63:, and licensed to NovoBiotic Pharmaceuticals. Over the years NovoBiotic has amassed a large collection of previously uncultivated microorganisms utilizing the diffusion chamber, and screens them for antibiotic activity. NovoBiotic holds the patent rights to any potentially useful molecules that are extracted, identified and characterized. This approach has resulted the discovery of several new antibiotic compounds, including teixobactin.
183:
197:
Ling, Losee; Schneider, Tanja; Peoples, Aaron; Spoering, Amy; Engels, Ina; Conlon, Brian; Mueller, Anna; Schäberle, Till; Hughes, Dallas; Epstein, Slava; Jones, Michael; Lazarides, Linos; Steadman, Victoria; Cohen, Douglas; Felix, Cintia; Fetterman, K. Ashley; Millett, William; Nitti, Anthony; Zullo,
50:
The founders had led the development of new techniques to search for useful molecules produced by the untapped vast majority of soil and marine bacteria that cannot be initially cultured in the laboratory. They developed diffusion chambers
90:
to available approved antibiotics. The discovery and characterization of the compound was reported in 2015 in a collaboration between NovoBiotic, Northeastern
University (Boston MA), University of Bonn (Germany) and Selcia Ltd. (UK).
336:
42:, while Epstein is on the faculty of the Department of Biology. Both Lewis and Epstein are paid consultants to this company. The focus of the company is on the discovery of new antibiotics and oncology drugs.
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to relatively mutable proteins in the bacterial cells, it binds to less mutable fatty molecules that are essential cell wall precursors.
151:
22:
is a privately held, early-stage biotechnology company focused on the discovery and development of new drugs from natural sources.
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181:, "Novel depsipeptide and uses thereof", published 12 June 2014, assigned to Novobiotic Pharmaceuticals LLC
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251:"NovoBiotic reports the discovery of teixobactin, a new antibiotic without detectable resistance"
156:
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404:
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122:"The Unseen: Millions of microbes are yet to be discovered. Will one hold the ultimate cure?"
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59:, so that they could then be extracted for study. A patent for these techniques is held by
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of the target pathogens because of its unusual antibiotic mechanism. Rather than
38:
professors Kim Lewis and Slava
Epstein. Lewis is the director of Northeastern’s
1005:
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55:) to be embedded in natural settings to grow "uncultivable" microorganisms
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284:"Antibiotics: US discovery labelled 'game-changer' for medicine"
200:"A new antibiotic kills pathogens without detectable resistance"
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152:"From a Pile of Dirt, Hope for a Powerful New Antibiotic"
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198:Ashley; Chen, Chao; Lewis, Kim (7 January 2015).
1114:Pharmaceutical companies of the United States
346:Pharmaceutical companies of the United States
330:
8:
1119:Health care companies based in Massachusetts
731:
337:
323:
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79:that has been shown to be active against
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260:, MA (USA): NovoBiotic Pharmaceuticals
120:Khatchadourian, Raffi (20 June 2016).
95:is believed to be more robust against
277:
275:
145:
143:
7:
282:Gallagher, James (7 January 2015).
30:The company was founded in 2003 in
624:Pharmaceutical Product Development
14:
1093:List of pharmaceutical companies
40:Antimicrobial Discovery Center
16:American biotechnology company
1:
500:Institute for OneWorld Health
249:Lewis, Kim (7 January 2015).
46:Research and drug development
719:West Pharmaceutical Services
1135:
525:McNeil Consumer Healthcare
20:NovoBiotic Pharmaceuticals
1088:
1031:Smith, Kline & French
582:Northwest Biotherapeutics
567:Merrimack Pharmaceuticals
61:Northeastern University
36:Northeastern University
26:Early history and focus
956:Leiner Health Products
400:Amneal Pharmaceuticals
128:. New York: Condé Nast
84:Gram-positive bacteria
510:Johnson & Johnson
804:Jazz Pharmaceuticals
794:Horizon Therapeutics
664:Sarepta Therapeutics
639:Proteon Therapeutics
634:Procter & Gamble
547:Melinta Therapeutics
440:Bristol Myers Squibb
86:that have developed
1011:Repros Therapeutics
926:Forest Laboratories
911:Cutter Laboratories
629:Prasco Laboratories
370:Acorda Therapeutics
360:Abbott Laboratories
306:External References
218:10.1038/nature14098
971:Miles Laboratories
961:Martek Biosciences
784:Endo International
704:Ventria Bioscience
470:Danco Laboratories
311:Official home page
157:The New York Times
1101:
1100:
1084:
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916:DNAPrint Genomics
405:Avax Technologies
1126:
732:
679:Tec Laboratories
552:Melior Discovery
537:Kinetic Concepts
480:Galena Biopharma
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936:ImClone Systems
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572:Myriad Genetics
562:Merck & Co.
520:Janssen Biotech
490:Gilead Sciences
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212:(7535): 455–9.
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150:Denise, Grady.
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53:isolation chips
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34:, MA (USA), by
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836:(Canada, 2010)
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814:Mallinckrodt
699:Upsher-Smith
530:Ortho-McNeil
309:
291:. Retrieved
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262:. Retrieved
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161:. Retrieved
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130:. Retrieved
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56:
49:
29:
19:
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1006:Parke-Davis
689:Trevena Inc
557:Mentholatum
365:AbbVie Inc.
93:Teixobactin
73:teixobactin
67:Teixobactin
1108:Categories
1066:ViroPharma
966:Massengill
694:Ultragenyx
425:Bioverativ
107:References
88:resistance
81:pathogenic
77:antibiotic
1016:Qualitest
886:CancerVax
669:Sheffield
659:RespireRx
654:Regeneron
505:Intercept
485:Genentech
475:Eli Lilly
460:CytoSport
450:Ceragenix
293:7 January
264:7 January
258:Cambridge
163:7 January
32:Cambridge
896:CoTherix
891:Cephalon
774:Covidien
764:Allergan
754:Alkermes
674:Spectrum
542:McKesson
435:Biovista
415:BioCryst
236:25561178
97:mutation
1051:Trubion
901:Covance
881:Bradley
830:, 2013)
828:Ireland
824:Perrigo
820:, 2013)
818:Ireland
810:, 2012)
808:Ireland
800:, 2014)
798:Ireland
790:, 2014)
788:Ireland
780:, 2007)
778:Ireland
770:, 2015)
768:Ireland
760:, 2011)
758:Ireland
750:, 2013)
748:Ireland
744:Actavis
714:Viatris
612:Hospira
602:Ovation
597:Organon
592:NovaBay
577:Moderna
515:Ethicon
445:Century
430:Biovest
390:Alnylam
385:Alexion
375:Advaxis
353:Current
227:7414797
132:27 June
101:binding
57:in situ
1076:Zonite
1056:Upjohn
991:Nuvelo
986:Nereus
981:Naurex
906:Cubist
876:Biolex
861:Amylin
728:Former
709:Vertex
617:Searle
607:Pfizer
420:Biogen
410:Baxter
234:
224:
205:Nature
185:
1071:Wyeth
1061:Verus
1041:Tanox
1021:Rib-X
996:Ortho
976:Mylan
931:Genta
866:ARIAD
844:Other
684:Titan
649:Quark
495:Ionis
465:CytRx
455:Combe
395:Amgen
380:Alcon
254:(PDF)
75:, an
946:King
941:ISTA
921:Epix
871:Barr
851:Alza
295:2015
266:2015
232:PMID
165:2015
134:2016
1046:TAP
1001:OSI
288:BBC
222:PMC
214:doi
210:517
1110::
951:KV
286:.
274:^
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142:^
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338:e
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51:(
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