146:, in a November 2005 article entitled "Curb Your Cravings For This Stock", wrote "If the venture works out for patients and the investing public, it'll be a rare success for Peizer, who's promoted a series of disappointing small-cap medical or technology stocks ... since his days at Drexel". Peizer said: "Hythiam is my biggest triumph. If it's the only thing I did, then my life would have been a tremendous success."
322:, where the local judge, Charles Sandoval, reported a "spectacular" success rate (even though, when asked, stated that he hadn't kept any records). Other courts in the state were more skeptical about the lack of clinical research supporting Gabasync, however, and only four other counties requested funding. About half of the amount budgeted for the initial year was spent.
317:
Also in 2007, Jerry Madden, chair of the Texas House
Corrections Committee, secured $ 2 million of funding over two years in the state budget for Gabasync treatment programs. In contrast with officials in Washington, Madden said he had no financial ties to Hythiam. In support of the budget request he
299:
These revelations led the Pierce County
Council to suspend its funding for the program in October 2007. An unspent $ 175,000, along with $ 400,000 Ladenburg had requested for 2008, were instead set aside with the proviso that they could be used for "evidence-based programs that are directed towards
242:
The effects of the flumazenil/gabapentin combination in the treatment of alcohol dependence are less clear. In a randomized, placebo-controlled trial alcohol-dependent subjects taking flumazenil/gabapentin had more abstinent days and time to first heavy drinking if they had high alcohol withdrawal
183:
opined: "most of what Peizer says is dubious-sounding hype". In June 2008, Hythiam had generated a net loss each year for 5 straight years, and while its stock had traded at $ 61.26 a share in 2007, it traded at $ 0.18 per share three years later. According to independent investment research firm
238:
Dr. Urschel has also completed a double-blind, placebo controlled study of
Gabasync's active ingredients, where 68 patients were randomized to active and 67 patients to placebo treatment for 30 days. The study reported a decrease in both cravings and methamphetamine use following the initial
208:. The treatment is similar for stimulant dependence, with additional flumazenil administrations. The dosing regimen of the drug combination is discussed in Urschel’s study. The initial intravenous administrations are followed up by orally prescribed medications and behavioral treatment.
296:, state legislator Dennis Flannigan, and officials at the treatment center had bought Hythiam stock. A county audit also questioned the effectiveness of the program, in part because auditors took a different approach than the treatment center in determining whether Gabasync was successful.
255:, would offer the treatment that was to become known as Gabasync in that court's drug program. However, the program was never implemented, and the judge there said he was uncomfortable that the evidence for it was not as strong as the company's marketing. As a result, the first Gabasync
81:
relative to another company. Hythiam has sought to patent the protocol and charges up to $ 15,000 per patient to license its use (of which half goes to the prescribing physician, and half to
Hythiam). Lower rates are offered to the criminal justice system, where it has been used in
288:, initiated a 40-person pilot program in 2006 through a nonprofit treatment center serving the county's drug court, and officials reported very promising results. With this they were able to get $ 900,000 for Gabasync funding in the state and county budgets for 2007, including a
300:
breaking the cycle of drug addiction". Ladenburg and
Flannigan also had to amend their state financial disclosure forms, although Ladenburg reported he had sold his stock at a loss and insisted it did not influence his actions. The news from Pierce County, along with a
107:. It concluded that Gabasync is ineffective: "The PROMETA protocol, consisting of flumazenil, gabapentin and hydroxyzine, appears to be no more effective than placebo in reducing methamphetamine use, retaining patients in treatment or reducing methamphetamine craving."
123:
salesman, founded
Hythiam Inc., a tiny pharmaceutical company, from which in 2006 when he was majority shareholder he received $ 1.3 million in compensation. The firm bought the rights to an ineffective addiction treatment, and marketed it. Despite the fact that no
216:
Preliminary evidence that a regimen combining hydroxyzine, flumazenil, and gabapentin (the active pharmacological components of
Gabasync) can help decrease methamphetamine cravings and use was first published in October 2007 following a relatively small,
846:
Urschel 3rd, Harold C; Hanselka, Larry L; Gromov, Irin; White, Lenae; Baron, Michael (2007). "Open-label study of a proprietary treatment program targeting type A gamma-aminobutyric acid receptor dysregulation in methamphetamine dependence".
563:
1024:
939:
Anton, RF; Myrick, H; Baros, AM; et al. (August 2009). "Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms".
140:
had been obtained, Hythiam advertised the "innovative, medically based treatment" (which could cost $ 15,000 per patient) and franchised doctors to use
Prometa, in exchange for a per-patient fee.
306:
investigation of
Gabasync that aired in December, battered Hythiam's stock, as it fell in value nearly two-thirds by the end of the year. However, at the same time the city council in nearby
310:, approved a small $ 20,000 Gabasync trial at the suggestion of a city council member whose employee, one of Gabasync's successes, had been treated in Pierce County and featured in the
334:, Hythiam started a national advertising campaign in 2006, utilizing billboards, radio spots, as well as Internet ads and paid search results. In one of the billboard ads the image of
767:
589:
1391:
365:, in which recovering methamphetamine addict "Dustin" allowed the network to film his treatment with Gabasync, as well as his life before and after he quit using the drug.
272:
1123:
1101:
882:
416:
355:
reported that she was being treated by Dr. Matthew
Torrington, director of the Gabasync Center in Santa Monica. Gabasync was also featured in an episode of the
896:
Urschel, HC; Hanselka, LL; Baron, M (November 2009). "A controlled trial of flumazenil and gabapentin for initial treatment of methylamphetamine dependence".
700:
338:(who had died of a drug overdose) was used, which caused significant controversy. Ads with other dead celebrities were planned (according to Hythiam's CEO,
263:, beginning in November 2005. According to Hythiam the trial was a success and had been adopted, but, according to the Tahoma audit, it was ended early and
282:, ended early because it was not deemed effective; one report mentioned physician misconduct, but court officials would not comment about the issue.
1189:
811:
49:. It was marketed as PROMETA. The treatment, based loosely on research of a Spanish psychologist, involved a combination of three medications (
983:
1006:
775:
1207:
1025:"Hythiam, Inc. Appoints Past Indiana State Attorney General and Former Head of National Drug Court Institute to Board of Directors"
726:
745:
1340:
792:
497:"Addiction treatment, novel but unproved; Prometa's promoters point to anecdotal success. But critics want to see hard numbers"
1261:
342:, who has since been indicted for securities fraud relative to another company), but it seems none were actually published.
179:
and government approval when bringing to market Prometa; the addiction drug proved to be completely ineffective. Journalist
1422:
1225:
243:
symptoms prior to treatment, whereas the patients with low withdrawal symptoms actually did worse with active treatment.
1407:
62:
413:
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331:
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125:
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reported that Dr. Urschel's addiction clinic sold the Gabasync treatment. However Urschel denied this was a
171:
142:
1412:
279:
452:
Prescription For Addiction, 60 Minutes' Scott Pelley Reports On A New Addiction Treatment, Dec. 7, 2007,
876:
133:
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319:
268:
252:
232:
516:"Double-blind placebo-controlled evaluation of the PROMETA™ protocol for methamphetamine dependence"
38:
965:
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154:
136:
of its "Prometa" (the marketing name for Gabasync) approach had been undertaken, and although no
188:: "Over the long haul, this company has posted some of its industry's worst returns on assets."
957:
913:
864:
583:
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185:
1385:
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292:
study to evaluate the treatment. However, it was subsequently revealed that county executive
949:
905:
856:
535:
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477:
218:
176:
78:
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153:
said to Peizer in 2007: "Depending and who you talk to, you're either a revolutionary or a
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420:
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34:
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42:
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260:
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116:
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70:
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Maynard, Steve (November 22, 2007). "In Federal Way, Prometa gets council support".
969:
925:
654:
609:
335:
150:
137:
129:
414:
http://www.drugfree.org/join-together/prometa-founders-spotty-background-explored/
1085:
Otto, M. Alexander (October 24, 2007). "Local officials owned stock in company".
953:
793:"Biotech Notebook: Hythiam, Shire, Genentech; Talk is proving cheap at Hythiam,"
201:
65:, their off-label use for addiction treatment has not. Gabasync was marketed by
58:
1144:
Wickert, David (November 21, 2007). "Council rejects Prometa funding request".
302:
205:
197:
159:
83:
54:
50:
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by Dr. Harold C. Urschel. The study, funded by Hythiam, was published in the
1279:
361:
120:
103:
74:
1159:
Wickert, David (November 6, 2007). "Politicians revise stock disclosures".
961:
917:
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549:
1007:"Effectiveness of Prometa Treatment Protocol in Pierce County Drug Courts"
61:) as well as therapy. While the individual drugs had been approved by the
1315:
165:
1392:
Effectiveness of Prometa Treatment Protocol in Pierce County Drug Courts
1045:
Robinson, Sean (December 23, 2007). "Data show mixed value of Prometa".
349:
was connected to Gabasync as one of her rehab efforts during 2007, when
860:
481:
90:
46:
17:
514:
Ling, W.; Shoptaw, S.; Hillhouse, M.; Bholat, M. A. (November 2011).
570:. November 21, 2019. Archived from the original on November 21, 2019
1382:- Clinicaltrials.gov listing for University of South Carolina study
768:"Texas' Prometa program for treating meth addicts draws skeptics"
37:
addiction, although it had also been claimed to be effective for
412:
Prometa Founder's Spotty Background Explored, November 3, 2006,
94:
27:
Proposed but ineffective treatment for methamphetamine addiction
1190:"Junk Bonds to Junk Science? Drug Treatment Program Questioned"
812:"Junk Bonds to Junk Science? Drug Treatment Program Questioned"
356:
1226:"Actor who died of overdose stars in addiction treatment ads"
251:
A Hythiam press release in 2004 announced that a center in
746:"The Rise and Fall of a "Miracle Cure" for Drug Addiction"
271:, who had been promoting the Gabasync trial as the CEO of
93:-controlled study (financed by Hythiam and carried out at
564:"Hythiam EVP Lamacchia in long string of company layoffs"
454:
http://www.cbsnews.com/news/prescription-for-addiction/
239:
treatment and throughout the 30 days treatment period.
1386:
Prometa Pharmacotherapy for Methamphetamine Dependence
1394:- Pierce County performance audit of Gabasync program
466:"Prometa under fire in Washington drug court program"
275:, later joined the Board of Directors at Hythiam.
196:For alcohol dependence, the treatment consists of
89:In November 2011, the results of a double-blind,
588:: CS1 maint: bot: original URL status unknown (
273:National Association of Drug Court Professionals
318:cited a 20-person pilot paid for by Hythiam in
1040:
1038:
727:"Unproven meth, cocaine 'remedy' hits market"
175:criticized Peizer after the company bypassed
8:
1262:"Addiction treatment's effectiveness argued"
383:
381:
379:
377:
1388:- Clinicaltrials.gov listing for UCLA study
984:"PROMETA Protocol Adopted by Gary, Indiana"
881:: CS1 maint: numeric names: authors list (
1062:"Pilot program helps ease drug addictions"
841:
839:
1011:Pierce County Performance Audit Committee
806:
804:
761:
759:
676:
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77:salesman who has since been indicted for
33:is an ineffective treatment promoted for
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1380:Prometa Protocol for Alcohol Dependence
1347:. MTV. December 6, 2007. Archived from
1122:Otto, M. Alexander (October 24, 2007).
373:
874:
581:
430:
428:
1102:"Success or failure? Probing Prometa"
1060:Clarridge, Christine (July 9, 2006).
744:Humphreys, Keith (January 24, 2012).
627:Bartholomew, Dana (7 December 2018).
7:
1100:Robinson, Sean (November 11, 2007).
766:Ramshaw, Emily (January 20, 2008).
655:"Curb Your Cravings For This Stock"
610:"Curb Your Cravings For This Stock"
436:"UNITED STATES V. TERREN S. PEIZER"
225:, a peer reviewed medical journal.
1208:"The Worst Judge in Dallas County"
699:Polien Light, Nina (May 8, 2008).
470:Alcoholism & Drug Abuse Weekly
25:
1316:"Lindsay's Shocking Drug Therapy"
1298:"Chris Farley Lives on Billboard"
608:Alpert, Bill (November 7, 2005).
532:10.1111/j.1360-0443.2011.03619.x
1124:"Council cuts off drug program"
629:"Catasys Thrives on Data Dives"
495:Roan, Shari (October 9, 2006).
332:marketing of off-label drug use
200:(administered intravenously),
725:Kari Huus (February 5, 2007).
1:
954:10.1097/JCP.0b013e3181aba6a4
898:J. Psychopharmacol. (Oxford)
701:"An entrepreneur with heart"
682:"Prescription For Addiction"
633:Los Angeles Business Journal
395:. CBS News. December 9, 2007
389:"Prescription For Addiction"
326:Popular culture connections
1439:
1280:"Billboard in Los Angeles"
1244:"A warning sign on Sunset"
286:Pierce County, Washington
134:peer-reviewed publication
69:, Inc. which is owned by
910:10.1177/0269881109349837
290:University of Washington
97:) were published in the
614:The Wall Street Journal
476:(3). January 21, 2008.
308:Federal Way, Washington
223:Mayo Clinic Proceedings
172:The Dallas Morning News
942:J Clin Psychopharmacol
280:Fulton County, Georgia
830:"Hythiam stock price"
791:(November 13, 2007).
705:Cleveland Jewish News
1423:Substance dependence
1341:"I'm Going to Rehab"
269:Karen Freeman-Wilson
253:Covington, Louisiana
233:conflict of interest
1408:Drug rehabilitation
1214:. 18 November 2009.
1194:prisonlegalnews.org
772:Dallas Morning News
688:. December 7, 2007.
1322:. October 24, 2007
861:10.4065/82.10.1170
750:Washington Monthly
568:Treatment Magazine
482:10.1002/adaw.20121
419:2015-09-23 at the
212:Controlled studies
155:snake oil salesman
126:placebo-controlled
1266:The Seattle Times
1248:Los Angeles Times
816:Prison Legal News
501:Los Angeles Times
330:Despite a ban on
278:Another trial in
16:(Redirected from
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818:. June 15, 2008.
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442:. March 1, 2023.
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219:open-label trial
177:clinical studies
86:pilot programs.
79:securities fraud
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1304:. 3 April 2006.
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181:Adam Feuerstein
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35:methamphetamine
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1089:. p. 106.
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855:(10): 1170–8.
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653:Alpert, Bill.
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526:(2): 361–369.
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294:John Ladenburg
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1356:. Retrieved
1349:the original
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