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cortex) very little rough endoplasmic reticulum is present. The pattern of coloration with Nissl stains once was used to classify neurons. For various reasons, this practice has largely ceased, but specific neuronal types do manifest characteristic types of Nissl bodies.
118:). The term "Nissl bodies" generally refers to discrete clumps of rough endoplasmic reticulum and free ribosomes in nerve cells. Masses of rough endoplasmic reticulum also occur in some non-neuronal cells, where they are referred to as
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bodies, or chromophilic substance. While these organelles differ in some ways from Nissl bodies in neurons, large amounts of rough endoplasmic reticulum are generally linked to the copious production of proteins.
204:
The functions of Nissl bodies are thought to be the same as those of the rough endoplasmic reticulum in general, primarily the synthesis and segregation of proteins. Similar to the ergastoplasm of
151:("base-loving"). The dense accumulation of membrane-bound and free ribosomes in Nissl bodies results in their intense coloration by Nissl stains, allowing them to be seen with a light
58:
Drawing of a motor neuron from the ventral horn of the medulla spinals of a rabbit. The angular and spindle-shaped Nissl bodies in the cytoplasm are well shown.
236:). If the neuron is successful in repairing the damage, the Nissl bodies gradually reappear and return to their characteristic distribution within the cell.
524: – Histology Learning System at Boston University - "Nervous Tissue and Neuromuscular Junction: spinal cord, cell bodies of anterior horn cells"
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191:, where they appear as large, blocky assemblies. In other neurons, they may be smaller, and in some (such as the granule neurons of the
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326:"Franz Nissl (1860-1919), noted neuropsychiatrist and neuropathologist, staining the neuron, but not limiting it"
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of Nissl bodies suggests they are primarily concerned with the synthesis of proteins for intracellular use.
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135:"Nissl stains" refers to various basic dyes that selectively label negatively charged molecules such as
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179:. They vary in size, shape, and intracellular location; they are most conspicuous in the
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cells, Nissl bodies are the main site of protein synthesis in the neuronal
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Nissl bodies show changes under various physiological conditions and in
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Brain Damage and Repair: From
Molecular Research to Clinical Therapy
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Color Atlas of
Cytology, Histology, and Microscopic Anatomy
232:, during which they may dissolve and largely disappear (
102:
surface of the membranes. Nissl bodies were named after
16:
Rough endoplasmic reticulum structure found in neurons
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of Nissl bodies (two are indicated by arrows) in the
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533:Tissues containing Nissl bodies at harvard.edu
462:T. Herdegen; J. Delgado-Garcia (25 May 2005).
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30:of motor neurons in the anterior horn of the
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262:Junqueira LC, Carniero J, Kelley RO (1995).
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90:, a collection of parallel, membrane-bound
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514:at the U.S. National Library of Medicine
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405:The Fine Structure of the Nervous System
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403:Peters A, Palay SL, Webster Hd (1991).
367:The Cell: Its Organelles and Inclusions
245:
82:) are discrete granular structures in
290:Richard H. Thompson (29 March 2000).
7:
14:
499:
342:10.1590/1980-57642018dn13-030014
293:The Brain: A Neuroscience Primer
143:. Because ribosomes are rich in
724:Oligodendrocyte progenitor cell
330:Dementia & Neuropsychologia
171:of neurons, though not in the
1:
528:Histology at anhb.uwa.edu.au
38:stain (purple) along with a
834:Postganglionic nerve fibers
407:. Oxford University Press.
296:. Macmillan. pp. 35–.
1395:
829:Preganglionic nerve fibers
468:. Springer. pp. 37–.
163:Nissl bodies occur in the
1339:Olfactory receptor neuron
1003:Neurofibril/neurofilament
522:Histology image: 04103loa
434:. Thieme. pp. 182–.
369:. W.B. Saunders Company.
114:method bearing his name (
516:Medical Subject Headings
428:Wolfgang Kühnel (2003).
365:Fawcett, Don W. (1966).
324:Da Mota Gomes M (2019).
266:. Appleton & Lange.
1286:Neuromuscular junction
1149:III or Aδ or fast pain
86:that consist of rough
59:
51:
159:Size and distribution
88:endoplasmic reticulum
64:cellular neuroscience
57:
22:
1379:Nervous tissue cells
1304:Meissner's corpuscle
1269:Postsynaptic density
1166:Efferent nerve fiber
1154:IV or C or slow pain
1096:Afferent nerve fiber
922:Satellite glial cell
508:at Wikimedia Commons
147:, they are strongly
1309:Merkel nerve ending
228:conditions such as
1344:Photoreceptor cell
1314:Pacinian corpuscle
1245:Electrical synapse
1199:Lower motor neuron
1194:Upper motor neuron
915:Internodal segment
855:Connective tissues
825:Autonomic ganglion
60:
52:
1366:
1365:
1362:
1361:
1329:Free nerve ending
1296:Sensory receptors
1224:
1223:
1139:Ib or Golgi or Aα
1047:
1046:
930:
929:
807:Ramus communicans
746:
745:
742:
741:
612:Commissural fiber
607:Association fiber
602:Projection fibers
504:Media related to
475:978-1-4020-1892-3
441:978-3-13-562404-4
303:978-0-7167-3226-6
110:who invented the
80:tigroid substance
46:. Scale bar = 30
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1259:Synaptic vesicle
1254:Chemical synapse
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1144:II or Aβ and Aγ
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1033:Apical dendrite
1028:Dendritic spine
1007:
969:
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910:Node of Ranvier
905:Myelin incisure
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729:Oligodendrocyte
712:Ependymal cells
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264:Basic Histology
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200:Functional role
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76:Nissl substance
40:luxol fast blue
24:Photomicrograph
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234:chromatolysis
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181:motor neurons
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145:ribosomal RNA
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94:studded with
93:
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70:(also called
69:
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49:
45:
41:
37:
36:cresyl violet
33:
29:
25:
21:
1249:Gap junction
1171:Motor neuron
1022:
965:Axon hillock
941:nerve fibers
895:Schwann cell
805:
788:
766:
684:Medium spiny
597:White matter
585:Tissue Types
512:Nissl+Bodies
479:. Retrieved
464:
457:
445:. Retrieved
430:
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404:
366:
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329:
319:
307:. Retrieved
292:
263:
226:pathological
223:
203:
177:axon hillock
162:
134:
120:ergastoplasm
79:
75:
71:
68:Nissl bodies
67:
61:
1264:Active zone
1229:Termination
1079:Interneuron
983:Telodendron
891:Myelination
873:Endoneurium
868:Perineurium
689:Interneuron
679:Von Economo
627:Decussation
622:Nerve tract
592:Grey matter
506:Nissl stain
230:axonotmesis
185:spinal cord
106:, a German
104:Franz Nissl
32:spinal cord
1334:Nociceptor
1074:Multipolar
1023:Nissl body
900:Neurilemma
863:Epineurium
648:Cell Types
240:References
193:cerebellar
153:microscope
149:basophilic
124:basophilic
42:stain for
1349:Hair cell
883:Neuroglia
845:Funiculus
734:Microglia
707:Astrocyte
664:Pyramidal
617:Lemniscus
481:4 January
447:4 January
309:4 January
220:Pathology
210:cytoplasm
206:glandular
189:brainstem
169:dendrites
100:cytosolic
96:ribosomes
92:cisternae
50:(0.03mm).
28:cytoplasm
1373:Category
1134:Ia or Aα
1064:Unipolar
1013:Dendrite
998:Axolemma
993:Axoplasm
777:Ganglion
717:Tanycyte
669:Purkinje
656:Neuronal
639:Meninges
634:Neuropil
131:Staining
112:staining
1276:Autapse
1237:Synapse
1084:Renshaw
1059:Bipolar
936:Neurons
789:Ventral
760:General
674:Granule
351:6753910
183:of the
98:on the
84:neurons
48:microns
1129:fibers
767:Dorsal
518:(MeSH)
472:
438:
411:
373:
348:
300:
270:
212:. The
165:somata
44:myelin
1052:Types
949:Parts
818:White
799:Ramus
782:Ramus
699:Glial
975:Axon
957:Soma
813:Gray
794:Root
772:Root
483:2013
470:ISBN
449:2013
436:ISBN
409:ISBN
371:ISBN
311:2013
298:ISBN
268:ISBN
187:and
173:axon
167:and
139:and
1189:SVE
1184:GVE
1179:GSE
1124:SVA
1119:SSA
1114:GVA
1109:GSA
752:PNS
577:CNS
346:PMC
338:doi
175:or
141:RNA
137:DNA
78:or
62:In
1375::
893::
385:^
344:.
334:13
332:.
328:.
282:^
248:^
155:.
122:,
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561:e
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547:v
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379:.
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340::
313:.
276:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
