32:. The system mimics the elements of human physiology and keeps organs in an environment and temperature similar to the human body. The system allows for organ preservation that last longer than the standard organ preservation method of putting organs on ice, static cold storage, which can cause cold ischemia. When put on ice, organs begin to deteriorate about three to four hours after retrieval. On the other hand, the Paragonix SherpaPak Cardiac Transport System can offer uniform cooling by suspending the donor heart in a preservation solution, and provides continuous temperature monitoring.
439:
41:
circuit through the pulmonary artery. Organ Care system has been successfully used in clinical practice and has demonstrated that is able to prolong the ischemic time of donors' hearts by perfusing the organ in a beating state in normothermia while allowing the surgeon to assess the quality of the donor heart before surgery. Recently, it has been successfully used in high-risk heart recipients.
40:
A portable system designed for “extracorporeal heart perfusion, assessment, and resuscitation”, the system allows for the heart to remain beating though a process of retrograde perfusion. The process involves oxygenated donor blood moves through the coronary arteries via the aorta and returns to the
61:
The OCS Liver System was granted pre-market approval by the FDA in
September 2021. The system is designed to preserve the organ by keeping it at temperatures similar to a human body and maintains its function by perfusing the liver with blood, oxygen, and vital nutrients like bile salts. The device
206:
53:, designed to mimic the human system, keeps the lungs “breathing,” blood pumping through the vessels, and is kept at a human body-regulated temperature while in transportation to a donor patient.
480:
104:
Alomari, Mohammad; Garg, Pankaj; Yazji, John H; Wadiwala, Ishaq J; Alamouti-fard, Emad; Hussain, Md Walid Akram; Elawady, Mohamed S; Jacob, Samuel (2022).
163:
Mohite, PN; Sef, D; Umakumar, K; Maunz, O; Smail, H; Stock, U (16 June 2021). "Utilization of
Paragonix SherpaPak for human donor heart preservation".
106:"Is the Organ Care System (OCS) Still the First Choice With Emerging New Strategies for Donation After Circulatory Death (DCD) in Heart Transplant?"
473:
330:
232:"Combating Donor Organ Shortage: Organ Care System Prolonging Organ Storage Time and Improving the Outcome of Heart Transplantations"
504:
403:
509:
466:
283:"Heart Transplantation in Adult Congenital Heart Disease with the Organ Care System Use: A 4-Year Single-Center Experience"
80:
281:
Verzelloni Sef, A; Sef, D; Garcia Saez, D; Trkulja, V; Walker, C; Mitchell, J; McGovern, I; Stock, U (1 August 2021).
499:
50:
384:
312:
188:
376:
304:
263:
180:
145:
127:
450:
356:
368:
294:
253:
243:
172:
135:
117:
29:
25:
446:
258:
231:
140:
105:
21:
493:
388:
316:
192:
438:
62:
also assists in monitoring and regulating the pressure and flow of the perfusion.
357:"The TrnsMedics Organ Care System for the liver receives FDA pre-market approval"
299:
282:
331:"'Lung-in-a-Box' Offers Hope, Options for Patients Awaiting Lung Transplants"
131:
424:
380:
308:
267:
248:
184:
176:
149:
122:
372:
207:"Improving Heart Transplantation by Expanding the Donor Pool"
402:
Health, Center for
Devices and Radiological (2021-11-08).
81:"Four heart transplants performed in whirlwind 48 hours"
454:
28:
to be maintained for longer periods of time prior to
49:Referred to colloquially as “lung-in-a-box,” the
474:
8:
165:Multimedia Manual of Cardio-Thoracic Surgery
481:
467:
404:"Organ Care System (OCS) Liver – P200031"
298:
257:
247:
139:
121:
71:
355:Chang, Donald D. (November 15, 2022).
7:
435:
433:
453:. You can help Knowledge (XXG) by
14:
230:Sunjaya, AF; Sunjaya, AP (2019).
24:designed by Transmedics to allow
437:
211:American College of Cardiology
1:
300:10.1097/MAT.0000000000001482
236:Cardiovascular Therapeutics
526:
432:
505:Transplantation medicine
445:This article related to
510:Medical equipment stubs
57:Organ Care System Liver
36:Organ Care System Heart
18:Organ Care System (OCS)
177:10.1510/mmcts.2021.035
45:Organ Care System Lung
85:Vanderbilt University
425:Transmedics homepage
249:10.1155/2019/9482797
123:10.7759/cureus.26281
79:Batcheldor, Matt.
462:
461:
447:medical equipment
373:10.1111/aor.14115
361:Artificial Organs
517:
483:
476:
469:
441:
434:
412:
411:
399:
393:
392:
352:
346:
345:
343:
342:
327:
321:
320:
302:
278:
272:
271:
261:
251:
227:
221:
220:
218:
217:
203:
197:
196:
160:
154:
153:
143:
125:
101:
95:
94:
92:
91:
76:
525:
524:
520:
519:
518:
516:
515:
514:
500:Medical devices
490:
489:
488:
487:
430:
421:
416:
415:
401:
400:
396:
354:
353:
349:
340:
338:
329:
328:
324:
280:
279:
275:
229:
228:
224:
215:
213:
205:
204:
200:
162:
161:
157:
103:
102:
98:
89:
87:
78:
77:
73:
68:
59:
51:OCS Lung System
47:
38:
12:
11:
5:
523:
521:
513:
512:
507:
502:
492:
491:
486:
485:
478:
471:
463:
460:
459:
442:
428:
427:
420:
419:External links
417:
414:
413:
394:
347:
322:
293:(8): 862–868.
273:
222:
198:
155:
96:
70:
69:
67:
64:
58:
55:
46:
43:
37:
34:
22:medical device
13:
10:
9:
6:
4:
3:
2:
522:
511:
508:
506:
503:
501:
498:
497:
495:
484:
479:
477:
472:
470:
465:
464:
458:
456:
452:
448:
443:
440:
436:
431:
426:
423:
422:
418:
409:
405:
398:
395:
390:
386:
382:
378:
374:
370:
366:
362:
358:
351:
348:
336:
332:
326:
323:
318:
314:
310:
306:
301:
296:
292:
288:
287:ASAIO Journal
284:
277:
274:
269:
265:
260:
255:
250:
245:
241:
237:
233:
226:
223:
212:
208:
202:
199:
194:
190:
186:
182:
178:
174:
170:
166:
159:
156:
151:
147:
142:
137:
133:
129:
124:
119:
116:(6): e26281.
115:
111:
107:
100:
97:
86:
82:
75:
72:
65:
63:
56:
54:
52:
44:
42:
35:
33:
31:
27:
23:
19:
455:expanding it
444:
429:
407:
397:
367:(1): 25–26.
364:
360:
350:
339:. Retrieved
337:. 2022-04-22
334:
325:
290:
286:
276:
239:
235:
225:
214:. Retrieved
210:
201:
168:
164:
158:
113:
109:
99:
88:. Retrieved
84:
74:
60:
48:
39:
26:donor organs
17:
15:
242:: 9482797.
494:Categories
341:2022-11-02
216:2022-10-25
90:2022-10-25
66:References
30:transplant
389:244481677
317:235217756
193:235470558
132:2168-8184
381:34802155
309:34039886
268:31772620
185:34143579
150:35754437
259:6739795
141:9229932
387:
379:
315:
307:
266:
256:
191:
183:
148:
138:
130:
110:Cureus
449:is a
385:S2CID
335:UKNow
313:S2CID
189:S2CID
20:is a
451:stub
377:PMID
305:PMID
264:PMID
240:2019
181:PMID
169:2021
146:PMID
128:ISSN
16:The
408:FDA
369:doi
295:doi
254:PMC
244:doi
173:doi
136:PMC
118:doi
496::
406:.
383:.
375:.
365:46
363:.
359:.
333:.
311:.
303:.
291:67
289:.
285:.
262:.
252:.
238:.
234:.
209:.
187:.
179:.
171:.
167:.
144:.
134:.
126:.
114:14
112:.
108:.
83:.
482:e
475:t
468:v
457:.
410:.
391:.
371::
344:.
319:.
297::
270:.
246::
219:.
195:.
175::
152:.
120::
93:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.