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Muniscins are known as alternate cargo adaptors. That is, they participate in selecting which cargo molecules are internalized via CME. Additionally, the structure of the dimer, with its concave face oriented toward the plasma membrane, is thought to help curve the membrane as the clathrin coated pit
446:
Dergai O, Novokhatska O, Dergai M, Skrypkina I, Tsyba L, Moreau J, Rynditch A (2010). "Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits".
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forms. The muniscins are early arriving proteins involved in CME. FCHO proteins are required for CME, but do not appear to be required to
100:
86:
The μ homology domain of muniscins has been reported to have evolved from part of an ancient cargo adaptor protein complex named TSET.
37:
659:
176:"Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 μ homology domain"
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Boettner DR, D'Agostino JL, Torres OT, Daugherty-Clarke K, Uygur A, Reider A, Wendland B, Lemmon SK, Goode BL (2009).
649:
654:
268:"Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation"
125:"A clathrin coat assembly role for the muniscin protein central linker revealed by TALEN-mediated gene editing"
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Hirst J, Schlacht A, Norcott JP, Traynor D, Bloomfield G, Antrobus R, Kay RR, Dacks JB, Robinson MS (2014).
399:"The F-BAR protein Syp1 negatively regulates WASp-Arp2/3 complex activity during endocytic patch formation"
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Reider A, Barker SL, Mishra SK, Im YJ, Maldonado-Báez L, Hurley JH, Traub LM, Wendland B (2009).
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was initially defined in 2009 as proteins having 2 homologous domains that are involved in
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Henne WM, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT (2010).
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589:"Characterization of TSET, an ancient and widespread membrane trafficking complex"
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Umasankar PK, Ma L, Thieman JR, Jha A, Doray B, Watkins SC, Traub LM (2014).
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Weissenhorn W (2005). "Crystal structure of the endophilin-A1 BAR domain".
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483:"FCHo proteins are nucleators of clathrin-mediated endocytosis"
540:"The first five seconds in the life of a clathrin-coated pit"
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and is involved in CME, even though it does not contain the
20:
Structure of
Muniscin proteins and a dimer of FCHO proteins
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Ribbon representation of BAR domains from two monomers of
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is also included in the family because it contains the
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Cocucci E, Aguet F, Boulant S, Kirchhausen T (2012).
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The μ homology domain of muniscins evolved from TCUP
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56:(CME) and have been reviewed. In addition to
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373:"SYP1 [Saccharomyces cerevisiae]"
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324:"Forty Years of Clathrin-coated Vesicles"
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174:Shimada A, Yamaguchi A, Kohda D (2016).
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7:
101:Vesicular transport adaptor protein
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1:
665:Vesicular transport proteins
645:Peripheral membrane proteins
233:Journal of Molecular Biology
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556:10.1016/j.cell.2012.05.047
460:10.1016/j.bbrc.2010.10.045
415:10.1016/j.cub.2009.10.062
245:10.1016/j.jmb.2005.06.013
507:10.1126/science.1188462
46:muniscin protein family
284:10.1038/emboj.2009.248
70:μ (mu) homology domain
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322:Robinson MS (2015).
660:Molecular evolution
606:10.7554/eLife.02866
499:2010Sci...328.1281H
192:2016NatSR...619565S
142:10.7554/eLife.04137
96:AP2 adaptor complex
180:Scientific Reports
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650:Protein complexes
377:ncbi.nlm.nih.gov/
341:10.1111/tra.12335
200:10.1038/srep19565
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655:Protein families
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493:(5983): 1281–4.
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30:endophilin-A1
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54:endocytosis
639:Categories
599:: e02866.
107:References
64:and Syp1,
186:: 19565.
52:mediated
625:24867644
574:22863004
525:20448150
468:20946875
433:19962315
358:13761396
350:26403691
302:19713939
253:16023669
218:26822536
161:25303365
90:See also
81:initiate
50:clathrin
616:4031984
565:3413093
516:2883440
495:Bibcode
487:Science
424:2828323
328:Traffic
293:2771086
209:4731787
188:Bibcode
152:4215538
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382:26 May
371:anon.
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593:eLife
354:S2CID
129:eLife
83:CME.
66:SGIP1
62:FCHO2
58:FCHO1
621:PMID
570:PMID
544:Cell
521:PMID
464:PMID
429:PMID
384:2017
346:PMID
298:PMID
249:PMID
214:PMID
157:PMID
44:The
611:PMC
601:doi
560:PMC
552:doi
548:150
511:PMC
503:doi
491:328
456:doi
452:402
419:PMC
411:doi
336:doi
288:PMC
280:doi
241:doi
237:351
204:PMC
196:doi
147:PMC
137:doi
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