158:
and was excised from the transcript during processing in the cell, and led to the observation that the processing of the T4 phage RNA is similar to the splicing pathway used by eukaryotes Her work subsequently showed that the introns move to different places within a bacterial genome and she was able
163:, which are protein-splicing elements. Because inteins are sometimes found in essential proteins, her group is exploring whether inhibitors of intein splicing could be used as anti-fungal drugs. Belfort has also collaborated with
1852:
1842:
1343:
Li, Zhong; Tharappel, Anil Mathew; Xu, Jimin; Lang, Yuekun; Green, Cathleen M.; Zhang, Jing; Lin, Qishan; Chaturvedi, Sudha; Zhou, Jia; Belfort, Marlene; Li, Hongmin (2021-01-12).
150:. She subsequently found a bacterial structural gene in this virus, which was the first example of a intron-containing prokaryotic structural gene. Prior to her research, this
1857:
1502:
Huang, Tao; Shaikh, Tanvir R.; Gupta, Kushol; Contreras-Martin, Lydia M.; Grassucci, Robert A.; Van Duyne, Gregory D.; Frank, Joachim; Belfort, Marlene (2010-12-03).
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was only known to occur in more complex organisms. Her research then determined that the gene of the T4 phage was processed by RNA in a mechanism known as
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where she received her bachelor's degree in 1965 and an earned an honors degree in physiological chemistry in 1966. She went on to earn her Ph.D. from the
330:
85:
372:
In 1967 Belfort married
Georges Belfort. Between 1970 and 1976 the Belfort's welcomed three sons. In her spare time she enjoys writing and knitting.
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1190:"Escherichia coli proteins, including ribosomal protein S12, facilitate in vitro splicing of phage T4 introns by acting as RNA chaperones"
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847:"Characterization of the intron in the phage T4 thymidylate synthase gene and evidence for its self-excision from the primary transcript"
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80:(born 1945) is an American biochemist known for her research on the factors that interrupt genes and proteins. She is a fellow of the
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Shub, D. A.; Gott, J. M.; Xu, M. Q.; Lang, B. F.; Michel, F.; Tomaschewski, J.; Pedersen-Lane, J.; Belfort, M. (1988-02-01).
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Slagter-JΓ€ger, Jacoba G.; Allen, Gregory S.; Smith, Dorie; Hahn, Ingrid A.; Frank, Joachim; Belfort, Marlene (2006-06-27).
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to determine the mechanism guiding this movement of genetic material. Her most recent research also includes self-cleaving
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902:"Structural conservation among three homologous introns of bacteriophage T4 and the group I introns of eukaryotes"
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393:"Her South African Alma Mater from the Days of Apartheid Honors Marlene Belfort - University at Albany-SUNY"
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275:"A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes"
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562:"Characterization of the Escherichia coli thyA gene and its amplified thymidylate synthetase product"
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743:"Processing of the intron-containing thymidylate synthase (td) gene of phage T4 is at the RNA level"
696:"Processing of the intron-containing thymidylate synthase (td) gene of phage T4 is at the RNA level"
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969:"Processing of phage T4 td-encoded RNA is analogous to the eukaryotic group I splicing pathway"
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Involvement of bacterial genotype in bacteriophage lambda's decision between lysogeny and lysis
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Involvement of bacterial genotype in bacteriophage lambda's decision between lysogeny and lysis
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Chu, Frederick K.; Maley, Gladys F.; West, Deborah K.; Belfort, Marlene; Maley, Frank (1986).
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Ehrenman, K.; Pedersen-Lane, J.; West, D.; Herman, R.; Maley, F.; Belfort, M. (1986-08-01).
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446:"Marlene Belfort | The Howard P. Isermann Department of Chemical and Biological Engineering"
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Mid-career
Leadership Award, American Society for Biochemistry and Molecular Biology (2022)
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Wood, David W.; Wu, Wei; Belfort, Georges; Derbyshire, Victoria; Belfort, Marlene (1999).
495:"Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product"
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1504:"The group II intron ribonucleoprotein precursor is a large, loosely packed structure"
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BELFORT, M; PEDERSENLANE, J; WEST, D; EHRENMAN, K; MALEY, G; CHU, F; MALEY, F (1985).
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Belfort, M; Pedersenlane, J; West, D; Ehrenman, K; Maley, G; Chu, F; Maley, F (1985).
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winner in chemistry, in studying three-dimensional images of group II introns
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Belfort was one of the first undergraduate women to study microbiology at the
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470:"Marlene Belfort: Stellar Researcher and Mentor - University at Albany-SUNY"
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629:"Intervening sequence in the thymidylate synthase gene of bacteriophage T4"
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798:"Another Bridge between Kingdoms: tRNA Splicing in Archaea and Eukaryotes"
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1437:"Visualization of a group II intron in the 23S rRNA of a stable ribosome"
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1633:"Past ASM Awardees: ASM Alice C. Evans Award for Advancement of Women"
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in the
Departments of Biological Sciences and Biomedical Sciences at
44:
1345:"Small-molecule inhibitors for the Prp8 intein as antifungal agents"
493:
Belfort, M.; Maley, G.; Pedersen-Lane, J.; Maley, F. (1983-08-01).
1254:
1239:"A genetic system yields self-cleaving inteins for bioseparations"
1817:
1746:"Grondahl: From South Africa's Cape Town, an improbable journey"
1721:"2023 RNA Society Lifetime Achievement in Science Award Winner"
627:
Chu, F. K.; Maley, G. F.; Maley, F.; Belfort, M. (1984-05-01).
1086:"Spontaneous shuffling of domains between introns of phage T4"
1673:"'We live in an age where women no longer need to lose out'"
1294:"Enigmatic Distribution, Evolution, and Function of Inteins"
1292:
Novikova, Olga; Topilina, Natalya; Belfort, Marlene (2014).
346:
Distinguished
Professor, State University of New York (2003)
1853:
Members of the United States
National Academy of Sciences
1807:
Guest speakers
Professors Georges and Marlene Belfort
1843:
Fellows of the
American Academy of Arts and Sciences
1188:Coetzee, T; Herschlag, D; Belfort, M (1994-07-01).
560:Belfort, M.; Maley, G. F.; Maley, F. (1983-04-01).
423:(Thesis). Ann Arbor, Mich.: University Microfilms.
336:
Excellence in
Research, University of Albany (2000)
181:Lambowitz, Alan M.; Belfort, Marlene (1993-06-01).
136:Belfort's early research was on a gene involved in
61:
43:
28:
21:
224:"Homing endonucleases: keeping the house in order"
1441:Proceedings of the National Academy of Sciences
1349:Proceedings of the National Academy of Sciences
973:Proceedings of the National Academy of Sciences
906:Proceedings of the National Academy of Sciences
633:Proceedings of the National Academy of Sciences
566:Proceedings of the National Academy of Sciences
499:Proceedings of the National Academy of Sciences
1147:Belfort, Marlene; Perlman, Philip S. (1995).
8:
363:Lifetime Achievement in Science Award (2023)
1818:The Belfort lab at the University of Albany
331:United States National Academy of Sciences
86:United States National Academy of Sciences
18:
1535:
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1411:"Congratulations to a Nobel Prize winner"
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1858:University of California, Irvine alumni
1565:. American Academy of Arts and Sciences
1560:"Book of Members, 1780-2010: Chapter B"
796:Belfort, Marlene; Weiner, Alan (1997).
381:
1084:Bryk, Mary; Belfort, Marlene (1990).
324:American Academy of Arts and Sciences
120:. As of 2021, she is a Distinguished
82:American Academy of Arts and Sciences
7:
1039:"Introns as Mobile Genetic Elements"
440:
438:
387:
385:
183:"Introns as mobile genetic elements"
1770:"Belfort strikes the right balance"
1055:10.1146/annurev.bi.62.070193.003103
199:10.1146/annurev.bi.62.070193.003103
1868:University at Albany, SUNY faculty
1671:Krige, Nadia (December 17, 2019).
14:
353:), University of Cape Town (2019)
341:American Society for Microbiology
1697:"ASBMB names 2022 award winners"
102:University of California, Irvine
32:University of California, Irvine
1298:Journal of Biological Chemistry
1153:Journal of Biological Chemistry
1149:"Mechanisms of Intron Mobility"
16:American biochemist (born 1945)
1863:University of Cape Town alumni
1:
1744:Grondahl, Paul (2020-02-25).
1043:Annual Review of Biochemistry
815:10.1016/S0092-8674(00)80287-1
759:10.1016/s0092-8674(85)80010-6
712:10.1016/S0092-8674(85)80010-6
273:Roberts, R. J. (2003-04-01).
187:Annual Review of Biochemistry
84:and has been admitted to the
1658:"SUNY Distinguished Academy"
1609:"The 2000 Excellence Awards"
863:10.1016/0092-8674(86)90379-x
1878:21st-century American women
1037:; Belfort, Marlene (1993).
1894:
1838:American women biochemists
417:Belfort, Marlene (1973).
222:Belfort, M (1997-09-01).
71:
36:
1799:publications indexed by
1166:10.1074/jbc.270.51.30237
1462:10.1073/pnas.0603956103
1370:10.1073/pnas.2008815118
1311:10.1074/jbc.R114.548255
1194:Genes & Development
994:10.1073/pnas.83.16.5875
654:10.1073/pnas.81.10.3049
520:10.1073/pnas.80.16.4914
128:and the RNA Institute.
118:Northwestern University
98:University of Cape Town
1508:Nucleic Acids Research
927:10.1073/pnas.85.4.1151
587:10.1073/pnas.80.7.1858
339:Alice C. Evans Award,
279:Nucleic Acids Research
240:10.1093/nar/25.17.3379
228:Nucleic Acids Research
1207:10.1101/gad.8.13.1575
175:Selected publications
106:postdoctoral research
1873:Molecular biologists
1243:Nature Biotechnology
138:thymidylate synthase
92:Education and career
1814:, December 17, 2019
1520:10.1093/nar/gkq1202
1453:2006PNAS..103.9838S
1361:2021PNAS..11808815L
1304:(21): 14490β14497.
1159:(51): 30237β30240.
1102:1990Natur.346..394B
985:1986PNAS...83.5875E
918:1988PNAS...85.1151S
645:1984PNAS...81.3049C
578:1983PNAS...80.1858B
511:1983PNAS...80.4914B
349:Doctor of Science (
1725:www.rnasociety.org
1677:www.news.uct.ac.za
1355:(2): e2008815118.
1035:Lambowitz, Alan M.
399:. January 21, 2020
291:10.1093/nar/gkg274
1589:www.nasonline.org
1585:"Marlene Belfort"
1447:(26): 9838β9843.
1200:(13): 1575β1588.
1096:(6282): 394β396.
979:(16): 5875β5879.
639:(10): 3049β3053.
505:(16): 4914β4918.
234:(17): 3379β3388.
110:Hebrew University
75:
74:
38:Scientific career
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912:(4): 1151β1155.
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808:(7): 1003β1006.
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329:Elected member,
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285:(7): 1805β1812.
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143:Escherichia coli
140:in the bacteria
104:in 1972 and did
63:Doctoral advisor
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1797:Marlene Belfort
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1638:. June 1, 2020
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1415:www.rfsuny.org
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1249:(9): 889β892.
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