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nature of neuronal cells in the adult central nervous system, this results in an irreversible and fatal process of neurodegeneration. There is also the presence of several movement related disorders including chorea, dystonia and bradykinesia, one of the more incapacitating ones includes
Truncal
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is a treatment that has varied effects on the people suffering from the symptoms of this disease, for some it has helped in a large way and for other people it did not help whatsoever, it is more effective on specific symptoms of the disease. Patients with chorea-acanthocytosis should undergo a
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Protein function tests that demonstrate a reduce in chorein levels and also genetic analysis can confirm the diagnosis given to a patient. For a disease like this it is often necessary to sample the blood of the patient on multiple occasions with a specific request given to the haematologist to
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Choreoacanthocytosis patients may have a "rubber man" appearance with truncal instability and sudden, violent trunk spasms. Patients develop generalized chorea and a minority of
Choreoacanthocytosis patients develops Parkinsonism.
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Chorea-acanthocytosis is a very complex autosomal recessive adult-onset neurodegenerative disorder. It often shows itself as a mixed movement disorder, in which chorea, tics, dystonia and even parkinsonism may appear as a symptom.
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In a least one third of patients, seizures, typically generalized, are the first manifestation of disease. Impairment of memory and executive functions is frequent, although not invariable.
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Garcia Ruiz, Pedro J; Ayerbe, Joaquin; Bader, Benedikt; Danek, Adrian; Sainz, Maria Jose; Cabo, Iria; Frech, Fernando Alonso (2009). "Deep brain stimulation in chorea acanthocytosis".
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examine the film for acanthocytes. Another point is that the diagnosis of the disease can be confirmed by the absence of chorein in the western blot of the erythrocyte membranes.
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Coco, Daniele Lo; Caruso, Giuseppe; Mattaliano, Alfredo (2009). "REM sleep behavior disorder in patients with DJ-1 mutations and parkinsonism-dementia-ALS complex".
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People afflicted by this disease also experience a loss of neurons. Loss of neurons is a hallmark of neurodegenerative diseases. Due to the generally
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Another one of them would be that this disease should be considered in patients who have elevated levels of acanthocytes in a peripheral blood film.
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Bader, B; Arzberger, T; Heinsen, H; Dobson-Stone, C; Kretzschmar, H. A; Danek, A (2008). "Neuropathology of Chorea-Acanthocytosis".
87:. When a patient's blood is viewed under a microscope, some of the red blood cells appear thorny. These thorny cells are called
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This disease is also characterized by the presence of a few different movement disorders including chorea, dystonia etc.
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in blood (these acanthocytes can sometimes be absent or even make a late appearance in the course of the disease.) and
110:. The average age of onset of symptoms is 35 years. The disease is incurable and inevitably leads to premature death.
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There are multiple symptoms that can help this disease to be diagnosed, this disease is marked by the presence of
242:"Chorea Acanthocytosis." Genetics Home Reference. Genetics Home Reference, ::May 2008. Web. 07 Feb. 2010.
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The serum creatine kinase is often elevated in the body of the people who are affected by this disease.
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The treatment to battle the disease chorea-acanthocytosis is completely symptomatic. For example,
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Raasch, S; Hadjikoutis, S (2008). "50. Neuromuscular involvement in chorea-acanthocytosis".
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Choreo-acanthocytosis is caused by a mutation in both copies of the gene
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Acanthocytosis with neurologic disorder, Levine-Critchley syndrome, ChAc
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cardiac evaluation every five years to look for cardiomyopathy.
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This condition is inherited via autosomal recessive manner
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caused by a mutation in a gene that directs structural
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GeneReviews/NCBI/NIH/UW entry on chorea-acanthocytosis
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525:"OMIM Entry - # 200150 - CHOREOACANTHOCYTOSIS; CHAC"
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263:; Bain, Peter G (2012). "Chorea-acanthocytosis".
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27:Rare autosomal recessive genetic condition
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203:can help to control orolingual dystonia.
94:Other effects of the disease may include
147:causing a choreiform movement disorder.
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120:Chorea-acanthocytosis is considered an
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475:"Neuroacanthocytosis Syndromes - PMC"
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228:Online Mendelian Inheritance in Man
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479:Orphanet Journal of Rare Diseases
439:Neuroacanthocytosis Syndromes II
277:10.1136/practneurol-2011-000045
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665:Autosomal recessive disorders
131:inheritance have been noted.
447:10.1007/978-3-540-71693-8_15
411:10.1016/j.clinph.2007.11.100
473:Jung, Hans H (2011-10-25).
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201:botulinum toxin injections
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399:Clinical Neurophysiology
106:degradation similar to
71:) is a rare hereditary
492:10.1186/1750-1172-6-68
205:Deep brain stimulation
98:, behaviour changes,
65:Chorea-acanthocytosis
627:Choreoacanthocytosis
441:. pp. 187–195.
261:Schneider, Susanne A
259:Sokolov, Elisaveta;
108:Huntington's disease
69:choreoacanthocytosis
18:Choreoacanthocytosis
265:Practical Neurology
85:neuroacanthocytosis
67:(ChAc, also called
36:Neuroacanthocytosis
613:External resources
356:Movement Disorders
313:Movement Disorders
135:Signs and symptoms
102:degeneration, and
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456:978-3-540-71692-1
368:10.1002/mds.22592
362:(10): 1546–1547.
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319:(10): 1555–1556.
145:neurodegeneration
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622:GeneReviews
41:Other names
654:Categories
598:DiseasesDB
534:2020-01-29
405:(3): e42.
212:References
341:139082877
293:219191328
195:Treatment
186:Diagnosis
168:spasms.
125:recessive
122:autosomal
633:Orphanet
529:omim.org
511:22027213
419:54432895
384:35801172
376:19425062
333:19441133
285:22258171
230:(OMIM):
129:dominant
104:neuronal
96:epilepsy
77:proteins
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592:200150
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179:VPS13A
100:muscle
603:29707
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289:S2CID
172:Cause
638:2388
587:OMIM
507:PMID
451:ISBN
372:PMID
329:PMID
281:PMID
575:ICD
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