244:
are not associated with a larger increase in plasma IL-6 than exercise involving concentric “nondamaging” muscle contractions. This finding demonstrates that muscle damage is not required to provoke an increase in plasma IL-6 during exercise. In fact, eccentric exercise may result in a delayed peak
1034:
Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV (2016).
778:
240:. IL-6 had previously been classified as a proinflammatory cytokine. Therefore, it was first thought that the exercise-induced IL-6 response was related to muscle damage. However, it has become evident that
1160:
572:"Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic diseases: systematic literature review and meta-analysis informing a consensus statement"
630:
Korneev, KV; Atretkhany, KN; Drutskaya, MS; Grivennikov, SI; Kuprash, DV; Nedospasov, SA (January 2017). "TLR-signaling and proinflammatory cytokines as drivers of tumorigenesis".
690:
181:
e.g. for rheumatoid arthritis : clazakizumab, olokizumab, sarilumab and sirukumab have all reported encouraging phase 2 results. Sirukumab is in multiple phase 3 trials.
764:
245:
and a much slower decrease of plasma IL-6 during recovery. Anti-IL-6 therapies should therefore take into consideration the (beneficial) anti-inflammatory effects of
792:
1153:
1146:
855:
Mutua, Victor; Henry, Brandon
Michael; Csefalvay, Chris von; Cheruiyot, Isaac; Vikse, Jens; Lippi, Giuseppe; Bundi, Brian; Mong'are, Newnex (2022).
2358:
1625:
806:
2362:
2348:
2308:
344:
Barton BE (2005). "Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes".
2377:
175:
236:
New research has found IL-6 to be an anti-inflammatory cytokine with multiple beneficial effects when released by contracting muscle as a
209:
2282:
694:
1230:
1010:
122:
779:"RuiYi (Formerly Anaphore) and arGEN-X Announce Exclusive Worldwide License Agreement for ARGX-109, a Novel anti-IL-6 Antibody"
1037:"Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts"
793:"Formatech to Donate Services to Formulate and Fill Femta Pharmaceuticals' FM101 Monoclonal Antibody under Its "Fillanthrop"
717:"The novel guanylhydrazone CPSI-2364 ameliorates ischemia reperfusion injury after experimental small bowel transplantation"
2243:
2222:
2423:
76:. Siltuximab was also tested in the phase I/II study for therapy of patients with metastatic castration-associated
912:
531:"IL-6 targeting compared to TNF targeting in rheumatoid arthritis: studies of olokizumab, sarilumab and sirukumab"
115:
715:
Websky Mv FJ, Ohsawa I, Praktiknjo M, Wehner S, Abu-Elmagd K, Kitamura K, Kalff JC, Schaefer N, Pech T (2013).
618:
2201:
2161:
2140:
2084:
2052:
2011:
1969:
1923:
1842:
1816:
1760:
1719:
1693:
1667:
1321:
1776:
1636:
1616:
1595:
1514:
1453:
1397:
1351:
1275:
1180:
479:
Yokota S (2003). "Interleukin 6 as a therapeutic target in systemic-onset juvenile idiopathic arthritis".
268:, and work has suggested that IL-6 plays a role in regulating disease severity in obesity-related asthma.
73:
57:
1086:"Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1"
1286:
2398:
2181:
1169:
1097:
85:
42:
41:
relevant to many inflammatory diseases and many cancers. Hence, anti-IL6 agents have been sought. In
1311:
857:"Tocilizumab in addition to standard of care in the management of COVID-19: a meta-analysis of RCTs"
2172:
1730:
1525:
1301:
1195:
241:
2042:
2037:
2022:
1934:
1913:
1362:
1296:
1255:
1199:
1172:
746:
504:
369:
1903:
1771:
1678:
1657:
1408:
1377:
1372:
1316:
1235:
1949:
1382:
1210:
1205:
171:
1555:
1540:
1504:
1474:
1220:
1125:
1066:
1016:
1006:
968:
894:
876:
738:
647:
601:
552:
496:
420:
361:
326:
201:
185:
2393:
1115:
1105:
1056:
1048:
998:
958:
950:
937:
Bruunsgaard H, Galbo H, Halkjaer-Kristensen J, Johansen TL, MacLean DA, Pedersen BK (1997).
884:
868:
728:
664:
639:
591:
583:
571:
542:
488:
447:
410:
400:
353:
316:
308:
1869:
1865:
1861:
2185:
77:
465:
1101:
939:"Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage"
2383:
2373:
2368:
2354:
2340:
2330:
2325:
2272:
2254:
2233:
2212:
2191:
2177:
2151:
2095:
2063:
2027:
1990:
1985:
1980:
1944:
1939:
1853:
1832:
1786:
1735:
1704:
1683:
1418:
1387:
1120:
1085:
1061:
1036:
963:
938:
889:
596:
415:
388:
321:
296:
205:
119:
89:
1052:
676:
451:
196:
Anti-IL-6 Receptor antibodies: Treatment of
Coronavirus-associated pulmonary pathology
2417:
2125:
1781:
1647:
1606:
1530:
1464:
1413:
1367:
1306:
1191:
492:
250:
93:
46:
34:
750:
587:
547:
530:
508:
373:
2299:
2120:
1806:
1801:
1796:
1545:
1484:
1443:
954:
159:
1138:
765:"ArGEN-X Wins €1.5M IWT Grant to Progress Camelid-Derived Human Antibody Pipeline"
2130:
2110:
2073:
1908:
1898:
1750:
1745:
1580:
1550:
1489:
1331:
1291:
1250:
1245:
733:
716:
217:
155:
111:
53:
1090:
Proceedings of the
National Academy of Sciences of the United States of America
643:
2115:
2105:
2000:
1893:
1888:
1709:
1570:
1560:
1494:
1428:
1341:
1336:
1265:
225:
151:
65:
61:
880:
872:
807:"Regeneron, Sanofi Launch Clinical Trial of Kevzara as Coronavirus Treatment"
357:
249:
generally, including the now-established multiple benefits of muscle-derived
1585:
1575:
1565:
1438:
1110:
221:
167:
163:
140:
126:
81:
1129:
1070:
1020:
898:
831:
742:
651:
605:
556:
500:
424:
365:
330:
972:
677:"UCB Announces Start Of Phase I Study For Antibody Drug Candidate CDP6038"
619:
http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/125496s000lbl.pdf
297:"Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling"
125:
pathway upregulation was observed and after inhibition of this pathway by
1225:
1002:
271:
213:
38:
17:
2344:
1827:
261:
246:
237:
68:
is approved for treatment of human immunodeficiency virus-negative and
913:"EUSA Pharma initiates study of siltuximab to treat Covid-19 patients"
466:"Interleukin-6 – new target in the battle against Ras-induced cancers"
1959:
312:
265:
144:
101:
856:
204:, antagonistic antibodies against the IL-6 receptors were tested in
405:
2266:
2262:
2258:
1877:
1873:
1857:
189:
69:
691:"Article > UCB's RA drug does not overly impress in Phase II"
570:
Schoels MM, van der Heijde D, Breedveld FC, et al. (2013).
438:
Stein and
Sutherland (1998). "IL-6 as a drug discovery target".
105:
97:
1142:
2334:
92:
resulted in 39% of patients showed disease stabilization via
665:
FDA Gives Nod to
Sarilumab for Rheumatoid Arthritis. 2017
290:
288:
286:
264:
is a known risk factor in the development of severe
2318:
2298:
2291:
2242:
2221:
2200:
2160:
2139:
2083:
2051:
2010:
1968:
1922:
1841:
1815:
1759:
1718:
1692:
1666:
1635:
1615:
1594:
1513:
1452:
1396:
1350:
1274:
1179:
989:Pedersen BK (2013). "Muscle as a secretory organ".
174:an apparent macrophage-specific inhibitor of the
811:GEN - Genetic Engineering and Biotechnology News
984:
982:
56:(Actemra), is an antibody directed against the
208:to assess their use in treating or preventing
1154:
52:The first approved medication in this class,
8:
524:
522:
520:
518:
64:(Sylvant), is directed against IL-6 itself.
228:, were also investigated. Also: Levilimab.
184:Agents in pre-clinical development include
2295:
1161:
1147:
1139:
295:Jones SA, Scheller J, Rose-John S (2011).
224:. Antibodies against IL-6 itself, such as
1119:
1109:
1060:
962:
888:
732:
595:
546:
414:
404:
389:"Interleukin-6: a new therapeutic target"
320:
274:reduces IL-6 production in some neurons.
2326:Interleukin 14 (taxilin alpha, HMW-BCGF)
150:Several agents are in clinical trials:
118:. In phase I/II trial of tocilizumab in
282:
45:they can help patients unresponsive to
1624:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
1084:Jang S, Kelley KW, Johnson RW (2008).
346:Expert Opinion on Therapeutic Targets
301:The Journal of Clinical Investigation
72:-negative patients with multicentric
7:
176:p38 mitogen-activated protein kinase
33:agents are a class of therapeutics.
216:patients. Such antibodies include
147:in 2017 for rheumatoid arthritis.
25:
27:Drugs to suppress IL-6 signalling
861:Acta Biomedica: Atenei Parmensis
535:Annals of the Rheumatic Diseases
529:Tanaka Y, Martin Mola E (2014).
493:10.1097/00002281-200309000-00010
393:Arthritis Research & Therapy
129:tumor growth was decreased both
2152:Interleukin 27 (interleukin 30)
1041:The Lancet Respiratory Medicine
588:10.1136/annrheumdis-2012-202470
548:10.1136/annrheumdis-2013-205002
481:Current Opinion in Rheumatology
955:10.1113/jphysiol.1997.sp021972
1:
1053:10.1016/S2213-2600(16)30048-0
832:"ChinaXiv.org 中国科学院科技论文预发布平台"
452:10.1016/S1359-6446(97)01164-1
96:-regulated downregulation of
387:Smolen JS, Maini RN (2006).
1502:Antisense oligonucleotides:
734:10.1097/TP.0b013e31828e72fa
2440:
644:10.1016/j.cyto.2016.01.021
943:The Journal of Physiology
116:large-cell lung carcinoma
991:Comprehensive Physiology
873:10.23750/abm.v93i1.12208
358:10.1517/14728222.9.4.737
2192:Interleukin-29 (IFN-λ1)
1337:Daclizumab (dacliximab)
1322:Tucotuzumab celmoleukin
1111:10.1073/pnas.0802865105
2173:Interferon λ4 (IFN-λ4)
1266:Rilonacept (IL-1 Trap)
162:(BMS-945429, ALD518),
2096:Interleukin 23 (SGRF)
1777:Cintredekin besudotox
1705:Interleukin 11 (AGIF)
1684:Interleukin 10 (CSIF)
917:Clinical Trials Arena
232:Exercise induced IL-6
88:; phase II trials in
1170:Interleukin receptor
1003:10.1002/cphy.c120033
440:Drug Discovery Today
86:renal cell carcinoma
80:in combination with
43:rheumatoid arthritis
1302:Denileukin diftitox
1102:2008PNAS..105.7534J
242:eccentric exercises
178:pathway. ALX-0061.
74:Castleman's disease
2424:Immunosuppressants
1874:E (interleukin 25)
212:in critically ill
114:was first used in
31:Anti-interleukin-6
2411:
2410:
2407:
2406:
2376:(signals through
2357:(signals through
2343:(signals through
2333:(signals through
1957:Binding proteins:
1287:Adargileukin alfa
202:COVID-19 pandemic
16:(Redirected from
2431:
2399:Efineptakin alfa
2394:Efavaleukin alfa
2296:
1263:Decoy receptors:
1163:
1156:
1149:
1140:
1134:
1133:
1123:
1113:
1081:
1075:
1074:
1064:
1031:
1025:
1024:
986:
977:
976:
966:
934:
928:
927:
925:
924:
909:
903:
902:
892:
852:
846:
845:
843:
842:
836:www.chinaxiv.org
828:
822:
821:
819:
818:
803:
797:
796:
789:
783:
782:
781:(Press release).
775:
769:
768:
761:
755:
754:
736:
712:
706:
705:
703:
702:
693:. Archived from
687:
681:
680:
673:
667:
662:
656:
655:
627:
621:
616:
610:
609:
599:
567:
561:
560:
550:
526:
513:
512:
476:
470:
469:
462:
456:
455:
435:
429:
428:
418:
408:
384:
378:
377:
341:
335:
334:
324:
313:10.1172/JCI57158
292:
210:severe pneumonia
143:was approved by
21:
2439:
2438:
2434:
2433:
2432:
2430:
2429:
2428:
2414:
2413:
2412:
2403:
2314:
2287:
2238:
2217:
2196:
2156:
2135:
2079:
2076:(against IL-22)
2047:
2006:
2003:(against IL-20)
1964:
1918:
1837:
1811:
1755:
1714:
1688:
1662:
1631:
1611:
1590:
1509:
1448:
1392:
1346:
1270:
1175:
1167:
1137:
1083:
1082:
1078:
1033:
1032:
1028:
1013:
988:
987:
980:
936:
935:
931:
922:
920:
911:
910:
906:
867:(1): e2021473.
854:
853:
849:
840:
838:
830:
829:
825:
816:
814:
805:
804:
800:
795:. 30 July 2010.
791:
790:
786:
777:
776:
772:
763:
762:
758:
727:(11): 1315–23.
721:Transplantation
714:
713:
709:
700:
698:
689:
688:
684:
675:
674:
670:
663:
659:
629:
628:
624:
617:
613:
576:Ann. Rheum. Dis
569:
568:
564:
528:
527:
516:
478:
477:
473:
464:
463:
459:
437:
436:
432:
399:(Suppl 2): S5.
386:
385:
381:
343:
342:
338:
294:
293:
284:
280:
259:
234:
206:clinical trials
198:
170:(BCD-089), and
78:prostate cancer
28:
23:
22:
15:
12:
11:
5:
2437:
2435:
2427:
2426:
2416:
2415:
2409:
2408:
2405:
2404:
2402:
2401:
2396:
2387:
2386:
2384:Interleukin 35
2381:
2374:Interleukin 34
2371:
2369:Interleukin 32
2366:
2355:Interleukin 26
2352:
2341:Interleukin 24
2338:
2331:Interleukin 16
2328:
2322:
2320:
2316:
2315:
2313:
2312:
2304:
2302:
2293:
2289:
2288:
2286:
2285:
2276:
2275:
2273:Interleukin 38
2270:
2255:Interleukin 36
2248:
2246:
2240:
2239:
2237:
2236:
2234:Interleukin 33
2227:
2225:
2219:
2218:
2216:
2215:
2213:Interleukin 31
2206:
2204:
2198:
2197:
2195:
2194:
2189:
2178:Interleukin 28
2175:
2166:
2164:
2158:
2157:
2155:
2154:
2145:
2143:
2137:
2136:
2134:
2133:
2128:
2123:
2118:
2113:
2108:
2099:
2098:
2089:
2087:
2081:
2080:
2078:
2077:
2067:
2066:
2064:Interleukin 22
2057:
2055:
2049:
2048:
2046:
2045:
2040:
2031:
2030:
2028:Interleukin 21
2025:
2016:
2014:
2008:
2007:
2005:
2004:
1994:
1993:
1991:Interleukin 24
1988:
1986:Interleukin 20
1983:
1981:Interleukin 19
1974:
1972:
1966:
1965:
1963:
1962:
1953:
1952:
1947:
1945:Interleukin 37
1942:
1940:Interleukin 18
1937:
1928:
1926:
1920:
1919:
1917:
1916:
1911:
1906:
1901:
1896:
1891:
1882:
1881:
1854:Interleukin 17
1847:
1845:
1839:
1838:
1836:
1835:
1833:Interleukin 15
1830:
1821:
1819:
1813:
1812:
1810:
1809:
1804:
1799:
1790:
1789:
1787:Interleukin 13
1784:
1779:
1774:
1765:
1763:
1757:
1756:
1754:
1753:
1748:
1739:
1738:
1736:Interleukin 12
1733:
1724:
1722:
1716:
1715:
1713:
1712:
1707:
1698:
1696:
1690:
1689:
1687:
1686:
1681:
1672:
1670:
1664:
1663:
1661:
1660:
1651:
1650:
1641:
1639:
1633:
1632:
1630:
1629:
1621:
1619:
1613:
1612:
1610:
1609:
1600:
1598:
1592:
1591:
1589:
1588:
1583:
1578:
1573:
1568:
1563:
1558:
1553:
1548:
1543:
1534:
1533:
1528:
1519:
1517:
1511:
1510:
1508:
1507:
1498:
1497:
1492:
1487:
1478:
1477:
1468:
1467:
1458:
1456:
1450:
1449:
1447:
1446:
1441:
1432:
1431:
1422:
1421:
1419:Interleukin 13
1416:
1411:
1402:
1400:
1394:
1393:
1391:
1390:
1388:Promegapoietin
1385:
1380:
1375:
1370:
1365:
1356:
1354:
1348:
1347:
1345:
1344:
1339:
1334:
1325:
1324:
1319:
1314:
1312:Pegaldesleukin
1309:
1304:
1299:
1294:
1289:
1280:
1278:
1272:
1271:
1269:
1268:
1259:
1258:
1253:
1248:
1239:
1238:
1233:
1228:
1223:
1214:
1213:
1208:
1203:
1185:
1183:
1177:
1176:
1168:
1166:
1165:
1158:
1151:
1143:
1136:
1135:
1096:(21): 7534–9.
1076:
1026:
1011:
997:(3): 1337–62.
978:
929:
904:
847:
823:
798:
784:
770:
767:. 27 Sep 2010.
756:
707:
682:
668:
657:
622:
611:
562:
514:
471:
457:
446:(5): 202–213.
430:
406:10.1186/ar1969
379:
336:
307:(9): 3375–83.
281:
279:
276:
258:
257:IL6 and asthma
255:
233:
230:
197:
194:
120:ovarian cancer
90:ovarian cancer
60:. The second,
47:TNF inhibitors
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2436:
2425:
2422:
2421:
2419:
2400:
2397:
2395:
2392:
2389:
2388:
2385:
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2379:
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2367:
2364:
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2356:
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2350:
2346:
2342:
2339:
2336:
2332:
2329:
2327:
2324:
2323:
2321:
2317:
2310:
2306:
2305:
2303:
2301:
2297:
2294:
2290:
2284:
2281:
2278:
2277:
2274:
2271:
2268:
2264:
2260:
2256:
2253:
2250:
2249:
2247:
2245:
2241:
2235:
2232:
2229:
2228:
2226:
2224:
2220:
2214:
2211:
2208:
2207:
2205:
2203:
2199:
2193:
2190:
2187:
2183:
2179:
2176:
2174:
2171:
2168:
2167:
2165:
2163:
2159:
2153:
2150:
2147:
2146:
2144:
2142:
2138:
2132:
2129:
2127:
2126:Tildrakizumab
2124:
2122:
2119:
2117:
2114:
2112:
2109:
2107:
2104:
2101:
2100:
2097:
2094:
2091:
2090:
2088:
2086:
2082:
2075:
2072:
2069:
2068:
2065:
2062:
2059:
2058:
2056:
2054:
2050:
2044:
2041:
2039:
2036:
2033:
2032:
2029:
2026:
2024:
2021:
2018:
2017:
2015:
2013:
2009:
2002:
1999:
1996:
1995:
1992:
1989:
1987:
1984:
1982:
1979:
1976:
1975:
1973:
1971:
1967:
1961:
1958:
1955:
1954:
1951:
1948:
1946:
1943:
1941:
1938:
1936:
1933:
1930:
1929:
1927:
1925:
1921:
1915:
1912:
1910:
1907:
1905:
1902:
1900:
1897:
1895:
1892:
1890:
1887:
1884:
1883:
1879:
1875:
1871:
1867:
1863:
1859:
1855:
1852:
1849:
1848:
1846:
1844:
1840:
1834:
1831:
1829:
1826:
1823:
1822:
1820:
1818:
1814:
1808:
1805:
1803:
1800:
1798:
1795:
1792:
1791:
1788:
1785:
1783:
1782:Interleukin 4
1780:
1778:
1775:
1773:
1770:
1767:
1766:
1764:
1762:
1758:
1752:
1749:
1747:
1744:
1741:
1740:
1737:
1734:
1732:
1731:Edodekin alfa
1729:
1726:
1725:
1723:
1721:
1717:
1711:
1708:
1706:
1703:
1700:
1699:
1697:
1695:
1691:
1685:
1682:
1680:
1677:
1674:
1673:
1671:
1669:
1665:
1659:
1656:
1653:
1652:
1649:
1648:Interleukin 9
1646:
1643:
1642:
1640:
1638:
1634:
1627:
1623:
1622:
1620:
1618:
1614:
1608:
1607:Interleukin 7
1605:
1602:
1601:
1599:
1597:
1593:
1587:
1584:
1582:
1579:
1577:
1574:
1572:
1569:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1542:
1539:
1536:
1535:
1532:
1531:Interleukin 6
1529:
1527:
1526:Atexakin alfa
1524:
1521:
1520:
1518:
1516:
1512:
1506:
1503:
1500:
1499:
1496:
1493:
1491:
1488:
1486:
1483:
1480:
1479:
1476:
1473:
1470:
1469:
1466:
1465:Interleukin 5
1463:
1460:
1459:
1457:
1455:
1451:
1445:
1442:
1440:
1437:
1434:
1433:
1430:
1427:
1424:
1423:
1420:
1417:
1415:
1414:Interleukin 4
1412:
1410:
1407:
1404:
1403:
1401:
1399:
1395:
1389:
1386:
1384:
1381:
1379:
1376:
1374:
1371:
1369:
1368:Interleukin 3
1366:
1364:
1361:
1358:
1357:
1355:
1353:
1349:
1343:
1340:
1338:
1335:
1333:
1330:
1327:
1326:
1323:
1320:
1318:
1315:
1313:
1310:
1308:
1307:Interleukin 2
1305:
1303:
1300:
1298:
1295:
1293:
1290:
1288:
1285:
1282:
1281:
1279:
1277:
1273:
1267:
1264:
1261:
1260:
1257:
1254:
1252:
1249:
1247:
1244:
1241:
1240:
1237:
1234:
1232:
1229:
1227:
1224:
1222:
1219:
1216:
1215:
1212:
1209:
1207:
1204:
1201:
1197:
1193:
1192:Interleukin 1
1190:
1187:
1186:
1184:
1182:
1178:
1174:
1171:
1164:
1159:
1157:
1152:
1150:
1145:
1144:
1141:
1131:
1127:
1122:
1117:
1112:
1107:
1103:
1099:
1095:
1091:
1087:
1080:
1077:
1072:
1068:
1063:
1058:
1054:
1050:
1047:(7): 574–84.
1046:
1042:
1038:
1030:
1027:
1022:
1018:
1014:
1012:9780470650714
1008:
1004:
1000:
996:
992:
985:
983:
979:
974:
970:
965:
960:
956:
952:
949:(3): 833–41.
948:
944:
940:
933:
930:
918:
914:
908:
905:
900:
896:
891:
886:
882:
878:
874:
870:
866:
862:
858:
851:
848:
837:
833:
827:
824:
812:
808:
802:
799:
794:
788:
785:
780:
774:
771:
766:
760:
757:
752:
748:
744:
740:
735:
730:
726:
722:
718:
711:
708:
697:on 2015-12-22
696:
692:
686:
683:
679:. 2 Dec 2008.
678:
672:
669:
666:
661:
658:
653:
649:
645:
641:
637:
633:
626:
623:
620:
615:
612:
607:
603:
598:
593:
589:
585:
581:
577:
573:
566:
563:
558:
554:
549:
544:
541:(9): 1595–7.
540:
536:
532:
525:
523:
521:
519:
515:
510:
506:
502:
498:
494:
490:
486:
482:
475:
472:
467:
461:
458:
453:
449:
445:
441:
434:
431:
426:
422:
417:
412:
407:
402:
398:
394:
390:
383:
380:
375:
371:
367:
363:
359:
355:
352:(4): 737–52.
351:
347:
340:
337:
332:
328:
323:
318:
314:
310:
306:
302:
298:
291:
289:
287:
283:
277:
275:
273:
269:
267:
263:
256:
254:
252:
251:Interleukin 6
248:
243:
239:
231:
229:
227:
223:
219:
215:
211:
207:
203:
195:
193:
191:
188:, FE301, and
187:
182:
179:
177:
173:
169:
165:
161:
157:
153:
148:
146:
142:
138:
136:
132:
128:
124:
121:
117:
113:
109:
107:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
55:
50:
48:
44:
40:
36:
35:Interleukin 6
32:
19:
2390:
2378:M-CSFR/CSF1R
2365:heterodimer)
2351:heterodimer)
2280:Antagonists:
2279:
2251:
2230:
2209:
2169:
2148:
2121:Risankizumab
2102:
2092:
2070:
2060:
2043:NNC0114-0006
2038:NNC0114-0005
2034:
2019:
1997:
1977:
1956:
1931:
1885:
1850:
1824:
1807:Tralokinumab
1802:Lebrikizumab
1797:Anrukinzumab
1793:
1768:
1742:
1727:
1701:
1675:
1654:
1644:
1603:
1546:Clazakizumab
1537:
1522:
1501:
1485:Benralizumab
1481:
1472:Antagonists:
1471:
1461:
1444:Pascolizumab
1435:
1426:Antagonists:
1425:
1405:
1359:
1328:
1283:
1262:
1242:
1218:Antagonists:
1217:
1188:
1093:
1089:
1079:
1044:
1040:
1029:
994:
990:
946:
942:
932:
921:. Retrieved
919:. 2020-03-19
916:
907:
864:
860:
850:
839:. Retrieved
835:
826:
815:. Retrieved
813:. 2020-03-16
810:
801:
787:
773:
759:
724:
720:
710:
699:. Retrieved
695:the original
685:
671:
660:
635:
631:
625:
614:
582:(4): 583–9.
579:
575:
565:
538:
534:
487:(5): 581–6.
484:
480:
474:
460:
443:
439:
433:
396:
392:
382:
349:
345:
339:
304:
300:
270:
260:
235:
199:
183:
180:
166:(CNTO 136),
160:clazakizumab
149:
139:
134:
130:
110:
58:IL6-receptor
51:
30:
29:
2131:Ustekinumab
2111:Briakinumab
2103:Antibodies:
2074:Fezakinumab
2071:Antibodies:
2035:Antibodies:
2023:Denenicokin
1998:Antibodies:
1935:Iboctadekin
1914:Vunakizumab
1909:Secukinumab
1899:Perakizumab
1886:Antibodies:
1794:Antibodies:
1751:Ustekinumab
1746:Briakinumab
1743:Antibodies:
1655:Antibodies:
1581:Tocilizumab
1551:Elsilimomab
1538:Antibodies:
1490:Mepolizumab
1482:Antibodies:
1436:Antibodies:
1363:Daniplestim
1332:Basiliximab
1329:Antibodies:
1297:Celmoleukin
1292:Aldesleukin
1256:Lutikizumab
1251:Gevokizumab
1246:Canakinumab
1243:Antibodies:
638:: 127–135.
218:tocilizumab
200:During the
156:elsilimomab
112:Tocilizumab
54:tocilizumab
2186:B (IFN-λ3)
2182:A (IFN-λ2)
2116:Guselkumab
2106:Brazikumab
2001:Fletikumab
1904:Remtolumab
1894:Ixekizumab
1889:Brodalumab
1772:Binetrakin
1710:Oprelvekin
1679:Ilodecakin
1658:Enokizumab
1571:Siltuximab
1561:Olokizumab
1495:Reslizumab
1429:Pitrakinra
1409:Binetrakin
1378:Milodistim
1373:Leridistim
1342:Inolimomab
1317:Teceleukin
1236:Isunakinra
1173:modulators
923:2020-04-11
841:2020-04-11
817:2020-04-11
701:2015-07-26
278:References
226:siltuximab
154:(CDP6038)
152:olokizumab
66:Siltuximab
62:siltuximab
2391:Unsorted:
2252:Agonists:
2231:Agonists:
2210:Agonists:
2170:Agonists:
2149:Agonists:
2093:Agonists:
2061:Agonists:
2020:Agonists:
1978:Agonists:
1950:Tadekinig
1932:Agonists:
1851:Agonists:
1825:Agonists:
1769:Agonists:
1728:Agonists:
1702:Agonists:
1676:Agonists:
1645:Agonists:
1604:Agonists:
1586:Levilimab
1576:Sirukumab
1566:Sarilumab
1523:Agonists:
1462:Agonists:
1439:Dupilumab
1406:Agonists:
1383:Muplestim
1360:Agonists:
1284:Agonists:
1211:Pifonakin
1206:Mobenakin
1189:Agonists:
881:2531-6745
222:sarilumab
172:CPSI-2364
168:levilimab
164:sirukumab
141:Sarilumab
127:gefitinib
82:docetaxel
18:Anti-IL-6
2418:Category
2345:IL-22Rα1
2311:instead.
1628:instead.
1556:mAb 1339
1541:ARGX-109
1505:TPI ASM8
1475:YM-90709
1226:Anakinra
1221:AF-12198
1130:18490655
1071:27283230
1021:23897689
899:35315395
751:45761175
743:23598944
652:26854213
632:Cytokine
606:23144446
557:24833786
509:24296997
501:12960484
425:16899109
374:45421426
366:16083340
331:21881215
272:Luteolin
247:myokines
214:COVID-19
186:ARGX-109
131:in vitro
39:cytokine
2363:IL-10Rβ
2359:IL-20Rα
2349:IL-20Rβ
2283:IL-36RA
1828:ALT-803
1121:2396685
1098:Bibcode
1062:5007068
973:9130176
964:1159298
890:8972884
597:3595140
468:. 2007.
416:3226077
322:3163962
262:Obesity
238:myokine
135:in vivo
84:and in
2319:Others
2292:Others
2244:IL1RL2
2223:IL1RL1
1960:IL18BP
1231:IL-1RA
1128:
1118:
1069:
1059:
1019:
1009:
971:
961:
897:
887:
879:
749:
741:
650:
604:
594:
555:
507:
499:
423:
413:
372:
364:
329:
319:
266:asthma
145:US FDA
102:CXCL12
2202:IL-31
2162:IL-28
2141:IL-27
2085:IL-23
2053:IL-22
2012:IL-21
1970:IL-20
1924:IL-18
1843:IL-17
1817:IL-15
1761:IL-13
1720:IL-12
1694:IL-11
1668:IL-10
747:S2CID
505:S2CID
370:S2CID
190:FM101
70:HHV-8
37:is a
2309:here
2307:See
1637:IL-9
1626:here
1617:IL-8
1596:IL-7
1515:IL-6
1454:IL-5
1398:IL-4
1352:IL-3
1276:IL-2
1181:IL-1
1126:PMID
1067:PMID
1017:PMID
1007:ISBN
969:PMID
895:PMID
877:ISSN
739:PMID
648:PMID
602:PMID
553:PMID
497:PMID
421:PMID
362:PMID
327:PMID
220:and
133:and
123:EGFR
106:VEGF
104:and
98:CCL2
94:IL-6
2335:CD4
2300:JAK
1116:PMC
1106:doi
1094:105
1057:PMC
1049:doi
999:doi
959:PMC
951:doi
947:499
885:PMC
869:doi
729:doi
640:doi
592:PMC
584:doi
543:doi
489:doi
448:doi
411:PMC
401:doi
354:doi
317:PMC
309:doi
305:121
2420::
2265:,
2261:,
2184:,
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1872:,
1868:,
1864:,
1860:,
1198:,
1124:.
1114:.
1104:.
1092:.
1088:.
1065:.
1055:.
1043:.
1039:.
1015:.
1005:.
993:.
981:^
967:.
957:.
945:.
941:.
915:.
893:.
883:.
875:.
865:93
863:.
859:.
834:.
809:.
745:.
737:.
725:95
723:.
719:.
646:.
636:89
634:.
600:.
590:.
580:72
578:.
574:.
551:.
539:73
537:.
533:.
517:^
503:.
495:.
485:15
483:.
442:.
419:.
409:.
395:.
391:.
368:.
360:.
348:.
325:.
315:.
303:.
299:.
285:^
253:.
192:.
158:,
137:.
108:.
100:,
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2380:)
2361:/
2347:/
2337:)
2269:)
2267:γ
2263:β
2259:α
2257:(
2188:)
2180:(
1880:)
1878:F
1870:D
1866:C
1862:B
1858:A
1856:(
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1200:β
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1194:(
1162:e
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1148:v
1132:.
1108::
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1001::
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901:.
871::
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820:.
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608:.
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545::
511:.
491::
454:.
450::
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427:.
403::
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376:.
356::
350:9
333:.
311::
20:)
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