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The risks of
Coculture are minimal. The procedure has been performed in over 1000 patients with no reported detrimental effects on embryo growth. Complications involving uterine infection or damage caused by endometrial biopsy are extremely rare.
128:. It involves placing a patient’s fertilized eggs on top of a layer of cells from her own uterine lining, creating a more natural environment for embryo development and maximizing the chance for an
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In addition to being noninvasive and relatively pain free, Coculture can be performed during a short office visit. The procedure also can improve embryo quality and stimulate embryo growth.
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198:; the rates (fraction) reaching blastocyst stage were 56% versus 46% in the coculture versus the sequential system, respectively, with own oocytes. With eggs from
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241:"Embryologic outcome and secretome profile of implanted blastocysts obtained after coculture in human endometrial epithelial cells versus the sequential system"
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Coculture can be an effective treatment for patients who have failed previous IVF cycles or who have poor embryo quality.
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1. Once a patient has been deemed an appropriate candidate for the procedure, she undergoes an endometrial
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3. The patient then undergoes a typical IVF cycle and is given medication to stimulate egg growth in her
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2. The uterine lining sample is sent to a research lab, where it is treated, purified and frozen.
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6. Over the next two days, the embryos are closely monitored for growth and development.
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Dominguez F, Gadea B, Mercader A, Esteban FJ, Pellicer A, SimĂłn C (December 2008).
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7. The patient’s embryos are transferred into her uterus for implantation and
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A study of 12,377 embryo cultures showed that endometrial coculture is
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are placed on top of her own (and now thawed) endometrial cells.
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during which a small piece of her uterine lining is removed.
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A typical
Coculture cycle consists of the following steps:
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4. The patient’s eggs are retrieved and mixed with the
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49:. Unsourced material may be challenged and removed.
162:5. Once fertilization is confirmed, the patient’s
680:Reproduction and pregnancy in speculative fiction
202:, the rates were 71% versus 56%, respectively.
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16:Technique of assisted reproductive technology
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109:Learn how and when to remove this message
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47:adding citations to reliable sources
58:"Autologous endometrial coculture"
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482:Preimplantation genetic diagnosis
701:Assisted reproductive technology
462:Intracytoplasmic sperm injection
437:Autologous endometrial coculture
308:Assisted reproductive technology
258:10.1016/j.fertnstert.2008.10.019
126:assisted reproductive technology
122:Autologous Endometrial Coculture
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34:needs additional citations for
545:Gamete intrafallopian transfer
492:Zygote intrafallopian transfer
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649:Genetic diagnosis of intersex
477:Partner-assisted reproduction
487:Transvaginal ovum retrieval
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136:How Coculture is performed
654:Religious response to ART
472:Ovarian hyperstimulation
196:sequential culture media
508:Artificial insemination
354:Male infertility crisis
178:The potential candidate
659:Mitochondrial donation
593:Donor Sibling Registry
432:Assisted zona hatching
421:In vitro fertilisation
130:in vitro fertilization
206:were 39% vs. 28% and
550:Reproductive surgery
442:Cytoplasmic transfer
372:Estrogen antagonists
364:Fertility medication
43:improve this article
562:Selective reduction
513:Ovulation induction
457:In vitro maturation
452:Gestational carrier
377:aromatase inhibitor
588:Donor registration
555:Vasectomy reversal
210:were 33% vs. 21%.
208:implantation rates
124:is a technique of
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639:Accidental incest
349:Fertility tourism
344:Fertility testing
251:(3): 774–782.e1.
132:(IVF) pregnancy.
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613:Semen collection
518:Cryopreservation
467:Oocyte selection
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54:Find sources:
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32:This article
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598:Egg donation
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194:better than
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99:January 2008
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41:Please help
36:verification
33:
404:menotropins
316:Infertility
618:Sperm bank
226:References
186:Advantages
69:newspapers
572:Surrogacy
382:clomifene
172:pregnancy
695:Category
623:Ova bank
581:Donation
267:19062008
673:Related
523:embryos
164:embryos
152:ovaries
83:scholar
632:Ethics
603:Embryo
528:oocyte
324:Female
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144:biopsy
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608:Sperm
538:semen
423:(IVF)
217:Risks
158:sperm
90:JSTOR
76:books
334:LGBT
329:Male
263:PMID
62:news
411:hCG
389:FSH
253:doi
45:by
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