145:-splicing relies on a 3' acceptor splice site on the outron, and a 5' donor splice site (GU dinucleotide) located on a separate RNA molecule, the SL RNA. Moreover, the outron of the premature mRNA contains a branchpoint
141:, the donor splice site in upstream position is required together with an acceptor site located on downstream position on the same pre-RNA molecule. By contrast, the SL
153:— which interacts with the intron-like portion of the SL RNA to form a 'Y' branched byproduct, reminiscent of the
78:-splice site is essentially defined as an acceptor (3') splice site without an upstream donor (5') splice site.
596:
377:
601:
129:, with the SL exon length ranging from 16 to 51 nt, and the full SL RNA length ranging from 46 to 141 nt.
157:
structure formed during intron splicing. Nuclear machinery then resolves this 'Y' branching structure by
591:
28:
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150:
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359:
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44:
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191:
188: – A region of a transcribed gene present in the final functional mRNA molecule
517:
138:
114:
64:
40:
110:
102:
82:
436:
294:
277:
276:
Stover, Nicholas A.; Kaye, Michelle S.; Cavalcanti, Andre R. O. (2006-01-10).
176:
of the polycistronic pre-mRNA, leading to distinct mature capped transcripts.
126:
98:
51:
sequences are located inside the gene, outron sequences lie outside the gene.
501:
444:
303:
241:
146:
122:
106:
94:
566:
509:
462:
355:
311:
233:
172:-spliced to distinct, unpaired, downstream acceptor sites adjacent to each
259:
548:
118:
90:
421:"Life without transcriptional control? From fly to man and back again"
60:
48:
347:
493:
212:
Conrad, Richard; Fen Liou, Ruey; Blumenthal, Thomas (1993-02-25).
154:
125:, the length of spliced leader (SL) outrons range from 30 to 102
185:
36:
476:
Blumenthal, Thomas; Gleason, Kathy
Seggerson (February 2003). "
533:"Evolutionary Insights into RNA trans-Splicing in Vertebrates"
194: – RNA that is read by the ribosome to produce a protein
531:
Lei Q, Li C, Zuo Z, Huang C, Cheng H, Zhou R (March 2016).
399:"The MISO Sequence Ontology Browser — Outron (SO:0001475)"
165:-splice acceptor site (AG dinucleotide) of the pre-mRNA.
330:
Lasda, Erika L.; Blumenthal, Thomas (2011-05-01). "
67:and a splice acceptor site that is the signal for
16:A gene sequence removed from RNA transcripts by
63:possessing similar characteristics such as the
8:
271:
269:
325:
323:
321:
168:When outrons are processed, the SL exon is
556:
452:
293:
249:
161:-splicing the SL RNA sequence to the 3′
204:
39:that is removed by a special form of
7:
419:Clayton, Christine E. (2002-04-15).
336:Wiley Interdisciplinary Reviews: RNA
47:of the final RNA product. Whereas
14:
278:"Spliced leader trans-splicing"
1:
480:operons: form and function".
537:Genome Biology and Evolution
378:"Oxford reference — Outron"
149:— followed by a downstream
618:
214:"Functional analysis of a
295:10.1016/j.cub.2005.12.019
482:Nature Reviews Genetics
437:10.1093/emboj/21.8.1881
478:Caenorhabditis elegans
222:Nucleic Acids Research
218:trans-splice acceptor"
81:In eukaryotes such as
31:at the 5' end of the
234:10.1093/nar/21.4.913
151:polypyrimidine tract
61:intron-like sequence
29:nucleotide sequence
549:10.1093/gbe/evw025
174:open reading frame
33:primary transcript
59:The outron is an
609:
571:
570:
560:
528:
522:
521:
473:
467:
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456:
431:(8): 1881–1888.
425:The EMBO Journal
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127:nucleotides (nt)
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597:Gene expression
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348:10.1002/wrna.71
329:
328:
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282:Current Biology
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211:
210:
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201:
182:
135:
87:dinoflagellates
57:
55:Characteristics
21:
12:
11:
5:
615:
613:
605:
604:
602:Non-coding DNA
599:
594:
589:
579:
578:
573:
572:
523:
494:10.1038/nrg995
488:(2): 110–118.
468:
411:
390:
369:
342:(3): 417–434.
317:
265:
228:(4): 913–919.
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543:(3): 562–77.
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192:Messenger RNA
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592:RNA splicing
540:
536:
526:
485:
481:
477:
471:
428:
424:
414:
404:26 September
402:. Retrieved
393:
383:26 September
381:. Retrieved
372:
339:
335:
334:-splicing".
331:
288:(1): R8–R9.
285:
281:
225:
221:
215:
207:
169:
167:
162:
158:
142:
139:cis-splicing
137:In standard
136:
115:chaetognaths
83:euglenozoans
80:
75:
69:
58:
41:RNA splicing
24:
22:
17:
587:Spliceosome
111:crustaceans
103:ctenophores
65:G+C content
581:Categories
216:C. elegans
199:References
133:Processing
99:cnidarians
45:maturation
502:1471-0056
445:1460-2075
364:209567118
304:0960-9822
242:0305-1048
147:adenosine
123:tunicates
107:flatworms
95:nematodes
74:. Such a
72:-splicing
20:-splicing
567:26966239
510:12560808
463:11953307
356:21957027
312:16401417
180:See also
119:rotifers
558:4824033
518:9864778
260:8451190
91:sponges
43:during
565:
555:
516:
508:
500:
461:
454:125970
451:
443:
362:
354:
310:
302:
258:
251:309224
248:
240:
121:, and
49:intron
25:outron
514:S2CID
360:S2CID
332:Trans
170:trans
163:trans
159:trans
155:lasso
143:trans
76:trans
70:trans
35:of a
27:is a
18:trans
563:PMID
506:PMID
498:ISSN
459:PMID
441:ISSN
406:2019
385:2019
352:PMID
308:PMID
300:ISSN
256:PMID
238:ISSN
186:Exon
37:gene
553:PMC
545:doi
490:doi
449:PMC
433:doi
344:doi
290:doi
246:PMC
230:doi
23:An
583::
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539:.
535:.
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504:.
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457:.
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429:21
427:.
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358:.
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338:.
320:^
306:.
298:.
286:16
284:.
280:.
268:^
254:.
244:.
236:.
226:21
224:.
220:.
117:,
113:,
109:,
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101:,
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85:,
569:.
547::
541:8
520:.
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486:4
465:.
435::
408:.
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366:.
346::
340:2
314:.
292::
262:.
232::
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