6 1166:10.1016/j.tcm.2016.12.001 1022:rarediseases.info.nih.gov 841:Australian rules football 781:Albert Frank Stanley Kent 655:cardiac electrophysiology 243:abnormally fast heartbeat 99:Abnormally fast heartbeat 71: 62: 57: 48: 4457:Lhermitte–Duclos disease 4055:McCune–Albright syndrome 4045:Pseudohypoparathyroidism 3951:Neurofibromatosis type I 3592:Ventricular fibrillation 2863:Coronary artery aneurysm 1293:10.1093/eurheartj/ehz467 1112:10.1136/bcr.05.2011.4192 910:Montel Vontavious Porter 740:calcium channel blockers 493:ventricular fibrillation 417:cardiac action potential 409:cardiac action potential 269:that occurs is known as 4215:Bardet–Biedl syndrome 3 3869:Diastolic heart failure 3843:Athletic heart syndrome 3804:Ventricular hypertrophy 3538:Pre-excitation syndrome 3392:Left posterior fascicle 2917:Acute coronary syndrome 2857:Coronary artery disease 1983:(12 Suppl 1): 189–197. 1918:"23: ECG Abnormalities" 1669:10.1067/mhj.2001.117779 1626:10.1542/peds.111.3.e245 1452:10.1161/01.CIR.87.3.866 981:Genetics Home Reference 322:pre-excitation syndrome 4363:Peutz–Jeghers syndrome 4349:Incontinentia pigmenti 4335:Li–Fraumeni syndrome 2 3986:Aarskog–Scott syndrome 3387:Left anterior fascicle 3167:infective endocarditis 2952:Hibernating myocardium 2833:Cardiovascular disease 2605:Chere R (2008-09-25). 2220:American Heart Journal 2049:American Heart Journal 1696:Doctors Lounge Website 1657:American Heart Journal 1280:European Heart Journal 641: 570: 533: 489:abnormal heart rhythms 412: 400: 4467:Proteus-like syndrome 4321:Coffin-Lowry syndrome 3551:Wolff–Parkinson–White 3511:Premature contraction 3409:Adams–Stokes syndrome 3112:Loeffler endocarditis 2922:Myocardial infarction 2657:, Bethesda, Maryland) 2143:Journal of Physiology 1720:Josephson ME (2015). 1488:on 17 September 2010. 914:professional wrestler 700:altered mental status 635: 622:mitochondrial disease 560: 527: 406: 394: 239:atrioventricular node 237:, thus bypassing the 111:loss of consciousness 4375:Myotonic dystrophy 1 3718:Right axis deviation 3680:Sudden cardiac death 3038:Pericardial effusion 2981:Ventricular aneurysm 2342:on December 22, 2008 2092:Kent AF (May 1893). 1586:10.1056/NEJMoa035345 1024:. 31 December 2012. 880:Arrested Development 606:("negative delta"). 131:sudden cardiac death 3723:Left axis deviation 3580:Atrial fibrillation 3575:Ventricular flutter 3498:Torsades de pointes 3372:Bundle branch block 3331:Sick sinus syndrome 3117:Cardiac amyloidosis 3102:Tachycardia-induced 2957:Myocardial stunning 2905:Prinzmetal's angina 2874:Coronary thrombosis 1500:"Ebstein's Anomaly" 1203:on 30 November 2020 900:, American musician 788:Frank Norman Wilson 628:Risk stratification 580:torsades de pointes 453:atrial fibrillation 373:shortness of breath 333:atrial fibrillation 316:(ECG) show a short 267:irregular heartbeat 251:shortness of breath 109:, lightheadedness, 107:shortness of breath 4694:Cardiac arrhythmia 4505:Metachondromatosis 4201:Joubert syndrome 8 4136:Carpenter syndrome 3971:Guanine nucleotide 3961:Tuberous sclerosis 3826:Atrial enlargement 3624:Pacemaker syndrome 3546:Lown–Ganong–Levine 3468:Junctional ectopic 3463:AV nodal reentrant 2969:Myocardial rupture 2879:Coronary vasospasm 2751:External resources 2492:Living Healthy 360 2160:Wilson FN (1915). 1941:. In Lex J (ed.). 904:Michael Montgomery 888:, British musician 696:low blood pressure 642: 571: 543:electrical circuit 534: 413: 407:Transmission of a 401: 399:of the human heart 375:, or infrequently 359:Signs and symptoms 339:or the medication 290:autosomal dominant 284:gene which may be 4681: 4680: 4515: 4514: 4495:Noonan syndrome 1 4389:Seckel syndrome 1 4225: 4224: 4100:Noonan syndrome 3 4086:Costello syndrome 4004: 4003: 3894: 3893: 3886:Obstructive shock 3790: 3789: 3737:Short QT syndrome 3704:Other / ungrouped 3695:Sinoatrial arrest 3610:Ectopic pacemaker 3506: 3505: 3326:Sinus bradycardia 3298: 3297: 3294: 3293: 3043:Cardiac tamponade 2996: 2995: 2986:Dressler syndrome 2884:Myocardial bridge 2799: 2798: 2316:. 2 December 2022 1958:978-0-7216-5944-2 1765:(14): e506–e574. 1731:978-1-4963-2661-4 1579:(19): 1803–1811. 1526:Clinical Genetics 1482:americanheart.org 1106:: bcr0520114192. 815:LaMarcus Aldridge 803:Paul Dudley White 765:Ebstein's anomaly 756:catheter ablation 750:Catheter ablation 698:or lethargy with 688:tachydysrhythmias 682:According to the 638:electrocardiogram 611:Ebstein's anomaly 485:cardiogenic shock 353:Paul Dudley White 314:electrocardiogram 227:accessory pathway 219:electrical system 208: 207: 172:from a delta wave 162:Electrocardiogram 157:Diagnostic method 149:Accessory pathway 30:Medical condition 16:(Redirected from 4711: 4500:LEOPARD syndrome 4403:Oguchi disease 2 4304:Serine/threonine 4292:ZAP70 deficiency 4259: 4015: 3939: 3921: 3914: 3907: 3898: 3859:Cardiac fibrosis 3751:T wave alternans 3644:Long QT syndrome 3438:Supraventricular 3434: 3367:Intraventricular 3314: 3154: 3005: 2850:Coronary disease 2847: 2826: 2819: 2812: 2803: 2667: 2628: 2627: 2625: 2624: 2602: 2596: 2595: 2593: 2592: 2572: 2566: 2565: 2563: 2562: 2553:. Archived from 2542: 2536: 2535: 2533: 2532: 2513: 2507: 2506: 2504: 2503: 2494:. Archived from 2483: 2477: 2476: 2460: 2454: 2453: 2451: 2450: 2435:"Alicia Hoskinn" 2431: 2425: 2424: 2422: 2421: 2412:. Archived from 2401: 2395: 2394: 2378: 2372: 2371: 2366:. Archived from 2360: 2351: 2350: 2348: 2347: 2338:. Archived from 2331: 2325: 2324: 2322: 2321: 2306: 2300: 2299: 2297: 2295: 2273: 2267: 2266: 2264: 2263: 2242: 2236: 2235: 2215: 2209: 2208: 2188: 2182: 2181: 2157: 2151: 2150: 2138: 2132: 2131: 2121: 2089: 2083: 2082: 2072: 2040: 2034: 2033: 2023: 1999: 1993: 1992: 1972: 1963: 1962: 1940: 1935:Wald DA (2009). 1932: 1926: 1925: 1913: 1907: 1906: 1878: 1872: 1871: 1831: 1822: 1821: 1819: 1817: 1794: 1785: 1784: 1774: 1750: 1744: 1743: 1717: 1711: 1710: 1708: 1707: 1687: 1681: 1680: 1648: 1642: 1641: 1620:(3): e245–e247. 1605: 1599: 1598: 1588: 1564: 1558: 1557: 1521: 1515: 1514: 1512: 1510: 1496: 1490: 1489: 1474: 1465: 1464: 1454: 1430: 1421: 1420: 1400: 1394: 1393: 1365: 1359: 1358: 1322: 1316: 1315: 1305: 1295: 1271: 1260: 1259: 1219: 1213: 1212: 1210: 1208: 1197:UWHealthkids.org 1189: 1178: 1177: 1149: 1134: 1133: 1123: 1100:BMJ Case Reports 1091: 1082: 1081: 1053: 1038: 1037: 1035: 1033: 1014: 997: 996: 994: 992: 973: 827:, Canadian actor 801:(1885–1976) and 769:cardiomyopathies 645:pre-excitation. 429:atrioventricular 181:Watchful waiting 67: 53: 33: 21: 4719: 4718: 4714: 4713: 4712: 4710: 4709: 4708: 4684: 4683: 4682: 4677: 4665: 4570: 4511: 4462:Cowden syndrome 4436: 4429: 4305: 4298: 4263:Tyrosine kinase 4243: 4221: 4064: 4000: 3973:exchange factor 3972: 3965: 3956:Watson syndrome 3928: 3925: 3895: 3890: 3881:Rheumatic fever 3847: 3786: 3699: 3666: 3638: 3596: 3555: 3532: 3502: 3474: 3421: 3413: 3307: 3290: 3198: 3147: 3138: 3054: 3048:Hemopericardium 2992: 2933: 2927:Unstable angina 2900:Angina pectoris 2893:Active ischemia 2888: 2836: 2830: 2800: 2795: 2794: 2746: 2745: 2678: 2637: 2632: 2631: 2622: 2620: 2604: 2603: 2599: 2590: 2588: 2574: 2573: 2569: 2560: 2558: 2551:aggiesports.com 2544: 2543: 2539: 2530: 2528: 2515: 2514: 2510: 2501: 2499: 2485: 2484: 2480: 2462: 2461: 2457: 2448: 2446: 2433: 2432: 2428: 2419: 2417: 2403: 2402: 2398: 2380: 2379: 2375: 2362: 2361: 2354: 2345: 2343: 2333: 2332: 2328: 2319: 2317: 2308: 2307: 2303: 2293: 2291: 2275: 2274: 2270: 2261: 2259: 2244: 2243: 2239: 2217: 2216: 2212: 2190: 2189: 2185: 2159: 2158: 2154: 2140: 2139: 2135: 2104:(4–5): i2-254. 2091: 2090: 2086: 2042: 2041: 2037: 2001: 2000: 1996: 1974: 1973: 1966: 1959: 1938:"Resuscitation" 1934: 1933: 1929: 1915: 1914: 1910: 1880: 1879: 1875: 1833: 1832: 1825: 1815: 1813: 1796: 1795: 1788: 1752: 1751: 1747: 1732: 1719: 1718: 1714: 1705: 1703: 1689: 1688: 1684: 1650: 1649: 1645: 1607: 1606: 1602: 1566: 1565: 1561: 1523: 1522: 1518: 1508: 1506: 1498: 1497: 1493: 1476: 1475: 1468: 1432: 1431: 1424: 1402: 1401: 1397: 1367: 1366: 1362: 1324: 1323: 1319: 1273: 1272: 1263: 1221: 1220: 1216: 1206: 1204: 1191: 1190: 1181: 1151: 1150: 1137: 1093: 1092: 1085: 1055: 1054: 1041: 1031: 1029: 1016: 1015: 1000: 990: 988: 975: 974: 949: 944: 932: 837:Nathan Eagleton 811: 777: 752: 708: 680: 630: 566: 555: 522: 509:encoded by the 467:(the time from 437:Purkinje fibers 389: 387:Pathophysiology 361: 306:Ebstein anomaly 255:lightheadedness 183:, medications, 31: 28: 23: 22: 15: 12: 11: 5: 4717: 4715: 4707: 4706: 4701: 4699:Rare syndromes 4696: 4686: 4685: 4679: 4678: 4670: 4667: 4666: 4664: 4663: 4662: 4661: 4649: 4648: 4647: 4635: 4634: 4633: 4621: 4620: 4619: 4617:Carney complex 4607: 4606: 4605: 4593: 4592: 4591: 4578: 4576: 4572: 4571: 4569: 4568: 4567: 4566: 4554: 4553: 4552: 4540: 4539: 4538: 4525: 4523: 4517: 4516: 4513: 4512: 4510: 4509: 4508: 4507: 4502: 4497: 4485: 4484: 4483: 4471: 4470: 4469: 4464: 4459: 4454: 4441: 4439: 4431: 4430: 4428: 4427: 4426: 4425: 4407: 4406: 4405: 4393: 4392: 4391: 4379: 4378: 4377: 4367: 4366: 4365: 4353: 4352: 4351: 4339: 4338: 4337: 4325: 4324: 4323: 4310: 4308: 4300: 4299: 4297: 4296: 4295: 4294: 4282: 4281: 4280: 4267: 4265: 4256: 4245: 4244: 4242: 4241: 4235: 4233: 4227: 4226: 4223: 4222: 4220: 4219: 4218: 4217: 4205: 4204: 4203: 4191: 4190: 4189: 4172: 4171: 4170: 4169: 4155: 4154: 4153: 4152: 4140: 4139: 4138: 4126: 4125: 4124: 4110: 4109: 4108: 4107: 4102: 4090: 4089: 4088: 4074: 4072: 4066: 4065: 4063: 4062: 4057: 4052: 4047: 4042: 4037: 4023: 4021: 4012: 4006: 4005: 4002: 4001: 3999: 3998: 3993: 3988: 3983: 3977: 3975: 3967: 3966: 3964: 3963: 3958: 3953: 3947: 3945: 3936: 3930: 3929: 3926: 3924: 3923: 3916: 3909: 3901: 3892: 3891: 3889: 3888: 3883: 3878: 3877: 3876: 3874:Cardiac asthma 3871: 3861: 3855: 3853: 3849: 3848: 3846: 3845: 3840: 3839: 3838: 3833: 3823: 3822: 3821: 3816: 3811: 3800: 3798: 3792: 3791: 3788: 3787: 3785: 3784: 3782:Strain pattern 3779: 3778: 3777: 3772: 3767: 3755: 3754: 3753: 3741: 3740: 3739: 3727: 3726: 3725: 3720: 3707: 3705: 3701: 3700: 3698: 3697: 3692: 3687: 3682: 3676: 3674: 3672:Cardiac arrest 3668: 3667: 3665: 3664: 3659: 3654: 3652:Andersen–Tawil 3648: 3646: 3640: 3639: 3637: 3636: 3631: 3626: 3621: 3616: 3606: 3604: 3598: 3597: 3595: 3594: 3589: 3588: 3587: 3577: 3572: 3570:Atrial flutter 3566: 3564: 3557: 3556: 3554: 3553: 3548: 3542: 3540: 3534: 3533: 3531: 3530: 3525: 3520: 3514: 3512: 3508: 3507: 3504: 3503: 3501: 3500: 3495: 3490: 3484: 3482: 3476: 3475: 3473: 3472: 3471: 3470: 3465: 3455: 3454: 3453: 3442: 3440: 3431: 3415: 3414: 3412: 3411: 3406: 3405: 3404: 3399: 3394: 3389: 3384: 3379: 3369: 3364: 3363: 3362: 3357: 3352: 3342: 3333: 3328: 3322: 3320: 3311: 3300: 3299: 3296: 3295: 3292: 3291: 3289: 3288: 3287: 3286: 3281: 3269: 3268: 3267: 3262: 3250: 3249: 3248: 3243: 3231: 3230: 3229: 3224: 3219: 3206: 3204: 3200: 3199: 3197: 3196: 3195: 3194: 3189: 3177: 3176: 3175: 3162: 3160: 3151: 3140: 3139: 3137: 3136: 3131: 3130: 3129: 3124: 3119: 3114: 3109: 3104: 3099: 3094: 3093: 3092: 3080:Cardiomyopathy 3077: 3076: 3075: 3073:Chagas disease 3064: 3062: 3056: 3055: 3053: 3052: 3051: 3050: 3045: 3035: 3034: 3033: 3024: 3013: 3011: 3002: 2998: 2997: 2994: 2993: 2991: 2990: 2989: 2988: 2983: 2973: 2972: 2971: 2961: 2960: 2959: 2954: 2943: 2941: 2935: 2934: 2932: 2931: 2930: 2929: 2924: 2914: 2913: 2912: 2907: 2896: 2894: 2890: 2889: 2887: 2886: 2881: 2876: 2871: 2865: 2860: 2853: 2851: 2844: 2838: 2837: 2831: 2829: 2828: 2821: 2814: 2806: 2797: 2796: 2793: 2792: 2781: 2767: 2755: 2754: 2752: 2748: 2747: 2744: 2743: 2732: 2721: 2710: 2695: 2679: 2674: 2673: 2671: 2670:Classification 2664: 2663: 2658: 2647: 2636: 2635:External links 2633: 2630: 2629: 2597: 2567: 2537: 2523:. 2003-11-28. 2508: 2478: 2455: 2426: 2396: 2373: 2370:on 2013-03-11. 2352: 2326: 2301: 2268: 2237: 2226:(6): 685–704. 2210: 2183: 2172:(6): 1008–27. 2152: 2133: 2084: 2035: 2014:(6): 771–776. 1994: 1979:(in Italian). 1964: 1957: 1927: 1908: 1889:(5): 576–583. 1873: 1846:(5): 421–426. 1823: 1786: 1745: 1730: 1712: 1682: 1663:(3): 530–536. 1643: 1600: 1559: 1532:(6): 535–537. 1516: 1491: 1466: 1445:(3): 866–873. 1422: 1411:(6): 681–687. 1407:(in Italian). 1395: 1376:(7): 705–714. 1360: 1333:(2): 134–135. 1317: 1286:(5): 655–720. 1261: 1234:(5): 421–426. 1214: 1179: 1160:(4): 260–268. 1135: 1083: 1039: 998: 946: 945: 943: 940: 939: 938: 931: 928: 927: 926: 916: 907: 901: 895: 892:Marilyn Manson 889: 883: 872: 866: 856: 853:Quentin Groves 850: 844: 834: 828: 822: 810: 807: 799:John Parkinson 776: 773: 767:and inherited 751: 748: 707: 704: 679: 676: 629: 626: 564: 554: 551: 530:bundle of Kent 521: 520:Bundle of Kent 518: 504:protein kinase 457:atrial flutter 419:arises in the 388: 385: 360: 357: 349:John Parkinson 263:cardiac arrest 206: 205: 202: 198: 197: 194: 188: 187: 178: 174: 173: 164:shows a short 159: 153: 152: 146: 142: 141: 138: 134: 133: 123:Cardiomyopathy 120: 114: 113: 96: 90: 89: 84: 78: 77: 69: 68: 60: 59: 55: 54: 46: 45: 42: 38: 37: 29: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 4716: 4705: 4702: 4700: 4697: 4695: 4692: 4691: 4689: 4676: 4675: 4668: 4660: 4657: 4656: 4655: 4654: 4650: 4646: 4643: 4642: 4641: 4640: 4636: 4632: 4629: 4628: 4627: 4626: 4622: 4618: 4615: 4614: 4613: 4612: 4608: 4604: 4601: 4600: 4599: 4598: 4594: 4590: 4587: 4586: 4585: 4584: 4580: 4579: 4577: 4573: 4565: 4562: 4561: 4560: 4559: 4555: 4551: 4548: 4547: 4546: 4545: 4541: 4537: 4534: 4533: 4532: 4531: 4527: 4526: 4524: 4522: 4518: 4506: 4503: 4501: 4498: 4496: 4493: 4492: 4491: 4490: 4486: 4482: 4479: 4478: 4477: 4476: 4472: 4468: 4465: 4463: 4460: 4458: 4455: 4453: 4450: 4449: 4448: 4447: 4443: 4442: 4440: 4438: 4432: 4424: 4421: 4420: 4419: 4418: 4413: 4412: 4408: 4404: 4401: 4400: 4399: 4398: 4394: 4390: 4387: 4386: 4385: 4384: 4380: 4376: 4373: 4372: 4371: 4368: 4364: 4361: 4360: 4359: 4358: 4354: 4350: 4347: 4346: 4345: 4344: 4340: 4336: 4333: 4332: 4331: 4330: 4326: 4322: 4319: 4318: 4317: 4316: 4312: 4311: 4309: 4307: 4301: 4293: 4290: 4289: 4288: 4287: 4283: 4279: 4276: 4275: 4274: 4273: 4269: 4268: 4266: 4264: 4260: 4257: 4255: 4251: 4246: 4240: 4237: 4236: 4234: 4232: 4228: 4216: 4213: 4212: 4211: 4210: 4206: 4202: 4199: 4198: 4197: 4196: 4192: 4188: 4185: 4184: 4183: 4182: 4177: 4174: 4173: 4168: 4165: 4164: 4163: 4162: 4157: 4156: 4151: 4148: 4147: 4146: 4145: 4141: 4137: 4134: 4133: 4132: 4131: 4127: 4123: 4120: 4119: 4118: 4117: 4112: 4111: 4106: 4103: 4101: 4098: 4097: 4096: 4095: 4091: 4087: 4084: 4083: 4082: 4081: 4076: 4075: 4073: 4071: 4067: 4061: 4058: 4056: 4053: 4051: 4048: 4046: 4043: 4041: 4038: 4036: 4032: 4028: 4025: 4024: 4022: 4020: 4019:Heterotrimeic 4016: 4013: 4011: 4007: 3997: 3994: 3992: 3989: 3987: 3984: 3982: 3979: 3978: 3976: 3974: 3968: 3962: 3959: 3957: 3954: 3952: 3949: 3948: 3946: 3944: 3940: 3937: 3935: 3931: 3922: 3917: 3915: 3910: 3908: 3903: 3902: 3899: 3887: 3884: 3882: 3879: 3875: 3872: 3870: 3867: 3866: 3865: 3864:Heart failure 3862: 3860: 3857: 3856: 3854: 3850: 3844: 3841: 3837: 3834: 3832: 3829: 3828: 3827: 3824: 3820: 3817: 3815: 3812: 3810: 3807: 3806: 3805: 3802: 3801: 3799: 3797: 3793: 3783: 3780: 3776: 3775:ST depression 3773: 3771: 3768: 3766: 3763: 3762: 3761: 3760: 3756: 3752: 3749: 3748: 3747: 3746: 3742: 3738: 3735: 3734: 3733: 3732: 3728: 3724: 3721: 3719: 3716: 3715: 3714: 3713: 3709: 3708: 3706: 3702: 3696: 3693: 3691: 3688: 3686: 3683: 3681: 3678: 3677: 3675: 3673: 3669: 3663: 3660: 3658: 3655: 3653: 3650: 3649: 3647: 3645: 3641: 3635: 3632: 3630: 3627: 3625: 3622: 3620: 3617: 3615: 3611: 3608: 3607: 3605: 3603: 3599: 3593: 3590: 3586: 3583: 3582: 3581: 3578: 3576: 3573: 3571: 3568: 3567: 3565: 3563: 3558: 3552: 3549: 3547: 3544: 3543: 3541: 3539: 3535: 3529: 3526: 3524: 3521: 3519: 3516: 3515: 3513: 3509: 3499: 3496: 3494: 3491: 3489: 3486: 3485: 3483: 3481: 3477: 3469: 3466: 3464: 3461: 3460: 3459: 3456: 3452: 3449: 3448: 3447: 3444: 3443: 3441: 3439: 3435: 3432: 3429: 3425: 3420: 3416: 3410: 3407: 3403: 3402:Trifascicular 3400: 3398: 3395: 3393: 3390: 3388: 3385: 3383: 3380: 3378: 3375: 3374: 3373: 3370: 3368: 3365: 3361: 3358: 3356: 3353: 3351: 3348: 3347: 3346: 3343: 3341: 3337: 3334: 3332: 3329: 3327: 3324: 3323: 3321: 3319: 3315: 3312: 3310: 3305: 3301: 3285: 3284:regurgitation 3282: 3280: 3277: 3276: 3275: 3274: 3270: 3266: 3265:regurgitation 3263: 3261: 3258: 3257: 3256: 3255: 3251: 3247: 3246:regurgitation 3244: 3242: 3239: 3238: 3237: 3236: 3232: 3228: 3227:regurgitation 3225: 3223: 3220: 3218: 3215: 3214: 3213: 3212: 3208: 3207: 3205: 3201: 3193: 3190: 3188: 3185: 3184: 3183: 3182: 3178: 3174: 3171: 3170: 3169: 3168: 3164: 3163: 3161: 3159: 3155: 3152: 3150: 3145: 3141: 3135: 3132: 3128: 3125: 3123: 3120: 3118: 3115: 3113: 3110: 3108: 3105: 3103: 3100: 3098: 3095: 3091: 3088: 3087: 3086: 3083: 3082: 3081: 3078: 3074: 3071: 3070: 3069: 3066: 3065: 3063: 3061: 3057: 3049: 3046: 3044: 3041: 3040: 3039: 3036: 3032: 3028: 3025: 3023: 3020: 3019: 3018: 3015: 3014: 3012: 3010: 3006: 3003: 2999: 2987: 2984: 2982: 2979: 2978: 2977: 2974: 2970: 2967: 2966: 2965: 2962: 2958: 2955: 2953: 2950: 2949: 2948: 2945: 2944: 2942: 2940: 2936: 2928: 2925: 2923: 2920: 2919: 2918: 2915: 2911: 2910:Stable angina 2908: 2906: 2903: 2902: 2901: 2898: 2897: 2895: 2891: 2885: 2882: 2880: 2877: 2875: 2872: 2869: 2866: 2864: 2861: 2858: 2855: 2854: 2852: 2848: 2845: 2843: 2839: 2834: 2827: 2822: 2820: 2815: 2813: 2808: 2807: 2804: 2791: 2787: 2786: 2782: 2780: 2777: 2773: 2772: 2768: 2766: 2762: 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749: 747: 745: 744:beta blockers 741: 737: 733: 729: 724: 721: 717: 712: 705: 703: 701: 697: 693: 692:cardioversion 689: 685: 677: 675: 671: 667: 665: 659: 656: 653:(PES) in the 652: 646: 639: 634: 627: 625: 623: 619: 614: 612: 607: 603: 599: 597: 593: 589: 584: 582: 581: 575: 567: 559: 552: 550: 548: 544: 539: 531: 526: 519: 517: 515: 512: 508: 505: 501: 496: 494: 490: 486: 480: 479:in duration. 478: 474: 470: 466: 462: 458: 454: 448: 446: 442: 438: 434: 433:bundle of His 430: 426: 422: 418: 410: 405: 398: 393: 386: 384: 382: 378: 374: 370: 366: 358: 356: 354: 350: 346: 342: 338: 337:cardioversion 334: 330: 325: 323: 319: 315: 311: 307: 303: 299: 295: 291: 287: 283: 279: 274: 272: 268: 264: 260: 256: 252: 248: 244: 240: 236: 232: 228: 225:involving an 224: 220: 216: 212: 203: 199: 195: 193: 189: 186: 182: 179: 175: 171: 167: 163: 160: 158: 154: 150: 147: 143: 139: 135: 132: 128: 124: 121: 119: 118:Complications 115: 112: 108: 104: 100: 97: 95: 91: 88: 85: 83: 79: 75: 70: 66: 61: 56: 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Index

Wolff-Parkinson-White Syndrome


PR interval
Specialty
Cardiology
Symptoms
Abnormally fast heartbeat
palpitations
shortness of breath
loss of consciousness
Complications
Cardiomyopathy
stroke
sudden cardiac death
Accessory pathway
Diagnostic method
Electrocardiogram
PR interval
QRS complex
Watchful waiting
radiofrequency catheter ablation
Prognosis
electrical system
heart
accessory pathway
atria
ventricles
atrioventricular node
abnormally fast heartbeat

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