58:
membrane. Eventually this results in the cell becoming wrapped in a microfibril layer. This layer becomes the cell wall. The organization of microfibrils forming the primary cell wall is rather disorganized. However, another mechanism is used in secondary cell walls leading to its organization. Essentially, lanes on the secondary cell wall are built with microtubules. These lanes force microfibrils to remain in a certain area while they wrap. During this process microtubules can spontaneously depolymerize and repolymerize in a different orientation. This leads to a different direction in which the cell continues getting wrapped.
357:
57:
or
Rosette terminal complexes which reside on a cells membrane. As cellulose fibrils are synthesized and grow extracellularly they push up against neighboring cells. Since the neighboring cell can not move easily the Rosette complex is instead pushed around the cell through the fluid phospholipid
44:
are surrounded by nine other pairs. Cellulose inside plants is one of the examples of non-protein compounds that are using this term with the same purpose. Cellulose microfibrils are laid down in the inner surface of the primary cell wall. As the cell absorbs water, its volume increases and the
72:
and provides elasticity. During the assembly, mirofibrils exhibit a repeating stringed-beads arrangement produced by the cross-linking of molecules forming a striated pattern with a given periodicity when viewed stained under an electron microscope. In the formation of
81:
and remains in the outer layer of mature elastin fibers. The microfibril is also associated in cell communication. Formation of fibrillin microfibrils in the pericellular region affects the activity of a growth factor called
106:, as microfibrils directly govern the activity of TGFβ. This hinders the formation of the extracellular matrix, and ultimately results in a severe phenotype which involves a few organ systems, including the
155:
Massam-Wu, Teresa; Chiu, Maybo; Choudhury, Rawshan; Chaudhry, Shazia S.; Baldwin, Andrew K.; McGovern, Amanda; Baldock, Claire; Shuttleworth, C. Adrian; Kielty, Cay M. (2010).
398:
257:
207:
Kielty, Cay M.; Baldock, Claire; Lee, David; Rock, Matthew J.; Ashworth, Jane L.; Shuttleworth, C. Adrian (28 February 2002).
422:
391:
32:. It is usually, but not always, used as a general term in describing the structure of protein fiber, e.g.
107:
384:
102:
protein impact nearly every one of its domains. Such defects in fibrillin-1 affect the signaling of
119:
295:
111:
54:
41:
156:
334:
326:
287:
279:
238:
189:
65:
40:
tail. Its most frequently observed structural pattern is the 9+2 pattern in which two central
368:
315:"Microfibrils: a cornerstone of extracellular matrix and a key to understand Marfan syndrome"
356:
269:
228:
220:
179:
171:
417:
95:
319:
Italian
Journal of Anatomy and Embryology = Archivio Italiano di Anatomia ed Embriologia
233:
208:
184:
45:
existing microfibrils separate and new ones are formed to help increase cell strength.
411:
115:
74:
25:
299:
157:"Assembly of fibrillin microfibrils governs extracellular deposition of latent TGFβ"
364:
78:
37:
274:
99:
69:
330:
283:
314:
61:
29:
338:
291:
242:
224:
193:
175:
103:
98:, a connective tissue disorder, mutations in the gene encoding for the
83:
131:
21:
209:"Fibrillin: from microfibril assembly to biomechanical function"
33:
372:
258:"Microfibril-associated Disorders: Fibrillinopathies"
77:, fibrillin microfibrils guides the deposit of
256:Reinhardt, Dieter P. (October–November 2014).
392:
8:
399:
385:
273:
232:
183:
142:
24:, or fiber-like strand, consisting of
7:
353:
351:
150:
148:
146:
313:Bonetti, Maria Ida (October 2009).
371:. You can help Knowledge (XXG) by
213:Philos Trans R Soc Lond B Biol Sci
14:
355:
1:
275:10.1097/IJG.0000000000000114
53:Cellulose is synthesized by
439:
350:
64:microfibrils are found in
68:, which mainly makes up
225:10.1098/rstb.2001.1029
108:central nervous system
49:Synthesis and function
268:(8 Suppl 1): S34-5.
262:Journal of Glaucoma
423:Biochemistry stubs
176:10.1242/jcs.073437
112:circulatory system
66:connective tissues
55:cellulose synthase
380:
379:
219:(1148): 207–217.
170:(17): 3006–3018.
430:
401:
394:
387:
359:
352:
343:
342:
310:
304:
303:
277:
253:
247:
246:
236:
204:
198:
197:
196:– via JCS.
187:
161:
152:
438:
437:
433:
432:
431:
429:
428:
427:
408:
407:
406:
405:
348:
346:
312:
311:
307:
255:
254:
250:
206:
205:
201:
159:
154:
153:
144:
140:
128:
120:skeletal system
96:Marfan syndrome
92:
90:Marfan syndrome
51:
20:is a very fine
12:
11:
5:
436:
434:
426:
425:
420:
410:
409:
404:
403:
396:
389:
381:
378:
377:
360:
345:
344:
325:(4): 201–224.
305:
248:
199:
141:
139:
136:
135:
134:
127:
124:
91:
88:
50:
47:
13:
10:
9:
6:
4:
3:
2:
435:
424:
421:
419:
416:
415:
413:
402:
397:
395:
390:
388:
383:
382:
376:
374:
370:
367:article is a
366:
361:
358:
354:
349:
340:
336:
332:
328:
324:
320:
316:
309:
306:
301:
297:
293:
289:
285:
281:
276:
271:
267:
263:
259:
252:
249:
244:
240:
235:
230:
226:
222:
218:
214:
210:
203:
200:
195:
191:
186:
181:
177:
173:
169:
165:
158:
151:
149:
147:
143:
137:
133:
130:
129:
125:
123:
121:
117:
116:ocular system
113:
109:
105:
101:
97:
89:
87:
85:
80:
76:
75:elastic fiber
71:
67:
63:
59:
56:
48:
46:
43:
39:
35:
31:
27:
26:glycoproteins
23:
19:
373:expanding it
365:biochemistry
362:
347:
322:
318:
308:
265:
261:
251:
216:
212:
202:
167:
163:
93:
79:tropoelastin
60:
52:
42:protofibrils
17:
15:
100:fibrillin-1
70:fibrillin-1
18:microfibril
412:Categories
164:J Cell Sci
138:References
331:1122-6714
284:1057-0829
62:Fibrillin
30:cellulose
339:20578676
300:31705597
292:25275902
243:11911778
194:20699357
126:See also
234:1692929
185:2923573
418:Fibers
337:
329:
298:
290:
282:
241:
231:
192:
182:
132:Fibril
118:, and
22:fibril
363:This
296:S2CID
160:(PDF)
38:sperm
369:stub
335:PMID
327:ISSN
288:PMID
280:ISSN
239:PMID
190:PMID
104:TGFβ
86:.
84:TGFβ
36:and
34:hair
28:and
323:114
270:doi
229:PMC
221:doi
217:357
180:PMC
172:doi
168:123
94:In
414::
333:.
321:.
317:.
294:.
286:.
278:.
266:23
264:.
260:.
237:.
227:.
215:.
211:.
188:.
178:.
166:.
162:.
145:^
122:.
114:,
110:,
16:A
400:e
393:t
386:v
375:.
341:.
302:.
272::
245:.
223::
174::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.