559:
29:
907:
5806:
1393:
1105:"Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase"
1441:
192:
2872:
1311:
147:
693:
1049:
1434:
4787:
1401:
2865:
1363:"Phase III trial shows lenvatinib meets primary endpoint of progression free survival benefit in treatment of radioiodine-refractory differentiated thyroid cancer"
5747:
59:
1235:
649:
677:
InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)
5403:
4551:
1427:
856:
4168:
2858:
1267:
Inoue K, Mizuo H, Kawaguchi S, Fukuda K, Kusano K, Yoshimura T (August 2014). "Oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase".
635:
4226:
5088:
4778:
4383:
2433:
2076:
864:
1323:
3368:
3051:
981:
status for treatment of various types of thyroid cancer that do not respond to radioiodine in the US and Japan in 2012 and in Europe in 2013.
5766:
5716:
5687:
5634:
4121:
3988:
5445:
5441:
5437:
5433:
2986:
2970:
1569:
3714:
3633:
3500:
3417:
5826:
5429:
2547:
1006:
In August 2018, the FDA approved lenvatinib for the first-line treatment of people with unresectable hepatocellular carcinoma (HCC).
5118:
4237:
3797:
3408:
930:(AO) to substances called M2' and M3', the main metabolites in the feces. Another metabolite, also mediated by a CYP enzyme, is the
860:
669:
974:
clinical trial in cancer patients was performed in 2006. A phase III trial treating thyroid cancer patients started in March 2011.
1023:
3066:
3010:
3001:
1967:
1493:
937:
M3. Non-enzymatic metabolization also occurs, resulting in a low potential for interactions with enzyme inhibitors and inducers.
5640:
328:
177:
77:
5727:
5703:
4843:
4399:
4262:
5693:
5796:
5737:
4133:
4015:
4005:
2313:
1241:
1198:
985:
769:
450:
5083:
1470:
971:
538:
96:
5108:
2494:
988:
approved lenvatinib for treatment of progressive, radioiodine refractory differentiated thyroid cancer. In May 2015,
5722:
3548:
2619:
2468:
2217:
1719:
5103:
5630:
1944:
1810:
1523:
1218:
989:
826:, addition of other drugs with this property could increase the risk of a type of abnormal heart rhythm, namely
3814:
3730:
3649:
3516:
3433:
1954:
1480:
784:
3248:
399:
5414:
3161:
3036:
1450:
133:
5093:
1382:
1192:
5836:
5698:
5314:
5218:
5078:
4838:
4257:
3243:
2881:
2322:
1805:
1534:
787:
that cannot be removed surgically in patients who have not received cancer therapy by mouth or injection.
718:
527:
253:
5851:
5841:
5831:
5772:
3969:
3613:
3253:
2892:
1880:
1820:
1790:
1693:
1529:
1419:
390:
959:
5712:
5098:
4030:
3979:
1735:
1630:
1467:
1000:
798:(high blood pressure) was the most common side effect in studies (73% of patients, versus 16% in the
777:
290:
4848:
2923:
879:. VEGFR2 inhibition is thought to be the main reason for the most common side effect, hypertension.
554:
28:
4853:
4267:
3964:
3156:
2588:
1855:
1845:
1665:
827:
345:
140:
3889:
5471:
5384:
5329:
5283:
5228:
4963:
4903:
4531:
3904:
3834:
3393:
2991:
2933:
2884:
2243:
1875:
1860:
1780:
1350:
1292:
940:
876:
872:
762:
107:
5466:
5344:
5243:
5029:
4918:
4718:
4678:
4426:
4345:
4207:
4148:
4110:
4055:
4050:
4040:
3914:
3909:
3879:
3854:
3849:
3839:
3725:
3644:
3583:
3511:
3490:
3475:
3428:
3081:
943:
is 28 hours, with about two thirds being excreted via the feces, and one quarter via the urine.
5566:
5424:
5359:
5339:
5258:
5238:
4953:
4933:
4913:
4556:
3884:
3608:
3141:
2938:
5389:
5379:
5334:
5288:
5278:
5233:
5158:
5057:
5024:
5004:
4968:
4958:
4908:
4868:
4340:
4320:
4287:
4070:
3919:
1920:
1284:
1126:
803:
507:
216:
204:
41:
5349:
5248:
5143:
5047:
4999:
4992:
4978:
4923:
4893:
4373:
4363:
4315:
4297:
4060:
3899:
3844:
439:
5576:
4708:
1760:
1602:
1597:
1276:
1214:
1116:
1077:
927:
915:
852:
831:
811:
730:
575:
354:
272:
235:
4100:
459:
69:
5810:
5188:
911:
892:
823:
263:
243:
558:
5846:
5762:
5683:
5625:
5319:
5168:
5163:
4277:
4272:
2918:
2908:
2903:
2697:
2595:
2543:
2141:
1454:
896:
835:
754:
722:
906:
5820:
5456:
5369:
5298:
5268:
5203:
5113:
5067:
4943:
4873:
4818:
4807:
4292:
4000:
3683:
3588:
3480:
2754:
2644:
2606:
2583:
2515:
2510:
2500:
2276:
2272:
2260:
2067:
1850:
1815:
1635:
1615:
1296:
1054:
2850:
1312:"A phase I dose finding study of E7080 in patients (pts) with advanced malignancies"
379:
5782:
5752:
5491:
5481:
5374:
5273:
5128:
4948:
4883:
4798:
4302:
4105:
3944:
3939:
3859:
3809:
3623:
3377:
3358:
3337:
3308:
3031:
3026:
2794:
2779:
2749:
2729:
2611:
2559:
2520:
2408:
2387:
2294:
2256:
2157:
2132:
2128:
2012:
1977:
1930:
1915:
1870:
1745:
1715:
1640:
1458:
1103:
Matsui J, Funahashi Y, Uenaka T, Watanabe T, Tsuruoka A, Asada M (September 2008).
895:
is estimated to be about 85%. The substance is almost completely (98–99%) bound to
888:
795:
160:
155:
1345:
1121:
1104:
1024:"Prescription medicines: registration of new chemical entities in Australia, 2016"
891:
concentrations after one to four hours (three to seven hours if taken with food).
5742:
5708:
5606:
5596:
5591:
5581:
5531:
5354:
5253:
5014:
4928:
4858:
4753:
4516:
4481:
4431:
4394:
4330:
4212:
4143:
4095:
4085:
4080:
4075:
3959:
3954:
3949:
3327:
3238:
3228:
3196:
3191:
3186:
3181:
3171:
3131:
3096:
2824:
2804:
2799:
2789:
2769:
2744:
2739:
2722:
2670:
2660:
2655:
2650:
2552:
2479:
2449:
2444:
2439:
2423:
2413:
2393:
2268:
2264:
2252:
2248:
2177:
2081:
2027:
2022:
1987:
1925:
1910:
1900:
1895:
1890:
1885:
1865:
1830:
1785:
1765:
1755:
1710:
1675:
1655:
1611:
1574:
1562:
1557:
1519:
1503:
978:
807:
1362:
5561:
5526:
5521:
5511:
5419:
5208:
5183:
5173:
5019:
4973:
4833:
4659:
4628:
4597:
4566:
4511:
4486:
4466:
4441:
4335:
4252:
4045:
4025:
3924:
3869:
3864:
3688:
3593:
3578:
3373:
3332:
3304:
3273:
3233:
3136:
3091:
3086:
3061:
3056:
3046:
2959:
2953:
2943:
2839:
2834:
2809:
2774:
2734:
2717:
2707:
2665:
2636:
2601:
2567:
2484:
2474:
2454:
2418:
2403:
2398:
2368:
2302:
2298:
2280:
2228:
2207:
2167:
2101:
2032:
2007:
1982:
1905:
1840:
1800:
1795:
1775:
1770:
1750:
1740:
1730:
1645:
1625:
1607:
1515:
996:
956:
773:
758:
611:
430:
280:
5586:
5556:
5551:
5546:
5541:
5536:
5516:
5506:
5496:
5486:
5178:
5138:
5034:
5009:
4768:
4763:
4758:
4748:
4743:
4738:
4728:
4649:
4587:
4521:
4501:
4496:
4491:
4476:
4471:
4461:
4456:
4350:
4325:
4090:
4010:
3929:
3874:
3764:
3703:
3693:
3598:
3485:
3283:
3278:
3268:
3176:
3166:
3151:
3126:
3121:
3111:
3106:
3101:
2829:
2819:
2814:
2784:
2764:
2712:
2702:
2690:
2685:
2631:
2626:
2572:
2505:
2378:
2373:
2358:
2353:
2348:
2338:
2333:
2328:
2233:
2223:
2202:
2197:
2192:
2187:
2182:
2172:
2152:
2116:
2111:
2106:
2096:
2091:
2058:
2053:
2048:
2017:
1997:
1992:
1835:
1825:
1650:
1498:
726:
303:
63:
1349:
for "A Trial of E7080 in 131I-Refractory
Differentiated Thyroid Cancer" at
1288:
1280:
1130:
20:
914:
enzymes (CYP), and further metabolized to the quinolinones M2' and M3' by
5757:
5476:
5133:
4733:
4723:
4703:
4638:
4607:
4576:
4540:
4446:
4436:
3783:
3263:
3206:
3116:
3076:
2579:
2343:
2147:
2086:
2042:
2002:
1972:
1725:
1589:
1585:
1510:
1175:
952:
410:
91:
753:
Lenvatinib is approved (since 2015) for the treatment of differentiated
419:
5732:
5153:
4618:
4020:
2981:
1683:
931:
926:
to desmethyl-lenvatinib (M2). M2 and lenvatinib itself are oxidized by
900:
799:
365:
806:(67% vs. 35%). Other common side effects included decreased appetite,
5645:
5309:
5198:
5123:
4828:
4823:
4247:
4242:
4196:
4192:
4188:
4184:
4180:
4176:
4172:
3824:
3363:
3041:
1394:"Summary of the European public assessment report (EPAR) for Lenvima"
923:
742:
738:
734:
518:
268:
1316:
Journal of
Clinical Oncology, ASCO Annual Meeting Proceedings Part I
1236:"FDA approves lenvatinib for unresectable hepatocellular carcinoma"
487:
479:
5677:
5673:
5669:
5665:
5661:
5657:
5653:
5649:
5364:
5263:
4938:
4878:
4692:
4415:
4411:
4407:
4403:
3894:
3758:
3677:
3673:
3572:
3568:
3564:
3560:
3469:
3465:
3316:
2563:
2289:
2123:
2072:
1552:
1380:
905:
868:
783:
The drug is also approved in the US and in the
European Union for
634:
625:
498:
313:
309:
5148:
3754:
3750:
3746:
3742:
3738:
3734:
3669:
3665:
3661:
3657:
3653:
3556:
3552:
3544:
3540:
3536:
3532:
3528:
3524:
3520:
3461:
3457:
3453:
3449:
3445:
3441:
3437:
3389:
3385:
3381:
3347:
3312:
3293:
2678:
2464:
1962:
1688:
1670:
1660:
1620:
1488:
470:
222:
2854:
1423:
210:
86:
543:
887:
Lenvatinib is absorbed quickly from the gut, reaching peak
186:
118:
1310:
Glen H, Boss D, Evans TR, Roelvink M, et al. (2007).
814:(low blood platelet count), nausea, muscle and bone pain.
1050:"Health Canada New Drug Authorizations: 2015 Highlights"
199:
700:
5748:
Pituitary adenylate cyclase-activating peptide (PACAP)
1159:(in German). Vienna: Österreichischer Apothekerverlag.
995:
In May 2016, the FDA approved it (in combination with
5794:
761:, progressive, and did not respond to treatment with
875:. Some of these proteins play roles in cancerogenic
5615:
5402:
5297:
5066:
4806:
4797:
4777:
4691:
4668:
4637:
4606:
4575:
4539:
4530:
4382:
4225:
4158:
4120:
3987:
3978:
3796:
3773:
3713:
3632:
3499:
3416:
3407:
3346:
3292:
3205:
3009:
3000:
2969:
2891:
2535:
2312:
1953:
1943:
1703:
1584:
1544:
1479:
1466:
725:and for other cancers as well. It was developed by
623:
610:
574:
569:
537:
517:
497:
469:
449:
429:
409:
398:
389:
364:
344:
319:
302:
289:
279:
262:
252:
242:
234:
176:
171:
146:
132:
106:
76:
58:
50:
40:
35:
5694:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
4552:Glial cell line-derived neurotrophic factor (GDNF)
4205:Cleavage products/derivatives with unknown target:
992:(EMA) approved the drug for the same indication.
657:C4CC4NC(=O)Nc3ccc(cc3Cl)Oc1ccnc(cc2OC)c1cc2C(=O)N
5728:Macrophage-stimulating protein (MSP; HLP, HGFLP)
802:group), followed by diarrhoea (67% vs. 17%) and
378:
3369:Heparin-binding EGF-like growth factor (HB-EGF)
3052:Heparin-binding EGF-like growth factor (HB-EGF)
353:
1230:
1228:
922:Lenvatinib is metabolized by the liver enzyme
5780:Additional growth factor receptor modulators:
2866:
1435:
1003:following one prior anti-angiogenic therapy.
780:following one prior anti-angiogenic therapy.
8:
4134:Insulin-like growth factor-2 (somatomedin A)
4016:Insulin-like growth factor-2 (somatomedin A)
4006:Insulin-like growth factor-1 (somatomedin C)
857:vascular endothelial growth factor receptors
95:
19:
1193:"Lenvatinib in combination with Everolimus"
1170:
1168:
1166:
4803:
4536:
3984:
3413:
3006:
2873:
2859:
2851:
1950:
1476:
1442:
1428:
1420:
557:
438:
27:
1187:
1185:
1120:
458:
5738:Migration-stimulating factor (MSF; PRG4)
1262:
1260:
5801:
3067:Transforming growth factor alpha (TGFα)
1015:
865:platelet-derived growth factor receptor
772:(FDA) approved it (in combination with
674:
654:
553:
418:
333:
5641:Connective tissue growth factor (CTGF)
1028:Therapeutic Goods Administration (TGA)
721:for the treatment of certain kinds of
18:
5704:Hepatoma-derived growth factor (HDGF)
1174:
526:
506:
68:
7:
1150:
1148:
1146:
1144:
1142:
1140:
757:that is either locally recurrent or
336:4--7-methoxy-quinoline-6-carboxamide
285:Desmethyl-lenvatinib (M2) and others
159:
1400:. 17 September 2018. Archived from
1378:U.S. Food and Drug Administration.
486:
478:
369:
951:Lenvatinib is used in form of the
861:fibroblast growth factor receptors
14:
1176:FDA Professional Drug Information
5804:
5723:Leukemia inhibitory factor (LIF)
999:) for the treatment of advanced
830:. No relevant interactions with
776:) for the treatment of advanced
595:
592:
586:
4891:Negative allosteric modulators:
1269:Drug Metabolism and Disposition
682:Key:WOSKHXYHFSIKNG-UHFFFAOYSA-N
5209:Gossypetin (3,5,7,8,3',4'-HHF)
4400:Platelet-derived growth factor
851:Lenvatinib acts as a multiple
601:
580:
1:
5415:Placental growth factor (PGF)
1122:10.1158/1078-0432.CCR-07-5270
855:. It inhibits the three main
5699:Glia maturation factor (GMF)
4208:Glypromate (GPE, (1-3)IGF-1)
1322:(18S): 14073. Archived from
1242:Food and Drug Administration
1199:Food and Drug Administration
859:VEGFR1, 2 and 3, as well as
770:Food and Drug Administration
713:, sold under the brand name
5868:
5631:Colony-stimulating factors
5623:Additional growth factors:
1945:Tyrosine kinase inhibitors
910:Lenvatinib is oxidized by
570:Chemical and physical data
5827:Protein kinase inhibitors
4979:SNA-120 (pegylated K252a)
4151:(against IGF-1 and IGF-2)
4113:(against IGF-1 and IGF-2)
1811:Mirvetuximab soravtansine
1398:European Medicines Agency
1368:. Eisai. 3 February 2014.
1219:European Medicines Agency
1155:Haberfeld H, ed. (2015).
1082:European Medicines Agency
990:European Medicines Agency
822:As lenvatinib moderately
690:
665:
645:
324:
26:
3815:Hepatocyte growth factor
3374:Neuregulins (heregulins)
3305:Neuregulins (heregulins)
3249:Trastuzumab duocarmazine
2962:(against angiopoietin 2)
2956:(against angiopoietin 3)
1955:Receptor tyrosine kinase
1481:Receptor tyrosine kinase
1109:Clinical Cancer Research
785:hepatocellular carcinoma
3162:Depatuxizumab mafodotin
1545:Others for solid tumors
1451:Targeted cancer therapy
977:Lenvatinib was granted
729:and acts as a multiple
5785:(neurotrophin mixture)
5773:Wnt signaling proteins
5454:Allosteric modulators:
5174:Norwogonin (5,7,8-THF)
3394:5 (tomoregulin, TMEFF)
3244:Trastuzumab deruxtecan
2882:Growth factor receptor
1806:Loncastuximab tesirine
1535:Trastuzumab deruxtecan
1343:Clinical trial number
1281:10.1124/dmd.114.058073
984:In February 2015, the
919:
863:(FGFR) 1, 2, 3 and 4,
810:(low blood pressure),
719:anti-cancer medication
5713:T-cell growth factors
3970:Telisotuzumab vedotin
3254:Trastuzumab emtansine
1881:Sacituzumab govitecan
1821:Moxetumomab pasudotox
1791:Inotuzumab ozogamicin
1694:Gemtuzumab ozogamicin
1530:Trastuzumab emtansine
1471:monoclonal antibodies
1455:antineoplastic agents
909:
4298:EVT-901 (SAR-127963)
4031:Mecasermin rinfabate
1736:Belantamab mafodotin
1001:renal cell carcinoma
778:renal cell carcinoma
768:In May 2016, the US
717:among others, is an
2589:Denileukin diftitox
2251:(ALK, ROS1, NTRK),
1856:Polatuzumab vedotin
1846:Oportuzumab monatox
877:signalling pathways
847:Mechanism of action
828:torsades de pointes
195:(Prescription only)
23:
5464:Kinase inhibitors:
5327:Kinase inhibitors:
5226:Kinase inhibitors:
4901:Kinase inhibitors:
4716:Kinase inhibitors:
4676:Kinase inhibitors:
4657:Kinase inhibitors:
4626:Kinase inhibitors:
4595:Kinase inhibitors:
4564:Kinase inhibitors:
4424:Kinase inhibitors:
4038:Kinase inhibitors:
3832:Kinase inhibitors:
3621:Kinase inhibitors:
3614:Aprutumab ixadotin
3261:Kinase inhibitors:
3074:Kinase inhibitors:
2931:Kinase inhibitors:
2275:(ROS1, TRK, ALK),
1781:Enfortumab vedotin
1351:ClinicalTrials.gov
941:Terminal half-life
920:
873:RET proto-oncogene
763:radioactive iodine
5792:
5791:
5398:
5397:
5159:N-Acetylserotonin
5058:ReN-1820 (TrkAd5)
4687:
4686:
4221:
4220:
4166:Binding proteins:
3825:Dihexa (PNB-0408)
3792:
3791:
3403:
3402:
3317:6 (neuroglycan C)
3037:EGF (urogastrone)
3015:
2848:
2847:
2531:
2530:
1939:
1938:
1921:Tisotumab vedotin
832:enzyme inhibitors
708:
707:
636:Interactive image
539:CompTox Dashboard
226:
214:
202:
190:
122:
89:
16:Chemical compound
5859:
5809:
5808:
5807:
5800:
5604:Decoy receptors:
5577:Alacizumab pegol
5055:Decoy receptors:
4804:
4709:Stem cell factor
4650:Persephin (PSPN)
4588:Neurturin (NRTN)
4537:
4374:LEVI-04 (p75-Fc)
4371:Decoy receptors:
3985:
3414:
3013:
3007:
2875:
2868:
2861:
2852:
2562:peptide against
2135:(AXL, ALK, LTK))
1951:
1761:Dinutuximab beta
1477:
1444:
1437:
1430:
1421:
1414:
1413:
1411:
1409:
1390:
1384:
1376:
1370:
1369:
1367:
1359:
1353:
1341:
1335:
1334:
1332:
1331:
1307:
1301:
1300:
1264:
1255:
1254:
1252:
1251:
1246:. 16 August 2018
1232:
1223:
1222:
1211:
1205:
1204:
1189:
1180:
1178:
1172:
1161:
1160:
1152:
1135:
1134:
1124:
1100:
1094:
1093:
1091:
1089:
1084:. 25 August 2016
1074:
1068:
1067:
1065:
1063:
1046:
1040:
1039:
1037:
1035:
1020:
928:aldehyde oxidase
916:aldehyde oxidase
883:Pharmacokinetics
853:kinase inhibitor
824:prolongs QT time
812:thrombocytopenia
731:kinase inhibitor
704:
703:
696:
638:
618:
603:
597:
594:
588:
582:
562:
561:
547:
545:
530:
510:
490:
482:
462:
442:
422:
402:
382:
372:
371:
357:
294:
273:aldehyde oxidase
224:
221:
212:
209:
201:
198:
188:
185:
163:
120:
117:
99:
88:
85:
72:
31:
24:
22:
5867:
5866:
5862:
5861:
5860:
5858:
5857:
5856:
5817:
5816:
5815:
5805:
5803:
5795:
5793:
5788:
5733:Midkine (NEGF2)
5611:
5394:
5293:
5062:
5000:ABT-110 (PG110)
4793:
4773:
4683:
4664:
4633:
4602:
4571:
4526:
4378:
4316:ABT-110 (PG110)
4217:
4154:
4116:
3974:
3788:
3769:
3709:
3706:(against FGF23)
3628:
3495:
3399:
3342:
3288:
3201:
3012:
2996:
2965:
2887:
2879:
2849:
2844:
2698:Pi3K inhibitors
2596:mTOR inhibitors
2527:
2308:
2279:(VEGFR, FGFR),
1935:
1699:
1580:
1540:
1462:
1448:
1418:
1417:
1407:
1405:
1404:on 20 June 2018
1392:
1391:
1387:
1377:
1373:
1365:
1361:
1360:
1356:
1342:
1338:
1329:
1327:
1309:
1308:
1304:
1266:
1265:
1258:
1249:
1247:
1234:
1233:
1226:
1213:
1212:
1208:
1191:
1190:
1183:
1173:
1164:
1154:
1153:
1138:
1115:(17): 5459–65.
1102:
1101:
1097:
1087:
1085:
1076:
1075:
1071:
1061:
1059:
1048:
1047:
1043:
1033:
1031:
1022:
1021:
1017:
1012:
968:
949:
912:cytochrome P450
897:plasma proteins
893:Bioavailability
885:
867:(PDGFR) alpha,
849:
844:
820:
793:
791:Adverse effects
765:(radioiodine).
751:
699:
697:
694:(what is this?)
691:
686:
683:
678:
673:
672:
661:
658:
653:
652:
641:
616:
606:
600:
591:
585:
565:
541:
533:
513:
493:
465:
445:
425:
405:
385:
368:
360:
340:
337:
332:
331:
292:
275:, non-enzymatic
254:Protein binding
248:85% (estimated)
244:Bioavailability
236:Pharmacokinetic
230:
167:
135:
128:
109:
102:
46:Lenvima, others
17:
12:
11:
5:
5865:
5863:
5855:
5854:
5849:
5844:
5839:
5834:
5829:
5819:
5818:
5814:
5813:
5790:
5789:
5787:
5786:
5776:
5775:
5770:
5763:Thrombopoietin
5760:
5755:
5750:
5745:
5740:
5735:
5730:
5725:
5720:
5706:
5701:
5696:
5691:
5684:Erythropoietin
5681:
5643:
5638:
5628:
5626:Adrenomedullin
5619:
5617:
5613:
5612:
5610:
5609:
5600:
5599:
5594:
5589:
5584:
5579:
5570:
5569:
5564:
5559:
5554:
5549:
5544:
5539:
5534:
5529:
5524:
5519:
5514:
5509:
5504:
5499:
5494:
5489:
5484:
5479:
5474:
5469:
5460:
5459:
5450:
5449:
5427:
5422:
5417:
5408:
5406:
5400:
5399:
5396:
5395:
5393:
5392:
5387:
5382:
5377:
5372:
5367:
5362:
5357:
5352:
5347:
5342:
5337:
5332:
5323:
5322:
5317:
5312:
5303:
5301:
5295:
5294:
5292:
5291:
5286:
5281:
5276:
5271:
5266:
5261:
5256:
5251:
5246:
5241:
5236:
5231:
5222:
5221:
5212:
5211:
5206:
5201:
5192:
5191:
5186:
5181:
5176:
5171:
5166:
5161:
5156:
5151:
5146:
5141:
5136:
5131:
5126:
5121:
5116:
5111:
5106:
5101:
5096:
5091:
5089:4'-DMA-7,8-DHF
5086:
5081:
5072:
5070:
5064:
5063:
5061:
5060:
5051:
5050:
5038:
5037:
5032:
5027:
5022:
5017:
5012:
5007:
5002:
4983:
4982:
4976:
4971:
4966:
4961:
4956:
4951:
4946:
4941:
4936:
4931:
4926:
4921:
4916:
4911:
4906:
4897:
4896:
4887:
4886:
4881:
4876:
4871:
4862:
4861:
4856:
4851:
4849:Gambogic amide
4846:
4841:
4836:
4831:
4826:
4821:
4812:
4810:
4801:
4795:
4794:
4792:
4791:
4783:
4781:
4775:
4774:
4772:
4771:
4766:
4761:
4756:
4751:
4746:
4741:
4736:
4731:
4726:
4721:
4712:
4711:
4706:
4697:
4695:
4689:
4688:
4685:
4684:
4682:
4681:
4672:
4670:
4666:
4665:
4663:
4662:
4653:
4652:
4643:
4641:
4635:
4634:
4632:
4631:
4622:
4621:
4619:Artemin (ARTN)
4612:
4610:
4604:
4603:
4601:
4600:
4591:
4590:
4581:
4579:
4573:
4572:
4570:
4569:
4560:
4559:
4554:
4545:
4543:
4534:
4528:
4527:
4525:
4524:
4519:
4514:
4505:
4504:
4499:
4494:
4489:
4484:
4479:
4474:
4469:
4464:
4459:
4454:
4449:
4444:
4439:
4434:
4429:
4420:
4419:
4397:
4388:
4386:
4380:
4379:
4377:
4376:
4367:
4366:
4354:
4353:
4348:
4343:
4338:
4333:
4328:
4323:
4318:
4306:
4305:
4300:
4295:
4290:
4281:
4280:
4275:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4231:
4229:
4223:
4222:
4219:
4218:
4216:
4215:
4210:
4201:
4200:
4162:
4160:
4156:
4155:
4153:
4152:
4146:
4137:
4136:
4126:
4124:
4118:
4117:
4115:
4114:
4108:
4103:
4098:
4093:
4088:
4083:
4078:
4073:
4064:
4063:
4058:
4053:
4048:
4043:
4034:
4033:
4028:
4023:
4018:
4013:
4008:
4003:
3993:
3991:
3982:
3976:
3975:
3973:
3972:
3967:
3962:
3957:
3952:
3947:
3942:
3933:
3932:
3927:
3922:
3917:
3912:
3907:
3902:
3897:
3892:
3887:
3882:
3877:
3872:
3867:
3862:
3857:
3852:
3847:
3842:
3837:
3828:
3827:
3818:
3817:
3812:
3802:
3800:
3794:
3793:
3790:
3789:
3787:
3786:
3777:
3775:
3771:
3770:
3768:
3767:
3762:
3728:
3719:
3717:
3711:
3710:
3708:
3707:
3697:
3696:
3691:
3686:
3681:
3647:
3638:
3636:
3630:
3629:
3627:
3626:
3617:
3616:
3611:
3602:
3601:
3596:
3591:
3586:
3581:
3576:
3514:
3505:
3503:
3497:
3496:
3494:
3493:
3488:
3483:
3478:
3473:
3431:
3422:
3420:
3411:
3405:
3404:
3401:
3400:
3398:
3397:
3371:
3366:
3361:
3352:
3350:
3344:
3343:
3341:
3340:
3335:
3330:
3321:
3320:
3298:
3296:
3290:
3289:
3287:
3286:
3281:
3276:
3271:
3266:
3257:
3256:
3251:
3246:
3241:
3236:
3231:
3222:
3221:
3211:
3209:
3203:
3202:
3200:
3199:
3194:
3189:
3184:
3179:
3174:
3169:
3164:
3159:
3154:
3145:
3144:
3139:
3134:
3129:
3124:
3119:
3114:
3109:
3104:
3099:
3094:
3089:
3084:
3079:
3070:
3069:
3064:
3059:
3054:
3049:
3044:
3039:
3034:
3029:
3019:
3017:
3004:
2998:
2997:
2995:
2994:
2989:
2984:
2975:
2973:
2967:
2966:
2964:
2963:
2957:
2947:
2946:
2941:
2936:
2927:
2926:
2924:Angiopoietin 3
2921:
2919:Angiopoietin 2
2912:
2911:
2909:Angiopoietin 4
2906:
2904:Angiopoietin 1
2897:
2895:
2889:
2888:
2880:
2878:
2877:
2870:
2863:
2855:
2846:
2845:
2843:
2842:
2837:
2832:
2827:
2822:
2817:
2812:
2807:
2802:
2797:
2792:
2787:
2782:
2777:
2772:
2767:
2762:
2757:
2752:
2747:
2742:
2737:
2732:
2727:
2726:
2725:
2720:
2715:
2710:
2705:
2695:
2694:
2693:
2688:
2675:
2674:
2673:
2668:
2663:
2658:
2653:
2645:CDK inhibitors
2641:
2640:
2639:
2634:
2629:
2616:
2615:
2614:
2609:
2604:
2592:
2576:
2556:
2544:fusion protein
2539:
2537:
2533:
2532:
2529:
2528:
2526:
2525:
2524:
2523:
2518:
2513:
2508:
2503:
2490:
2489:
2488:
2487:
2482:
2477:
2460:
2459:
2458:
2457:
2452:
2447:
2442:
2429:
2428:
2427:
2426:
2421:
2416:
2411:
2406:
2401:
2396:
2383:
2382:
2376:
2364:
2363:
2362:
2361:
2356:
2351:
2346:
2341:
2336:
2331:
2318:
2316:
2310:
2309:
2307:
2306:
2285:
2284:
2283:(VEGFR, EGFR).
2239:
2238:
2237:
2236:
2231:
2226:
2213:
2212:
2211:
2210:
2205:
2200:
2195:
2190:
2185:
2180:
2175:
2170:
2165:
2160:
2155:
2150:
2137:
2136:
2120:
2114:
2109:
2104:
2099:
2094:
2089:
2084:
2064:
2063:
2062:
2061:
2056:
2051:
2041:HER1/EGFR and
2037:
2036:
2030:
2025:
2020:
2015:
2010:
2005:
2000:
1995:
1990:
1985:
1980:
1975:
1959:
1957:
1948:
1941:
1940:
1937:
1936:
1934:
1933:
1928:
1923:
1918:
1913:
1908:
1903:
1898:
1893:
1888:
1883:
1878:
1873:
1868:
1863:
1858:
1853:
1848:
1843:
1838:
1833:
1828:
1823:
1818:
1813:
1808:
1803:
1798:
1793:
1788:
1783:
1778:
1773:
1768:
1763:
1758:
1753:
1748:
1743:
1738:
1733:
1728:
1723:
1720:+hyaluronidase
1713:
1707:
1705:
1701:
1700:
1698:
1697:
1680:
1679:
1653:
1648:
1643:
1638:
1633:
1628:
1594:
1592:
1582:
1581:
1579:
1578:
1566:
1560:
1548:
1546:
1542:
1541:
1539:
1538:
1532:
1527:
1524:+hyaluronidase
1507:
1501:
1485:
1483:
1474:
1464:
1463:
1449:
1447:
1446:
1439:
1432:
1424:
1416:
1415:
1385:
1371:
1354:
1336:
1302:
1275:(8): 1326–33.
1256:
1224:
1206:
1203:. 16 May 2016.
1181:
1162:
1136:
1095:
1078:"Kisplyx EPAR"
1069:
1041:
1030:. 21 June 2022
1014:
1013:
1011:
1008:
967:
964:
948:
945:
884:
881:
848:
845:
843:
840:
838:are expected.
819:
816:
792:
789:
755:thyroid cancer
750:
747:
723:thyroid cancer
706:
705:
688:
687:
685:
684:
681:
679:
676:
668:
667:
666:
663:
662:
660:
659:
656:
648:
647:
646:
643:
642:
640:
639:
631:
629:
621:
620:
614:
608:
607:
604:
598:
589:
583:
578:
572:
571:
567:
566:
564:
563:
555:DTXSID50194605
550:
548:
535:
534:
532:
531:
523:
521:
515:
514:
512:
511:
503:
501:
495:
494:
492:
491:
485:as salt:
483:
475:
473:
467:
466:
464:
463:
455:
453:
447:
446:
444:
443:
435:
433:
427:
426:
424:
423:
415:
413:
407:
406:
404:
403:
395:
393:
387:
386:
384:
383:
375:
373:
362:
361:
359:
358:
350:
348:
342:
341:
339:
338:
335:
327:
326:
325:
322:
321:
317:
316:
306:
300:
299:
296:
287:
286:
283:
277:
276:
266:
260:
259:
256:
250:
249:
246:
240:
239:
232:
231:
229:
228:
219:
207:
196:
182:
180:
174:
173:
169:
168:
166:
165:
152:
150:
144:
143:
138:
136:administration
130:
129:
127:
126:
124:
114:
112:
104:
103:
101:
100:
82:
80:
74:
73:
66:
56:
55:
52:
48:
47:
44:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
5864:
5853:
5850:
5848:
5845:
5843:
5840:
5838:
5837:Cyclopropanes
5835:
5833:
5830:
5828:
5825:
5824:
5822:
5812:
5802:
5798:
5784:
5781:
5778:
5777:
5774:
5771:
5768:
5764:
5761:
5759:
5756:
5754:
5751:
5749:
5746:
5744:
5741:
5739:
5736:
5734:
5731:
5729:
5726:
5724:
5721:
5718:
5714:
5710:
5707:
5705:
5702:
5700:
5697:
5695:
5692:
5689:
5685:
5682:
5679:
5675:
5671:
5667:
5663:
5659:
5655:
5651:
5647:
5644:
5642:
5639:
5636:
5632:
5629:
5627:
5624:
5621:
5620:
5618:
5614:
5608:
5605:
5602:
5601:
5598:
5595:
5593:
5590:
5588:
5585:
5583:
5580:
5578:
5575:
5572:
5571:
5568:
5565:
5563:
5560:
5558:
5555:
5553:
5550:
5548:
5545:
5543:
5540:
5538:
5535:
5533:
5530:
5528:
5525:
5523:
5520:
5518:
5515:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5488:
5485:
5483:
5480:
5478:
5475:
5473:
5470:
5468:
5465:
5462:
5461:
5458:
5457:Cyclotraxin B
5455:
5452:
5451:
5447:
5443:
5439:
5435:
5431:
5428:
5426:
5423:
5421:
5418:
5416:
5413:
5410:
5409:
5407:
5405:
5401:
5391:
5388:
5386:
5383:
5381:
5378:
5376:
5373:
5371:
5370:Larotrectinib
5368:
5366:
5363:
5361:
5358:
5356:
5353:
5351:
5348:
5346:
5343:
5341:
5338:
5336:
5333:
5331:
5328:
5325:
5324:
5321:
5318:
5316:
5313:
5311:
5308:
5305:
5304:
5302:
5300:
5296:
5290:
5287:
5285:
5282:
5280:
5277:
5275:
5272:
5270:
5269:Larotrectinib
5267:
5265:
5262:
5260:
5257:
5255:
5252:
5250:
5247:
5245:
5242:
5240:
5237:
5235:
5232:
5230:
5227:
5224:
5223:
5220:
5217:
5214:
5213:
5210:
5207:
5205:
5204:Cyclotraxin B
5202:
5200:
5197:
5194:
5193:
5190:
5187:
5185:
5182:
5180:
5177:
5175:
5172:
5170:
5167:
5165:
5162:
5160:
5157:
5155:
5152:
5150:
5147:
5145:
5142:
5140:
5137:
5135:
5132:
5130:
5127:
5125:
5122:
5120:
5117:
5115:
5114:Amitriptyline
5112:
5110:
5107:
5105:
5102:
5100:
5097:
5095:
5092:
5090:
5087:
5085:
5082:
5080:
5077:
5074:
5073:
5071:
5069:
5065:
5059:
5056:
5053:
5052:
5049:
5046:
5043:
5040:
5039:
5036:
5033:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5008:
5006:
5003:
5001:
4998:
4994:
4991:
4990:Against TrkA:
4988:
4985:
4984:
4980:
4977:
4975:
4972:
4970:
4967:
4965:
4962:
4960:
4957:
4955:
4952:
4950:
4947:
4945:
4944:Larotrectinib
4942:
4940:
4937:
4935:
4932:
4930:
4927:
4925:
4922:
4920:
4917:
4915:
4912:
4910:
4907:
4905:
4902:
4899:
4898:
4895:
4892:
4889:
4888:
4885:
4882:
4880:
4877:
4875:
4874:Dexamethasone
4872:
4870:
4867:
4864:
4863:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4840:
4837:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4819:Amitriptyline
4817:
4814:
4813:
4811:
4809:
4805:
4802:
4800:
4796:
4789:
4785:
4784:
4782:
4780:
4776:
4770:
4767:
4765:
4762:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4740:
4737:
4735:
4732:
4730:
4727:
4725:
4722:
4720:
4717:
4714:
4713:
4710:
4707:
4705:
4702:
4699:
4698:
4696:
4694:
4690:
4680:
4677:
4674:
4673:
4671:
4667:
4661:
4658:
4655:
4654:
4651:
4648:
4645:
4644:
4642:
4640:
4636:
4630:
4627:
4624:
4623:
4620:
4617:
4614:
4613:
4611:
4609:
4605:
4599:
4596:
4593:
4592:
4589:
4586:
4583:
4582:
4580:
4578:
4574:
4568:
4565:
4562:
4561:
4558:
4555:
4553:
4550:
4547:
4546:
4544:
4542:
4538:
4535:
4533:
4529:
4523:
4520:
4518:
4515:
4513:
4510:
4507:
4506:
4503:
4500:
4498:
4495:
4493:
4490:
4488:
4485:
4483:
4480:
4478:
4475:
4473:
4470:
4468:
4465:
4463:
4460:
4458:
4455:
4453:
4450:
4448:
4445:
4443:
4440:
4438:
4435:
4433:
4430:
4428:
4425:
4422:
4421:
4417:
4413:
4409:
4405:
4401:
4398:
4396:
4393:
4390:
4389:
4387:
4385:
4381:
4375:
4372:
4369:
4368:
4365:
4362:
4359:
4356:
4355:
4352:
4349:
4347:
4344:
4342:
4339:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4311:
4308:
4307:
4304:
4301:
4299:
4296:
4294:
4293:Dexamethasone
4291:
4289:
4286:
4283:
4282:
4279:
4276:
4274:
4271:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4233:
4232:
4230:
4228:
4224:
4214:
4211:
4209:
4206:
4203:
4202:
4198:
4194:
4190:
4186:
4182:
4178:
4174:
4170:
4167:
4164:
4163:
4161:
4157:
4150:
4147:
4145:
4142:
4139:
4138:
4135:
4131:
4128:
4127:
4125:
4123:
4119:
4112:
4109:
4107:
4104:
4102:
4099:
4097:
4094:
4092:
4089:
4087:
4084:
4082:
4079:
4077:
4074:
4072:
4069:
4066:
4065:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4039:
4036:
4035:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4012:
4009:
4007:
4004:
4002:
4001:des(1-3)IGF-1
3998:
3995:
3994:
3992:
3990:
3986:
3983:
3981:
3977:
3971:
3968:
3966:
3965:Telisotuzumab
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3941:
3938:
3935:
3934:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3901:
3898:
3896:
3893:
3891:
3888:
3886:
3883:
3881:
3878:
3876:
3873:
3871:
3868:
3866:
3863:
3861:
3858:
3856:
3853:
3851:
3848:
3846:
3843:
3841:
3838:
3836:
3833:
3830:
3829:
3826:
3823:
3822:Potentiators:
3820:
3819:
3816:
3813:
3811:
3807:
3804:
3803:
3801:
3799:
3795:
3785:
3782:
3779:
3778:
3776:
3772:
3766:
3763:
3760:
3756:
3752:
3748:
3744:
3740:
3736:
3732:
3729:
3727:
3724:
3721:
3720:
3718:
3716:
3712:
3705:
3702:
3699:
3698:
3695:
3692:
3690:
3687:
3685:
3684:Selpercatinib
3682:
3679:
3675:
3671:
3667:
3663:
3659:
3655:
3651:
3648:
3646:
3643:
3640:
3639:
3637:
3635:
3631:
3625:
3622:
3619:
3618:
3615:
3612:
3610:
3607:
3604:
3603:
3600:
3597:
3595:
3592:
3590:
3589:Selpercatinib
3587:
3585:
3582:
3580:
3577:
3574:
3570:
3566:
3562:
3558:
3554:
3550:
3546:
3542:
3538:
3534:
3530:
3526:
3522:
3518:
3515:
3513:
3510:
3507:
3506:
3504:
3502:
3498:
3492:
3489:
3487:
3484:
3482:
3481:Selpercatinib
3479:
3477:
3474:
3471:
3467:
3463:
3459:
3455:
3451:
3447:
3443:
3439:
3435:
3432:
3430:
3427:
3424:
3423:
3421:
3419:
3415:
3412:
3410:
3406:
3395:
3391:
3387:
3383:
3379:
3375:
3372:
3370:
3367:
3365:
3362:
3360:
3357:
3354:
3353:
3351:
3349:
3345:
3339:
3336:
3334:
3331:
3329:
3326:
3323:
3322:
3318:
3314:
3310:
3306:
3303:
3300:
3299:
3297:
3295:
3291:
3285:
3282:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3262:
3259:
3258:
3255:
3252:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3227:
3224:
3223:
3220:
3216:
3213:
3212:
3210:
3208:
3204:
3198:
3195:
3193:
3190:
3188:
3185:
3183:
3180:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3158:
3157:Depatuxizumab
3155:
3153:
3150:
3147:
3146:
3143:
3140:
3138:
3135:
3133:
3130:
3128:
3125:
3123:
3120:
3118:
3115:
3113:
3110:
3108:
3105:
3103:
3100:
3098:
3095:
3093:
3090:
3088:
3085:
3083:
3080:
3078:
3075:
3072:
3071:
3068:
3065:
3063:
3060:
3058:
3055:
3053:
3050:
3048:
3045:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3024:
3021:
3020:
3018:
3016:
3008:
3005:
3003:
2999:
2993:
2990:
2988:
2985:
2983:
2980:
2977:
2976:
2974:
2972:
2968:
2961:
2958:
2955:
2952:
2949:
2948:
2945:
2942:
2940:
2937:
2935:
2932:
2929:
2928:
2925:
2922:
2920:
2917:
2914:
2913:
2910:
2907:
2905:
2902:
2899:
2898:
2896:
2894:
2890:
2886:
2883:
2876:
2871:
2869:
2864:
2862:
2857:
2856:
2853:
2841:
2838:
2836:
2833:
2831:
2828:
2826:
2823:
2821:
2818:
2816:
2813:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2791:
2788:
2786:
2783:
2781:
2778:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2755:Larotrectinib
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2724:
2721:
2719:
2716:
2714:
2711:
2709:
2706:
2704:
2701:
2700:
2699:
2696:
2692:
2689:
2687:
2684:
2683:
2682:
2680:
2676:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2648:
2647:
2646:
2642:
2638:
2635:
2633:
2630:
2628:
2625:
2624:
2623:
2621:
2617:
2613:
2610:
2608:
2607:Ridaforolimus
2605:
2603:
2600:
2599:
2598:
2597:
2593:
2590:
2586:
2585:
2581:
2577:
2574:
2570:
2569:
2565:
2561:
2557:
2554:
2550:
2549:
2545:
2541:
2540:
2538:
2534:
2522:
2519:
2517:
2516:Pirtobrutinib
2514:
2512:
2511:Orelabrutinib
2509:
2507:
2504:
2502:
2501:Acalabrutinib
2499:
2498:
2497:
2496:
2492:
2491:
2486:
2483:
2481:
2478:
2476:
2473:
2472:
2471:
2470:
2466:
2462:
2461:
2456:
2453:
2451:
2448:
2446:
2443:
2441:
2438:
2437:
2436:
2435:
2431:
2430:
2425:
2422:
2420:
2417:
2415:
2412:
2410:
2407:
2405:
2402:
2400:
2397:
2395:
2392:
2391:
2390:
2389:
2385:
2384:
2380:
2377:
2375:
2371:
2370:
2366:
2365:
2360:
2357:
2355:
2352:
2350:
2347:
2345:
2342:
2340:
2337:
2335:
2332:
2330:
2327:
2326:
2325:
2324:
2320:
2319:
2317:
2315:
2311:
2304:
2300:
2296:
2293:
2291:
2287:
2286:
2282:
2278:
2277:Selpercatinib
2274:
2273:Repotrectinib
2270:
2266:
2262:
2261:Larotrectinib
2258:
2254:
2250:
2247:
2245:
2241:
2240:
2235:
2232:
2230:
2227:
2225:
2222:
2221:
2220:
2219:
2215:
2214:
2209:
2206:
2204:
2201:
2199:
2196:
2194:
2191:
2189:
2186:
2184:
2181:
2179:
2176:
2174:
2171:
2169:
2166:
2164:
2161:
2159:
2156:
2154:
2151:
2149:
2146:
2145:
2144:
2143:
2139:
2138:
2134:
2130:
2126:
2125:
2121:
2118:
2115:
2113:
2110:
2108:
2105:
2103:
2100:
2098:
2095:
2093:
2090:
2088:
2085:
2083:
2079:
2078:
2074:
2069:
2068:RTK class III
2066:
2065:
2060:
2057:
2055:
2052:
2050:
2047:
2046:
2045:
2044:
2039:
2038:
2034:
2031:
2029:
2026:
2024:
2021:
2019:
2016:
2014:
2011:
2009:
2006:
2004:
2001:
1999:
1996:
1994:
1991:
1989:
1986:
1984:
1981:
1979:
1976:
1974:
1970:
1969:
1964:
1961:
1960:
1958:
1956:
1952:
1949:
1946:
1942:
1932:
1929:
1927:
1924:
1922:
1919:
1917:
1914:
1912:
1909:
1907:
1904:
1902:
1899:
1897:
1894:
1892:
1889:
1887:
1884:
1882:
1879:
1877:
1874:
1872:
1869:
1867:
1864:
1862:
1859:
1857:
1854:
1852:
1851:Pembrolizumab
1849:
1847:
1844:
1842:
1839:
1837:
1834:
1832:
1829:
1827:
1824:
1822:
1819:
1817:
1816:Mogamulizumab
1814:
1812:
1809:
1807:
1804:
1802:
1799:
1797:
1794:
1792:
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1772:
1769:
1767:
1764:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1721:
1717:
1714:
1712:
1709:
1708:
1706:
1702:
1695:
1691:
1690:
1685:
1682:
1681:
1677:
1673:
1672:
1667:
1663:
1662:
1657:
1654:
1652:
1649:
1647:
1644:
1642:
1639:
1637:
1636:Mosunetuzumab
1634:
1632:
1629:
1627:
1623:
1622:
1617:
1616:Mosunetuzumab
1613:
1609:
1605:
1604:
1599:
1596:
1595:
1593:
1591:
1587:
1583:
1576:
1572:
1571:
1567:
1564:
1561:
1559:
1555:
1554:
1550:
1549:
1547:
1543:
1536:
1533:
1531:
1528:
1525:
1521:
1517:
1513:
1512:
1508:
1505:
1502:
1500:
1496:
1495:
1490:
1487:
1486:
1484:
1482:
1478:
1475:
1472:
1469:
1465:
1460:
1456:
1452:
1445:
1440:
1438:
1433:
1431:
1426:
1425:
1422:
1403:
1399:
1395:
1389:
1386:
1383:
1381:
1375:
1372:
1364:
1358:
1355:
1352:
1348:
1347:
1340:
1337:
1326:on 2012-02-24
1325:
1321:
1317:
1313:
1306:
1303:
1298:
1294:
1290:
1286:
1282:
1278:
1274:
1270:
1263:
1261:
1257:
1245:
1243:
1237:
1231:
1229:
1225:
1221:. 2015-05-28.
1220:
1216:
1210:
1207:
1202:
1200:
1194:
1188:
1186:
1182:
1177:
1171:
1169:
1167:
1163:
1158:
1157:Austria-Codex
1151:
1149:
1147:
1145:
1143:
1141:
1137:
1132:
1128:
1123:
1118:
1114:
1110:
1106:
1099:
1096:
1083:
1079:
1073:
1070:
1057:
1056:
1055:Health Canada
1051:
1045:
1042:
1029:
1025:
1019:
1016:
1009:
1007:
1004:
1002:
998:
993:
991:
987:
982:
980:
975:
973:
965:
963:
961:
958:
954:
946:
944:
942:
938:
936:
934:
929:
925:
917:
913:
908:
904:
902:
898:
894:
890:
882:
880:
878:
874:
870:
866:
862:
858:
854:
846:
841:
839:
837:
833:
829:
825:
817:
815:
813:
809:
805:
801:
797:
790:
788:
786:
781:
779:
775:
771:
766:
764:
760:
756:
748:
746:
744:
740:
736:
732:
728:
724:
720:
716:
712:
702:
695:
689:
680:
675:
671:
664:
655:
651:
644:
637:
633:
632:
630:
627:
622:
615:
613:
609:
579:
577:
573:
568:
560:
556:
552:
551:
549:
540:
536:
529:
528:ChEMBL1289601
525:
524:
522:
520:
516:
509:
505:
504:
502:
500:
496:
489:
484:
481:
477:
476:
474:
472:
468:
461:
457:
456:
454:
452:
448:
441:
437:
436:
434:
432:
428:
421:
417:
416:
414:
412:
408:
401:
397:
396:
394:
392:
388:
381:
377:
376:
374:
367:
363:
356:
352:
351:
349:
347:
343:
334:
330:
323:
318:
315:
311:
307:
305:
301:
297:
295:
288:
284:
282:
278:
274:
270:
267:
265:
261:
257:
255:
251:
247:
245:
241:
237:
233:
227: Rx-only
220:
218:
208:
206:
197:
194:
184:
183:
181:
179:
175:
170:
162:
157:
154:
153:
151:
149:
145:
142:
139:
137:
131:
125:
116:
115:
113:
111:
105:
98:
93:
84:
83:
81:
79:
75:
71:
67:
65:
61:
57:
53:
49:
45:
43:
39:
36:Clinical data
34:
30:
25:
5852:Carboxamides
5842:Chloroarenes
5832:Orphan drugs
5783:Cerebrolysin
5779:
5753:Pleiotrophin
5709:Interleukins
5622:
5603:
5573:
5501:
5492:Fruquintinib
5482:Cabozantinib
5463:
5453:
5411:
5375:Lestaurtinib
5326:
5306:
5274:Lestaurtinib
5225:
5215:
5196:Antagonists:
5195:
5129:Deoxygedunin
5084:3,7,8,2'-THF
5075:
5054:
5045:Against NGF:
5044:
5041:
4997:Against NGF:
4996:
4989:
4986:
4949:Lestaurtinib
4900:
4890:
4884:Testosterone
4866:Antagonists:
4865:
4815:
4715:
4700:
4675:
4656:
4646:
4625:
4615:
4594:
4584:
4563:
4548:
4508:
4451:
4423:
4391:
4370:
4361:Against NGF:
4360:
4357:
4313:Against NGF:
4312:
4309:
4303:Testosterone
4285:Antagonists:
4284:
4234:
4204:
4165:
4140:
4129:
4106:Teprotumumab
4067:
4037:
3996:
3945:Ficlatuzumab
3940:Emibetuzumab
3936:
3890:JNJ-38877605
3860:Cabozantinib
3831:
3821:
3810:Fosgonimeton
3805:
3780:
3722:
3700:
3641:
3624:Infigratinib
3620:
3605:
3508:
3425:
3359:Betacellulin
3355:
3338:Seribantumab
3324:
3301:
3260:
3225:
3219:Unknown/none
3218:
3214:
3148:
3073:
3032:Betacellulin
3027:Amphiregulin
3022:
3014:(ErbB1/HER1)
2978:
2950:
2930:
2916:Antagonists:
2915:
2900:
2893:Angiopoietin
2795:Pexidartinib
2780:Odronextamab
2759:
2750:Gilteritinib
2730:Cabozantinib
2677:
2643:
2618:
2612:Temsirolimus
2594:
2578:
2560:proapoptotic
2558:
2542:
2521:Zanubrutinib
2493:
2463:
2432:
2409:Lestaurtinib
2388:Janus kinase
2386:
2367:
2321:
2314:Non-receptor
2295:Cabozantinib
2288:
2257:Infigratinib
2242:
2216:
2162:
2158:Fruquintinib
2140:
2133:Gilteritinib
2129:Lestaurtinib
2122:
2071:
2040:
2013:Mobocertinib
1978:Aumolertinib
1966:
1931:Tremelimumab
1916:Tislelizumab
1871:Retifanlimab
1746:Blinatumomab
1716:Atezolizumab
1687:
1669:
1659:
1641:Obinutuzumab
1619:
1601:
1568:
1551:
1509:
1492:
1406:. Retrieved
1402:the original
1397:
1388:
1379:
1374:
1357:
1344:
1339:
1328:. Retrieved
1324:the original
1319:
1315:
1305:
1272:
1268:
1248:. Retrieved
1239:
1209:
1196:
1179:for Lenvima.
1156:
1112:
1108:
1098:
1086:. Retrieved
1081:
1072:
1060:. Retrieved
1058:. 4 May 2016
1053:
1044:
1032:. Retrieved
1027:
1018:
1005:
994:
983:
976:
969:
950:
939:
932:
921:
889:blood plasma
886:
850:
842:Pharmacology
821:
818:Interactions
796:Hypertension
794:
782:
767:
752:
749:Medical uses
733:against the
714:
710:
709:
698:
692:
291:Elimination
178:Legal status
172:Legal status
78:License data
5743:Oncomodulin
5607:Aflibercept
5597:Ranibizumab
5592:Ramucirumab
5582:Bevacizumab
5574:Antibodies:
5532:Regorafenib
5472:Altiratinib
5385:ONO-5390556
5355:Entrectinib
5330:Altiratinib
5284:ONO-5390556
5254:Entrectinib
5229:Altiratinib
5015:Frunevetmab
4987:Antibodies:
4964:ONO-5390556
4929:Entrectinib
4904:Altiratinib
4859:Tavilermide
4754:Quizartinib
4693:SCF (c-Kit)
4517:Ramucirumab
4509:Antibodies:
4482:Quizartinib
4432:Avapritinib
4395:Becaplermin
4331:Frunevetmab
4310:Antibodies:
4213:Trofinetide
4144:Dusigitumab
4141:Antibodies:
4096:Robatumumab
4086:Figitumumab
4081:Dalotuzumab
4076:Cixutumumab
4068:Antibodies:
3960:Rilotumumab
3955:Onartuzumab
3950:Flanvotumab
3937:Antibodies:
3905:PF-04217903
3835:Altiratinib
3798:HGF (c-Met)
3701:Antibodies:
3606:Antibodies:
3328:Duligotumab
3325:Antibodies:
3239:Trastuzumab
3229:Ertumaxomab
3226:Antibodies:
3197:Zalutumumab
3192:Panitumumab
3187:Nimotuzumab
3182:Necitumumab
3172:Imgatuzumab
3149:Antibodies:
3132:Osimertinib
3097:Dacomitinib
2992:Dapiclermin
2951:Antibodies:
2934:Altiratinib
2825:Tebentafusp
2805:Regorafenib
2800:Quizartinib
2790:Pemigatinib
2770:Midostaurin
2745:Erdafitinib
2740:Entrectinib
2723:Parsaclisib
2671:Trilaciclib
2661:Palbociclib
2656:Dalpiciclib
2651:Abemaciclib
2553:Aflibercept
2480:Entrectinib
2450:Selumetinib
2445:Cobimetinib
2440:Binimetinib
2424:Ruxolitinib
2414:Momelotinib
2394:Baricitinib
2292:inhibitors:
2269:Pralsetinib
2265:Pemigatinib
2253:Futibatinib
2249:Entrectinib
2246:inhibitors:
2178:Regorafenib
2082:Avapritinib
2028:Rociletinib
2023:Osimertinib
1988:Dacomitinib
1926:Toripalimab
1911:Teclistamab
1901:Talquetamab
1896:Tafasitamab
1891:Sugemalimab
1886:Serplulimab
1876:Sabatolimab
1866:Ramucirumab
1861:Prolgolimab
1831:Necitumumab
1786:Epcoritamab
1766:Dostarlimab
1756:Daratumumab
1711:Amivantamab
1676:Alemtuzumab
1666:Brentuximab
1656:Tositumomab
1631:Ibritumomab
1612:Elranatamab
1575:Bevacizumab
1563:Edrecolomab
1558:Catumaxomab
1520:Trastuzumab
1504:Panitumumab
1346:NCT01321554
979:orphan drug
960:857890-39-2
808:hypotension
619: g·mol
508:CHEBI:85994
355:417716-92-8
320:Identifiers
281:Metabolites
51:Other names
42:Trade names
5821:Categories
5562:Vandetanib
5527:Rebastinib
5522:Pegaptanib
5512:Nintedanib
5502:Lenvatinib
5467:Agerafenib
5420:Ripretinib
5345:CH-7057288
5244:CH-7057288
5109:7,8,3'-THF
5104:7,8,2'-THF
5030:Ranevetmab
5020:Fulranumab
4974:Rebastinib
4919:CH-7057288
4834:Cenegermin
4719:Agerafenib
4679:Agerafenib
4660:Vandetanib
4629:Vandetanib
4598:Vandetanib
4567:Vandetanib
4512:Olaratumab
4487:Ripretinib
4467:Nintedanib
4452:Lenvatinib
4442:Crenolanib
4427:Agerafenib
4346:Ranevetmab
4336:Fulranumab
4253:Cenegermin
4227:LNGF (p75)
4149:Xentuzumab
4111:Xentuzumab
4056:NVP-AEW541
4051:NVP-ADW742
4046:Linsitinib
4041:BMS-754807
4026:Mecasermin
3925:Tivantinib
3915:PHA-665752
3910:PF-2341066
3880:Golvatinib
3870:Crizotinib
3865:Capmatinib
3855:BMS-777607
3850:Amuvatinib
3726:Ersofermin
3689:Sprifermin
3645:Ersofermin
3594:Sprifermin
3584:Repifermin
3579:Palifermin
3512:Ersofermin
3491:Velafermin
3476:Repifermin
3429:Ersofermin
3348:ErbB4/HER4
3333:Patritumab
3294:ErbB3/HER3
3274:Mubritinib
3234:Pertuzumab
3207:ErbB2/HER2
3137:Vandetanib
3092:Canertinib
3087:Brigatinib
3082:Agerafenib
3062:Nepidermin
3057:Murodermin
3047:Epiregulin
3002:EGF (ErbB)
2960:Nesvacumab
2954:Evinacumab
2944:Rebastinib
2885:modulators
2840:Venetoclax
2835:Vandetanib
2810:Ripretinib
2775:Nintedanib
2760:Lenvatinib
2735:Capmatinib
2718:Idelalisib
2708:Copanlisib
2681:inhibitors
2666:Ribociclib
2637:Vismodegib
2622:inhibitors
2602:Everolimus
2568:prohibitin
2485:Lorlatinib
2475:Crizotinib
2455:Trametinib
2419:Pacritinib
2404:Filgotinib
2399:Fedratinib
2303:Crizotinib
2299:Capmatinib
2281:Vandetanib
2229:Brigatinib
2208:Vandetanib
2168:Nintedanib
2163:Lenvatinib
2102:Ripretinib
2033:Vandetanib
2008:Lazertinib
1983:Brigatinib
1906:Tarlatamab
1841:Olaratumab
1801:Isatuximab
1796:Ipilimumab
1776:Elotuzumab
1771:Durvalumab
1751:Cemiplimab
1741:Bermekimab
1731:Axatilimab
1646:Ofatumumab
1626:Glofitamab
1608:Glofitamab
1516:Pertuzumab
1330:2009-09-02
1250:2018-08-16
1010:References
997:everolimus
957:CAS number
871:, and the
774:everolimus
759:metastatic
711:Lenvatinib
624:3D model (
612:Molar mass
460:EE083865G2
431:ChemSpider
391:IUPHAR/BPS
346:CAS Number
329:IUPAC name
264:Metabolism
97:Lenvatinib
21:Lenvatinib
5587:Icrucumab
5567:WHI-P 154
5557:Tivozanib
5552:Toceranib
5547:Sunitinib
5542:Sorafenib
5537:Semaxanib
5517:Pazopanib
5507:Motesanib
5497:Lapatinib
5487:Cediranib
5425:Telbermin
5412:Agonists:
5360:GZ-389988
5340:CE-245677
5307:Agonists:
5259:GZ-389988
5239:CE-245677
5139:Diosmetin
5076:Agonists:
5042:Aptamers:
5035:Tanezumab
5010:Fasinumab
4954:Milciclib
4934:GZ-389988
4914:CE-245677
4816:Agonists:
4769:Toceranib
4764:Sunitinib
4759:Sorafenib
4749:Pazopanib
4744:Nilotinib
4739:Masitinib
4729:Dasatinib
4701:Agonists:
4647:Agonists:
4616:Agonists:
4585:Agonists:
4557:Liatermin
4549:Agonists:
4532:RET (GFL)
4522:Tovetumab
4502:Toceranib
4497:Sorafenib
4492:Sunitinib
4477:Radotinib
4472:Pazopanib
4462:Motesanib
4457:Masitinib
4392:Agonists:
4358:Aptamers:
4351:Tanezumab
4326:Fasinumab
4235:Agonists:
4091:Ganitumab
4011:IGF-1 LR3
3930:Volitinib
3885:INCB28060
3875:Foretinib
3781:Agonists:
3765:Trafermin
3723:Agonists:
3704:Burosumab
3694:Trafermin
3642:Agonists:
3609:Aprutumab
3599:Trafermin
3561:10 (KGF2)
3509:Agonists:
3486:Trafermin
3466:10 (KGF2)
3426:Agonists:
3356:Agonists:
3302:Agonists:
3284:Tucatinib
3279:Neratinib
3269:Lapatinib
3177:Matuzumab
3167:Futuximab
3152:Cetuximab
3142:WHI-P 154
3127:Neratinib
3122:Lapatinib
3112:Grandinin
3107:Gefitinib
3102:Erlotinib
2979:Agonists:
2939:CE-245677
2901:Agonists:
2830:Tepotinib
2820:Sunitinib
2815:Sorafenib
2785:Pazopanib
2765:Masitinib
2713:Duvelisib
2703:Alpelisib
2691:Sotorasib
2686:Adagrasib
2632:Sonidegib
2627:Glasdegib
2573:Adipotide
2506:Ibrutinib
2379:Dasatinib
2374:Bosutinib
2359:Radotinib
2354:Ponatinib
2349:Nilotinib
2339:Dasatinib
2334:Bosutinib
2329:Asciminib
2297:(VEGFR),
2255:(FGFR2),
2234:Ceritinib
2224:Alectinib
2203:Toceranib
2198:Tivozanib
2193:Sunitinib
2188:Sorafenib
2183:Semaxanib
2173:Pazopanib
2153:Cediranib
2117:Toceranib
2112:Sunitinib
2107:Sorafenib
2097:Pazopanib
2092:Masitinib
2059:Tucatinib
2054:Neratinib
2049:Lapatinib
2018:Olmutinib
1998:Gefitinib
1993:Erlotinib
1968:HER1/EGFR
1836:Nivolumab
1826:Naxitamab
1651:Rituximab
1499:Cetuximab
1494:HER1/EGFR
1408:9 January
1297:206497491
1215:"Lenvima"
1088:7 January
947:Chemistry
899:, mainly
745:kinases.
727:Eisai Co.
304:Excretion
293:half-life
134:Routes of
108:Pregnancy
70:Monograph
64:Drugs.com
5811:Medicine
5769:instead)
5758:Renalase
5719:instead)
5690:instead)
5637:instead)
5477:Axitinib
5446:D (FIGF)
5390:PLX-7486
5380:ONO-4474
5335:AZD-6918
5289:PLX-7486
5279:ONO-4474
5234:AZD-6918
5216:Ligands:
5134:Deprenyl
5094:7,3'-DHF
5025:MEDI-578
5005:ASP-6294
4969:PLX-7486
4959:ONO-4474
4909:AZD-6918
4869:ALE-0540
4790:instead.
4734:Imatinib
4724:Axitinib
4704:Ancestim
4669:Unsorted
4447:Imatinib
4437:Axitinib
4341:MEDI-578
4321:ASP-6294
4288:ALE-0540
4130:Agonists
4071:AVE-1642
3997:Agonists
3920:SU-11274
3806:Agonists
3784:FGF15/19
3774:Unsorted
3739:2 (bFGF)
3658:2 (bFGF)
3525:2 (bFGF)
3442:2 (bFGF)
3264:Afatinib
3215:Agonists
3117:Icotinib
3077:Afatinib
3023:Agonists
2620:hedgehog
2582:against
2580:exotoxin
2546:against
2495:Bruton's
2344:Imatinib
2267:(FGFR),
2263:(NTRK),
2148:Axitinib
2087:Axitinib
2043:HER2/neu
2003:Icotinib
1973:Afatinib
1947:("-nib")
1726:Avelumab
1598:lymphoid
1590:lymphoma
1586:Leukemia
1511:HER2/neu
1473:("-mab")
1289:24914245
1131:18765537
1034:10 April
986:U.S. FDA
953:mesylate
836:inducers
701:(verify)
411:DrugBank
298:28 hours
148:ATC code
141:By mouth
110:category
92:DailyMed
5646:Ephrins
5350:DS-6051
5249:DS-6051
5154:LM22A-4
5144:DMAQ-B1
5099:7,8-DHF
5079:3,7-DHF
5048:RBM-004
4993:GBR-900
4924:DS-6051
4894:VM-902A
4364:RBM-004
4061:OSl-906
4021:Insulin
3900:MK-2461
3845:AMG-458
2982:Axokine
2323:bcr-abl
1684:myeloid
1062:7 April
972:phase I
966:History
901:albumin
804:fatigue
800:placebo
715:Lenvima
576:Formula
440:7999567
420:DB09078
380:9823820
366:PubChem
203::
164:)
158: (
156:L01EX08
123: D
94::
5797:Portal
5616:Others
5310:BNN-20
5199:ANA-12
5124:BNN-20
4844:DHEA-S
4829:BNN-27
4824:BNN-20
4263:DHEA-S
4248:BNN-27
4243:BNN-20
4159:Others
3364:Epigen
3042:Epigen
1570:VEGF-A
1295:
1287:
1129:
955:salt (
935:-oxide
924:CYP3A4
743:VEGFR3
739:VEGFR2
735:VEGFR1
650:SMILES
617:426.86
519:ChEMBL
488:D09920
480:D09919
312:, 25%
269:CYP3A4
258:98–99%
217:℞-only
215:
205:℞-only
191:
90:
5847:Ureas
5765:(see
5715:(see
5686:(see
5633:(see
5365:K252a
5264:K252a
4939:K252a
4879:FX007
4639:GFRα4
4608:GFRα3
4577:GFRα2
4541:GFRα1
4169:IGFBP
4122:IGF-2
4101:R1507
3989:IGF-1
3895:K252a
3715:FGFR4
3634:FGFR3
3501:FGFR2
3418:FGFR1
2564:ANXA2
2536:Other
2434:MAP2K
2305:(ALK)
2290:c-MET
2142:VEGFR
2077:PDGFR
2073:C-kit
1704:Other
1553:EpCAM
1366:(PDF)
1293:S2CID
1244:(FDA)
1240:U.S.
1201:(FDA)
1197:U.S.
918:(AO).
869:c-Kit
670:InChI
626:JSmol
499:ChEBI
314:urine
310:feces
308:~65%
54:E7080
5767:here
5717:here
5688:here
5635:here
5430:VEGF
5404:VEGF
5320:NT-3
5315:DHEA
5299:TrkC
5219:DHEA
5189:TDP6
5169:NT-4
5164:NT-3
5149:HIOC
5119:BDNF
5068:TrkB
4839:DHEA
4808:TrkA
4788:here
4786:See
4779:TGFβ
4384:PDGF
4278:NT-4
4273:NT-3
4258:DHEA
4238:BDNF
2987:CNTF
2971:CNTF
2679:KRAS
2584:IL-2
2566:and
2548:VEGF
2465:EML4
2124:FLT3
2075:and
1963:ErbB
1689:CD33
1671:CD52
1661:CD30
1621:CD20
1489:ErbB
1410:2016
1285:PMID
1127:PMID
1090:2024
1064:2024
1036:2023
834:and
741:and
471:KEGG
451:UNII
400:7426
238:data
60:AHFS
5184:R13
4854:NGF
4799:Trk
4268:NGF
3980:IGF
3840:AM7
3731:FGF
3650:FGF
3551:),
3549:KGF
3517:FGF
3434:FGF
3409:FGF
3011:EGF
2469:ALK
2369:Src
2244:RET
2218:ALK
1668:),
1658:),
1618:),
1603:CD3
1459:L01
1277:doi
1117:doi
962:).
544:EPA
370:CID
161:WHO
5823::
5678:B3
5676:,
5674:B2
5672:,
5670:B1
5668:,
5666:A5
5664:,
5662:A4
5660:,
5658:A3
5656:,
5654:A2
5652:,
5650:A1
5444:,
5440:,
5436:,
5179:R7
4995:;
4414:,
4410:,
4406:,
4195:,
4191:,
4187:,
4183:,
4179:,
4175:,
4132::
3999::
3808::
3759:19
3757:,
3753:,
3749:,
3745:,
3741:,
3737:,
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