29:
638:
548:
Kawai S, Sugaya Y, Hagihara R, Tomita H, Katsuyama Y, Ohnishi Y (April 2021). "Complete
Biosynthetic Pathway of Alazopeptin, a Tripeptide Consisting of Two Molecules of 6-Diazo-5-oxo-l-norleucine and One Molecule of Alanine".
249:
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Kawai S, Katsuyama Y, Ohnishi Y (April 2022). "The ฮฑ/ฮฒ Hydrolase AzpM Catalyzes
Dipeptide Synthesis in Alazopeptin Biosynthesis Using Two Molecules of Carrier Protein-Tethered Amino Acid".
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InChI=1S/C15H20N6O5/c1-2-7-18-12(5-3-10(22)8-19-16)14(24)21-13(15(25)26)6-4-11(23)9-20-17/h2,8-9,12-13,18H,1,3-7H2,(H2-2,21,22,23,24,25,26)/b10-8-,11-9-
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380:"In vitro and in vivo antitrypanosomal activitiy [sic] of two microbial metabolites, KS-505a and alazopeptin"
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722:
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Patterson EL, Johnson BL, DeVoe SE, Bohonos N (1965). "Structure of the antitumor antibiotic alazopeptin".
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Ishiyama A, Otoguro K, Namatame M, Nishihara A, Furusawa T, Masuma R, et al. (October 2008).
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424:"Studies on the antitumor activity of an alazopeptin isolated from a new strain of Streptomyces"
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and one molecule of L-alanine. In 2021 the biosynthetic pathway of alazopeptin was elucidated.
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De Voe SE, Rigler NE, Shay AJ, Martin JH, Boyd TC, Backus EJ, et al. (1956โ1957).
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357:. Structurally, alazopeptin is a tripeptide and contains 2 molecules of
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492:"Alazopeptin; production, isolation, and chemical characteristics"
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Hata T, Umezawa I, Iwai Y, Katagiri M, Awaya J (March 1973).
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It is still largely produced via fermentation broths of that
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6-diazo-2-{6-diazo-5-oxo-2-hexanamido}-5-oxohexanoic acid
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Patterson EL, Johnson BL, DeVoe SE, Bohonos N (1965).
519:"Structure of the antitumor antibiotic alazopeptin"
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339:activity. It was originally isolated from
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271:C=CCNC(CCC(=C#N))C(=O)NC(CCC(=C#N))C(=O)O
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523:Antimicrobial Agents and Chemotherapy
465:Antimicrobial Agents and Chemotherapy
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659:. You can help Knowledge (XXG) by
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296:Key:RCQIFJCPIWRTAF-WGEIWTTOSA-N
708:Drugs not assigned an ATC code
342:Streptacidiphilus griseoplanus
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349:. It is also isolated from
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441:10.7164/antibiotics.26.181
428:The Journal of Antibiotics
384:The Journal of Antibiotics
359:6-diazo-5-oxo-L-norleucine
187:Chemical and physical data
345:, sourced from soil near
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563:10.1002/anie.202100462
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351:Kitasatospora azatica
331:, with moderate anti-
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496:Antibiotics Annual
397:10.1038/ja.2008.83
347:Williamsburg, Iowa
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600:(7): e202100700.
551:Angewandte Chemie
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250:Interactive image
16:Chemical compound
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728:Tripeptides
718:Allylamines
713:Antibiotics
594:ChemBioChem
529:: 115โ118.
498:: 730โ735.
471:: 115โ118.
325:Alazopeptin
233: gยทmol
177:ChEMBL92957
57:Identifiers
21:Alazopeptin
702:Categories
365:References
329:antibiotic
238:3D model (
226:Molar mass
157:H2QL5CU7EQ
128:ChemSpider
83:CAS Number
66:IUPAC name
622:246651326
579:232039107
337:antitumor
92:1397-84-8
614:35132756
571:33624374
504:13425456
406:19168977
355:organism
315:(verify)
137:16735646
42:ATC code
535:5883414
477:5883414
450:4205875
231:364.362
193:Formula
117:5486654
103:PubChem
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327:is an
264:SMILES
168:ChEMBL
644:This
618:S2CID
575:S2CID
284:InChI
240:JSmol
657:stub
653:drug
610:PMID
567:PMID
531:PMID
500:PMID
473:PMID
446:PMID
402:PMID
335:and
148:UNII
49:None
648:or
602:doi
559:doi
436:doi
392:doi
107:CID
704::
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219:5
216:O
213:6
210:N
204:H
198:C
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