665:. Because GABA-T degrades GABA, the inhibition of this enzyme has been the target of many medical studies. The goal of these studies is to find a way to inhibit GABA-T activity, which would reduce the rate that GABA and 2-oxoglutarate are converted to semialdehyde and L-glutamate, thus raising GABA concentration in the brain. There is also a genetic disorder in humans which can lead to a deficiency in GABA-T. This can lead to developmental impairment or mortality in extreme cases.
3021:
672:, GABA can be produced as a stress response. Plants also use GABA to for internal signaling and for interactions with other organisms near the plant. In all of these intra-plant pathways, GABA-T will take on the role of degrading GABA. It has also been demonstrated that the succinate produced in the GABA shunt makes up a significant proportion of the succinate needed by the mitochondrion.
29:
675:
In fungi, the breakdown of GABA in the GABA shunt is key in ensuring a high level of activity in the critic acid cycle. There is also experimental evidence that the breakdown of GABA by GABA-T plays a role in managing oxidative stress in fungi.
1344:"Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin"
2503:
1630:
1391:
Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT (August 2009). "Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity".
1115:
Ricci L, Frosini M, Gaggelli N, Valensin G, Machetti F, Sgaragli G, Valoti M (May 2006). "Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis".
2997:
2496:
424:
982:
Cao J, Barbosa JM, Singh N, Locy RD (July 2013). "GABA transaminases from
Saccharomyces cerevisiae and Arabidopsis thaliana complement function in cytosol and mitochondria".
2049:
2489:
1623:
194:
251:
213:
1616:
2986:
2660:
2129:
650:. The critic acid cycle can then produce 2-oxoglutarate, which can be used to make glutamate, which can in turn be made into GABA, continuing the cycle.
589:
630:
The primary role of GABA-T is to break down GABA as part of the GABA-Shunt. In the next step of the shunt, the semialdehyde produced by GABA-T will be
1503:
Schousboe A, Wu JY, Roberts E (July 1973). "Purification and characterization of the 4-aminobutyrate--2,ketoglutarate transaminase from mouse brain".
2119:
2042:
1768:
3066:
3041:
1533:
746:
of 4-aminobutyrate transaminase include Lys-329, which are found on each of the two subunits of the enzyme. This site will also bind with a
3051:
639:
2134:
3056:
2803:
2179:
1945:
1911:
1897:
1754:
275:
2979:
2212:
2035:
920:
1185:
1025:
Fait A, Fromm H, Walter D, Galili G, Fernie AR (January 2008). "Highway or byway: the metabolic role of the GABA shunt in plants".
657:
in animal brains, and a low concentration of GABA in mammalian brains has been linked to several neurological disorders, including
2109:
1906:
263:
206:
157:
133:
2368:
256:
1788:
1703:
1253:"Disruption of the GABA shunt affects mitochondrial respiration and virulence in the cereal pathogen Fusarium graminearum"
3011:
692:
accession codes, and published in peer-reviewed journals. At least 4 such structures have been solved using pig enzymes:
2972:
2535:
2481:
759:
727:
723:
719:
715:
705:
701:
697:
693:
2124:
1651:
1474:
Aurich H (October 1961). "" [On the beta-alanine-alpha-ketoglutarate transaminase from
Neurospora crassa].
2353:
2867:
2469:
2456:
2443:
2430:
2417:
2404:
2391:
2170:
2151:
2114:
2075:
1983:
1763:
780:
2645:
2363:
564:, and vice versa. In the case of GABA-T, it takes a nitrogen group from GABA and uses it to create L-glutamate.
151:
2819:
2765:
2317:
2260:
2066:
1589:
1302:"Crystal structures of unbound and aminooxyacetate-bound Escherichia coli gamma-aminobutyrate aminotransferase"
537:
431:
376:
44:
138:
2824:
2749:
2580:
2265:
1842:
1823:
1683:
498:
486:
556:
groups from one molecule to another. As a transaminase, GABA-T's role is to move functional groups from an
2839:
2512:
2087:
1892:
816:
662:
658:
605:
451:
2686:
2560:
409:
218:
2527:
2286:
2205:
2011:
1937:
1585:
490:
321:
126:
2358:
268:
1150:
Sherif FM, Ahmed SS (April 1995). "Basic aspects of GABA-transaminase in neuropsychiatric disorders".
2897:
2829:
2104:
2007:
1749:
1251:
Bönnighausen J, Gebhard D, Kröger C, Hadeler B, Tumforde T, Lieberei R, et al. (December 2015).
1210:
845:"In silico analysis of the inhibitory activities of GABA derivatives on 4-aminobutyrate transaminase"
482:
61:
580:
group from 2-oxoglutarate to GABA. This produces succinate semialdehyde and L-glutamate. In plants,
2834:
2770:
2322:
1803:
1798:
765:
747:
502:
447:
154:
56:
78:
2620:
2255:
2160:
1416:
1373:
1282:
1007:
685:
1440:
2640:
3046:
2892:
1793:
1566:
1520:
1491:
1462:
1408:
1365:
1321:
1274:
1230:
1167:
1132:
1094:
1042:
999:
916:
689:
647:
399:
145:
1342:
Storici P, De Biase D, Bossa F, Bruno S, Mozzarelli A, Peneff C, et al. (January 2004).
2882:
2691:
2544:
2524:
2301:
2296:
2270:
2198:
1643:
1556:
1548:
1512:
1483:
1452:
1400:
1355:
1313:
1264:
1222:
1159:
1124:
1084:
1076:
1034:
991:
962:
954:
908:
903:
Tunnicliff G (1986). "4-Aminobutyrate
Transaminase". In Boulton AA, Baker GB, Yu PH (eds.).
856:
710:
654:
597:
435:
325:
316:
2027:
114:
2872:
2348:
2332:
2245:
1949:
1708:
1597:
876:
786:
561:
470:
345:
90:
1608:
730:. There are actually some differences between the enzyme structure for these organisms.
49:
3025:
2775:
2716:
2706:
2681:
2615:
2386:
2327:
2003:
1561:
1300:
Liu W, Peterson PE, Carter RJ, Zhou X, Langston JA, Fisher AJ, Toney MD (August 2004).
585:
443:
189:
1457:
1089:
1064:
169:
3061:
3035:
2922:
2902:
2854:
2793:
2783:
2605:
2291:
2250:
1964:
1819:
1163:
942:
791:
643:
635:
466:
164:
1420:
1377:
1286:
2887:
2585:
2240:
2079:
1929:
1301:
1011:
877:"BRENDA - Information on EC 2.6.1.19 - 4-aminobutyrate-2-oxoglutarate transaminase"
843:
Iftikhar H, Batool S, Deep A, Narasimhan B, Sharma PC, Malhotra M (February 2017).
581:
549:
494:
2676:
2565:
1226:
1038:
572:
In animals, fungi, and bacteria, GABA-T helps facilitate a reaction that moves an
861:
844:
292:
2951:
2943:
2721:
2464:
2399:
2235:
2058:
1730:
1487:
912:
743:
553:
545:
541:
528:). Pigs have often been used when studying how this protein may work in humans.
462:
455:
355:
173:
3020:
1441:"Soluble gamma-aminobutyric-glutamic transaminase from Pseudomonas fluorescens"
2912:
2907:
2876:
2862:
2844:
2726:
2635:
2595:
2570:
2520:
1876:
1128:
796:
775:
770:
734:
enzymes of GABA-T lack an iron-sulfur cluster that is found in the pig model.
615:
557:
509:
478:
368:
299:
943:"4-Aminobutyrate (GABA): a metabolite and signal with practical significance"
2849:
2711:
2650:
2438:
2412:
1884:
1880:
1664:
1660:
395:
1570:
1495:
1466:
1412:
1369:
1360:
1343:
1325:
1278:
1234:
1136:
1098:
1046:
1003:
1524:
1171:
958:
477:. This enzyme participates in 5 metabolic pathways: alanine and aspartate
2630:
2610:
2600:
2062:
1925:
1726:
1722:
601:
304:
1534:"Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies"
1516:
379:
102:
2701:
2590:
1960:
1080:
619:
609:
121:
1552:
1317:
1269:
1252:
967:
2740:
2625:
2575:
2451:
2221:
1639:
1404:
995:
577:
521:
517:
391:
287:
201:
97:
85:
73:
817:"4-aminobutyrate aminotransferase - Identical Protein Groups - NCBI"
588:
can be used in the place of 2-oxoglutarate. catalyzed by the enzyme
552:
sub-subclass. As a nitrogenous transferase, its role is to transfer
2661:
1065:"The Metabolism and Functions of [gamma]-Aminobutyric Acid"
2425:
1211:"Highway or byway: the metabolic role of the GABA shunt in plants"
669:
631:
573:
525:
513:
1596:
Pearl PL, Parviz M, Hodgeman R, Gibson KM, Reimschisel T (2015).
2696:
2139:
2097:
2092:
1941:
439:
280:
109:
2485:
2194:
2031:
1612:
1209:
Fait A, Fromm H, Walter D, Galili G, Fernie AR (January 2008).
28:
2190:
642:, resulting in succinate. This succinate will then enter
2804:
1532:
Parviz M, Vogel K, Gibson KM, Pearl PL (November 2014).
413:
3009:
708:, and at least 4 such structures have been solved in
412:
1476:
2942:
2935:
2802:
2748:
2739:
2666:
Tooltip
Vesicular inhibitory amino acid transporter
2659:
2543:
2534:
2377:
2341:
2310:
2279:
2228:
2169:
2150:
2074:
1992:
1972:
1959:
1924:
1875:
1851:
1831:
1818:
1777:
1738:
1721:
1692:
1672:
1659:
1650:
351:
341:
336:
315:
310:
298:
286:
274:
262:
250:
242:
237:
232:
212:
200:
188:
183:
163:
144:
132:
120:
108:
96:
84:
72:
67:
55:
43:
38:
21:
418:
475:4-aminobutanoate:2-oxoglutarate aminotransferase
2750:
1337:
1335:
838:
836:
2497:
2206:
2043:
1624:
8:
2513:
388:4-aminobutyrate aminotransferase, or GABA-T
33:4-Aminobutyrate transaminase homodimer, Pig
2939:
2745:
2540:
2504:
2490:
2482:
2213:
2199:
2191:
2130:Branched-chain amino acid aminotransferase
2050:
2036:
2028:
1969:
1828:
1735:
1669:
1656:
1631:
1617:
1609:
333:
180:
2998:Glutamate metabolism/transport modulators
1588:at the U.S. National Library of Medicine
1560:
1456:
1359:
1268:
1088:
966:
860:
576:group from GABA to 2-oxoglutarate, and a
469:, which transfer nitrogenous groups. The
411:
2898:Valproate semisodium (divalproex sodium)
2809:Tooltip Îł-Aminobutyrate aminotransferase
2545:
688:solved for this class of enzymes, given
3016:
808:
540:2.6.1.19. This means that it is in the
1769:Phenylethanolamine N-methyltransferase
229:
18:
1246:
1244:
936:
934:
932:
898:
896:
590:4-aminobutyrate—pyruvate transaminase
461:This enzyme belongs to the family of
7:
2120:Kynurenine—oxoglutarate transaminase
1110:
1108:
1063:Bown AW, Shelp BJ (September 1997).
1058:
1056:
640:succinate-semialdehyde dehydrogenase
426:succinate semialdehyde + L-glutamate
2586:Deramciclane (EGIS-3886, EGYT-3886)
1912:Acetylserotonin O-methyltransferase
1445:The Journal of Biological Chemistry
1348:The Journal of Biological Chemistry
941:Shelp BJ, Bown AW, Zarei A (2017).
419:{\displaystyle \rightleftharpoons }
1439:Scott EM, Jakoby WB (April 1959).
406:4-aminobutanoate + 2-oxoglutarate
14:
907:. Vol. 5. pp. 389–420.
742:Amino acid residues found in the
3019:
2180:Pyridoxine 5'-phosphate synthase
1907:Aralkylamine N-acetyltransferase
27:
2755:Tooltip Glutamate decarboxylase
2135:Alanine—glyoxylate transaminase
1598:"GABA-transaminase deficiency"
1186:"GABA-TRANSAMINASE DEFICIENCY"
614:(2) 4-aminobutanoate (GABA) +
1:
2973:Receptor/signaling modulators
1789:Catechol-O-methyl transferase
1704:Histamine N-methyltransferase
1541:Journal of Pediatric Epilepsy
1458:10.1016/S0021-9258(18)70206-8
1227:10.1016/j.tplants.2007.10.005
1039:10.1016/j.tplants.2007.10.005
3067:Glutamate (neurotransmitter)
3042:Genes on human chromosome 16
2991:receptor positive modulators
1863:4-aminobutyrate transaminase
1586:4-Aminobutyrate+Transaminase
1164:10.1016/0009-9120(94)00074-6
862:10.1016/j.arabjc.2013.03.007
849:Arabian Journal of Chemistry
373:4-aminobutyrate transaminase
233:4-aminobutyrate transaminase
22:4-aminobutyrate transaminase
3052:Pyridoxal phosphate enzymes
2518:Tooltip Îł-Aminobutyric acid
1488:10.1515/bchm2.1961.326.1.25
760:GABA transaminase inhibitor
626:Cellular and metabolic role
618:⇌ succinate semialdehyde +
3083:
3057:Enzymes of known structure
2125:Ornithine aminotransferase
757:
2964:
2820:3-Hydrazinopropionic acid
2369:Michaelis–Menten kinetics
2115:Tyrosine aminotransferase
1984:Choline acetyltransferase
1902:-amino acid decarboxylase
1764:Dopamine beta-hydroxylase
1759:-amino acid decarboxylase
1129:10.1016/j.bcp.2006.02.007
913:10.1385/0-89603-079-2:389
781:Phenylethylidenehydrazine
748:pyridoxal 5'ôŹ°Ś- phosphate
653:GABA is a very important
332:
179:
26:
2980:GABA receptor modulators
2766:3-Mercaptopropionic acid
2550:Tooltip GABA transporter
2261:Diffusion-limited enzyme
1590:Medical Subject Headings
1117:Biochemical Pharmacology
905:Neurotransmitter Enzymes
684:There have been several
538:Enzyme Commission number
532:Enzyme Commission number
508:This enzyme is found in
473:of this enzyme class is
1843:Glutamate decarboxylase
1684:Histidine decarboxylase
1215:Trends in Plant Science
1027:Trends in Plant Science
646:and become part of the
546:nitrogenous transferase
487:beta-alanine metabolism
2088:Aspartate transaminase
1893:Tryptophan hydroxylase
1361:10.1074/jbc.M305884200
1257:Molecular Microbiology
881:www.brenda-enzymes.org
606:succinate semialdehyde
544:class of enzymes, the
452:succinate semialdehyde
420:
2354:Eadie–Hofstee diagram
2287:Allosteric regulation
2154:: Oximinotransferases
2012:Butyrylcholinesterase
1938:Nitric oxide synthase
1393:Phytotherapy Research
1152:Clinical Biochemistry
959:10.1139/cjb-2017-0135
491:propanoate metabolism
421:
2364:Lineweaver–Burk plot
2105:Alanine transaminase
2008:Acetylcholinesterase
1750:Tyrosine hydroxylase
821:www.ncbi.nlm.nih.gov
495:butanoate metabolism
483:glutamate metabolism
410:
2687:Chicago sky blue 6B
2561:4-Aminovaleric acid
1517:10.1021/bi00739a015
766:Aminooxyacetic acid
663:Parkinson's disease
659:Alzheimer's disease
503:pyridoxal phosphate
465:, specifically the
434:of this enzyme are
2323:Enzyme superfamily
2256:Enzyme promiscuity
2161:Oximinotransferase
1081:10.1104/pp.115.1.1
680:Structural Studies
548:sub-class and the
416:
3007:
3006:
2960:
2959:
2931:
2930:
2893:Valproate pivoxil
2857:
2830:Îł-Acetylenic-GABA
2735:
2734:
2479:
2478:
2188:
2187:
2110:GABA transaminase
2025:
2024:
2021:
2020:
1920:
1919:
1901:
1871:
1870:
1814:
1813:
1794:Monoamine oxidase
1758:
1717:
1716:
1644:neurotransmission
1602:MedLink Neurology
1553:10.3233/PEP-14097
1318:10.1021/bi049218e
1312:(34): 10896–905.
1270:10.1111/mmi.13203
648:citric acid cycle
497:. It employs one
400:chemical reaction
384:GABA transaminase
365:
364:
361:
360:
228:
227:
224:
223:
127:metabolic pathway
3074:
3024:
3023:
3015:
2940:
2883:Sodium valproate
2855:
2810:
2806:
2778:
2756:
2752:
2746:
2667:
2663:
2551:
2547:
2541:
2519:
2515:
2506:
2499:
2492:
2483:
2359:Hanes–Woolf plot
2302:Enzyme activator
2297:Enzyme inhibitor
2271:Enzyme catalysis
2215:
2208:
2201:
2192:
2052:
2045:
2038:
2029:
1997:
1977:
1970:
1899:
1856:
1836:
1829:
1782:
1756:
1743:
1736:
1697:
1677:
1670:
1657:
1633:
1626:
1619:
1610:
1605:
1574:
1564:
1538:
1528:
1499:
1470:
1460:
1425:
1424:
1405:10.1002/ptr.2712
1388:
1382:
1381:
1363:
1339:
1330:
1329:
1297:
1291:
1290:
1272:
1248:
1239:
1238:
1206:
1200:
1199:
1197:
1196:
1182:
1176:
1175:
1147:
1141:
1140:
1112:
1103:
1102:
1092:
1069:Plant Physiology
1060:
1051:
1050:
1022:
1016:
1015:
996:10.1002/yea.2962
979:
973:
972:
970:
938:
927:
926:
900:
891:
890:
888:
887:
873:
867:
866:
864:
840:
831:
830:
828:
827:
813:
711:Escherichia coli
655:neurotransmitter
598:4-aminobutanoate
568:Reaction pathway
436:4-aminobutanoate
425:
423:
422:
417:
334:
230:
181:
31:
19:
16:Class of enzymes
3082:
3081:
3077:
3076:
3075:
3073:
3072:
3071:
3032:
3031:
3030:
3018:
3010:
3008:
3003:
2990:
2956:
2927:
2873:Rosmarinic acid
2808:
2798:
2776:
2754:
2731:
2665:
2655:
2549:
2530:
2517:
2510:
2480:
2475:
2387:Oxidoreductases
2373:
2349:Enzyme kinetics
2337:
2333:List of enzymes
2306:
2275:
2246:Catalytic triad
2224:
2219:
2189:
2184:
2165:
2146:
2070:
2056:
2026:
2017:
1993:
1988:
1973:
1955:
1916:
1867:
1852:
1847:
1832:
1810:
1778:
1773:
1739:
1713:
1709:Diamine oxidase
1693:
1688:
1673:
1646:
1637:
1595:
1582:
1577:
1536:
1531:
1511:(15): 2868–73.
1502:
1473:
1438:
1434:
1432:Further reading
1429:
1428:
1390:
1389:
1385:
1341:
1340:
1333:
1299:
1298:
1294:
1250:
1249:
1242:
1208:
1207:
1203:
1194:
1192:
1184:
1183:
1179:
1149:
1148:
1144:
1114:
1113:
1106:
1062:
1061:
1054:
1024:
1023:
1019:
981:
980:
976:
953:(11): 1015–32.
940:
939:
930:
923:
902:
901:
894:
885:
883:
875:
874:
870:
842:
841:
834:
825:
823:
815:
814:
810:
805:
787:Rosmarinic acid
762:
756:
740:
682:
628:
570:
534:
471:systematic name
408:
407:
382:), also called
34:
17:
12:
11:
5:
3080:
3078:
3070:
3069:
3064:
3059:
3054:
3049:
3044:
3034:
3033:
3029:
3028:
3005:
3004:
3002:
3001:
2994:
2988:
2983:
2976:
2969:
2965:
2962:
2961:
2958:
2957:
2955:
2954:
2948:
2946:
2944:Antivitamin B6
2937:
2933:
2932:
2929:
2928:
2926:
2925:
2916:
2915:
2910:
2905:
2900:
2895:
2890:
2885:
2880:
2870:
2865:
2860:
2852:
2847:
2842:
2837:
2832:
2827:
2822:
2813:
2811:
2800:
2799:
2797:
2796:
2787:
2786:
2781:
2773:
2768:
2759:
2757:
2743:
2737:
2736:
2733:
2732:
2730:
2729:
2724:
2719:
2717:Nipecotic acid
2714:
2709:
2707:N-Butyric acid
2704:
2699:
2694:
2689:
2684:
2682:Bafilomycin A1
2679:
2670:
2668:
2657:
2656:
2654:
2653:
2648:
2643:
2638:
2633:
2628:
2623:
2618:
2616:Nipecotic acid
2613:
2608:
2603:
2598:
2593:
2588:
2583:
2578:
2573:
2568:
2563:
2554:
2552:
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2532:
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2511:
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2351:
2345:
2343:
2339:
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2336:
2335:
2330:
2325:
2320:
2314:
2312:
2311:Classification
2308:
2307:
2305:
2304:
2299:
2294:
2289:
2283:
2281:
2277:
2276:
2274:
2273:
2268:
2263:
2258:
2253:
2248:
2243:
2238:
2232:
2230:
2226:
2225:
2220:
2218:
2217:
2210:
2203:
2195:
2186:
2185:
2183:
2182:
2176:
2174:
2167:
2166:
2164:
2163:
2157:
2155:
2148:
2147:
2145:
2144:
2143:
2142:
2132:
2127:
2122:
2117:
2112:
2107:
2102:
2101:
2100:
2095:
2084:
2082:
2072:
2071:
2057:
2055:
2054:
2047:
2040:
2032:
2023:
2022:
2019:
2018:
2016:
2015:
2004:Cholinesterase
2000:
1998:
1990:
1989:
1987:
1986:
1980:
1978:
1967:
1957:
1956:
1954:
1953:
1934:
1932:
1922:
1921:
1918:
1917:
1915:
1914:
1909:
1904:
1895:
1889:
1887:
1873:
1872:
1869:
1868:
1866:
1865:
1859:
1857:
1849:
1848:
1846:
1845:
1839:
1837:
1826:
1816:
1815:
1812:
1811:
1809:
1808:
1807:
1806:
1801:
1791:
1785:
1783:
1775:
1774:
1772:
1771:
1766:
1761:
1752:
1746:
1744:
1733:
1719:
1718:
1715:
1714:
1712:
1711:
1706:
1700:
1698:
1690:
1689:
1687:
1686:
1680:
1678:
1667:
1654:
1648:
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1638:
1636:
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1628:
1621:
1613:
1607:
1606:
1593:
1581:
1580:External links
1578:
1576:
1575:
1547:(4): 217–227.
1529:
1500:
1471:
1435:
1433:
1430:
1427:
1426:
1399:(8): 1075–81.
1383:
1331:
1292:
1263:(6): 1115–32.
1240:
1201:
1177:
1142:
1123:(10): 1510–9.
1104:
1052:
1017:
974:
928:
921:
892:
868:
832:
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806:
804:
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758:Main article:
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678:
627:
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623:
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612:
569:
566:
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444:2-oxoglutarate
430:Thus, the two
428:
427:
415:
363:
362:
359:
358:
353:
349:
348:
343:
339:
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3:
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2999:
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2963:
2953:
2950:
2949:
2947:
2945:
2941:
2938:
2934:
2924:
2923:3-Methyl-GABA
2921:
2918:
2917:
2914:
2911:
2909:
2906:
2904:
2903:Valproic acid
2901:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2878:
2874:
2871:
2869:
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2828:
2826:
2823:
2821:
2818:
2815:
2814:
2812:
2807:
2801:
2795:
2794:3-Methyl-GABA
2792:
2789:
2788:
2785:
2784:Semicarbazide
2782:
2780:
2779:-Allylglycine
2774:
2772:
2769:
2767:
2764:
2761:
2760:
2758:
2753:
2747:
2744:
2742:
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2658:
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2649:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2606:Ibotenic acid
2604:
2602:
2599:
2597:
2594:
2592:
2589:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2569:
2567:
2564:
2562:
2559:
2556:
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2553:
2548:
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2500:
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2357:
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2347:
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2329:
2328:Enzyme family
2326:
2324:
2321:
2319:
2316:
2315:
2313:
2309:
2303:
2300:
2298:
2295:
2293:
2292:Cooperativity
2290:
2288:
2285:
2284:
2282:
2278:
2272:
2269:
2267:
2264:
2262:
2259:
2257:
2254:
2252:
2251:Oxyanion hole
2249:
2247:
2244:
2242:
2239:
2237:
2234:
2233:
2231:
2227:
2223:
2216:
2211:
2209:
2204:
2202:
2197:
2196:
2193:
2181:
2178:
2177:
2175:
2172:
2168:
2162:
2159:
2158:
2156:
2153:
2149:
2141:
2138:
2137:
2136:
2133:
2131:
2128:
2126:
2123:
2121:
2118:
2116:
2113:
2111:
2108:
2106:
2103:
2099:
2096:
2094:
2091:
2090:
2089:
2086:
2085:
2083:
2081:
2080:Transaminases
2077:
2073:
2068:
2064:
2060:
2053:
2048:
2046:
2041:
2039:
2034:
2033:
2030:
2013:
2009:
2005:
2002:
2001:
1999:
1996:
1991:
1985:
1982:
1981:
1979:
1976:
1971:
1968:
1966:
1965:Acetylcholine
1962:
1958:
1951:
1947:
1943:
1939:
1936:
1935:
1933:
1931:
1927:
1923:
1913:
1910:
1908:
1905:
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1896:
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1478:(in German).
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1398:
1394:
1387:
1384:
1379:
1375:
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1367:
1362:
1357:
1354:(1): 363–73.
1353:
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1323:
1319:
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1158:(2): 145–54.
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1032:
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1005:
1001:
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990:(7): 279–89.
989:
985:
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975:
969:
964:
960:
956:
952:
948:
944:
937:
935:
933:
929:
924:
922:0-89603-079-2
918:
914:
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906:
899:
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872:
869:
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850:
846:
839:
837:
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822:
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802:
798:
795:
793:
792:Valproic acid
790:
788:
785:
782:
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772:
769:
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764:
763:
761:
753:
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695:
691:
687:
679:
677:
673:
671:
666:
664:
660:
656:
651:
649:
645:
644:mitochondrion
641:
637:
636:succinic acid
633:
625:
621:
617:
613:
611:
607:
603:
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595:
594:
593:
591:
587:
583:
579:
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563:
559:
555:
551:
547:
543:
539:
531:
529:
527:
523:
519:
515:
511:
506:
504:
500:
496:
492:
488:
484:
480:
476:
472:
468:
467:transaminases
464:
459:
457:
453:
449:
445:
441:
437:
433:
405:
404:
403:
401:
397:
393:
389:
385:
381:
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374:
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357:
354:
350:
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344:
340:
335:
331:
328:
327:
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309:
306:
303:
301:
297:
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279:
277:
273:
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267:
265:
261:
258:
255:
253:
249:
245:
241:
236:
231:
220:
217:
215:
211:
208:
205:
203:
199:
196:
193:
191:
187:
182:
178:
175:
171:
168:
166:
165:Gene Ontology
162:
159:
156:
153:
150:
147:
143:
140:
137:
135:
131:
128:
125:
123:
119:
116:
113:
111:
107:
104:
103:NiceZyme view
101:
99:
95:
92:
89:
87:
83:
80:
77:
75:
71:
66:
63:
60:
58:
54:
51:
48:
46:
42:
37:
30:
25:
20:
2996:
2985:
2978:
2971:
2919:
2888:Valnoctamide
2858:-Cycloserine
2816:
2790:
2762:
2673:
2557:
2465:Translocases
2462:
2449:
2436:
2423:
2410:
2400:Transferases
2397:
2384:
2241:Binding site
1994:
1974:
1862:
1853:
1833:
1779:
1740:
1694:
1674:
1642:involved in
1601:
1544:
1540:
1508:
1505:Biochemistry
1504:
1479:
1475:
1451:(4): 932–6.
1448:
1444:
1396:
1392:
1386:
1351:
1347:
1309:
1306:Biochemistry
1305:
1295:
1260:
1256:
1218:
1214:
1204:
1193:. Retrieved
1190:www.omim.org
1189:
1180:
1155:
1151:
1145:
1120:
1116:
1072:
1068:
1030:
1026:
1020:
987:
983:
977:
950:
946:
904:
884:. Retrieved
880:
871:
855:: S1267–75.
852:
848:
824:. Retrieved
820:
811:
741:
738:Active sites
731:
709:
683:
674:
667:
652:
629:
571:
550:transaminase
535:
507:
474:
463:transferases
460:
429:
387:
383:
372:
366:
324:
91:BRENDA entry
2952:Ginkgotoxin
2920:Activators:
2817:Inhibitors:
2791:Activators:
2763:Inhibitors:
2722:Valinomycin
2674:Inhibitors:
2621:NNC 05-2090
2558:Inhibitors:
2536:Transporter
2236:Active site
2063:nitrogenous
2059:Transferase
1995:catabolism:
1854:catabolism:
1780:catabolism:
1731:epinephrine
1695:catabolism:
1221:(1): 14–9.
1033:(1): 14–9.
750:co-enzyme.
744:active site
562:α-keto acid
554:nitrogenous
542:transferase
524:(including
510:prokaryotes
456:L-glutamate
346:Swiss-model
238:Identifiers
79:IntEnz view
39:Identifiers
3036:Categories
2913:Vigabatrin
2908:Valpromide
2877:lemon balm
2863:Phenelzine
2845:Gabaculine
2727:Vigabatrin
2692:Evans blue
2636:SKF-89976A
2596:Gabaculine
2571:Arecaidine
2528:modulators
2521:metabolism
2439:Isomerases
2413:Hydrolases
2280:Regulation
1975:anabolism:
1877:tryptophan
1834:anabolism:
1741:anabolism:
1675:anabolism:
1195:2020-10-18
1075:(1): 1–5.
968:1807/79639
886:2020-09-24
826:2020-09-29
803:References
797:Vigabatrin
776:Phenelzine
771:Gabaculine
754:Inhibitors
686:structures
616:glyoxylate
586:glyoxylate
558:amino acid
536:GABA-T is
479:metabolism
446:. The two
432:substrates
369:enzymology
342:Structures
337:Search for
311:Other data
148:structures
115:KEGG entry
62:9037-67-6
2850:Isoniazid
2712:Nigericin
2677:β-Alanine
2651:Tiagabine
2641:SNAP-5114
2566:β-Alanine
2525:transport
2318:EC number
1898:Aromatic
1885:melatonin
1881:serotonin
1820:glutamate
1755:Aromatic
1665:histamine
1661:histidine
1652:monoamine
1482:: 25–33.
600:(GABA) +
414:⇌
396:catalyzes
293:NM_020686
252:NCBI gene
68:Databases
3047:EC 2.6.1
2968:See also
2631:Riluzole
2611:Muscimol
2601:Guvacine
2342:Kinetics
2266:Cofactor
2229:Activity
2065:groups (
1926:arginine
1727:dopamine
1723:tyrosine
1571:25485164
1496:13863304
1467:13654294
1421:23127112
1413:19165747
1378:42918710
1370:14534310
1326:15323550
1287:45755014
1279:26305050
1235:18155636
1137:16540097
1099:12223787
1047:18155636
1004:23740823
632:oxidized
602:pyruvate
582:pyruvate
499:cofactor
448:products
390:, is an
380:2.6.1.19
356:InterPro
219:proteins
207:articles
195:articles
152:RCSB PDB
50:2.6.1.19
3026:Biology
2702:Glycine
2591:EF-1502
2452:Ligases
2222:Enzymes
2173:: Other
1961:choline
1640:Enzymes
1562:4256671
1525:4719123
1172:7628073
1012:1303165
732:E. coli
620:glycine
610:alanine
522:animals
352:Domains
322:Chr. 16
300:UniProt
174:QuickGO
139:profile
122:MetaCyc
57:CAS no.
3012:Portal
2805:GABA-T
2741:Enzyme
2626:NO-711
2576:CI-966
2426:Lyases
2171:2.6.99
1592:(MeSH)
1569:
1559:
1523:
1494:
1465:
1419:
1411:
1376:
1368:
1324:
1285:
1277:
1233:
1170:
1135:
1097:
1090:158453
1087:
1045:
1010:
1002:
947:Botany
919:
670:plants
578:ketone
560:and a
526:humans
520:, and
514:plants
493:, and
442:) and
392:enzyme
305:P80404
288:RefSeq
281:137150
243:Symbol
202:PubMed
184:Search
170:AmiGO
158:PDBsum
98:ExPASy
86:BRENDA
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45:EC no.
2936:Other
2662:VIAAT
2378:Types
2152:2.6.3
2076:2.6.1
1537:(PDF)
1417:S2CID
1374:S2CID
1283:S2CID
1008:S2CID
984:Yeast
783:(PEH)
574:amine
518:fungi
394:that
326:p13.2
317:Locus
134:PRIAM
3062:GABA
2987:GABA
2835:AOAA
2825:DABA
2771:AAOA
2697:GABA
2646:TACA
2581:DABA
2523:and
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2470:list
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2457:list
2450:EC6
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2431:list
2424:EC4
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2392:list
2385:EC1
2140:AGXT
2098:GOT2
2093:GOT1
2069:2.6)
1950:NOS3
1946:NOS2
1942:NOS1
1824:GABA
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1492:PMID
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1409:PMID
1366:PMID
1322:PMID
1275:PMID
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1168:PMID
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1000:PMID
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398:the
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264:HGNC
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1549:doi
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1453:doi
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1356:doi
1352:279
1314:doi
1265:doi
1223:doi
1160:doi
1125:doi
1085:PMC
1077:doi
1073:115
1035:doi
992:doi
963:hdl
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909:doi
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638:by
634:to
386:or
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