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Marlene Belfort

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and was excised from the transcript during processing in the cell, and led to the observation that the processing of the T4 phage RNA is similar to the splicing pathway used by eukaryotes Her work subsequently showed that the introns move to different places within a bacterial genome and she was able
163:, which are protein-splicing elements. Because inteins are sometimes found in essential proteins, her group is exploring whether inhibitors of intein splicing could be used as anti-fungal drugs. Belfort has also collaborated with 1852: 1842: 1343:
Li, Zhong; Tharappel, Anil Mathew; Xu, Jimin; Lang, Yuekun; Green, Cathleen M.; Zhang, Jing; Lin, Qishan; Chaturvedi, Sudha; Zhou, Jia; Belfort, Marlene; Li, Hongmin (2021-01-12).
150:. She subsequently found a bacterial structural gene in this virus, which was the first example of a intron-containing prokaryotic structural gene. Prior to her research, this 1857: 1502:
Huang, Tao; Shaikh, Tanvir R.; Gupta, Kushol; Contreras-Martin, Lydia M.; Grassucci, Robert A.; Van Duyne, Gregory D.; Frank, Joachim; Belfort, Marlene (2010-12-03).
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was only known to occur in more complex organisms. Her research then determined that the gene of the T4 phage was processed by RNA in a mechanism known as
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where she received her bachelor's degree in 1965 and an earned an honors degree in physiological chemistry in 1966. She went on to earn her Ph.D. from the
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In 1967 Belfort married Georges Belfort. Between 1970 and 1976 the Belfort's welcomed three sons. In her spare time she enjoys writing and knitting.
1862: 323: 81: 1877: 1190:"Escherichia coli proteins, including ribosomal protein S12, facilitate in vitro splicing of phage T4 introns by acting as RNA chaperones" 1672: 847:"Characterization of the intron in the phage T4 thymidylate synthase gene and evidence for its self-excision from the primary transcript" 1837: 80:(born 1945) is an American biochemist known for her research on the factors that interrupt genes and proteins. She is a fellow of the 340: 1745: 101: 1632: 900:
Shub, D. A.; Gott, J. M.; Xu, M. Q.; Lang, B. F.; Michel, F.; Tomaschewski, J.; Pedersen-Lane, J.; Belfort, M. (1988-02-01).
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Slagter-JΓ€ger, Jacoba G.; Allen, Gregory S.; Smith, Dorie; Hahn, Ingrid A.; Frank, Joachim; Belfort, Marlene (2006-06-27).
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to determine the mechanism guiding this movement of genetic material. Her most recent research also includes self-cleaving
1872: 1769: 1811: 1410: 902:"Structural conservation among three homologous introns of bacteriophage T4 and the group I introns of eukaryotes" 1696: 1608: 393:"Her South African Alma Mater from the Days of Apartheid Honors Marlene Belfort - University at Albany-SUNY" 117: 97: 1847: 1038: 182: 275:"A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes" 1832: 1448: 1356: 1097: 980: 913: 640: 573: 562:"Characterization of the Escherichia coli thyA gene and its amplified thymidylate synthetase product" 506: 147: 137: 743:"Processing of the intron-containing thymidylate synthase (td) gene of phage T4 is at the RNA level" 696:"Processing of the intron-containing thymidylate synthase (td) gene of phage T4 is at the RNA level" 1584: 1274: 1129: 882: 827: 778: 723: 695: 1796: 1559: 969:"Processing of phage T4 td-encoded RNA is analogous to the eukaryotic group I splicing pathway" 420:
Involvement of bacterial genotype in bacteriophage lambda's decision between lysogeny and lysis
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Involvement of bacterial genotype in bacteriophage lambda's decision between lysogeny and lysis
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Chu, Frederick K.; Maley, Gladys F.; West, Deborah K.; Belfort, Marlene; Maley, Frank (1986).
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Ehrenman, K.; Pedersen-Lane, J.; West, D.; Herman, R.; Maley, F.; Belfort, M. (1986-08-01).
939: 921: 858: 809: 754: 707: 666: 648: 599: 581: 532: 514: 446:"Marlene Belfort | The Howard P. Isermann Department of Chemical and Biological Engineering" 294: 286: 251: 235: 194: 160: 142: 62: 356:
Mid-career Leadership Award, American Society for Biochemistry and Molecular Biology (2022)
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Wood, David W.; Wu, Wei; Belfort, Georges; Derbyshire, Victoria; Belfort, Marlene (1999).
495:"Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product" 1452: 1360: 1101: 1054: 984: 917: 644: 577: 510: 198: 1800: 1536: 1479: 1436: 1387: 1344: 1320: 1293: 1034: 151: 125: 1657: 1504:"The group II intron ribonucleoprotein precursor is a large, loosely packed structure" 1011: 968: 944: 901: 814: 797: 758: 741:
BELFORT, M; PEDERSENLANE, J; WEST, D; EHRENMAN, K; MALEY, G; CHU, F; MALEY, F (1985).
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Belfort, M; Pedersenlane, J; West, D; Ehrenman, K; Maley, G; Chu, F; Maley, F (1985).
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winner in chemistry, in studying three-dimensional images of group II introns
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Belfort was one of the first undergraduate women to study microbiology at the
1527: 1470: 1378: 1262: 1238: 1215: 1165: 1148: 1117: 1062: 1002: 935: 870: 766: 662: 595: 528: 247: 239: 206: 1461: 1369: 1310: 993: 653: 519: 470:"Marlene Belfort: Stellar Researcher and Mentor - University at Albany-SUNY" 469: 121: 113: 1545: 1488: 1396: 1329: 1270: 926: 629:"Intervening sequence in the thymidylate synthase gene of bacteriophage T4" 586: 428: 308: 1519: 1223: 1206: 1189: 1174: 1125: 1085: 1070: 1020: 953: 878: 823: 798:"Another Bridge between Kingdoms: tRNA Splicing in Archaea and Eukaryotes" 774: 719: 680: 613: 546: 265: 214: 1437:"Visualization of a group II intron in the 23S rRNA of a stable ribosome" 290: 223: 418: 392: 50: 105: 1633:"Past ASM Awardees: ASM Alice C. Evans Award for Advancement of Women" 1503: 1109: 124:
in the Departments of Biological Sciences and Biomedical Sciences at
44: 1345:"Small-molecule inhibitors for the Prp8 intein as antifungal agents" 493:
Belfort, M.; Maley, G.; Pedersen-Lane, J.; Maley, F. (1983-08-01).
1254: 1239:"A genetic system yields self-cleaving inteins for bioseparations" 1817: 1746:"Grondahl: From South Africa's Cape Town, an improbable journey" 1721:"2023 RNA Society Lifetime Achievement in Science Award Winner" 627:
Chu, F. K.; Maley, G. F.; Maley, F.; Belfort, M. (1984-05-01).
1086:"Spontaneous shuffling of domains between introns of phage T4" 1673:"'We live in an age where women no longer need to lose out'" 1294:"Enigmatic Distribution, Evolution, and Function of Inteins" 1292:
Novikova, Olga; Topilina, Natalya; Belfort, Marlene (2014).
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Distinguished Professor, State University of New York (2003)
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Members of the United States National Academy of Sciences
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Guest speakers Professors Georges and Marlene Belfort
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Fellows of the American Academy of Arts and Sciences
1188:Coetzee, T; Herschlag, D; Belfort, M (1994-07-01). 560:Belfort, M.; Maley, G. F.; Maley, F. (1983-04-01). 423:(Thesis). Ann Arbor, Mich.: University Microfilms. 336:
Excellence in Research, University of Albany (2000)
181:Lambowitz, Alan M.; Belfort, Marlene (1993-06-01). 136:Belfort's early research was on a gene involved in 61: 43: 28: 21: 224:"Homing endonucleases: keeping the house in order" 1441:Proceedings of the National Academy of Sciences 1349:Proceedings of the National Academy of Sciences 973:Proceedings of the National Academy of Sciences 906:Proceedings of the National Academy of Sciences 633:Proceedings of the National Academy of Sciences 566:Proceedings of the National Academy of Sciences 499:Proceedings of the National Academy of Sciences 1147:Belfort, Marlene; Perlman, Philip S. (1995). 8: 363:Lifetime Achievement in Science Award (2023) 1818:The Belfort lab at the University of Albany 331:United States National Academy of Sciences 86:United States National Academy of Sciences 18: 1535: 1478: 1460: 1411:"Congratulations to a Nobel Prize winner" 1386: 1368: 1319: 1309: 1205: 1164: 1010: 992: 943: 925: 813: 670: 652: 603: 585: 536: 518: 298: 255: 1858:University of California, Irvine alumni 1565:. American Academy of Arts and Sciences 1560:"Book of Members, 1780-2010: Chapter B" 796:Belfort, Marlene; Weiner, Alan (1997). 381: 1084:Bryk, Mary; Belfort, Marlene (1990). 324:American Academy of Arts and Sciences 120:. As of 2021, she is a Distinguished 82:American Academy of Arts and Sciences 7: 1039:"Introns as Mobile Genetic Elements" 440: 438: 387: 385: 183:"Introns as mobile genetic elements" 1770:"Belfort strikes the right balance" 1055:10.1146/annurev.bi.62.070193.003103 199:10.1146/annurev.bi.62.070193.003103 1868:University at Albany, SUNY faculty 1671:Krige, Nadia (December 17, 2019). 14: 353:), University of Cape Town (2019) 341:American Society for Microbiology 1697:"ASBMB names 2022 award winners" 102:University of California, Irvine 32:University of California, Irvine 1298:Journal of Biological Chemistry 1153:Journal of Biological Chemistry 1149:"Mechanisms of Intron Mobility" 16:American biochemist (born 1945) 1863:University of Cape Town alumni 1: 1744:Grondahl, Paul (2020-02-25). 1043:Annual Review of Biochemistry 815:10.1016/S0092-8674(00)80287-1 759:10.1016/s0092-8674(85)80010-6 712:10.1016/S0092-8674(85)80010-6 273:Roberts, R. J. (2003-04-01). 187:Annual Review of Biochemistry 84:and has been admitted to the 1658:"SUNY Distinguished Academy" 1609:"The 2000 Excellence Awards" 863:10.1016/0092-8674(86)90379-x 1878:21st-century American women 1037:; Belfort, Marlene (1993). 1894: 1838:American women biochemists 417:Belfort, Marlene (1973). 222:Belfort, M (1997-09-01). 71: 36: 1799:publications indexed by 1166:10.1074/jbc.270.51.30237 1462:10.1073/pnas.0603956103 1370:10.1073/pnas.2008815118 1311:10.1074/jbc.R114.548255 1194:Genes & Development 994:10.1073/pnas.83.16.5875 654:10.1073/pnas.81.10.3049 520:10.1073/pnas.80.16.4914 128:and the RNA Institute. 118:Northwestern University 98:University of Cape Town 1508:Nucleic Acids Research 927:10.1073/pnas.85.4.1151 587:10.1073/pnas.80.7.1858 339:Alice C. Evans Award, 279:Nucleic Acids Research 240:10.1093/nar/25.17.3379 228:Nucleic Acids Research 1207:10.1101/gad.8.13.1575 175:Selected publications 106:postdoctoral research 1873:Molecular biologists 1243:Nature Biotechnology 138:thymidylate synthase 92:Education and career 1814:, December 17, 2019 1520:10.1093/nar/gkq1202 1453:2006PNAS..103.9838S 1361:2021PNAS..11808815L 1304:(21): 14490–14497. 1159:(51): 30237–30240. 1102:1990Natur.346..394B 985:1986PNAS...83.5875E 918:1988PNAS...85.1151S 645:1984PNAS...81.3049C 578:1983PNAS...80.1858B 511:1983PNAS...80.4914B 349:Doctor of Science ( 1725:www.rnasociety.org 1677:www.news.uct.ac.za 1355:(2): e2008815118. 1035:Lambowitz, Alan M. 399:. January 21, 2020 291:10.1093/nar/gkg274 1589:www.nasonline.org 1585:"Marlene Belfort" 1447:(26): 9838–9843. 1200:(13): 1575–1588. 1096:(6282): 394–396. 979:(16): 5875–5879. 639:(10): 3049–3053. 505:(16): 4914–4918. 234:(17): 3379–3388. 110:Hebrew University 75: 74: 38:Scientific career 1885: 1808: 1784: 1783: 1781: 1780: 1766: 1760: 1759: 1757: 1756: 1741: 1735: 1734: 1732: 1731: 1717: 1711: 1710: 1708: 1707: 1693: 1687: 1686: 1684: 1683: 1668: 1662: 1661: 1654: 1648: 1647: 1645: 1643: 1637: 1629: 1623: 1622: 1620: 1619: 1605: 1599: 1598: 1596: 1595: 1581: 1575: 1574: 1572: 1570: 1564: 1556: 1550: 1549: 1539: 1514:(7): 2845–2854. 1499: 1493: 1492: 1482: 1464: 1432: 1426: 1425: 1423: 1422: 1407: 1401: 1400: 1390: 1372: 1340: 1334: 1333: 1323: 1313: 1289: 1283: 1282: 1234: 1228: 1227: 1209: 1185: 1179: 1178: 1168: 1144: 1138: 1137: 1110:10.1038/346394a0 1081: 1075: 1074: 1031: 1025: 1024: 1014: 996: 964: 958: 957: 947: 929: 912:(4): 1151–1155. 897: 891: 890: 842: 836: 835: 817: 808:(7): 1003–1006. 793: 787: 786: 738: 732: 731: 691: 685: 684: 674: 656: 624: 618: 617: 607: 589: 572:(7): 1858–1861. 557: 551: 550: 540: 522: 490: 484: 483: 481: 480: 466: 460: 459: 457: 456: 442: 433: 432: 414: 408: 407: 405: 404: 389: 329:Elected member, 312: 302: 285:(7): 1805–1812. 269: 259: 218: 143:Escherichia coli 140:in the bacteria 104:in 1972 and did 63:Doctoral advisor 57: 19: 1893: 1892: 1888: 1887: 1886: 1884: 1883: 1882: 1823: 1822: 1806: 1797:Marlene Belfort 1793: 1788: 1787: 1778: 1776: 1768: 1767: 1763: 1754: 1752: 1743: 1742: 1738: 1729: 1727: 1719: 1718: 1714: 1705: 1703: 1695: 1694: 1690: 1681: 1679: 1670: 1669: 1665: 1656: 1655: 1651: 1641: 1639: 1635: 1631: 1630: 1626: 1617: 1615: 1607: 1606: 1602: 1593: 1591: 1583: 1582: 1578: 1568: 1566: 1562: 1558: 1557: 1553: 1501: 1500: 1496: 1434: 1433: 1429: 1420: 1418: 1409: 1408: 1404: 1342: 1341: 1337: 1291: 1290: 1286: 1236: 1235: 1231: 1187: 1186: 1182: 1146: 1145: 1141: 1083: 1082: 1078: 1033: 1032: 1028: 966: 965: 961: 899: 898: 894: 844: 843: 839: 795: 794: 790: 740: 739: 735: 693: 692: 688: 626: 625: 621: 559: 558: 554: 492: 491: 487: 478: 476: 468: 467: 463: 454: 452: 444: 443: 436: 416: 415: 411: 402: 400: 391: 390: 383: 378: 370: 319: 272: 221: 180: 177: 134: 94: 78:Marlene Belfort 55: 29:Alma mater 24: 23:Marlene Belfort 17: 12: 11: 5: 1891: 1889: 1881: 1880: 1875: 1870: 1865: 1860: 1855: 1850: 1845: 1840: 1835: 1825: 1824: 1821: 1820: 1815: 1803: 1801:Google Scholar 1792: 1791:External links 1789: 1786: 1785: 1761: 1736: 1712: 1688: 1663: 1649: 1638:. 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Index

Thesis
Involvement of bacterial genotype in bacteriophage lambda's decision between lysogeny and lysis
Doctoral advisor
American Academy of Arts and Sciences
United States National Academy of Sciences
University of Cape Town
University of California, Irvine
postdoctoral research
Hebrew University
Jerusalem
Northwestern University
Professor
SUNY at Albany
thymidylate synthase
Escherichia coli
T4 phage
junk DNA
splicing
inteins
Joachim Frank
Nobel Prize
"Introns as mobile genetic elements"
doi
10.1146/annurev.bi.62.070193.003103
ISSN
0066-4154
PMID
8352597
"Homing endonucleases: keeping the house in order"
doi

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