56:
177:
120:
201:
32:
189:
104:, which can also present radiographically as white densities interspersed throughout bone. Blastic metastasis tends to present with larger and more irregular densities in less of a uniform pattern. Another differentiating factor is age, with blastic metastasis mostly affecting older people, and osteopoikilosis being found in people 20 years of age and younger.
542:
527:
221:
465:
Mumm S, Wenkert D, Zhang X, McAlister WH, Mier RJ, Whyte MP (2007). "Deactivating germline mutations in LEMD3 cause osteopoikilosis and
Buschke–Ollendorff syndrome, but not sporadic melorheostosis".
1713:
1987:
1949:
1349:
1546:
1023:
100:
is characterized by a pattern of numerous white densities of similar size spread throughout all the bones. This is a systemic condition. It must be differentiated from
315:
642:
1482:
1432:
1126:
154:
Men and women are affected in equal number, reflecting the fact that osteopoikilosis attacks indiscriminately. Additionally, the disease is often associated with
1551:
1970:
1938:
1673:
704:
1663:
1655:
727:
1954:
1077:
1746:
1623:
1571:
1051:
1089:
385:
932:
913:
737:
709:
635:
557:
1119:
1082:
299:
200:
1056:
1779:
176:
1774:
1693:
163:
1583:
681:
2001:
1882:
1836:
1668:
1658:
628:
1683:
1322:
2021:
1831:
1800:
1751:
1628:
1598:
1502:
1452:
1422:
1112:
856:
800:
732:
1218:
805:
1472:
1406:
1292:
1269:
1246:
1208:
1170:
372:
Nevin NC, Thomas PS, Davis RI, Cowie GH (1999). "Melorheostosis in a family with autosomal dominant osteopoikilosis".
922:
1871:
1852:
1769:
967:
1043:
1028:
158:, despite the apparent lack of correlation between melorheostosis and genetic heritability. It has been tied to
1933:
1928:
1826:
1650:
1401:
568:
409:"Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke–Ollendorff syndrome and melorheostosis"
1708:
1228:
1965:
1907:
1512:
1016:
953:
1618:
1576:
1175:
983:
904:
1365:
1223:
1180:
1033:
821:
699:
659:
651:
101:
1877:
188:
77:
243:"A cause for concern? Osteopoikilosis found incidentally in the emergency department: a case report"
55:
1339:
1072:
850:
788:
546:
329:
Serdaroğlu M, Capkin E, Uçüncü F, Tosun M (2007). "Case report of a patient with osteopoikilosis".
1846:
1522:
1492:
1462:
1442:
1411:
990:
490:
354:
309:
73:
1587:
1274:
1251:
1203:
1185:
946:
892:
579:
482:
430:
389:
346:
295:
272:
44:
1814:
970:
881:
826:
795:
474:
420:
381:
338:
262:
254:
49:
107:
The distribution is variable, though it does not tend to affect the ribs, spine, or skull.
1380:
1344:
1317:
1011:
978:
453:
1895:
1392:
1213:
1003:
941:
887:
841:
755:
747:
664:
551:
267:
242:
155:
119:
2015:
1614:
1144:
765:
494:
358:
31:
1135:
608:
573:
1961:
1924:
1890:
1729:
1644:
1540:
1388:
1334:
1261:
1153:
872:
85:
584:
448:
1977:
1594:
1518:
1508:
1498:
1488:
1478:
1468:
1418:
691:
536:
342:
1902:
1795:
1458:
1448:
1438:
1428:
1396:
1384:
1312:
868:
719:
673:
603:
386:
10.1002/(SICI)1096-8628(19990219)82:5<409::AID-AJMG10>3.0.CO;2-2
258:
207:
81:
486:
434:
393:
350:
276:
1822:
1238:
831:
620:
519:
478:
1945:
1862:
1842:
1738:
1329:
1104:
1000:
1761:
1567:
1195:
531:
69:
292:
Get through FRCR part 2B : rapid reporting of plain radiographs
425:
408:
1536:
1532:
1528:
1284:
1162:
222:
List of radiographic findings associated with cutaneous conditions
167:
159:
97:
1982:
782:
562:
1108:
624:
407:
Hellemans J, Preobrazhenska O, Willaert A, et al. (2004).
114:
1714:
Hydrops-ectopic calcification-moth-eaten skeletal dysplasia
1988:
Microcephalic osteodysplastic primordial dwarfism type II
130:
166:
is a similar condition, which is also associated with
16:
Formation of hard nodules within the interior of bones
1950:
Epidermolysis bullosa simplex with muscular dystrophy
96:
The radiographic appearance of osteopoikilosis on an
509:
1917:
1861:
1813:
1788:
1760:
1737:
1728:
1637:
1607:
1560:
1373:
1364:
1305:
1283:
1260:
1237:
1194:
1161:
1152:
1143:
1065:
1042:
999:
966:
931:
912:
903:
867:
840:
820:
774:
746:
718:
690:
672:
658:
594:
513:
43:
24:
1350:Terminal osseous dysplasia with pigmentary defects
84:of bone characterized by the presence of numerous
1024:Autosomal recessive multiple epiphyseal dysplasia
1483:Meesmann juvenile epithelial corneal dystrophy
1433:Meesmann juvenile epithelial corneal dystrophy
1120:
636:
241:Bull M, Calderbank P, Ramachandran N (2007).
8:
1971:Arrhythmogenic right ventricular dysplasia 9
1939:Arrhythmogenic right ventricular dysplasia 8
314:: CS1 maint: multiple names: authors list (
1552:Reticular pigmented anomaly of the flexures
1734:
1370:
1158:
1149:
1127:
1113:
1105:
909:
837:
669:
643:
629:
621:
510:
54:
30:
21:
424:
266:
1547:Naegeli–Franceschetti–Jadassohn syndrome
39:Osteopoikilosis on an X-ray of the hands
233:
172:
728:Spondyloepiphyseal dysplasia congenita
307:
1955:Epidermolysis bullosa simplex of Ogna
1224:DFN A3, 4, 11, 17, 22; B2, 30, 37, 48
705:Jansen's metaphyseal chondrodysplasia
294:. London: Royal Society of Medicine.
7:
1572:Desmin-related myofibrillar myopathy
1209:Hypertrophic cardiomyopathy 1, 8, 10
1052:Rhizomelic chondrodysplasia punctata
1664:Emery–Dreifuss muscular dystrophy 2
738:Otospondylomegaepiphyseal dysplasia
710:Schmid metaphyseal chondrodysplasia
1929:Striate palmoplantar keratoderma 2
1624:Charcot–Marie–Tooth disease 1F, 2E
1402:Striate palmoplantar keratoderma 3
182:Osteopoikilosis of the hips on CT.
14:
1780:Asphyxiating thoracic dysplasia 3
1669:Limb-girdle muscular dystrophy 1B
290:Balan, Nisha Sharma, Anu (2008).
1775:Short rib-polydactyly syndrome 3
1752:Hereditary spastic paraplegia 10
1247:Hypertrophic cardiomyopathy 7, 2
1078:Short rib – polydactyly syndrome
210:in a person with osteopoikilosis
199:
187:
175:
118:
1674:Charcot–Marie–Tooth disease 2B1
1083:Majewski's polydactyly syndrome
1883:Familial adenomatous polyposis
1837:Hereditary elliptocytosis 2, 3
1747:Charcot–Marie–Tooth disease 2A
1659:Familial partial lipodystrophy
1171:Hypertrophic cardiomyopathy 11
1:
1832:Hereditary spherocytosis 2, 3
1801:Cavernous venous malformation
1629:Amyotrophic lateral sclerosis
1599:Amyotrophic lateral sclerosis
1503:Epidermolysis bullosa simplex
1453:Epidermolysis bullosa simplex
1423:Ichthyosis bullosa of Siemens
1293:Hypertrophic cardiomyopathy 9
1270:Hypertrophic cardiomyopathy 3
857:Hereditary multiple exostoses
801:Polyostotic fibrous dysplasia
733:Multiple epiphyseal dysplasia
1473:Epidermolytic hyperkeratosis
1407:Epidermolytic hyperkeratosis
1090:Léri–Weill dyschondrosteosis
1694:Buschke–Ollendorff syndrome
164:Buschke–Ollendorff syndrome
2038:
1853:Hereditary spherocytosis 1
1770:Primary ciliary dyskinesia
1176:Dilated cardiomyopathy 1AA
1057:Conradi–Hünermann syndrome
682:Camurati–Engelmann disease
1997:
1684:Barraquer–Simons syndrome
1577:Dilated cardiomyopathy 1I
1323:Weill–Marchesani syndrome
1044:Chondrodysplasia punctata
1029:Atelosteogenesis, type II
343:10.1007/s00296-006-0262-9
38:
29:
1827:Spinocerebellar ataxia 5
1651:Mandibuloacral dysplasia
1219:Freeman–Sheldon syndrome
806:McCune–Albright syndrome
1966:Skin fragility syndrome
1908:Giant axonal neuropathy
1513:Steatocystoma multiplex
954:Thanatophoric dysplasia
259:10.1136/emj.2006.045765
1252:Nemaline myopathy 4, 5
923:Antley–Bixler syndrome
905:Growth factor receptor
652:Osteochondrodysplasias
127:This section is empty.
2002:Cytoskeletal proteins
1034:Diastrophic dysplasia
700:Metaphyseal dysplasia
2022:Cytoskeletal defects
1709:Pelger–Huet anomaly
1619:Parkinson's disease
1340:Boomerang dysplasia
1275:Nemaline myopathy 1
1229:May–Hegglin anomaly
1186:Nemaline myopathy 3
1073:Fibrochondrogenesis
851:osteochondromatosis
789:Boomerang dysplasia
479:10.1359/jbmr.061102
1878:Gardner's syndrome
1847:Long QT syndrome 4
1523:Familial cirrhosis
1493:White sponge nevus
1463:Familial cirrhosis
1443:White sponge nevus
991:Hypochondrogenesis
595:External resources
467:J. Bone Miner. Res
102:blastic metastasis
74:autosomal dominant
2009:
2008:
1934:Carvajal syndrome
1809:
1808:
1724:
1723:
1588:Alexander disease
1360:
1359:
1301:
1300:
1214:Usher syndrome 1B
1204:Elejalde syndrome
1102:
1101:
1098:
1097:
962:
961:
947:Hypochondroplasia
893:Maffucci syndrome
816:
815:
618:
617:
374:Am. J. Med. Genet
147:
146:
88:in the skeleton.
63:
62:
19:Medical condition
2029:
2000:Related topics:
1735:
1371:
1159:
1150:
1129:
1122:
1115:
1106:
1004:sulfation defect
971:collagen disease
910:
882:enchondromatosis
838:
827:chondrodystrophy
822:Chondrodysplasia
796:Opsismodysplasia
670:
645:
638:
631:
622:
511:
499:
498:
462:
456:
445:
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438:
428:
404:
398:
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129:You can help by
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59:
58:
50:Medical genetics
34:
22:
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2036:
2032:
2031:
2030:
2028:
2027:
2026:
2012:
2011:
2010:
2005:
1993:
1913:
1857:
1805:
1784:
1756:
1720:
1699:Osteopoikilosis
1633:
1603:
1556:
1356:
1345:Larsen syndrome
1318:Marfan syndrome
1297:
1279:
1256:
1233:
1190:
1139:
1133:
1103:
1094:
1061:
1038:
1012:Achondrogenesis
995:
979:Achondrogenesis
958:
927:
899:
863:
829:
825:
812:
775:Other/ungrouped
770:
761:Osteopoikilosis
742:
714:
686:
663:
654:
649:
619:
614:
613:
590:
589:
522:
508:
503:
502:
464:
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446:
442:
406:
405:
401:
371:
370:
366:
328:
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323:
306:
302:
289:
288:
284:
240:
239:
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218:
211:
204:
195:
194:Osteopoikilosis
192:
183:
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152:
143:
137:
134:
113:
94:
66:Osteopoikilosis
53:
25:Osteopoikilosis
20:
17:
12:
11:
5:
2035:
2033:
2025:
2024:
2014:
2013:
2007:
2006:
1998:
1995:
1994:
1992:
1991:
1974:
1973:
1968:
1958:
1957:
1952:
1942:
1941:
1936:
1931:
1921:
1919:
1915:
1914:
1912:
1911:
1899:
1896:Naxos syndrome
1887:
1886:
1885:
1880:
1867:
1865:
1859:
1858:
1856:
1855:
1840:
1839:
1834:
1829:
1819:
1817:
1811:
1810:
1807:
1806:
1804:
1803:
1798:
1792:
1790:
1786:
1785:
1783:
1782:
1777:
1772:
1766:
1764:
1758:
1757:
1755:
1754:
1749:
1743:
1741:
1732:
1726:
1725:
1722:
1721:
1719:
1718:
1717:
1716:
1711:
1703:
1702:
1701:
1696:
1688:
1687:
1686:
1678:
1677:
1676:
1671:
1666:
1661:
1653:
1641:
1639:
1635:
1634:
1632:
1631:
1626:
1621:
1611:
1609:
1605:
1604:
1602:
1601:
1591:
1590:
1580:
1579:
1574:
1564:
1562:
1558:
1557:
1555:
1554:
1549:
1544:
1526:
1516:
1506:
1496:
1486:
1476:
1466:
1456:
1446:
1436:
1426:
1416:
1415:
1414:
1409:
1404:
1393:hyperkeratosis
1377:
1375:
1368:
1362:
1361:
1358:
1357:
1355:
1354:
1353:
1352:
1347:
1342:
1337:
1327:
1326:
1325:
1320:
1309:
1307:
1303:
1302:
1299:
1298:
1296:
1295:
1289:
1287:
1281:
1280:
1278:
1277:
1272:
1266:
1264:
1258:
1257:
1255:
1254:
1249:
1243:
1241:
1235:
1234:
1232:
1231:
1226:
1221:
1216:
1211:
1206:
1200:
1198:
1192:
1191:
1189:
1188:
1183:
1178:
1173:
1167:
1165:
1156:
1147:
1145:Microfilaments
1141:
1140:
1134:
1132:
1131:
1124:
1117:
1109:
1100:
1099:
1096:
1095:
1093:
1092:
1087:
1086:
1085:
1075:
1069:
1067:
1066:Other dwarfism
1063:
1062:
1060:
1059:
1054:
1048:
1046:
1040:
1039:
1037:
1036:
1031:
1026:
1021:
1020:
1019:
1008:
1006:
997:
996:
994:
993:
988:
987:
986:
975:
973:
964:
963:
960:
959:
957:
956:
951:
950:
949:
942:Achondroplasia
938:
936:
929:
928:
926:
925:
919:
917:
907:
901:
900:
898:
897:
896:
895:
890:
888:Ollier disease
877:
875:
865:
864:
862:
861:
860:
859:
846:
844:
842:Osteochondroma
835:
818:
817:
814:
813:
811:
810:
809:
808:
798:
793:
792:
791:
778:
776:
772:
771:
769:
768:
763:
758:
756:Raine syndrome
752:
750:
748:Osteosclerosis
744:
743:
741:
740:
735:
730:
724:
722:
716:
715:
713:
712:
707:
702:
696:
694:
688:
687:
685:
684:
678:
676:
667:
665:osteodystrophy
660:Osteodysplasia
656:
655:
650:
648:
647:
640:
633:
625:
616:
615:
612:
611:
599:
598:
596:
592:
591:
588:
587:
576:
565:
554:
539:
523:
518:
517:
515:
514:Classification
507:
506:External links
504:
501:
500:
457:
440:
426:10.1038/ng1453
419:(11): 1213–8.
399:
364:
331:Rheumatol. Int
321:
301:978-1853157547
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174:
156:melorheostosis
151:
148:
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138:September 2021
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90:
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60:
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9:
6:
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3:
2:
2034:
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2004:
2003:
1996:
1989:
1985:
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1765:
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1733:
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1662:
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1646:
1643:
1642:
1640:
1636:
1630:
1627:
1625:
1622:
1620:
1616:
1615:Neurofilament
1613:
1612:
1610:
1606:
1600:
1596:
1593:
1592:
1589:
1585:
1582:
1581:
1578:
1575:
1573:
1569:
1566:
1565:
1563:
1559:
1553:
1550:
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1534:
1530:
1527:
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1500:
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1413:
1410:
1408:
1405:
1403:
1400:
1399:
1398:
1394:
1390:
1386:
1382:
1381:Keratinopathy
1379:
1378:
1376:
1372:
1369:
1367:
1363:
1351:
1348:
1346:
1343:
1341:
1338:
1336:
1335:FG syndrome 2
1333:
1332:
1331:
1328:
1324:
1321:
1319:
1316:
1315:
1314:
1311:
1310:
1308:
1304:
1294:
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1288:
1286:
1282:
1276:
1273:
1271:
1268:
1267:
1265:
1263:
1259:
1253:
1250:
1248:
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1244:
1242:
1240:
1236:
1230:
1227:
1225:
1222:
1220:
1217:
1215:
1212:
1210:
1207:
1205:
1202:
1201:
1199:
1197:
1193:
1187:
1184:
1182:
1179:
1177:
1174:
1172:
1169:
1168:
1166:
1164:
1160:
1157:
1155:
1151:
1148:
1146:
1142:
1137:
1130:
1125:
1123:
1118:
1116:
1111:
1110:
1107:
1091:
1088:
1084:
1081:
1080:
1079:
1076:
1074:
1071:
1070:
1068:
1064:
1058:
1055:
1053:
1050:
1049:
1047:
1045:
1041:
1035:
1032:
1030:
1027:
1025:
1022:
1018:
1015:
1014:
1013:
1010:
1009:
1007:
1005:
1002:
998:
992:
989:
985:
982:
981:
980:
977:
976:
974:
972:
969:
965:
955:
952:
948:
945:
944:
943:
940:
939:
937:
934:
930:
924:
921:
920:
918:
915:
911:
908:
906:
902:
894:
891:
889:
886:
885:
884:
883:
879:
878:
876:
874:
870:
866:
858:
855:
854:
853:
852:
848:
847:
845:
843:
839:
836:
833:
828:
823:
819:
807:
804:
803:
802:
799:
797:
794:
790:
787:
786:
785:
784:
780:
779:
777:
773:
767:
766:Osteopetrosis
764:
762:
759:
757:
754:
753:
751:
749:
745:
739:
736:
734:
731:
729:
726:
725:
723:
721:
717:
711:
708:
706:
703:
701:
698:
697:
695:
693:
689:
683:
680:
679:
677:
675:
671:
668:
666:
661:
657:
653:
646:
641:
639:
634:
632:
627:
626:
623:
610:
606:
605:
601:
600:
597:
593:
586:
582:
581:
577:
575:
571:
570:
566:
564:
560:
559:
555:
553:
549:
548:
544:
540:
538:
534:
533:
529:
525:
524:
521:
516:
512:
505:
496:
492:
488:
484:
480:
476:
473:(2): 243–50.
472:
468:
461:
458:
455:
454:Who Named It?
451:
450:
444:
441:
436:
432:
427:
422:
418:
414:
410:
403:
400:
395:
391:
387:
383:
380:(5): 409–14.
379:
375:
368:
365:
360:
356:
352:
348:
344:
340:
336:
332:
325:
322:
317:
311:
303:
297:
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278:
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197:
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149:
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132:
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117:
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105:
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99:
91:
89:
87:
83:
79:
75:
71:
67:
57:
51:
48:
46:
42:
37:
33:
28:
23:
1999:
1981:
1901:
1889:
1870:
1841:
1730:Microtubules
1698:
1136:Cytoskeletal
880:
849:
781:
760:
602:
578:
567:
556:
541:
526:
470:
466:
460:
447:
443:
416:
412:
402:
377:
373:
367:
337:(7): 683–6.
334:
330:
324:
291:
285:
250:
246:
236:
153:
150:Epidemiology
135:
131:adding to it
126:
106:
95:
92:Presentation
86:bone islands
80:(hardening)
65:
64:
1962:plakophilin
1925:desmoplakin
1891:plakoglobin
1645:Laminopathy
1541:Monilethrix
1389:keratoderma
1262:Tropomyosin
1154:Myofilament
873:enchondroma
830:(including
247:Emerg Med J
1978:centrosome
1595:Peripherin
692:Metaphysis
580:DiseasesDB
413:Nat. Genet
253:(5): e29.
228:References
78:sclerosing
1796:Tauopathy
1385:keratosis
1313:Fibrillin
869:Chondroma
720:Epiphysis
674:Diaphysis
604:eMedicine
449:synd/1803
310:cite book
208:bone scan
82:dysplasia
45:Specialty
2016:Category
1823:Spectrin
1815:Membrane
1656:Dunnigan
1239:Troponin
832:dwarfism
609:derm/733
495:28338454
487:17087626
435:15489854
394:10069713
359:20299738
351:17106662
277:17452689
216:See also
1946:plectin
1863:Catenin
1843:Ankyrin
1739:Kinesin
1647:: LMNA
1330:Filamin
1138:defects
1017:type 1B
1001:SLC26A2
574:D010023
268:2658513
206:Normal
1762:Dynein
1690:LEMD3
1568:Desmin
1196:Myosin
1181:DFNA20
984:type 2
968:COL2A1
563:166700
552:756.53
493:
485:
433:
392:
357:
349:
298:
275:
265:
70:benign
52:
1918:Other
1789:Other
1680:LMNB
1537:KRT86
1533:KRT83
1529:KRT81
1519:KRT18
1509:KRT17
1499:KRT14
1489:KRT13
1479:KRT12
1469:KRT10
1419:KRT2E
1306:Other
1285:Titin
1163:Actin
933:FGFR3
914:FGFR2
585:30071
537:Q78.8
491:S2CID
355:S2CID
168:LEMD3
160:LEMD3
111:Cause
98:X-ray
68:is a
1983:PCNT
1705:LBR
1584:GFAP
1459:KRT8
1449:KRT5
1439:KRT4
1429:KRT3
1412:IHCM
1397:KRT1
783:FLNB
569:MeSH
558:OMIM
547:9-CM
483:PMID
431:PMID
390:PMID
347:PMID
316:link
296:ISBN
273:PMID
1903:GAN
1872:APC
1395:):
1374:1/2
543:ICD
528:ICD
475:doi
452:at
421:doi
382:doi
339:doi
263:PMC
255:doi
133:.
2018::
1980::
1964::
1948::
1927::
1845::
1825::
1617::
1597::
1586::
1570::
1391:,
1387:,
1366:IF
607::
583::
572::
561::
550::
535::
532:10
489:.
481:.
471:22
469:.
429:.
417:36
415:.
411:.
388:.
378:82
376:.
353:.
345:.
335:27
333:.
312:}}
308:{{
271:.
261:.
251:24
249:.
245:.
170:.
162:.
76:,
72:,
1990:)
1986:(
1910:)
1906:(
1898:)
1894:(
1638:5
1608:4
1561:3
1543:)
1539:(
1535:/
1531:/
1525:)
1521:(
1515:)
1511:(
1505:)
1501:(
1495:)
1491:(
1485:)
1481:(
1475:)
1471:(
1465:)
1461:(
1455:)
1451:(
1445:)
1441:(
1435:)
1431:(
1425:)
1421:(
1383:(
1128:e
1121:t
1114:v
935::
916::
871:/
834:)
824:/
662:/
644:e
637:t
630:v
545:-
530:-
520:D
497:.
477::
437:.
423::
396:.
384::
361:.
341::
318:)
304:.
279:.
257::
140:)
136:(
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