83:"Myxedema" is a synonym with severe hypothyroidism. It was first described in 1888 by “the Committee of the Clinical Society of London appointed in 1883 to consider the subject of myxedema”, as "Delusions and hallucinations occur in nearly half the cases, mainly where the disease is advanced... acute or chronic manias, dementia, or melancholia, with a marked predominance of suspicion and self-accusation."
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Examplecase report: a 42 year-old women who had suffered from papillary thyroid carcinoma and had a thyroidectomy which ultimately resulted in her developing paranoid delusions and visual/auditory hallucinations whilst undergoing treatment for elective radioactive iodine treatment, according to the
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Myxedematous psychosis, more commonly referred to as the myxedema madness is manifested through hypothyroidism which is a condition in where the thyroid gland does not produce enough thyroid hormones, some of the most common symptoms linked with both of these conditions include: Fatigue, Cold
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intolerance, Menstrual abnormalities, Decreased appetite, Constipation, Hoarse voice, Bradycardia, Non-pitting edema, Facial puffiness, Slow speech, and
Delayed relaxation of deep tendon reflex and fatigue.
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report it states that “she had no history of mental illness” and that “the patient was immediately treated with thyroid hormone replacement therapy”
296:"Myxedema Psychosis after Levothyroxine Withdrawal in Radioactive Iodine Treatment of Differentiated Thyroid Cancer: A Case Report"
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Pattaravimonporn, Nutnicha; Chaikijurajai, Thanat; Chamroonrat, Wichana; Sriphrapradang, Chutintorn (8 November 2021).
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or in patients who have had the thyroid surgically removed and are not taking thyroxine. A chronically under-active
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The name "myxedema madness" was proposed in 1949. It is diagnosed through the measurement of
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94:. With treatment, over 80% of patients achieve complete remission of psychosis.
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KrĂĽger, Jana; Kraschewski, Adrian; Jockers-ScherĂĽbl, Maria C. (2021-09-01).
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198:"Myxedema Madness – Systematic literature review of published case reports"
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345:"Hypothyroidism Presenting as Psychosis: Myxedema Madness Revisited"
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Parikh, Nimesh; Sharma, Prateek; Parmar, Chirag (January 2014).
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Symptoms and signs: Endocrinology, nutrition, and metabolism
245:"A Case Report on Myxedema Madness: Curable Psychosis"
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249:Indian Journal of Psychological Medicine
48:is a relatively uncommon consequence of
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343:Heinrich TW, Grahm G (December 2003).
349:Prim Care Companion J Clin Psychiatry
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214:10.1016/j.genhosppsych.2021.08.005
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80:, particularly in the elderly.
60:can lead to slowly progressive
90:and treated by application of
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202:General Hospital Psychiatry
137:The British Medical Journal
88:thyroid stimulating hormone
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112:Hashimoto's encephalopathy
68:, and in extreme cases to
300:Case Reports in Oncology
262:10.4103/0253-7176.127260
133:"Myxoedematous Madness"
54:Hashimoto's thyroiditis
149:10.1136/bmj.2.4627.555
33:Myxedematous psychosis
361:10.4088/PCC.v05n0603
131:Asher, R. (1949).
46:Myxedema psychosis
22:Myxedema psychosis
312:10.1159/000520128
143:(4627): 555–562.
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16:Medical condition
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208:: 102–116.
92:L-thyroxine
27:Other names
391:Categories
118:References
222:0163-8343
157:0007-1447
78:psychosis
379:15213796
330:34950002
281:24701017
230:34419786
183:18148089
165:25373396
106:See also
66:delirium
62:dementia
321:8647114
272:3959026
174:2051123
58:thyroid
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370:419396
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161:JSTOR
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326:PMID
277:PMID
226:PMID
218:ISSN
179:PMID
153:ISSN
74:coma
365:PMC
357:doi
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210:doi
169:PMC
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