Knowledge (XXG)

Mammalian-wide interspersed repeat

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MIR elements have been first described in human genome 1989-1991 and were first referred as MB1 family repeats (mirror to sequences of mouse B1 repeat). Then this family repeats were found in other mammalian genomes. Then this family was renamed as "Mammalian interspersed repeats" in 1992 Later
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Korotkov, Eugene V.; Korotkova, Maria A.; Rudenko, Valentina M. (2000). "MIR--family of repeats common for vertebrate genomes".
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Jurka, Jerzy; Walichiewicz, Jolanta; Milosavljevic, Aleksandar (October 1992). "Prototypic sequences for human repetitive DNA".
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Donehower, Lawrence A.; Slagle, Betty L.; Wilde, Margaret; Darlington, Gretchen; Butel, Janet S. (1989).
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Korotkov, Eugene V. (1991). "A new family of widely propagated MB1-repeats in the human genome".
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for their propagation in the genome, which took place around 130 million years ago. They cannot
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Korotkov, Eugene V. (1992). "The MB1 family of repeats in clones from the genomes of mammals".
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Korotkov, Eugene V. (1990). "A family of mirror B1-like sequences from human genome".
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Krull, M; Petrusma, M; Makalowski, W; Brosius, J; Schmitz, J (August 2007).
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in the genomes of some organisms and belong to the group of
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this family was shown to be common for vertebrate genomes.
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It is estimated that there are around 368,000 MIRs in the
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Transposable elements in the genomes of some organisms
173:"Initial sequencing and analysis of the human genome" 938: 891: 759: 727: 704: 681: 672: 663: 638: 598: 555: 546: 90:anymore since the loss of activity of the required 70:is 260 basepairs long and has an A/T-rich 3' end. 503: 8: 122:Smit, Arian F. A.; Riggs, Arthur D. (1995). 80:Short interspersed nuclear elements (SINEs) 28:Short interspersed nuclear elements (SINEs) 678: 669: 552: 510: 496: 488: 297: 248: 199: 147: 111: 117: 115: 82:, MIR elements used the machinery of 7: 379:(in Russian). Jul–Aug (4): 546–557. 20:Mammalian-wide interspersed repeats 579:Short tandem repeat/Microsatellite 14: 583:Trinucleotide repeat disorders 400:Journal of Molecular Evolution 1: 570:Variable number tandem repeat 171:Lander; et al. (2001). 1020: 537: 999:Mobile genetic elements 377:Izv Akad Nauk SSSR Biol 978:Protein tandem repeats 906:Tandemly arrayed genes 278:Nucleic Acids Research 128:Nucleic Acids Research 38:MIRs are found in all 323:Dokl. Akad. Nauk SSSR 92:reverse transcriptase 24:transposable elements 951:Pathogenicity island 290:10.1093/nar/17.2.699 98:History of discovery 412:1992JMolE..35..286J 192:2001Natur.409..860L 140:10.1093/nar/23.1.98 901:Gene amplification 463:10.1007/BF02759556 420:10.1007/BF00161166 241:10.1101/gr.6320607 68:consensus sequence 1004:Molecular biology 986: 985: 887: 886: 755: 754: 659: 658: 548:Repeated sequence 523:repeated sequence 186:(6822): 860–921. 1011: 963:Low copy repeats 956:Symbiosis island 893:Gene duplication 679: 670: 553: 531:gene duplication 512: 505: 498: 489: 483: 482: 446: 440: 439: 395: 389: 388: 372: 366: 365: 345: 339: 338: 318: 312: 311: 301: 269: 263: 262: 252: 220: 214: 213: 203: 201:10.1038/35057062 177: 168: 162: 161: 151: 119: 1019: 1018: 1014: 1013: 1012: 1010: 1009: 1008: 989: 988: 987: 982: 934: 883: 751: 723: 700: 674:Retrotransposon 655: 646:Inverted repeat 634: 619:DNA transposon 615:Retrotransposon 610:Gene conversion 601: 594: 591: 542: 533: 516: 486: 451:Mol Biol (Mosk) 448: 447: 443: 397: 396: 392: 374: 373: 369: 350:Mol Biol (Mosk) 347: 346: 342: 320: 319: 315: 271: 270: 266: 229:Genome Research 222: 221: 217: 175: 170: 169: 165: 121: 120: 113: 109: 100: 76: 64: 52: 36: 17: 12: 11: 5: 1017: 1015: 1007: 1006: 1001: 991: 990: 984: 983: 981: 980: 975: 970: 965: 960: 959: 958: 953: 946:Genomic island 942: 940: 936: 935: 933: 932: 927: 926: 925: 915: 914: 913: 903: 897: 895: 889: 888: 885: 884: 882: 881: 876: 871: 866: 861: 856: 851: 846: 841: 836: 831: 826: 821: 816: 811: 806: 801: 796: 791: 786: 781: 776: 771: 765: 763: 761:DNA transposon 757: 756: 753: 752: 750: 749: 744: 739: 733: 731: 725: 724: 722: 721: 716: 710: 708: 702: 701: 699: 698: 693: 687: 685: 676: 667: 661: 660: 657: 656: 654: 653: 648: 642: 640: 636: 635: 633: 632: 631: 630: 625: 617: 612: 606: 604: 596: 595: 593: 592: 589:Macrosatellite 586: 576: 567: 561: 559: 557:Tandem repeats 550: 544: 543: 538: 535: 534: 517: 515: 514: 507: 500: 492: 485: 484: 457:(4): 553–559. 453:(in Russian). 441: 406:(4): 286–291. 390: 367: 356:(1): 250–263. 352:(in Russian). 340: 329:(1): 238–242. 325:(in Russian). 313: 284:(2): 699–722. 264: 235:(8): 1139–45. 215: 163: 110: 108: 105: 99: 96: 88:retrotranspose 75: 72: 63: 60: 51: 48: 35: 32: 15: 13: 10: 9: 6: 4: 3: 2: 1016: 1005: 1002: 1000: 997: 996: 994: 979: 976: 974: 971: 969: 966: 964: 961: 957: 954: 952: 949: 948: 947: 944: 943: 941: 937: 931: 928: 924: 921: 920: 919: 916: 912: 911:Ribosomal DNA 909: 908: 907: 904: 902: 899: 898: 896: 894: 890: 880: 877: 875: 872: 870: 867: 865: 862: 860: 857: 855: 852: 850: 847: 845: 842: 840: 837: 835: 832: 830: 827: 825: 822: 820: 817: 815: 812: 810: 807: 805: 802: 800: 797: 795: 792: 790: 787: 785: 782: 780: 777: 775: 772: 770: 767: 766: 764: 762: 758: 748: 745: 743: 740: 738: 735: 734: 732: 730: 726: 720: 717: 715: 712: 711: 709: 707: 703: 697: 694: 692: 689: 688: 686: 684: 680: 677: 675: 671: 668: 666: 662: 652: 651:Direct repeat 649: 647: 644: 643: 641: 637: 629: 626: 624: 621: 620: 618: 616: 613: 611: 608: 607: 605: 603: 597: 590: 587: 584: 580: 577: 575: 574:Minisatellite 571: 568: 566: 565:Satellite DNA 563: 562: 560: 558: 554: 551: 549: 545: 541: 536: 532: 528: 524: 520: 513: 508: 506: 501: 499: 494: 493: 490: 480: 476: 472: 468: 464: 460: 456: 452: 445: 442: 437: 433: 429: 425: 421: 417: 413: 409: 405: 401: 394: 391: 386: 382: 378: 371: 368: 363: 359: 355: 351: 344: 341: 336: 332: 328: 324: 317: 314: 309: 305: 300: 295: 291: 287: 283: 279: 275: 268: 265: 260: 256: 251: 246: 242: 238: 234: 230: 226: 219: 216: 211: 207: 202: 197: 193: 189: 185: 181: 174: 167: 164: 159: 155: 150: 145: 141: 137: 134:(1): 98–102. 133: 129: 125: 118: 116: 112: 106: 104: 97: 95: 93: 89: 85: 84:LINE elements 81: 73: 71: 69: 61: 59: 57: 49: 47: 45: 41: 33: 31: 29: 25: 21: 923:Gene cluster 695: 691:Alu sequence 600:Interspersed 454: 450: 444: 403: 399: 393: 376: 370: 353: 349: 343: 326: 322: 316: 281: 277: 267: 232: 228: 218: 183: 179: 166: 131: 127: 101: 77: 65: 56:human genome 53: 37: 19: 18: 918:Gene family 829:Tc1/mariner 784:EnSpm/CACTA 78:Like other 74:Propagation 42:(including 22:(MIRs) are 993:Categories 930:Pseudogene 747:retroposon 665:Transposon 527:transposon 107:References 44:marsupials 849:P element 799:Harbinger 540:Repeatome 62:Structure 34:Incidence 973:Telomere 939:See also 879:Zisupton 859:Polinton 854:PiggyBac 809:Helitron 628:Helitron 623:Polinton 519:Genetics 471:11042848 436:22946894 259:17623809 210:11237011 66:The MIR 50:In human 869:Transib 844:Novosib 824:Kolobok 794:Ginger2 789:Ginger1 774:Crypton 479:9524833 428:1404414 408:Bibcode 385:1452902 362:1896037 335:2357927 308:2536922 250:1933517 188:Bibcode 158:7870595 40:mammals 968:CRISPR 834:Merlin 819:ISL2EU 769:Academ 602:repeat 477:  469:  434:  426:  383:  360:  333:  306:  299:331613 296:  257:  247:  208:  180:Nature 156:  149:306635 146:  874:Zator 814:IS3EU 719:LINE2 714:LINE1 706:LINEs 683:SINEs 639:Other 475:S2CID 432:S2CID 176:(PDF) 864:Sola 839:MuDR 779:Dada 742:MER4 737:HERV 729:LTRs 467:PMID 424:PMID 381:PMID 358:PMID 331:PMID 304:PMID 255:PMID 206:PMID 154:PMID 804:hAT 696:MIR 459:doi 416:doi 327:311 294:PMC 286:doi 245:PMC 237:doi 196:doi 184:409 144:PMC 136:doi 46:). 995:: 529:, 525:, 521:: 473:. 465:. 455:34 430:. 422:. 414:. 404:35 402:. 354:25 302:. 292:. 282:17 280:. 276:. 253:. 243:. 233:17 231:. 227:. 204:. 194:. 182:. 178:. 152:. 142:. 132:23 130:. 126:. 114:^ 94:. 58:. 30:. 585:) 581:( 572:/ 511:e 504:t 497:v 481:. 461:: 438:. 418:: 410:: 387:. 364:. 337:. 310:. 288:: 261:. 239:: 212:. 198:: 190:: 160:. 138::

Index

transposable elements
Short interspersed nuclear elements (SINEs)
mammals
marsupials
human genome
consensus sequence
Short interspersed nuclear elements (SINEs)
LINE elements
retrotranspose
reverse transcriptase


"MIRs are classic, tRNA-derived SINEs that amplified before the mammalian radiation"
doi
10.1093/nar/23.1.98
PMC
306635
PMID
7870595
"Initial sequencing and analysis of the human genome"
Bibcode
2001Natur.409..860L
doi
10.1038/35057062
PMID
11237011
"Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs)"
doi
10.1101/gr.6320607
PMC

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