902:, anxiety, depression, and confusion, peripheral neuropathy, tingling, and tremor, tinnitus, atrial fibrillation, low blood pressure, blocked veins, paleness, chills, fistulas forming in the trachea and esophagus, blood clots in the lungs, and bleeding in the respiratory tract, GI perforation, bleeding in the stomach and intestines, pancreatitis, hemorrhoids, anal fissure, anal inflammation, gallstones, hard skin growths, acne, blisters, abnormal hair growth, loss of skin color and skin flaking, chest pain, blood or protein in urine, wounds that don't heal well, and facial swelling.
620:
597:
29:
6456:
1861:
1675:
1639:
889:
levels; distorted sense of taste, headache, and dizziness; high blood pressure; distorted sense of hearing, earaches and sore throat; diarrhea, nausea, constipation, vomiting, stomach pain and upset stomach, and inflammation of the mouth and lips and a burning sensation in the mouth; skin sloughing
998:
In
December 2017, the FDA granted approval to cabozantinib (Cabometyx, Exelixis, Inc.) for the treatment of people with advanced renal cell carcinoma (RCC). The approval was based on data from CABOSUN (NCT01835158), a randomized, open-label phase II multicenter study in 157 participants with
846:
Cabozantinib has not been tested in pregnant women; it causes harm to fetuses in rodents. Pregnant women should not take this drug, and women should not become pregnant while taking it. It is not known if cabozantinib is excreted in breast milk.
2062:
for "A Study of
Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy" at
897:
Common adverse effects (between 1% and 10% of people) include abscesses (inside the body, on the skin, and in teeth skin), pneumonia, inflamed hair follicles, fungal infections, low thyroid levels, dehydration, loss of
1006:. The approval was based on CELESTIAL (NCT01908426), a randomized (2:1), double-blind, placebo-controlled, multicenter trial in participants with hepatocellular carcinoma who had previously received sorafenib and had
818:. The capsule form was approved in the European Union for the same purpose in 2014. In April 2016, the FDA granted approval for marketing the tablet formulation (Cabometyx) as a second line treatment for
2091:
206:
3522:
1620:
1878:
734:
InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
867:(tunnels between the GI tract and the skin). The black box also warns against the risk of uncontrolled bleeding. The tablet formulation (Cabometyx) warns of these effects as well.
161:
977:
with the FDA in 2012, and in
November 2012, cabozantinib in its capsule formulation was granted marketing approval by the FDA under the name Cometriq for treating people with
692:
2084:
5437:
822:
and the same was approved in the
European Union in September of that year. The brands Cometriq and Cabometyx have different formulations and are not interchangeable.
3515:
1797:
6397:
59:
1255:
879:
706:
6053:
5201:
2077:
1002:
In
January 2019, the FDA approved cabozantinib (Cabometyx, Exelixis, Inc.) for people with hepatocellular carcinoma who have been previously treated with
890:
off the palms and soles, hair color changes and hair loss, rash, dry skin, and red skin; joint pain and muscle spasms; fatigue and weakness; weight loss,
4818:
3508:
1656:
4876:
1506:
915:
5738:
5428:
885:
Very common adverse effects (greater than 10% of people) include decreased appetite; low calcium, potassium, phosphate, and magnesium levels; high
5033:
3083:
2726:
4018:
3701:
2038:
for "Cabozantinib-s-malate or
Sunitinib Malate in Treating Patients With Previously Untreated Locally Advanced or Metastatic Kidney Cancer" at
6416:
6366:
6337:
6284:
4771:
4638:
6095:
6091:
6087:
6083:
3636:
3620:
2219:
2050:
for "Study of
Cabozantinib (XL184) vs Placebo in Subjects With Hepatocellular Carcinoma Who Have Received Prior Sorafenib (CELESTIAL)" at
6501:
4364:
4283:
4150:
4067:
875:
1227:
6079:
3197:
6486:
5768:
4887:
4447:
4058:
1824:
922:
of cabozantinib and potentially increase its adverse effects; drugs that activate them may cause cabozantinib to be less effective.
726:
1879:"Search of: cabozantinib | Recruiting, Active, not recruiting, Enrolling by invitation Studies - List Results - ClinicalTrials.gov"
1149:
3716:
3660:
3651:
2617:
2143:
1409:
1372:
6290:
331:
191:
91:
1694:"Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth"
6377:
6353:
5493:
5049:
4912:
1771:
1741:
6476:
6343:
1075:
6446:
2005:
6387:
4783:
4665:
4655:
2963:
1846:
1801:
1775:
1747:
1660:
1624:
1593:
1564:
1560:
1535:
1510:
967:
943:
860:
811:
792:
464:
110:
5733:
2120:
1035:
870:
The labels also warn of the risk of clots forming and causing heart attacks or strokes, high blood pressure including
576:
5758:
3144:
6372:
4198:
3269:
3118:
2867:
2369:
951:
800:
5753:
6280:
2594:
2460:
2173:
1589:
1531:
1479:
1445:
780:
4464:
4380:
4299:
4166:
4083:
2604:
2130:
1842:
1103:
1079:
1023:
978:
931:
831:
815:
773:
765:
3898:
6064:
3811:
3686:
2100:
2017:
991:
In April 2016, the FDA granted approval for marketing the tablet formulation as a second line treatment for
147:
5743:
1514:
615:
6506:
6481:
6348:
5964:
5868:
5728:
5488:
4907:
3893:
3531:
2972:
2455:
2184:
1071:
891:
761:
565:
557:
270:
6491:
6422:
4619:
4263:
3903:
3542:
2530:
2470:
2440:
2343:
2179:
2069:
1059:
6362:
5748:
4680:
4629:
2385:
2280:
2117:
1099:
1087:
1019:
974:
919:
835:
769:
297:
5498:
3573:
592:
6496:
5503:
4917:
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3806:
3238:
2505:
2495:
2315:
1955:
Choueiri TK, Escudier B, Powles T, Mainwaring PN, Rini BI, Donskov F, et al. (November 2015).
871:
355:
154:
4539:
6121:
6034:
5979:
5933:
5878:
5613:
5553:
5181:
4554:
4484:
4043:
3641:
3583:
3534:
2893:
2525:
2510:
2430:
2064:
2051:
2039:
1723:
1095:
947:
796:
121:
6116:
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5679:
5568:
5368:
5328:
5076:
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4857:
4798:
4760:
4705:
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4690:
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4529:
4504:
4499:
4489:
4375:
4294:
4233:
4161:
4140:
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4078:
3731:
6216:
6074:
6009:
5989:
5908:
5888:
5603:
5583:
5563:
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4534:
4258:
3791:
3588:
6039:
6029:
5984:
5938:
5928:
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5674:
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5518:
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4970:
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4569:
2570:
1986:
1933:
1902:
Fisher MJ, Shih CS, Rhodes SD, Armstrong AE, Wolters PL, Dombi E, et al. (January 2021).
1715:
1693:
1474:
1201:
1047:
1031:
856:
537:
529:
453:
445:
243:
230:
218:
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5628:
5573:
5543:
5023:
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4965:
4947:
4710:
4549:
4494:
1440:
372:
69:
6226:
5358:
2410:
2252:
2247:
1976:
1968:
1923:
1915:
1904:"Cabozantinib for neurofibromatosis type 1-related plexiform neurofibromas: a phase 2 trial"
1705:
632:
364:
262:
4750:
481:
473:
6460:
5838:
1039:
1027:
280:
619:
596:
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6275:
5969:
5818:
5813:
4927:
4922:
3568:
3558:
3553:
3347:
3245:
3193:
2791:
2104:
1981:
1956:
1928:
1903:
1256:"Drug and medical device highlights 2018: Helping you maintain and improve your health"
1051:
1043:
777:
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6106:
6019:
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5918:
5853:
5763:
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5593:
5523:
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5457:
4942:
4650:
4333:
4238:
4130:
3404:
3294:
3256:
3233:
3165:
3160:
3150:
2926:
2922:
2910:
2717:
2500:
2465:
2285:
2265:
2025:
1865:
1679:
1643:
1260:
1232:
1091:
992:
819:
608:
397:
83:
3500:
1727:
1123:
981:. The capsule form was approved in the European Union for the same purpose in 2014.
6432:
6402:
6141:
6024:
5923:
5778:
5598:
5533:
5448:
4952:
4755:
4594:
4589:
4459:
4273:
4027:
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3261:
3209:
3170:
3058:
3037:
2906:
2807:
2782:
2778:
2662:
2627:
2580:
2565:
2520:
2395:
2365:
2290:
2108:
1338:"Cometriq 20 & 80 mg hard capsules - Summary of Product Characteristics (SmPC)"
1067:
174:
169:
2058:
2046:
2034:
1710:
1337:
1302:
1176:"Cabometyx cabozantinib (as (S)-malate) 20 mg film-coated tablet bottle (283800)"
810:
In
November 2012, cabozantinib in its capsule formulation was approved by the US
6392:
6358:
6256:
6246:
6241:
6231:
6181:
6004:
5903:
5664:
5578:
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2415:
2405:
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2305:
2261:
2224:
2212:
2207:
2169:
2153:
1692:
Yakes FM, Chen J, Tan J, Yamaguchi K, Shi Y, Yu P, et al. (December 2011).
1063:
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77:
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2632:
2555:
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2450:
2445:
2425:
2420:
2400:
2390:
2380:
2295:
2275:
2257:
2165:
830:
Cabozantinib is used in two forms. A capsule form (Cometriq) is used to treat
668:
436:
988:
worldwide rights (outside the US, Canada, and Japan) to market cabozantinib.
425:
20:
6236:
6206:
6201:
6196:
6191:
6186:
6166:
6156:
6146:
6136:
5828:
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5393:
5388:
5378:
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5106:
5000:
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3155:
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2978:
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2837:
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2822:
2802:
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2761:
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2746:
2741:
2708:
2703:
2698:
2667:
2647:
2642:
2485:
2475:
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2148:
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886:
310:
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1990:
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1719:
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and the same was approved in the
European Union in September of that year.
1972:
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6126:
5783:
5383:
5373:
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5288:
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2652:
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2160:
1055:
864:
804:
408:
105:
1621:"FDA grants regular approval to Cabometyx for first-line treatment of a"
1303:"Cabometyx 20mg, 40mg, 60mg - Summary of Product Characteristics (SmPC)"
417:
6382:
5803:
5268:
4670:
3631:
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1083:
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383:
6295:
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4892:
4846:
4842:
4838:
4834:
4830:
4826:
4822:
4474:
4013:
3691:
1532:"Drug Approval Package: Cometriq (cabozantinib) Capsules NDA #203756"
939:
911:
788:
548:
289:
894:, higher cholesterol levels, and loss of red and white blood cells.
509:
501:
6327:
6323:
6319:
6315:
6311:
6307:
6303:
6299:
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5913:
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5528:
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5065:
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5057:
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4544:
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4218:
4214:
4210:
4119:
4115:
3966:
3213:
2939:
2773:
2722:
2202:
985:
935:
880:
a syndrome with headaches, confusion, loss of vision, and seizures
838:, hepatocellular carcinoma, and differentiated thyroid carcinoma.
784:
691:
682:
520:
315:
285:
1957:"Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma"
1864:
This article incorporates text from this source, which is in the
1678:
This article incorporates text from this source, which is in the
1642:
This article incorporates text from this source, which is in the
1018:
Cabozantinib is being researched for efficacy as a treatment for
5798:
4404:
4400:
4396:
4392:
4388:
4384:
4319:
4315:
4311:
4307:
4303:
4206:
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4194:
4190:
4186:
4182:
4178:
4174:
4170:
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4095:
4091:
4087:
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4035:
4031:
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3962:
3943:
3328:
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2612:
2338:
2320:
2310:
2270:
2138:
492:
249:
224:
3504:
2073:
237:
100:
1825:"Ipsen bets up to $ 855M on Exelixis' once-failed cancer drug"
1657:"FDA approves cabozantinib for differentiated thyroid cancer"
1404:
1402:
1400:
1398:
1396:
1394:
714:
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC
1507:"FDA approves Cometriq to treat rare type of thyroid cancer"
1367:
1365:
1363:
1361:
1359:
581:
1410:"Cometriq- cabozantinib kit Cometriq- cabozantinib capsule"
200:
132:
1615:
1613:
1611:
1584:
1582:
1843:"FDA approves cabozantinib for hepatocellular carcinoma"
1526:
1524:
855:
In the US, the capsule formulation (Cometriq) carries a
213:
814:(FDA) under the name Cometriq for treating people with
6398:
Pituitary adenylate cyclase-activating peptide (PACAP)
6444:
1742:"Cabozantinib Orphan Drug Designations and Approvals"
999:
intermediate and poor-risk previously untreated RCC.
918:; drugs that inhibit these enzymes will increase the
6265:
6052:
5947:
5716:
5456:
5447:
5427:
5341:
5318:
5287:
5256:
5225:
5189:
5180:
5032:
4875:
4808:
4770:
4637:
4628:
4446:
4423:
4363:
4282:
4149:
4066:
4057:
3996:
3942:
3855:
3659:
3650:
3619:
3541:
3185:
2962:
2603:
2593:
2353:
2234:
2194:
2129:
2116:
680:
667:
631:
626:
607:
575:
547:
519:
491:
463:
435:
407:
382:
354:
322:
309:
296:
279:
269:
261:
190:
185:
160:
146:
120:
90:
76:
58:
50:
40:
35:
6344:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
5202:Glial cell line-derived neurotrophic factor (GDNF)
4855:Cleavage products/derivatives with unknown target:
1469:
1467:
1465:
6378:Macrophage-stimulating protein (MSP; HLP, HGFLP)
1435:
1433:
1431:
1332:
1330:
1328:
1326:
1324:
396:
4019:Heparin-binding EGF-like growth factor (HB-EGF)
3702:Heparin-binding EGF-like growth factor (HB-EGF)
1798:"Thyroid cancer drug cabozantinib prolongs PFS"
1772:"Search Orphan Drug Designations and Approvals"
1297:
1295:
1293:
1291:
1289:
1287:
1285:
1283:
1281:
1279:
1228:"Summary Basis of Decision (SBD) for Cabometyx"
834:and a tablet form (Cabometyx) is used to treat
371:
363:
346:-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
2020:. National Cancer Institute. 19 December 2012.
970:(FDA) in November 2010, and in February 2017.
6430:Additional growth factor receptor modulators:
3516:
2085:
1555:
1553:
874:, osteonecrosis of the jaw, severe diarrhea,
342:-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-
8:
4784:Insulin-like growth factor-2 (somatomedin A)
4666:Insulin-like growth factor-2 (somatomedin A)
4656:Insulin-like growth factor-1 (somatomedin C)
109:
19:
5453:
5186:
4634:
4063:
3656:
3523:
3509:
3501:
2600:
2126:
2092:
2078:
2070:
1501:
1499:
861:holes forming in the stomach or intestines
618:
595:
452:
444:
27:
1980:
1927:
1709:
916:multidrug resistance-associated protein 2
480:
472:
6388:Migration-stimulating factor (MSF; PRG4)
2026:"Cabozantinib (liver and kidney cancer)"
6451:
3717:Transforming growth factor alpha (TGFα)
1513:(FDA). 29 November 2012. Archived from
1115:
731:
711:
591:
424:
416:
336:
82:
54:XL184, BMS907351, cabozantinib s-malate
6291:Connective tissue growth factor (CTGF)
1206:Therapeutic Goods Administration (TGA)
1180:Therapeutic Goods Administration (TGA)
1154:Therapeutic Goods Administration (TGA)
1088:head and neck squamous cell carcinomas
876:skin sloughing off the palms and soles
609:
18:
6354:Hepatoma-derived growth factor (HDGF)
803:. It was discovered and developed by
564:
556:
536:
528:
68:
7:
984:In March 2016, Exelixis licensed to
930:Cabozantinib inhibits the following
173:
1961:The New England Journal of Medicine
1124:"Cabozantinib Use During Pregnancy"
1008:Child Pugh Class A liver impairment
508:
500:
387:
1590:"Cabometyx (cabozantinib) Tablets"
882:, and protein appearing in urine.
14:
6454:
6373:Leukemia inhibitory factor (LIF)
1859:
1673:
1637:
1373:"Cabometyx- cabozantinib tablet"
652:
649:
643:
5541:Negative allosteric modulators:
910:Cabozantinib is a substrate of
739:Key:ONIQOQHATWINJY-UHFFFAOYSA-N
5859:Gossypetin (3,5,7,8,3',4'-HHF)
5050:Platelet-derived growth factor
658:
637:
1:
6065:Placental growth factor (PGF)
1711:10.1158/1535-7163.MCT-11-0264
1698:Molecular Cancer Therapeutics
752:, sold under the brand names
6349:Glia maturation factor (GMF)
4858:Glypromate (GPE, (1-3)IGF-1)
2012:. National Cancer Institute.
1847:Food and Drug Administration
1776:Food and Drug Administration
1748:Food and Drug Administration
1661:Food and Drug Administration
1625:Food and Drug Administration
1594:Food and Drug Administration
1565:Food and Drug Administration
1536:Food and Drug Administration
1511:Food and Drug Administration
968:Food and Drug Administration
812:Food and Drug Administration
1150:"Cabometyx (Ipsen Pty Ltd)"
46:Cometriq, Cabometyx, others
6523:
6502:Tyrosine kinase inhibitors
6281:Colony-stimulating factors
6273:Additional growth factors:
2595:Tyrosine kinase inhibitors
1920:10.1038/s41591-020-01193-6
1561:"Cabozantinib (Cabometyx)"
1076:non-small cell lung cancer
627:Chemical and physical data
5629:SNA-120 (pegylated K252a)
4801:(against IGF-1 and IGF-2)
4763:(against IGF-1 and IGF-2)
2461:Mirvetuximab soravtansine
1823:Garde D (March 1, 2016).
1480:European Medicines Agency
1446:European Medicines Agency
962:Cabozantinib was granted
932:receptor tyrosine kinases
781:tyrosine-kinase inhibitor
722:
702:
327:
26:
6487:4-Fluorophenyl compounds
4465:Hepatocyte growth factor
4024:Neuregulins (heregulins)
3955:Neuregulins (heregulins)
3899:Trastuzumab duocarmazine
3612:(against angiopoietin 2)
3606:(against angiopoietin 3)
2605:Receptor tyrosine kinase
2131:Receptor tyrosine kinase
1663:(FDA). 22 September 2021
1104:neurofibromatosis type 1
1080:adrenocortical carcinoma
1024:hepatocellular carcinoma
979:medullary thyroid cancer
863:as well as formation of
832:medullary thyroid cancer
816:medullary thyroid cancer
774:hepatocellular carcinoma
766:medullary thyroid cancer
3812:Depatuxizumab mafodotin
2195:Others for solid tumors
2101:Targeted cancer therapy
2018:"Cabozantinib-S-Malate"
2006:"Cabozantinib s-malate"
1627:(FDA). 19 December 2017
1068:glioblastoma multiforme
1048:gastroesophageal cancer
6435:(neurotrophin mixture)
6423:Wnt signaling proteins
6104:Allosteric modulators:
5824:Norwogonin (5,7,8-THF)
4044:5 (tomoregulin, TMEFF)
3894:Trastuzumab deruxtecan
3532:Growth factor receptor
2456:Loncastuximab tesirine
2185:Trastuzumab deruxtecan
2056:Clinical trial number
2044:Clinical trial number
2032:Clinical trial number
1849:(FDA). 14 January 2019
1596:(FDA). 12 January 2018
1509:(Press release). U.S.
1202:"AusPAR: Cabozantinib"
1100:neuroendocrine cancers
1072:anaplastic astrocytoma
892:elevated transaminases
762:anti-cancer medication
6363:T-cell growth factors
4620:Telisotuzumab vedotin
3904:Trastuzumab emtansine
2531:Sacituzumab govitecan
2471:Moxetumomab pasudotox
2441:Inotuzumab ozogamicin
2344:Gemtuzumab ozogamicin
2180:Trastuzumab emtansine
2121:monoclonal antibodies
2105:antineoplastic agents
1973:10.1056/nejmoa1510016
1060:merkel cell carcinoma
6477:Antineoplastic drugs
4948:EVT-901 (SAR-127963)
4681:Mecasermin rinfabate
2386:Belantamab mafodotin
1567:(FDA). 25 April 2016
1020:renal cell carcinoma
975:new drug application
836:renal cell carcinoma
791:, and also inhibits
770:renal cell carcinoma
760:among others, is an
3239:Denileukin diftitox
2901:(ALK, ROS1, NTRK),
2506:Polatuzumab vedotin
2496:Oportuzumab monatox
2010:NCI Drug Dictionary
1778:(FDA). 2 March 2017
1484:. 17 September 2018
1450:. 17 September 2018
872:hypertensive crisis
233:(Prescription only)
209:(Prescription only)
23:
6114:Kinase inhibitors:
5977:Kinase inhibitors:
5876:Kinase inhibitors:
5551:Kinase inhibitors:
5366:Kinase inhibitors:
5326:Kinase inhibitors:
5307:Kinase inhibitors:
5276:Kinase inhibitors:
5245:Kinase inhibitors:
5214:Kinase inhibitors:
5074:Kinase inhibitors:
4688:Kinase inhibitors:
4482:Kinase inhibitors:
4271:Kinase inhibitors:
4264:Aprutumab ixadotin
3911:Kinase inhibitors:
3724:Kinase inhibitors:
3581:Kinase inhibitors:
2925:(ROS1, TRK, ALK),
2431:Enfortumab vedotin
2065:ClinicalTrials.gov
2052:ClinicalTrials.gov
2040:ClinicalTrials.gov
1883:clinicaltrials.gov
1752:. 29 November 2010
1416:. 11 February 2020
1096:endometrial cancer
318:(54%), urine (27%)
6442:
6441:
6048:
6047:
5809:N-Acetylserotonin
5708:ReN-1820 (TrkAd5)
5337:
5336:
4871:
4870:
4816:Binding proteins:
4475:Dihexa (PNB-0408)
4442:
4441:
4053:
4052:
3967:6 (neuroglycan C)
3687:EGF (urogastrone)
3665:
3498:
3497:
3181:
3180:
2589:
2588:
2571:Tisotumab vedotin
1967:(19): 1814–1823.
1704:(12): 2298–2308.
1264:. 14 October 2020
1236:. 23 October 2014
1156:. 13 January 2023
1036:urothelial cancer
1032:colorectal cancer
973:Exelixis filed a
966:status by the US
857:black box warning
842:Contraindications
747:
746:
693:Interactive image
577:CompTox Dashboard
253:
241:
228:
216:
204:
136:
103:
16:Chemical compound
6514:
6459:
6458:
6457:
6450:
6254:Decoy receptors:
6227:Alacizumab pegol
5705:Decoy receptors:
5454:
5359:Stem cell factor
5300:Persephin (PSPN)
5238:Neurturin (NRTN)
5187:
5024:LEVI-04 (p75-Fc)
5021:Decoy receptors:
4635:
4064:
3663:
3657:
3525:
3518:
3511:
3502:
3212:peptide against
2785:(AXL, ALK, LTK))
2601:
2411:Dinutuximab beta
2127:
2094:
2087:
2080:
2071:
2029:
2021:
2013:
1994:
1984:
1942:
1941:
1931:
1899:
1893:
1892:
1890:
1889:
1875:
1869:
1863:
1862:
1858:
1856:
1854:
1839:
1833:
1832:
1820:
1814:
1813:
1811:
1809:
1800:. Archived from
1794:
1788:
1787:
1785:
1783:
1768:
1762:
1761:
1759:
1757:
1738:
1732:
1731:
1713:
1689:
1683:
1677:
1676:
1672:
1670:
1668:
1653:
1647:
1641:
1640:
1636:
1634:
1632:
1617:
1606:
1605:
1603:
1601:
1586:
1577:
1576:
1574:
1572:
1557:
1548:
1547:
1545:
1543:
1528:
1519:
1518:
1517:on July 7, 2014.
1503:
1494:
1493:
1491:
1489:
1475:"Cabometyx EPAR"
1471:
1460:
1459:
1457:
1455:
1437:
1426:
1425:
1423:
1421:
1406:
1389:
1388:
1386:
1384:
1369:
1354:
1353:
1351:
1349:
1344:. 6 October 2022
1334:
1319:
1318:
1316:
1314:
1309:. 7 October 2022
1299:
1274:
1273:
1271:
1269:
1252:
1246:
1245:
1243:
1241:
1224:
1218:
1217:
1215:
1213:
1198:
1192:
1191:
1189:
1187:
1172:
1166:
1165:
1163:
1161:
1146:
1140:
1139:
1137:
1135:
1120:
695:
675:
660:
654:
651:
645:
639:
622:
611:
600:
599:
585:
583:
568:
560:
540:
532:
512:
504:
484:
476:
456:
448:
428:
420:
400:
390:
389:
375:
367:
301:
251:
248:
239:
236:
226:
223:
215:
212:
202:
199:
177:
134:
131:
113:
102:
99:
86:
72:
31:
24:
22:
6522:
6521:
6517:
6516:
6515:
6513:
6512:
6511:
6467:
6466:
6465:
6455:
6453:
6445:
6443:
6438:
6383:Midkine (NEGF2)
6261:
6044:
5943:
5712:
5650:ABT-110 (PG110)
5443:
5423:
5333:
5314:
5283:
5252:
5221:
5176:
5028:
4966:ABT-110 (PG110)
4867:
4804:
4766:
4624:
4438:
4419:
4359:
4356:(against FGF23)
4278:
4145:
4049:
3992:
3938:
3851:
3662:
3646:
3615:
3537:
3529:
3499:
3494:
3348:Pi3K inhibitors
3246:mTOR inhibitors
3177:
2958:
2929:(VEGFR, FGFR),
2585:
2349:
2230:
2190:
2112:
2098:
2024:
2016:
2004:
2001:
1954:
1951:
1949:Further reading
1946:
1945:
1908:Nature Medicine
1901:
1900:
1896:
1887:
1885:
1877:
1876:
1872:
1860:
1852:
1850:
1841:
1840:
1836:
1822:
1821:
1817:
1807:
1805:
1796:
1795:
1791:
1781:
1779:
1770:
1769:
1765:
1755:
1753:
1740:
1739:
1735:
1691:
1690:
1686:
1674:
1666:
1664:
1655:
1654:
1650:
1638:
1630:
1628:
1619:
1618:
1609:
1599:
1597:
1588:
1587:
1580:
1570:
1568:
1559:
1558:
1551:
1541:
1539:
1530:
1529:
1522:
1505:
1504:
1497:
1487:
1485:
1473:
1472:
1463:
1453:
1451:
1441:"Cometriq EPAR"
1439:
1438:
1429:
1419:
1417:
1408:
1407:
1392:
1382:
1380:
1371:
1370:
1357:
1347:
1345:
1336:
1335:
1322:
1312:
1310:
1301:
1300:
1277:
1267:
1265:
1254:
1253:
1249:
1239:
1237:
1226:
1225:
1221:
1211:
1209:
1200:
1199:
1195:
1185:
1183:
1174:
1173:
1169:
1159:
1157:
1148:
1147:
1143:
1133:
1131:
1130:. 30 March 2020
1122:
1121:
1117:
1112:
1040:prostate cancer
1028:cervical cancer
1016:
960:
928:
908:
859:of the risk of
853:
851:Adverse effects
844:
828:
743:
740:
735:
730:
729:
718:
715:
710:
709:
698:
673:
663:
657:
648:
642:
603:
579:
571:
543:
515:
487:
459:
431:
403:
386:
378:
350:
347:
335:
334:
299:
271:Protein binding
263:Pharmacokinetic
257:
181:
149:
142:
123:
116:
17:
12:
11:
5:
6520:
6518:
6510:
6509:
6504:
6499:
6494:
6489:
6484:
6479:
6469:
6468:
6464:
6463:
6440:
6439:
6437:
6436:
6426:
6425:
6420:
6413:Thrombopoietin
6410:
6405:
6400:
6395:
6390:
6385:
6380:
6375:
6370:
6356:
6351:
6346:
6341:
6334:Erythropoietin
6331:
6293:
6288:
6278:
6276:Adrenomedullin
6269:
6267:
6263:
6262:
6260:
6259:
6250:
6249:
6244:
6239:
6234:
6229:
6220:
6219:
6214:
6209:
6204:
6199:
6194:
6189:
6184:
6179:
6174:
6169:
6164:
6159:
6154:
6149:
6144:
6139:
6134:
6129:
6124:
6119:
6110:
6109:
6100:
6099:
6077:
6072:
6067:
6058:
6056:
6050:
6049:
6046:
6045:
6043:
6042:
6037:
6032:
6027:
6022:
6017:
6012:
6007:
6002:
5997:
5992:
5987:
5982:
5973:
5972:
5967:
5962:
5953:
5951:
5945:
5944:
5942:
5941:
5936:
5931:
5926:
5921:
5916:
5911:
5906:
5901:
5896:
5891:
5886:
5881:
5872:
5871:
5862:
5861:
5856:
5851:
5842:
5841:
5836:
5831:
5826:
5821:
5816:
5811:
5806:
5801:
5796:
5791:
5786:
5781:
5776:
5771:
5766:
5761:
5756:
5751:
5746:
5741:
5739:4'-DMA-7,8-DHF
5736:
5731:
5722:
5720:
5714:
5713:
5711:
5710:
5701:
5700:
5688:
5687:
5682:
5677:
5672:
5667:
5662:
5657:
5652:
5633:
5632:
5626:
5621:
5616:
5611:
5606:
5601:
5596:
5591:
5586:
5581:
5576:
5571:
5566:
5561:
5556:
5547:
5546:
5537:
5536:
5531:
5526:
5521:
5512:
5511:
5506:
5501:
5499:Gambogic amide
5496:
5491:
5486:
5481:
5476:
5471:
5462:
5460:
5451:
5445:
5444:
5442:
5441:
5433:
5431:
5425:
5424:
5422:
5421:
5416:
5411:
5406:
5401:
5396:
5391:
5386:
5381:
5376:
5371:
5362:
5361:
5356:
5347:
5345:
5339:
5338:
5335:
5334:
5332:
5331:
5322:
5320:
5316:
5315:
5313:
5312:
5303:
5302:
5293:
5291:
5285:
5284:
5282:
5281:
5272:
5271:
5269:Artemin (ARTN)
5262:
5260:
5254:
5253:
5251:
5250:
5241:
5240:
5231:
5229:
5223:
5222:
5220:
5219:
5210:
5209:
5204:
5195:
5193:
5184:
5178:
5177:
5175:
5174:
5169:
5164:
5155:
5154:
5149:
5144:
5139:
5134:
5129:
5124:
5119:
5114:
5109:
5104:
5099:
5094:
5089:
5084:
5079:
5070:
5069:
5047:
5038:
5036:
5030:
5029:
5027:
5026:
5017:
5016:
5004:
5003:
4998:
4993:
4988:
4983:
4978:
4973:
4968:
4956:
4955:
4950:
4945:
4940:
4931:
4930:
4925:
4920:
4915:
4910:
4905:
4900:
4895:
4890:
4881:
4879:
4873:
4872:
4869:
4868:
4866:
4865:
4860:
4851:
4850:
4812:
4810:
4806:
4805:
4803:
4802:
4796:
4787:
4786:
4776:
4774:
4768:
4767:
4765:
4764:
4758:
4753:
4748:
4743:
4738:
4733:
4728:
4723:
4714:
4713:
4708:
4703:
4698:
4693:
4684:
4683:
4678:
4673:
4668:
4663:
4658:
4653:
4643:
4641:
4632:
4626:
4625:
4623:
4622:
4617:
4612:
4607:
4602:
4597:
4592:
4583:
4582:
4577:
4572:
4567:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4478:
4477:
4468:
4467:
4462:
4452:
4450:
4444:
4443:
4440:
4439:
4437:
4436:
4427:
4425:
4421:
4420:
4418:
4417:
4412:
4378:
4369:
4367:
4361:
4360:
4358:
4357:
4347:
4346:
4341:
4336:
4331:
4297:
4288:
4286:
4280:
4279:
4277:
4276:
4267:
4266:
4261:
4252:
4251:
4246:
4241:
4236:
4231:
4226:
4164:
4155:
4153:
4147:
4146:
4144:
4143:
4138:
4133:
4128:
4123:
4081:
4072:
4070:
4061:
4055:
4054:
4051:
4050:
4048:
4047:
4021:
4016:
4011:
4002:
4000:
3994:
3993:
3991:
3990:
3985:
3980:
3971:
3970:
3948:
3946:
3940:
3939:
3937:
3936:
3931:
3926:
3921:
3916:
3907:
3906:
3901:
3896:
3891:
3886:
3881:
3872:
3871:
3861:
3859:
3853:
3852:
3850:
3849:
3844:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3804:
3795:
3794:
3789:
3784:
3779:
3774:
3769:
3764:
3759:
3754:
3749:
3744:
3739:
3734:
3729:
3720:
3719:
3714:
3709:
3704:
3699:
3694:
3689:
3684:
3679:
3669:
3667:
3654:
3648:
3647:
3645:
3644:
3639:
3634:
3625:
3623:
3617:
3616:
3614:
3613:
3607:
3597:
3596:
3591:
3586:
3577:
3576:
3574:Angiopoietin 3
3571:
3569:Angiopoietin 2
3562:
3561:
3559:Angiopoietin 4
3556:
3554:Angiopoietin 1
3547:
3545:
3539:
3538:
3530:
3528:
3527:
3520:
3513:
3505:
3496:
3495:
3493:
3492:
3487:
3482:
3477:
3472:
3467:
3462:
3457:
3452:
3447:
3442:
3437:
3432:
3427:
3422:
3417:
3412:
3407:
3402:
3397:
3392:
3387:
3382:
3377:
3376:
3375:
3370:
3365:
3360:
3355:
3345:
3344:
3343:
3338:
3325:
3324:
3323:
3318:
3313:
3308:
3303:
3295:CDK inhibitors
3291:
3290:
3289:
3284:
3279:
3266:
3265:
3264:
3259:
3254:
3242:
3226:
3206:
3194:fusion protein
3189:
3187:
3183:
3182:
3179:
3178:
3176:
3175:
3174:
3173:
3168:
3163:
3158:
3153:
3140:
3139:
3138:
3137:
3132:
3127:
3110:
3109:
3108:
3107:
3102:
3097:
3092:
3079:
3078:
3077:
3076:
3071:
3066:
3061:
3056:
3051:
3046:
3033:
3032:
3026:
3014:
3013:
3012:
3011:
3006:
3001:
2996:
2991:
2986:
2981:
2968:
2966:
2960:
2959:
2957:
2956:
2935:
2934:
2933:(VEGFR, EGFR).
2889:
2888:
2887:
2886:
2881:
2876:
2863:
2862:
2861:
2860:
2855:
2850:
2845:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2805:
2800:
2787:
2786:
2770:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2714:
2713:
2712:
2711:
2706:
2701:
2691:HER1/EGFR and
2687:
2686:
2680:
2675:
2670:
2665:
2660:
2655:
2650:
2645:
2640:
2635:
2630:
2625:
2609:
2607:
2598:
2591:
2590:
2587:
2586:
2584:
2583:
2578:
2573:
2568:
2563:
2558:
2553:
2548:
2543:
2538:
2533:
2528:
2523:
2518:
2513:
2508:
2503:
2498:
2493:
2488:
2483:
2478:
2473:
2468:
2463:
2458:
2453:
2448:
2443:
2438:
2433:
2428:
2423:
2418:
2413:
2408:
2403:
2398:
2393:
2388:
2383:
2378:
2373:
2370:+hyaluronidase
2363:
2357:
2355:
2351:
2350:
2348:
2347:
2330:
2329:
2303:
2298:
2293:
2288:
2283:
2278:
2244:
2242:
2232:
2231:
2229:
2228:
2216:
2210:
2198:
2196:
2192:
2191:
2189:
2188:
2182:
2177:
2174:+hyaluronidase
2157:
2151:
2135:
2133:
2124:
2114:
2113:
2099:
2097:
2096:
2089:
2082:
2074:
2068:
2067:
2054:
2042:
2030:
2028:. MedlinePlus.
2022:
2014:
2000:
1999:External links
1997:
1996:
1995:
1950:
1947:
1944:
1943:
1914:(1): 165–173.
1894:
1870:
1834:
1815:
1789:
1763:
1733:
1684:
1648:
1607:
1578:
1549:
1520:
1495:
1461:
1427:
1390:
1379:. 21 July 2020
1355:
1320:
1275:
1247:
1219:
1208:. 21 June 2022
1193:
1167:
1141:
1114:
1113:
1111:
1108:
1052:bladder cancer
1015:
1012:
959:
956:
927:
924:
907:
904:
852:
849:
843:
840:
827:
824:
778:small-molecule
764:used to treat
745:
744:
742:
741:
738:
736:
733:
725:
724:
723:
720:
719:
717:
716:
713:
705:
704:
703:
700:
699:
697:
696:
688:
686:
678:
677:
671:
665:
664:
661:
655:
646:
640:
635:
629:
628:
624:
623:
613:
605:
604:
602:
601:
593:DTXSID10233968
588:
586:
573:
572:
570:
569:
563:as salt:
561:
553:
551:
545:
544:
542:
541:
535:as salt:
533:
525:
523:
517:
516:
514:
513:
507:as salt:
505:
497:
495:
489:
488:
486:
485:
479:as salt:
477:
469:
467:
461:
460:
458:
457:
451:as salt:
449:
441:
439:
433:
432:
430:
429:
423:as salt:
421:
413:
411:
405:
404:
402:
401:
393:
391:
380:
379:
377:
376:
370:as salt:
368:
360:
358:
352:
351:
349:
348:
338:
330:
329:
328:
325:
324:
320:
319:
313:
307:
306:
303:
294:
293:
283:
277:
276:
273:
267:
266:
259:
258:
256:
255:
246:
234:
221:
210:
196:
194:
188:
187:
183:
182:
180:
179:
166:
164:
158:
157:
152:
150:administration
144:
143:
141:
140:
138:
128:
126:
118:
117:
115:
114:
96:
94:
88:
87:
80:
74:
73:
66:
56:
55:
52:
48:
47:
44:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
6519:
6508:
6507:Diaryl ethers
6505:
6503:
6500:
6498:
6495:
6493:
6490:
6488:
6485:
6483:
6482:Cyclopropanes
6480:
6478:
6475:
6474:
6472:
6462:
6452:
6448:
6434:
6431:
6428:
6427:
6424:
6421:
6418:
6414:
6411:
6409:
6406:
6404:
6401:
6399:
6396:
6394:
6391:
6389:
6386:
6384:
6381:
6379:
6376:
6374:
6371:
6368:
6364:
6360:
6357:
6355:
6352:
6350:
6347:
6345:
6342:
6339:
6335:
6332:
6329:
6325:
6321:
6317:
6313:
6309:
6305:
6301:
6297:
6294:
6292:
6289:
6286:
6282:
6279:
6277:
6274:
6271:
6270:
6268:
6264:
6258:
6255:
6252:
6251:
6248:
6245:
6243:
6240:
6238:
6235:
6233:
6230:
6228:
6225:
6222:
6221:
6218:
6215:
6213:
6210:
6208:
6205:
6203:
6200:
6198:
6195:
6193:
6190:
6188:
6185:
6183:
6180:
6178:
6175:
6173:
6170:
6168:
6165:
6163:
6160:
6158:
6155:
6153:
6150:
6148:
6145:
6143:
6140:
6138:
6135:
6133:
6130:
6128:
6125:
6123:
6120:
6118:
6115:
6112:
6111:
6108:
6107:Cyclotraxin B
6105:
6102:
6101:
6097:
6093:
6089:
6085:
6081:
6078:
6076:
6073:
6071:
6068:
6066:
6063:
6060:
6059:
6057:
6055:
6051:
6041:
6038:
6036:
6033:
6031:
6028:
6026:
6023:
6021:
6020:Larotrectinib
6018:
6016:
6013:
6011:
6008:
6006:
6003:
6001:
5998:
5996:
5993:
5991:
5988:
5986:
5983:
5981:
5978:
5975:
5974:
5971:
5968:
5966:
5963:
5961:
5958:
5955:
5954:
5952:
5950:
5946:
5940:
5937:
5935:
5932:
5930:
5927:
5925:
5922:
5920:
5919:Larotrectinib
5917:
5915:
5912:
5910:
5907:
5905:
5902:
5900:
5897:
5895:
5892:
5890:
5887:
5885:
5882:
5880:
5877:
5874:
5873:
5870:
5867:
5864:
5863:
5860:
5857:
5855:
5854:Cyclotraxin B
5852:
5850:
5847:
5844:
5843:
5840:
5837:
5835:
5832:
5830:
5827:
5825:
5822:
5820:
5817:
5815:
5812:
5810:
5807:
5805:
5802:
5800:
5797:
5795:
5792:
5790:
5787:
5785:
5782:
5780:
5777:
5775:
5772:
5770:
5767:
5765:
5764:Amitriptyline
5762:
5760:
5757:
5755:
5752:
5750:
5747:
5745:
5742:
5740:
5737:
5735:
5732:
5730:
5727:
5724:
5723:
5721:
5719:
5715:
5709:
5706:
5703:
5702:
5699:
5696:
5693:
5690:
5689:
5686:
5683:
5681:
5678:
5676:
5673:
5671:
5668:
5666:
5663:
5661:
5658:
5656:
5653:
5651:
5648:
5644:
5641:
5640:Against TrkA:
5638:
5635:
5634:
5630:
5627:
5625:
5622:
5620:
5617:
5615:
5612:
5610:
5607:
5605:
5602:
5600:
5597:
5595:
5594:Larotrectinib
5592:
5590:
5587:
5585:
5582:
5580:
5577:
5575:
5572:
5570:
5567:
5565:
5562:
5560:
5557:
5555:
5552:
5549:
5548:
5545:
5542:
5539:
5538:
5535:
5532:
5530:
5527:
5525:
5524:Dexamethasone
5522:
5520:
5517:
5514:
5513:
5510:
5507:
5505:
5502:
5500:
5497:
5495:
5492:
5490:
5487:
5485:
5482:
5480:
5477:
5475:
5472:
5470:
5469:Amitriptyline
5467:
5464:
5463:
5461:
5459:
5455:
5452:
5450:
5446:
5439:
5435:
5434:
5432:
5430:
5426:
5420:
5417:
5415:
5412:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5390:
5387:
5385:
5382:
5380:
5377:
5375:
5372:
5370:
5367:
5364:
5363:
5360:
5357:
5355:
5352:
5349:
5348:
5346:
5344:
5340:
5330:
5327:
5324:
5323:
5321:
5317:
5311:
5308:
5305:
5304:
5301:
5298:
5295:
5294:
5292:
5290:
5286:
5280:
5277:
5274:
5273:
5270:
5267:
5264:
5263:
5261:
5259:
5255:
5249:
5246:
5243:
5242:
5239:
5236:
5233:
5232:
5230:
5228:
5224:
5218:
5215:
5212:
5211:
5208:
5205:
5203:
5200:
5197:
5196:
5194:
5192:
5188:
5185:
5183:
5179:
5173:
5170:
5168:
5165:
5163:
5160:
5157:
5156:
5153:
5150:
5148:
5145:
5143:
5140:
5138:
5135:
5133:
5130:
5128:
5125:
5123:
5120:
5118:
5115:
5113:
5110:
5108:
5105:
5103:
5100:
5098:
5095:
5093:
5090:
5088:
5085:
5083:
5080:
5078:
5075:
5072:
5071:
5067:
5063:
5059:
5055:
5051:
5048:
5046:
5043:
5040:
5039:
5037:
5035:
5031:
5025:
5022:
5019:
5018:
5015:
5012:
5009:
5006:
5005:
5002:
4999:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4961:
4958:
4957:
4954:
4951:
4949:
4946:
4944:
4943:Dexamethasone
4941:
4939:
4936:
4933:
4932:
4929:
4926:
4924:
4921:
4919:
4916:
4914:
4911:
4909:
4906:
4904:
4901:
4899:
4896:
4894:
4891:
4889:
4886:
4883:
4882:
4880:
4878:
4874:
4864:
4861:
4859:
4856:
4853:
4852:
4848:
4844:
4840:
4836:
4832:
4828:
4824:
4820:
4817:
4814:
4813:
4811:
4807:
4800:
4797:
4795:
4792:
4789:
4788:
4785:
4781:
4778:
4777:
4775:
4773:
4769:
4762:
4759:
4757:
4754:
4752:
4749:
4747:
4744:
4742:
4739:
4737:
4734:
4732:
4729:
4727:
4724:
4722:
4719:
4716:
4715:
4712:
4709:
4707:
4704:
4702:
4699:
4697:
4694:
4692:
4689:
4686:
4685:
4682:
4679:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4657:
4654:
4652:
4651:des(1-3)IGF-1
4648:
4645:
4644:
4642:
4640:
4636:
4633:
4631:
4627:
4621:
4618:
4616:
4615:Telisotuzumab
4613:
4611:
4608:
4606:
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4585:
4584:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4480:
4479:
4476:
4473:
4472:Potentiators:
4470:
4469:
4466:
4463:
4461:
4457:
4454:
4453:
4451:
4449:
4445:
4435:
4432:
4429:
4428:
4426:
4422:
4416:
4413:
4410:
4406:
4402:
4398:
4394:
4390:
4386:
4382:
4379:
4377:
4374:
4371:
4370:
4368:
4366:
4362:
4355:
4352:
4349:
4348:
4345:
4342:
4340:
4337:
4335:
4334:Selpercatinib
4332:
4329:
4325:
4321:
4317:
4313:
4309:
4305:
4301:
4298:
4296:
4293:
4290:
4289:
4287:
4285:
4281:
4275:
4272:
4269:
4268:
4265:
4262:
4260:
4257:
4254:
4253:
4250:
4247:
4245:
4242:
4240:
4239:Selpercatinib
4237:
4235:
4232:
4230:
4227:
4224:
4220:
4216:
4212:
4208:
4204:
4200:
4196:
4192:
4188:
4184:
4180:
4176:
4172:
4168:
4165:
4163:
4160:
4157:
4156:
4154:
4152:
4148:
4142:
4139:
4137:
4134:
4132:
4131:Selpercatinib
4129:
4127:
4124:
4121:
4117:
4113:
4109:
4105:
4101:
4097:
4093:
4089:
4085:
4082:
4080:
4077:
4074:
4073:
4071:
4069:
4065:
4062:
4060:
4056:
4045:
4041:
4037:
4033:
4029:
4025:
4022:
4020:
4017:
4015:
4012:
4010:
4007:
4004:
4003:
4001:
3999:
3995:
3989:
3986:
3984:
3981:
3979:
3976:
3973:
3972:
3968:
3964:
3960:
3956:
3953:
3950:
3949:
3947:
3945:
3941:
3935:
3932:
3930:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3909:
3908:
3905:
3902:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3880:
3877:
3874:
3873:
3870:
3866:
3863:
3862:
3860:
3858:
3854:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3807:Depatuxizumab
3805:
3803:
3800:
3797:
3796:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3722:
3721:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3700:
3698:
3695:
3693:
3690:
3688:
3685:
3683:
3680:
3678:
3674:
3671:
3670:
3668:
3666:
3658:
3655:
3653:
3649:
3643:
3640:
3638:
3635:
3633:
3630:
3627:
3626:
3624:
3622:
3618:
3611:
3608:
3605:
3602:
3599:
3598:
3595:
3592:
3590:
3587:
3585:
3582:
3579:
3578:
3575:
3572:
3570:
3567:
3564:
3563:
3560:
3557:
3555:
3552:
3549:
3548:
3546:
3544:
3540:
3536:
3533:
3526:
3521:
3519:
3514:
3512:
3507:
3506:
3503:
3491:
3488:
3486:
3483:
3481:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3461:
3458:
3456:
3453:
3451:
3448:
3446:
3443:
3441:
3438:
3436:
3433:
3431:
3428:
3426:
3423:
3421:
3418:
3416:
3413:
3411:
3408:
3406:
3405:Larotrectinib
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3350:
3349:
3346:
3342:
3339:
3337:
3334:
3333:
3332:
3330:
3326:
3322:
3319:
3317:
3314:
3312:
3309:
3307:
3304:
3302:
3299:
3298:
3297:
3296:
3292:
3288:
3285:
3283:
3280:
3278:
3275:
3274:
3273:
3271:
3267:
3263:
3260:
3258:
3257:Ridaforolimus
3255:
3253:
3250:
3249:
3248:
3247:
3243:
3240:
3236:
3235:
3231:
3227:
3224:
3220:
3219:
3215:
3211:
3207:
3204:
3200:
3199:
3195:
3191:
3190:
3188:
3184:
3172:
3169:
3167:
3166:Pirtobrutinib
3164:
3162:
3161:Orelabrutinib
3159:
3157:
3154:
3152:
3151:Acalabrutinib
3149:
3148:
3147:
3146:
3142:
3141:
3136:
3133:
3131:
3128:
3126:
3123:
3122:
3121:
3120:
3116:
3112:
3111:
3106:
3103:
3101:
3098:
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3016:
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3007:
3005:
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2987:
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2965:
2961:
2954:
2950:
2946:
2943:
2941:
2937:
2936:
2932:
2928:
2927:Selpercatinib
2924:
2923:Repotrectinib
2920:
2916:
2912:
2911:Larotrectinib
2908:
2904:
2900:
2897:
2895:
2891:
2890:
2885:
2882:
2880:
2877:
2875:
2872:
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2718:RTK class III
2716:
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2697:
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2527:
2524:
2522:
2519:
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2509:
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2504:
2502:
2501:Pembrolizumab
2499:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2477:
2474:
2472:
2469:
2467:
2466:Mogamulizumab
2464:
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2459:
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2313:
2312:
2307:
2304:
2302:
2299:
2297:
2294:
2292:
2289:
2287:
2286:Mosunetuzumab
2284:
2282:
2279:
2277:
2273:
2272:
2267:
2266:Mosunetuzumab
2263:
2259:
2255:
2254:
2249:
2246:
2245:
2243:
2241:
2237:
2233:
2226:
2222:
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2023:
2019:
2015:
2011:
2007:
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2002:
1998:
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1874:
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1867:
1866:public domain
1848:
1844:
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1835:
1830:
1829:FierceBiotech
1826:
1819:
1816:
1804:on 2012-04-02
1803:
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1699:
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1688:
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1681:
1680:public domain
1662:
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1649:
1645:
1644:public domain
1626:
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1263:
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1261:Health Canada
1257:
1251:
1248:
1235:
1234:
1233:Health Canada
1229:
1223:
1220:
1207:
1203:
1197:
1194:
1182:. 27 May 2022
1181:
1177:
1171:
1168:
1155:
1151:
1145:
1142:
1129:
1125:
1119:
1116:
1109:
1107:
1105:
1101:
1097:
1093:
1092:breast cancer
1089:
1085:
1081:
1077:
1073:
1069:
1065:
1064:brain cancers
1061:
1057:
1053:
1049:
1045:
1041:
1037:
1033:
1029:
1025:
1021:
1013:
1011:
1009:
1005:
1000:
996:
994:
993:kidney cancer
989:
987:
982:
980:
976:
971:
969:
965:
957:
955:
953:
949:
945:
941:
937:
933:
925:
923:
921:
917:
913:
905:
903:
901:
895:
893:
888:
883:
881:
877:
873:
868:
866:
862:
858:
850:
848:
841:
839:
837:
833:
825:
823:
821:
820:kidney cancer
817:
813:
808:
806:
802:
798:
794:
790:
786:
782:
779:
775:
771:
767:
763:
759:
755:
751:
737:
732:
728:
721:
712:
708:
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694:
690:
689:
687:
684:
679:
672:
670:
666:
636:
634:
630:
625:
621:
617:
614:
612:
610:ECHA InfoCard
606:
598:
594:
590:
589:
587:
578:
574:
567:
566:ChEMBL2103868
562:
559:
558:ChEMBL2105717
555:
554:
552:
550:
546:
539:
534:
531:
527:
526:
524:
522:
518:
511:
506:
503:
499:
498:
496:
494:
490:
483:
478:
475:
471:
470:
468:
466:
462:
455:
450:
447:
443:
442:
440:
438:
434:
427:
422:
419:
415:
414:
412:
410:
406:
399:
395:
394:
392:
385:
381:
374:
369:
366:
362:
361:
359:
357:
353:
345:
341:
337:
333:
326:
321:
317:
314:
312:
308:
304:
302:
295:
291:
287:
284:
282:
278:
274:
272:
268:
264:
260:
254: Rx-only
247:
245:
235:
232:
222:
220:
211:
208:
198:
197:
195:
193:
189:
184:
176:
171:
168:
167:
165:
163:
159:
156:
153:
151:
145:
139:
130:
129:
127:
125:
119:
112:
107:
98:
97:
95:
93:
89:
85:
81:
79:
75:
71:
67:
65:
61:
57:
53:
49:
45:
43:
39:
36:Clinical data
34:
30:
25:
6492:Orphan drugs
6433:Cerebrolysin
6429:
6403:Pleiotrophin
6359:Interleukins
6272:
6253:
6223:
6142:Fruquintinib
6132:Cabozantinib
6131:
6113:
6103:
6061:
6025:Lestaurtinib
5976:
5956:
5924:Lestaurtinib
5875:
5865:
5846:Antagonists:
5845:
5779:Deoxygedunin
5734:3,7,8,2'-THF
5725:
5704:
5695:Against NGF:
5694:
5691:
5647:Against NGF:
5646:
5639:
5636:
5599:Lestaurtinib
5550:
5540:
5534:Testosterone
5516:Antagonists:
5515:
5465:
5365:
5350:
5325:
5306:
5296:
5275:
5265:
5244:
5234:
5213:
5198:
5158:
5073:
5041:
5020:
5011:Against NGF:
5010:
5007:
4963:Against NGF:
4962:
4959:
4953:Testosterone
4935:Antagonists:
4934:
4884:
4854:
4815:
4790:
4779:
4756:Teprotumumab
4717:
4687:
4646:
4595:Ficlatuzumab
4590:Emibetuzumab
4586:
4540:JNJ-38877605
4510:Cabozantinib
4509:
4481:
4471:
4460:Fosgonimeton
4455:
4430:
4372:
4350:
4291:
4274:Infigratinib
4270:
4255:
4158:
4075:
4009:Betacellulin
4005:
3988:Seribantumab
3974:
3951:
3910:
3875:
3869:Unknown/none
3868:
3864:
3798:
3723:
3682:Betacellulin
3677:Amphiregulin
3672:
3664:(ErbB1/HER1)
3628:
3600:
3580:
3566:Antagonists:
3565:
3550:
3543:Angiopoietin
3445:Pexidartinib
3430:Odronextamab
3400:Gilteritinib
3380:Cabozantinib
3379:
3327:
3293:
3268:
3262:Temsirolimus
3244:
3228:
3210:proapoptotic
3208:
3192:
3171:Zanubrutinib
3143:
3113:
3082:
3059:Lestaurtinib
3038:Janus kinase
3036:
3017:
2971:
2964:Non-receptor
2945:Cabozantinib
2944:
2938:
2907:Infigratinib
2892:
2866:
2808:Fruquintinib
2790:
2783:Gilteritinib
2779:Lestaurtinib
2772:
2721:
2690:
2663:Mobocertinib
2628:Aumolertinib
2616:
2581:Tremelimumab
2566:Tislelizumab
2521:Retifanlimab
2396:Blinatumomab
2366:Atezolizumab
2337:
2319:
2309:
2291:Obinutuzumab
2269:
2251:
2218:
2201:
2159:
2142:
2057:
2045:
2033:
2009:
1964:
1960:
1911:
1907:
1897:
1886:. Retrieved
1882:
1873:
1853:23 September
1851:. Retrieved
1837:
1828:
1818:
1806:. Retrieved
1802:the original
1792:
1780:. Retrieved
1766:
1754:. Retrieved
1745:
1736:
1701:
1697:
1687:
1667:22 September
1665:. Retrieved
1651:
1631:23 September
1629:. Retrieved
1600:23 September
1598:. Retrieved
1571:23 September
1569:. Retrieved
1542:23 September
1540:. Retrieved
1515:the original
1488:23 September
1486:. Retrieved
1478:
1454:23 September
1452:. Retrieved
1444:
1420:23 September
1418:. Retrieved
1413:
1383:23 September
1381:. Retrieved
1376:
1346:. Retrieved
1341:
1311:. Retrieved
1306:
1266:. Retrieved
1259:
1250:
1238:. Retrieved
1231:
1222:
1210:. Retrieved
1205:
1196:
1184:. Retrieved
1179:
1170:
1158:. Retrieved
1153:
1144:
1134:23 September
1132:. Retrieved
1127:
1118:
1017:
1001:
997:
990:
983:
972:
961:
929:
926:Pharmacology
909:
906:Interactions
896:
884:
869:
854:
845:
829:
826:Medical uses
809:
757:
753:
750:Cabozantinib
749:
748:
426:DBSALT001762
373:1140909-48-3
343:
339:
298:Elimination
192:Legal status
186:Legal status
111:Cabozantinib
92:License data
21:Cabozantinib
6393:Oncomodulin
6257:Aflibercept
6247:Ranibizumab
6242:Ramucirumab
6232:Bevacizumab
6224:Antibodies:
6182:Regorafenib
6122:Altiratinib
6035:ONO-5390556
6005:Entrectinib
5980:Altiratinib
5934:ONO-5390556
5904:Entrectinib
5879:Altiratinib
5665:Frunevetmab
5637:Antibodies:
5614:ONO-5390556
5579:Entrectinib
5554:Altiratinib
5509:Tavilermide
5404:Quizartinib
5343:SCF (c-Kit)
5167:Ramucirumab
5159:Antibodies:
5132:Quizartinib
5082:Avapritinib
5045:Becaplermin
4981:Frunevetmab
4960:Antibodies:
4863:Trofinetide
4794:Dusigitumab
4791:Antibodies:
4746:Robatumumab
4736:Figitumumab
4731:Dalotuzumab
4726:Cixutumumab
4718:Antibodies:
4610:Rilotumumab
4605:Onartuzumab
4600:Flanvotumab
4587:Antibodies:
4555:PF-04217903
4485:Altiratinib
4448:HGF (c-Met)
4351:Antibodies:
4256:Antibodies:
3978:Duligotumab
3975:Antibodies:
3889:Trastuzumab
3879:Ertumaxomab
3876:Antibodies:
3847:Zalutumumab
3842:Panitumumab
3837:Nimotuzumab
3832:Necitumumab
3822:Imgatuzumab
3799:Antibodies:
3782:Osimertinib
3747:Dacomitinib
3642:Dapiclermin
3601:Antibodies:
3584:Altiratinib
3475:Tebentafusp
3455:Regorafenib
3450:Quizartinib
3440:Pemigatinib
3420:Midostaurin
3395:Erdafitinib
3390:Entrectinib
3373:Parsaclisib
3321:Trilaciclib
3311:Palbociclib
3306:Dalpiciclib
3301:Abemaciclib
3203:Aflibercept
3130:Entrectinib
3100:Selumetinib
3095:Cobimetinib
3090:Binimetinib
3074:Ruxolitinib
3064:Momelotinib
3044:Baricitinib
2942:inhibitors:
2919:Pralsetinib
2915:Pemigatinib
2903:Futibatinib
2899:Entrectinib
2896:inhibitors:
2828:Regorafenib
2732:Avapritinib
2678:Rociletinib
2673:Osimertinib
2638:Dacomitinib
2576:Toripalimab
2561:Teclistamab
2551:Talquetamab
2546:Tafasitamab
2541:Sugemalimab
2536:Serplulimab
2526:Sabatolimab
2516:Ramucirumab
2511:Prolgolimab
2481:Necitumumab
2436:Epcoritamab
2416:Dostarlimab
2406:Daratumumab
2361:Amivantamab
2326:Alemtuzumab
2316:Brentuximab
2306:Tositumomab
2281:Ibritumomab
2262:Elranatamab
2225:Bevacizumab
2213:Edrecolomab
2208:Catumaxomab
2170:Trastuzumab
2154:Panitumumab
2059:NCT03690388
2047:NCT01908426
2035:NCT01835158
1782:11 November
1756:11 November
1066:(including
964:orphan drug
787:(HGFR) and
676: g·mol
616:100.221.147
538:CHEBI:72319
530:CHEBI:72317
365:849217-68-1
323:Identifiers
78:MedlinePlus
51:Other names
42:Trade names
6497:Quinolines
6471:Categories
6212:Vandetanib
6177:Rebastinib
6172:Pegaptanib
6162:Nintedanib
6152:Lenvatinib
6117:Agerafenib
6070:Ripretinib
5995:CH-7057288
5894:CH-7057288
5759:7,8,3'-THF
5754:7,8,2'-THF
5680:Ranevetmab
5670:Fulranumab
5624:Rebastinib
5569:CH-7057288
5484:Cenegermin
5369:Agerafenib
5329:Agerafenib
5310:Vandetanib
5279:Vandetanib
5248:Vandetanib
5217:Vandetanib
5162:Olaratumab
5137:Ripretinib
5117:Nintedanib
5102:Lenvatinib
5092:Crenolanib
5077:Agerafenib
4996:Ranevetmab
4986:Fulranumab
4903:Cenegermin
4877:LNGF (p75)
4799:Xentuzumab
4761:Xentuzumab
4706:NVP-AEW541
4701:NVP-ADW742
4696:Linsitinib
4691:BMS-754807
4676:Mecasermin
4575:Tivantinib
4565:PHA-665752
4560:PF-2341066
4530:Golvatinib
4520:Crizotinib
4515:Capmatinib
4505:BMS-777607
4500:Amuvatinib
4376:Ersofermin
4339:Sprifermin
4295:Ersofermin
4244:Sprifermin
4234:Repifermin
4229:Palifermin
4162:Ersofermin
4141:Velafermin
4126:Repifermin
4079:Ersofermin
3998:ErbB4/HER4
3983:Patritumab
3944:ErbB3/HER3
3924:Mubritinib
3884:Pertuzumab
3857:ErbB2/HER2
3787:Vandetanib
3742:Canertinib
3737:Brigatinib
3732:Agerafenib
3712:Nepidermin
3707:Murodermin
3697:Epiregulin
3652:EGF (ErbB)
3610:Nesvacumab
3604:Evinacumab
3594:Rebastinib
3535:modulators
3490:Venetoclax
3485:Vandetanib
3460:Ripretinib
3425:Nintedanib
3410:Lenvatinib
3385:Capmatinib
3368:Idelalisib
3358:Copanlisib
3331:inhibitors
3316:Ribociclib
3287:Vismodegib
3272:inhibitors
3252:Everolimus
3218:prohibitin
3135:Lorlatinib
3125:Crizotinib
3105:Trametinib
3069:Pacritinib
3054:Filgotinib
3049:Fedratinib
2953:Crizotinib
2949:Capmatinib
2931:Vandetanib
2879:Brigatinib
2858:Vandetanib
2818:Nintedanib
2813:Lenvatinib
2752:Ripretinib
2683:Vandetanib
2658:Lazertinib
2633:Brigatinib
2556:Tarlatamab
2491:Olaratumab
2451:Isatuximab
2446:Ipilimumab
2426:Elotuzumab
2421:Durvalumab
2401:Cemiplimab
2391:Bermekimab
2381:Axatilimab
2296:Ofatumumab
2276:Glofitamab
2258:Glofitamab
2166:Pertuzumab
1888:2021-08-09
1808:24 October
1110:References
1082:, various
776:. It is a
681:3D model (
669:Molar mass
482:DR7ST46X58
474:1C39JW444G
437:ChemSpider
356:CAS Number
332:IUPAC name
292:-mediated)
281:Metabolism
6237:Icrucumab
6217:WHI-P 154
6207:Tivozanib
6202:Toceranib
6197:Sunitinib
6192:Sorafenib
6187:Semaxanib
6167:Pazopanib
6157:Motesanib
6147:Lapatinib
6137:Cediranib
6075:Telbermin
6062:Agonists:
6010:GZ-389988
5990:CE-245677
5957:Agonists:
5909:GZ-389988
5889:CE-245677
5789:Diosmetin
5726:Agonists:
5692:Aptamers:
5685:Tanezumab
5660:Fasinumab
5604:Milciclib
5584:GZ-389988
5564:CE-245677
5466:Agonists:
5419:Toceranib
5414:Sunitinib
5409:Sorafenib
5399:Pazopanib
5394:Nilotinib
5389:Masitinib
5379:Dasatinib
5351:Agonists:
5297:Agonists:
5266:Agonists:
5235:Agonists:
5207:Liatermin
5199:Agonists:
5182:RET (GFL)
5172:Tovetumab
5152:Toceranib
5147:Sorafenib
5142:Sunitinib
5127:Radotinib
5122:Pazopanib
5112:Motesanib
5107:Masitinib
5042:Agonists:
5008:Aptamers:
5001:Tanezumab
4976:Fasinumab
4885:Agonists:
4741:Ganitumab
4661:IGF-1 LR3
4580:Volitinib
4535:INCB28060
4525:Foretinib
4431:Agonists:
4415:Trafermin
4373:Agonists:
4354:Burosumab
4344:Trafermin
4292:Agonists:
4259:Aprutumab
4249:Trafermin
4211:10 (KGF2)
4159:Agonists:
4136:Trafermin
4116:10 (KGF2)
4076:Agonists:
4006:Agonists:
3952:Agonists:
3934:Tucatinib
3929:Neratinib
3919:Lapatinib
3827:Matuzumab
3817:Futuximab
3802:Cetuximab
3792:WHI-P 154
3777:Neratinib
3772:Lapatinib
3762:Grandinin
3757:Gefitinib
3752:Erlotinib
3629:Agonists:
3589:CE-245677
3551:Agonists:
3480:Tepotinib
3470:Sunitinib
3465:Sorafenib
3435:Pazopanib
3415:Masitinib
3363:Duvelisib
3353:Alpelisib
3341:Sotorasib
3336:Adagrasib
3282:Sonidegib
3277:Glasdegib
3223:Adipotide
3156:Ibrutinib
3029:Dasatinib
3024:Bosutinib
3009:Radotinib
3004:Ponatinib
2999:Nilotinib
2989:Dasatinib
2984:Bosutinib
2979:Asciminib
2947:(VEGFR),
2905:(FGFR2),
2884:Ceritinib
2874:Alectinib
2853:Toceranib
2848:Tivozanib
2843:Sunitinib
2838:Sorafenib
2833:Semaxanib
2823:Pazopanib
2803:Cediranib
2767:Toceranib
2762:Sunitinib
2757:Sorafenib
2747:Pazopanib
2742:Masitinib
2709:Tucatinib
2704:Neratinib
2699:Lapatinib
2668:Olmutinib
2648:Gefitinib
2643:Erlotinib
2618:HER1/EGFR
2486:Nivolumab
2476:Naxitamab
2301:Rituximab
2149:Cetuximab
2144:HER1/EGFR
1128:Drugs.com
1090:(HNSCC),
1078:(NSCLC),
1004:sorafenib
920:half-life
887:bilirubin
783:(TKI) of
758:Cabometyx
311:Excretion
305:110 hours
300:half-life
148:Routes of
122:Pregnancy
70:Monograph
64:Drugs.com
6461:Medicine
6419:instead)
6408:Renalase
6369:instead)
6340:instead)
6287:instead)
6127:Axitinib
6096:D (FIGF)
6040:PLX-7486
6030:ONO-4474
5985:AZD-6918
5939:PLX-7486
5929:ONO-4474
5884:AZD-6918
5866:Ligands:
5784:Deprenyl
5744:7,3'-DHF
5675:MEDI-578
5655:ASP-6294
5619:PLX-7486
5609:ONO-4474
5559:AZD-6918
5519:ALE-0540
5440:instead.
5384:Imatinib
5374:Axitinib
5354:Ancestim
5319:Unsorted
5097:Imatinib
5087:Axitinib
4991:MEDI-578
4971:ASP-6294
4938:ALE-0540
4780:Agonists
4721:AVE-1642
4647:Agonists
4570:SU-11274
4456:Agonists
4434:FGF15/19
4424:Unsorted
4389:2 (bFGF)
4308:2 (bFGF)
4175:2 (bFGF)
4092:2 (bFGF)
3914:Afatinib
3865:Agonists
3767:Icotinib
3727:Afatinib
3673:Agonists
3270:hedgehog
3232:against
3230:exotoxin
3196:against
3145:Bruton's
2994:Imatinib
2917:(FGFR),
2913:(NTRK),
2798:Axitinib
2737:Axitinib
2693:HER2/neu
2653:Icotinib
2623:Afatinib
2597:("-nib")
2376:Avelumab
2248:lymphoid
2240:lymphoma
2236:Leukemia
2161:HER2/neu
2123:("-mab")
1991:26406150
1938:33442015
1728:16709393
1720:21926191
1414:DailyMed
1377:DailyMed
1268:17 April
1084:sarcomas
1056:melanoma
1014:Research
938:(HGFR),
934:(RTKs):
865:fistulas
805:Exelixis
754:Cometriq
454:25948203
446:25948202
409:DrugBank
398:25102847
162:ATC code
155:By mouth
124:category
106:DailyMed
6296:Ephrins
6000:DS-6051
5899:DS-6051
5804:LM22A-4
5794:DMAQ-B1
5749:7,8-DHF
5729:3,7-DHF
5698:RBM-004
5643:GBR-900
5574:DS-6051
5544:VM-902A
5014:RBM-004
4711:OSl-906
4671:Insulin
4550:MK-2461
4495:AMG-458
3632:Axokine
2973:bcr-abl
2334:myeloid
1982:5024539
1929:8275010
1845:. U.S.
1774:. U.S.
1659:. U.S.
1623:. U.S.
1592:. U.S.
1563:. U.S.
1534:. U.S.
1348:9 April
1313:9 April
1212:9 April
1186:9 April
1160:9 April
1044:gastric
1034:(CRC),
1026:(HCC),
1022:(RCC),
958:History
900:albumin
674:501.514
633:Formula
418:DB08875
384:PubChem
217::
178:)
172: (
170:L01EX07
137: D
108::
84:a613015
6447:Portal
6266:Others
5960:BNN-20
5849:ANA-12
5774:BNN-20
5494:DHEA-S
5479:BNN-27
5474:BNN-20
4913:DHEA-S
4898:BNN-27
4893:BNN-20
4809:Others
4014:Epigen
3692:Epigen
2220:VEGF-A
1989:
1979:
1936:
1926:
1726:
1718:
1240:29 May
1102:, and
950:, and
940:VEGFR2
912:CYP3A4
799:, and
789:VEGFR2
772:, and
707:SMILES
549:ChEMBL
510:D10095
502:D10062
290:CYP3A4
275:≥99.7%
244:℞-only
242:
229:
219:℞-only
205:
104:
6415:(see
6365:(see
6336:(see
6283:(see
6015:K252a
5914:K252a
5589:K252a
5529:FX007
5289:GFRα4
5258:GFRα3
5227:GFRα2
5191:GFRα1
4819:IGFBP
4772:IGF-2
4751:R1507
4639:IGF-1
4545:K252a
4365:FGFR4
4284:FGFR3
4151:FGFR2
4068:FGFR1
3214:ANXA2
3186:Other
3084:MAP2K
2955:(ALK)
2940:c-MET
2792:VEGFR
2727:PDGFR
2723:C-kit
2354:Other
2203:EpCAM
1750:(FDA)
1746:U.S.
1724:S2CID
1538:(FDA)
1482:(EMA)
1448:(EMA)
1342:(emc)
1307:(emc)
986:Ipsen
936:c-Met
807:Inc.
785:c-Met
727:InChI
683:JSmol
521:ChEBI
316:Feces
286:Liver
6417:here
6367:here
6338:here
6285:here
6080:VEGF
6054:VEGF
5970:NT-3
5965:DHEA
5949:TrkC
5869:DHEA
5839:TDP6
5819:NT-4
5814:NT-3
5799:HIOC
5769:BDNF
5718:TrkB
5489:DHEA
5458:TrkA
5438:here
5436:See
5429:TGFβ
5034:PDGF
4928:NT-4
4923:NT-3
4908:DHEA
4888:BDNF
3637:CNTF
3621:CNTF
3329:KRAS
3234:IL-2
3216:and
3198:VEGF
3115:EML4
2774:FLT3
2725:and
2613:ErbB
2339:CD33
2321:CD52
2311:CD30
2271:CD20
2139:ErbB
1987:PMID
1934:PMID
1855:2020
1810:2011
1784:2020
1758:2020
1716:PMID
1669:2021
1633:2020
1602:2020
1573:2020
1544:2020
1490:2020
1456:2020
1422:2020
1385:2020
1350:2023
1315:2023
1270:2024
1242:2022
1214:2023
1188:2023
1162:2023
1136:2020
1070:and
1046:and
952:FLT3
914:and
801:FLT3
756:and
493:KEGG
465:UNII
265:data
60:AHFS
5834:R13
5504:NGF
5449:Trk
4918:NGF
4630:IGF
4490:AM7
4381:FGF
4300:FGF
4201:),
4199:KGF
4167:FGF
4084:FGF
4059:FGF
3661:EGF
3119:ALK
3019:Src
2894:RET
2868:ALK
2318:),
2308:),
2268:),
2253:CD3
2109:L01
1977:PMC
1969:doi
1965:373
1924:PMC
1916:doi
1706:doi
1074:),
948:RET
944:AXL
797:RET
793:AXL
582:EPA
388:CID
231:POM
175:WHO
6473::
6328:B3
6326:,
6324:B2
6322:,
6320:B1
6318:,
6316:A5
6314:,
6312:A4
6310:,
6308:A3
6306:,
6304:A2
6302:,
6300:A1
6094:,
6090:,
6086:,
5829:R7
5645:;
5064:,
5060:,
5056:,
4845:,
4841:,
4837:,
4833:,
4829:,
4825:,
4782::
4649::
4458::
4409:19
4407:,
4403:,
4399:,
4395:,
4391:,
4387:,
4328:23
4326:,
4324:18
4322:,
4318:,
4314:,
4310:,
4306:,
4223:22
4221:,
4219:18
4217:,
4215:17
4213:,
4209:,
4205:,
4193:,
4189:,
4185:,
4181:,
4177:,
4173:,
4120:20
4118:,
4114:,
4110:,
4106:,
4102:,
4098:,
4094:,
4090:,
4042:,
4038:,
4034:,
4030:,
3965:,
3961:,
3867::
3675::
2951:,
2921:,
2909:,
2781:,
2720::
2615::
2336::
2264:,
2260:,
2250::
2168:,
2141::
2118:CI
2103:/
2008:.
1985:.
1975:.
1963:.
1959:.
1932:.
1922:.
1912:27
1910:.
1906:.
1881:.
1827:.
1744:.
1722:.
1714:.
1702:10
1700:.
1696:.
1610:^
1581:^
1552:^
1523:^
1498:^
1477:.
1464:^
1443:.
1430:^
1412:.
1393:^
1375:.
1358:^
1340:.
1323:^
1305:.
1278:^
1258:.
1230:.
1204:.
1178:.
1152:.
1126:.
1106:.
1098:,
1094:,
1086:,
1062:,
1058:,
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1038:,
1030:,
1010:.
954:.
946:,
942:,
878:,
795:,
768:,
647:24
641:28
344:N'
250:EU
238:US
225:UK
214:CA
207:S4
201:AU
133:AU
101:US
6449::
6361:/
6330:)
6298:(
6098:)
6092:C
6088:B
6084:A
6082:(
5631:)
5068:)
5066:D
5062:C
5058:B
5054:A
5052:(
4849:)
4847:7
4843:6
4839:5
4835:4
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4411:)
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62:/
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