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develops as if a shade was drawn upward or downward over the eye, rarely sideward. Single or multiple attacks are possible. Some patients experience hundreds, if not thousands, of episodes. Pain, scintillations, and diplopia are usually not present. The prognosis for retinal recovery is good in most patients; retinal infarction occurs in a few.
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Leber's congenital amaurosis (LCA) is the most severe and earliest of the inherited retinal dystrophies that cause congenital blindness. It has an incidence of 2-3 per 100,000 births and accounts for 10-18% of cases of congenital blindness among children in blind institutes and 5% of all retinal
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Amaurosis fugax, also known as transient monocular blindness, is caused by a sudden, temporary decrease in blood flow to one eye. The loss of vision is abrupt, lasting only seconds or minutes. Blindness is total, though it is sometimes limited to a specific area of vision. Blindness frequently
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In most cases, LCA is inherited in an autosomal recessive pattern, as established by Alström and Olson in 1957. Some patients only have retinal blindness, whereas others have multi-systemic involvement that includes renal, cardiac, skeletal, and, most notably, central nervous system anomalies.
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Although amaurosis caused by quinine poisoning is now uncommon, it does occur on occasion. When quinine is used as an abortifacient, the initial history may be deceptive, but the presence of characteristic changes in the fundi usually allows certainty of a diagnosis.
66:, indicating partial or complete blindness with a dark pupil, e.g., a cataract. Milton, already totally blind for twelve years (some scholars think from retinal detachment; others have diagnosed glaucoma) by the time he published
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Theodor von Leber, a German ophthalmologist, described LCA in 1869 as a disorder characterized by profound visual loss present at or shortly after birth, nystagmus, sluggish pupillary reactions, and pigmentary retinopathy.
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Fazzi, Elisa; Signorini, Sabrina
Giovanna; Scelsa, Barbara; Bova, Stefania Maria; Lanzi, Giovanni (2003). "Leber's congenital amaurosis: an update".
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39:. It may result from either a medical condition or excess acceleration, as in flight. The term is the same as the
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dystrophies, a figure that is likely to be greater in countries with a greater percentage of consanguinity.
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is a condition of partial or complete blindness with a transparent, clear pupil. This term contrasts with
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or weakness that occurs without an apparent lesion affecting the
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Gautier, Jean-Claude (1993-08-05). "Amaurosis Fugax".
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70:, refers to these terms in Book 3, lines 25–26.
328:(6). Massachusetts Medical Society: 426–428.
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253:The Encyclopedia of World Problems
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369:British Journal of Ophthalmology
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322:New England Journal of Medicine
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291:10.1016/s1090-3798(02)00135-6
224:"Dorlands Medical Dictionary"
363:Drance, S. M. (1955-03-01).
85:Leber's congenital amaurosis
79:Leber's congenital amaurosis
334:10.1056/nejm199308053290611
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285:(1). Elsevier BV: 13–22.
46:, which means, in Latin,
62:which means, in Latin,
469:Neurological disorders
187:This section is empty.
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382:10.1136/bjo.39.3.178
375:(3). BMJ: 178–181.
365:"Quinine Amaurosis"
117:Quinidine toxicity
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249:"Amaurosis"
52:bright drop
33:vision loss
458:Categories
258:2023-11-04
234:2005-09-25
210:References
171:In animals
132:Management
48:clear drop
437:SNOMED CT
391:0007-1161
342:0028-4793
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198:July 2024
159:July 2024
123:Quinidine
21:darkening
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