52:, is produced in limited quantities following treatment with Zeuterin, but after two years, testosterone production is similar to that in untreated dogs. The continuing presence of testosterone means that, unlike surgical castration, chemical castration does not remove the risk of testosterone-associated disease, such as prostatic disease.
86:
Outside of the United States, Zeuterin is known by the trade name
Esterilsol. Zeuterin is based work done by Mostafa S. Fahim to develop a "drug, herein called Kastrin" for use on mammals: "the present treatment can be used on male sheep, pigs, horses and other similar mammals having scrotal testes,
82:
in 2003, under the trade name
Neutersol, and was marketed from 2003 to 2005 by Pet Healthcare International. In 2005, Pet Healthcare International severed ties with its manufacturing partner Addison Biologicals, and production of the drug stopped. Ark Sciences acquired the intellectual property to
47:
and causes sterility. Sperm production continues for up to 60 days after product administration, and in some dogs does not stop completely, although the product is 99.6% effective when given to dogs aged 3-10 months of age. Following administration, the testicles atrophy; the degree of atrophy may
70:
or testicular disease is present. If the product is not injected correctly, scrotal ulceration and swelling may occur. The manufacturer, Ark
Sciences, certifies veterinarians to use Zeuterin after they have completed a 5-hour course regarding the correct location and manner to inject the drug.
171:
250:
35:
young male dogs without the removal of the testicles. The product is injected directly into the testicle, where the zinc gluconate destroys the
233:
208:
152:
120:
292:
83:
Neutersol, rebranded it as
Zeuterin, and relaunched it in 2014. In 2016, Ark Sciences suspended distribution of Zeuterin.
79:
353:
337:
Injectable male animal sterilant for selectively controlling the function of testes, US Patent 4156427A
229:
204:
148:
116:
56:
60:
24:
347:
75:
49:
40:
36:
199:
Tobias, KM; Johnston, Spencer A. (2011). "Nonsurgical sterilization techniques".
67:
111:
Macpherson, CNL; Meslin, F-X; Wandeler, AI, eds. (2012). "Chemosterilants".
32:
224:
Tobias, KM (2011). "Chapter 29: Canine
Castration - Chemical castration".
44:
28:
64:
317:
272:"Neutersol and Esterilsol: Injectable Sterilization for Male Dogs"
271:
147:. Clifton Park, NY: Thomson Delmar Learning. pp. 162–4.
115:(2nd ed.). Wallingford, Oxfordshire: CABI. p. 265.
318:"Zeuterin marketer falters two years after U.S. debut - VIN"
143:
Romich, Janet
Amundson (2005). "Male hormone-like drugs".
172:"Zeuterin/Esterilsol: Product profile and position paper"
23:) is the trade name of an injectable product containing
145:
Fundamentals of pharmacology for veterinary technicians
48:
vary noticeably between testicles. The male hormone,
203:. London: Elsevier Health Sciences. p. 1910.
293:"Ark Sciences Releases Canine Sterilization Drug"
106:
104:
102:
100:
179:Alliance for Contraception in Cats & Dogs
138:
136:
134:
132:
8:
295:. Veterinary Practice News. 18 February 2014
166:
164:
311:
309:
226:Manual of Small Animal Soft Tissue Surgery
96:
251:"New Strides in Spaying and Neutering"
55:This method of chemical castration is
7:
249:Quenqua, Douglas (2 December 2013).
78:, this product was approved by the
59:in cases of undescended testicles (
14:
113:Dogs, zoonoses and public health
1:
253:. The New York Times Company
80:Food and Drug Administration
316:Lau, Edie (22 April 2016).
370:
228:. John Wiley & Sons.
87:including human males."
320:. The VIN News Service
31:, which is used for
27:and the amino acid
201:Veterinary Surgery
43:, which leads to
361:
338:
335:
329:
328:
326:
325:
313:
304:
303:
301:
300:
289:
283:
282:
280:
278:
268:
262:
261:
259:
258:
246:
240:
239:
221:
215:
214:
196:
190:
189:
187:
186:
176:
168:
159:
158:
140:
127:
126:
108:
369:
368:
364:
363:
362:
360:
359:
358:
354:Dog medications
344:
343:
342:
341:
336:
332:
323:
321:
315:
314:
307:
298:
296:
291:
290:
286:
276:
274:
270:
269:
265:
256:
254:
248:
247:
243:
236:
223:
222:
218:
211:
198:
197:
193:
184:
182:
174:
170:
169:
162:
155:
142:
141:
130:
123:
110:
109:
98:
93:
57:contraindicated
12:
11:
5:
367:
365:
357:
356:
346:
345:
340:
339:
330:
305:
284:
263:
241:
234:
216:
209:
191:
160:
153:
128:
121:
95:
94:
92:
89:
61:cryptorchidism
25:zinc gluconate
13:
10:
9:
6:
4:
3:
2:
366:
355:
352:
351:
349:
334:
331:
319:
312:
310:
306:
294:
288:
285:
273:
267:
264:
252:
245:
242:
237:
235:9781119949541
231:
227:
220:
217:
212:
210:9780323263375
206:
202:
195:
192:
180:
173:
167:
165:
161:
156:
154:9781401842932
150:
146:
139:
137:
135:
133:
129:
124:
122:9781845938352
118:
114:
107:
105:
103:
101:
97:
90:
88:
84:
81:
77:
76:United States
72:
69:
66:
62:
58:
53:
51:
46:
42:
38:
34:
30:
26:
22:
18:
333:
322:. Retrieved
297:. Retrieved
287:
275:. Retrieved
266:
255:. Retrieved
244:
225:
219:
200:
194:
183:. Retrieved
178:
144:
112:
85:
73:
54:
50:testosterone
41:inflammation
20:
16:
15:
181:. June 2015
39:and causes
33:sterilizing
324:2017-05-20
299:2017-05-20
257:2017-05-20
185:2017-05-20
91:References
68:dermatitis
277:3 January
63:), or if
21:zū-tur-in
348:Category
45:fibrosis
29:arginine
17:Zeuterin
74:In the
65:scrotal
232:
207:
151:
119:
175:(PDF)
37:sperm
279:2010
230:ISBN
205:ISBN
149:ISBN
117:ISBN
350::
308:^
177:.
163:^
131:^
99:^
327:.
302:.
281:.
260:.
238:.
213:.
188:.
157:.
125:.
19:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.