151:(resins, e.g. cholestyramine) are particularly effective for lowering LDL-C by sequestering the cholesterol-containing bile acids released into the intestine and preventing their reabsorption from the intestine. It decreases LDL by 15–30% and raises HDL by 3–5%, with little effect on triglycerides, but can cause a slight increase. Bile acid sequestrants may cause gastrointestinal problems and may also reduce the absorption of other drugs and vitamins from the gut.
1910:
1931:
109:(HMG-CoA reductase inhibitors) are particularly well suited for lowering LDL, the cholesterol with the strongest links to vascular diseases. In studies using standard doses, statins have been found to lower LDL-C by 18% to 55%, depending on the specific statin being used. A risk exists of muscle damage (
512:"A randomized controlled trial investigating the effect of Pycnogenol and BacopaCDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: the Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910)"
127:. Fibrates typically lower triglycerides by 20% to 50%. Level of the good cholesterol HDL is also increased. Fibrates may decrease LDL, though generally to a lesser degree than statins. Similar to statins, the risk of muscle damage exists.
214:
may be found naturally in plants. Similar to ezetimibe, phytosterols reduce the absorption of cholesterol in the gut, so they are most effective when consumed with meals. However, their precise mechanism of action differs from
509:
Stough, Con K; Pase, Matthew P; Cropley, Vanessa; Myers, Stephen; Nolidin, Karen; King, Rebecca; Camfield, David; Wesnes, Keith; Pipingas, Andrew; Croft, Kevin; Chang, Dennis; Scholey, Andrew B (December 2012).
395:
1862:
942:
798:
Schulze, Friedrich; Glos, Sabrina; Petruschka, Dörte; Altenburg, Christiane; Maas, Renke; Benndorf, Ralf; Schwedhelm, Edzard; Beil, Ulrich; Böger, Rainer H. (May 2009).
747:
Ahangarpour, Akram; Heidari, Hamid; Fatemeh, Ramezani Ali Akbari; Pakmehr, Mostafa; Shahbazian, Hajeye; Ahmadi, Iraj; Mombeini, Zahra; Mehrangiz, Babadi Hajani (2014).
242:
is the natural source from which statins were discovered, but the FDA currently disallows any RYR with significant amounts of statin to be sold as a dietary supplement
1968:
1919:
117:) with statins. Hypercholesterolemia is not a risk factor for mortality in persons older than 70 years and risks from statin drugs are more increased after age 85.
932:
1713:
53:). The American Heart Association recommends the descriptor 'lipid lowering agent' be used for this class of drugs rather than the term 'hypolipidemic'.
61:
The several classes of lipid lowering drugs may differ in both their impact on the cholesterol profile and adverse effects. For example, some may lower
133:, like fibrates, is also well suited for lowering triglycerides by 20–50%. It may also lower LDL by 5–25% and increase HDL by 15–35%. Niacin may cause
2635:
2220:
910:
164:
85:
functions of the patient, evaluated against the balancing of risks and benefits of the medications. In the United States, this is guided by the
449:
Wójcicki, J.; Pawlik, A.; Samochowiec, L.; Kaldo??Ska, M.; Myśliwiec, Z. (1995). "Clinical evaluation of lecithin as a lipid-lowering agent".
2689:
1286:
74:
1961:
1573:
1566:
1673:
1316:
1179:
888:
1999:
221:
supplements taken at high doses can reduce levels of triglycerides. They are associated with a very modest increase in LDL (~5%).
749:"Effect of Boswellia serrata supplementation on blood lipid, hepatic enzymes and fructosamine levels in type2 diabetic patients"
1954:
1469:
925:
90:
2733:
299:
1168:
839:"Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but magnitude of effect depend on food type"
2224:
1990:
950:
2706:
1779:
281:
800:"L-Arginine enhances the triglyceride-lowering effect of simvastatin in patients with elevated plasma triglycerides"
723:"Pharmanex Inc. v. Shalala, United States District Court, D. Utah, Central Division Mar 1, 2001 Case No. 2:97CV262K"
1429:
918:
837:
Kristensen, M; Jensen, MG; Aarestrup, J; Petersen, KE; Søndergaard, L; Mikkelsen, MS; Astrup, A (3 February 2012).
94:
208:
has been shown to effectively decrease cholesterol concentration by 33%, lower LDL by 38% and increase HDL by 46%.
2650:
2549:
2515:
2430:
2172:
66:
2694:
2574:
2569:
2544:
2511:
2473:
2257:
2176:
2112:
2039:
1484:
1162:
1013:
86:
62:
901:
2559:
2554:
1521:
1276:
2341:
610:"Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review"
130:
2564:
2031:
1206:
1142:
987:
148:
658:
2605:
2331:
2190:
1281:
1261:
1130:
124:
82:
1977:
1890:
1626:
1412:
1191:
1018:
174:
78:
1930:
2589:
2035:
1924:
1789:
1648:
1102:
704:
590:
466:
218:
49:
that are used to lower the level of lipids and lipoproteins, such as cholesterol, in the blood (
484:
2584:
2253:
2210:
2108:
1885:
1668:
1658:
1561:
1391:
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1331:
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1125:
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359:
245:
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1301:
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760:
678:
670:
629:
621:
574:
533:
523:
458:
367:
351:
399:
253:
may enhance the effects of a Statin, but will not lead to a reduction in cholesterol alone.
2469:
2285:
1935:
1880:
1749:
1744:
1583:
1516:
1511:
1397:
1343:
1184:
1075:
1028:
408:
404:
2700:
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1914:
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1809:
1663:
1653:
1603:
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1402:
1374:
1326:
1321:
1053:
1008:
1004:
865:
838:
775:
748:
634:
609:
608:
Koppen, Laura M.; Whitaker, Andrea; Rosene, Audrey; Beckett, Robert D. (October 2017).
538:
511:
372:
339:
305:
271:
239:
138:
114:
50:
722:
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1407:
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708:
286:
134:
470:
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2313:
2304:
2276:
2205:
2156:
2146:
2126:
2121:
1981:
1804:
1723:
1459:
1417:
1251:
1241:
1157:
1152:
594:
318:
256:
46:
1362:
17:
815:
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2610:
2579:
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2151:
2131:
2081:
2048:
1688:
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1338:
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1236:
1119:
1085:
275:
211:
70:
674:
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2620:
2615:
2524:
2497:
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2482:
2396:
2366:
2361:
2356:
2290:
2238:
2200:
2141:
2136:
2058:
2053:
2016:
1946:
1866:
1837:
1795:
1764:
1759:
1698:
1693:
1683:
1621:
1607:
1547:
1502:
1450:
1370:
1366:
1307:
1267:
1222:
1218:
1108:
1044:
994:
959:
955:
578:
295:
250:
229:
182:
178:
160:
692:
625:
363:
278:) It is expected that these drugs will mainly increase HDL while lowering LDL
2381:
2068:
2021:
2011:
1774:
1754:
1728:
1703:
1638:
1616:
1444:
1357:
1231:
902:
FDA approves new orphan drug
Kynamro to treat inherited cholesterol disorder
799:
765:
657:
Cicero, Arrigo F. G.; Fogacci, Federica; Zambon, Alberto (9 February 2021).
562:
528:
234:
154:
874:
823:
784:
700:
643:
586:
547:
462:
381:
355:
65:(LDL) levels more so than others, while others may preferentially increase
855:
2665:
2660:
2640:
2412:
2185:
2077:
1875:
1739:
1735:
1708:
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1080:
999:
205:
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142:
110:
683:
2507:
2323:
1851:
1769:
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1201:
1023:
973:
291:
Succinobucol (AGI-1067), a novel antioxidant, failed a phase-III trial.
224:
120:
2195:
2104:
2003:
1533:
1196:
186:
106:
69:(HDL). Clinically, the choice of an agent depends on the patient's
2095:
1833:
1543:
1038:
614:
Journal of
Evidence-Based Complementary & Alternative Medicine
170:
274:(cholesteryl ester transfer protein), 1 candidate is in trials. (
1537:
1950:
914:
412:, AMDA – The Society for Post-Acute and Long-Term Care Medicine
659:"Red Yeast Rice for Hypercholesterolemia: JACC Focus Seminar"
439:
Gugliano RP, Desai NR, Kohli P et al Lancet 2012; 380:2007-17
396:
AMDA – The
Society for Post-Acute and Long-Term Care Medicine
904:
157:
is a selective inhibitor of dietary cholesterol absorption.
430:
Koren MJ, Scott R, Kim JB et al Lancet 2012; 380:1995-2006
943:
563:"Berberine--a novel approach to cholesterol lowering"
400:"Ten Things Physicians and Patients Should Question"
2598:
2537:
2506:
2468:
2425:
2405:
2322:
2312:
2303:
2275:
2252:
2219:
2170:
2103:
2094:
2030:
1998:
1989:
1860:
1832:
1788:
1597:
1532:
1495:
1443:
1356:
1300:
1260:
1217:
1101:
1037:
949:
889:F.D.A. Approves Genetic Drug to Treat Rare Disease
267:Investigational classes of hypolipidemic agents:
145:is also associated with a modest decrease in LDL.
338:Alenghat, Francis J.; Davis, Andrew M. (2019).
89:guideline most recently updated in 2018 by the
1962:
926:
891:The New York Times, Retrieved 31 January 2013
663:Journal of the American College of Cardiology
8:
941:Major chemical drug groups – based upon the
753:Journal of Diabetes and Metabolic Disorders
2319:
2309:
2100:
1995:
1969:
1955:
1947:
933:
919:
911:
2636:Magnesium pyridoxal 5-phosphate glutamate
864:
854:
774:
764:
682:
633:
537:
527:
371:
298:(approved by the FDA in 2013 homozygous
165:microsomal triglyceride transfer protein
567:Expert Opinion on Investigational Drugs
330:
1920:Pharmacological classification systems
1287:Selective estrogen receptor modulators
1567:Non-steroidal anti-inflammatory drugs
7:
185:) They are used in combination with
1180:Angiotensin II receptor antagonists
804:Nutrition Research (New York, N.Y.)
887:Pollack, Andrew (29 January 2013)
25:
2000:Cholesterol absorption inhibitors
340:"Management of Blood Cholesterol"
1929:
1909:
1908:
308:, an ATP citrate lyase inhibitor
195:(withdrawn in several countries)
33:, also sometimes referred to as
1317:Hypothalamic–pituitary hormones
485:"Omega-3 Supplements: In Depth"
91:American College of Cardiology
1:
1069:Thrombolytics / fibrinolytics
300:familial hypercholesterolemia
1780:Wakefulness-promoting agents
816:10.1016/j.nutres.2009.04.004
177:for refractory cases. (e.g.
282:Squalene synthase inhibitor
2750:
1430:Intravenous immunoglobulin
843:Nutrition & Metabolism
675:10.1016/j.jacc.2020.11.056
95:American Heart Association
39:cholesterol-lowering drugs
2684:
2651:Omega−3-acid ethyl esters
1904:
579:10.1517/13543784.14.5.683
561:Doggrell, SA (May 2005).
43:antihyperlipidemic agents
2550:Bempedoic acid/ezetimibe
2171:Niacin and derivatives (
1485:Topoisomerase inhibitors
1169:renin–angiotensin system
1163:Calcium channel blockers
900:Staff (29 January 2013)
626:10.1177/2156587216687695
141:. The niacin derivative
67:high density lipoprotein
2575:Fenofibrate/simvastatin
2570:Fenofibrate/pravastatin
2545:Amlodipine/atorvastatin
766:10.1186/2251-6581-13-29
529:10.1186/1475-2891-11-11
407:: an initiative of the
294:Apoprotein-B inhibitor
63:low density lipoprotein
45:are a diverse group of
2560:Ezetimibe/rosuvastatin
2555:Ezetimibe/atorvastatin
2032:Bile acid sequestrants
1277:Hormonal contraception
1207:Bile acid sequestrants
988:Proton-pump inhibitors
951:gastrointestinal tract
463:10.1002/ptr.2650090814
356:10.1001/jama.2019.0015
149:Bile acid sequestrants
2565:Ezetimibe/simvastatin
1978:Lipid-lowering agents
856:10.1186/1743-7075-9-8
451:Phytotherapy Research
175:monoclonal antibodies
31:Lipid-lowering agents
2734:Hypolipidemic agents
2606:Alipogene tiparvovec
2332:Aluminium clofibrate
2191:Aluminium nicotinate
1886:Radiopharmaceuticals
1674:Antiparkinson agents
125:hypertriglyceridemia
35:hypolipidemic agents
2342:Choline fenofibrate
1669:Antimigraine agents
1659:Antidementia agents
1562:Anti-inflammatories
1252:Medicated dressings
1192:Antihyperlipidemics
1019:Diabetes medication
137:and may also cause
75:cardiovascular risk
71:cholesterol profile
2711:Never to phase III
2590:Niacin/simvastatin
2580:Niacin/laropiprant
1522:Immunosuppressants
1392:Antimycobacterials
1348:Antithyroid agents
1332:Mineralocorticoids
1136:Cardiac stimulants
1126:Cardiac glycosides
1118:cardiac therapy /
1014:Anti-obesity drugs
123:are indicated for
18:Antilipemic agents
2721:
2720:
2585:Niacin/lovastatin
2533:
2532:
2421:
2420:
2299:
2298:
2254:ATP citrate lyase
2211:Nicotinyl alcohol
2109:HMG-CoA reductase
2090:
2089:
1944:
1943:
1847:Ophthalmologicals
1557:Anabolic steroids
1460:Anticancer agents
1423:Ectoparasiticides
1143:Antihypertensives
1091:Antifibrinolytics
516:Nutrition Journal
398:(February 2014),
246:Boswellia serrata
27:Fat reducing drug
16:(Redirected from
2741:
2470:PCSK9 inhibitors
2320:
2310:
2101:
1996:
1971:
1964:
1957:
1948:
1933:
1912:
1911:
1896:Senotherapeutics
1750:Neuroprotectives
1745:Mood stabilizers
1644:Anti-ADHD agents
1584:Muscle relaxants
1517:Immunostimulants
1512:Immunomodulators
1344:Thyroid hormones
1282:Fertility agents
1185:Renin inhibitors
1076:Antihemorrhagics
1043:forming organs (
1029:Dietary minerals
935:
928:
921:
912:
905:
898:
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858:
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335:
21:
2749:
2748:
2744:
2743:
2742:
2740:
2739:
2738:
2724:
2723:
2722:
2717:
2716:
2701:Clinical trials
2680:
2594:
2529:
2502:
2464:
2427:CETP inhibitors
2417:
2401:
2295:
2286:Dextrothyroxine
2271:
2248:
2215:
2166:
2086:
2026:
1985:
1975:
1945:
1940:
1936:Medicine portal
1900:
1856:
1828:
1823:
1815:Cough medicines
1810:Bronchodilators
1791:
1784:
1664:Antidepressants
1654:Anticonvulsants
1602:
1593:
1589:Bisphosphonates
1579:Corticosteroids
1541:
1528:
1500:
1491:
1475:Spindle poisons
1465:Antimetabolites
1448:
1439:
1361:
1352:
1327:Glucocorticoids
1322:Corticosteroids
1303:
1296:
1263:
1256:
1213:
1131:Antiarrhythmics
1104:
1097:
1054:Antithrombotics
1042:
1033:
1009:Antipropulsives
1005:Antidiarrhoeals
982:
953:
945:
939:
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908:
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882:
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448:
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429:
425:
415:
413:
409:ABIM Foundation
405:Choosing Wisely
394:
393:
389:
337:
336:
332:
327:
315:
272:CETP inhibitors
265:
202:
173:inhibitors are
103:
59:
47:pharmaceuticals
28:
23:
22:
15:
12:
11:
5:
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2288:
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2273:
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2270:
2269:
2267:Bempedoic acid
2263:
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2250:
2249:
2247:
2246:
2241:
2236:
2230:
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2217:
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2028:
2027:
2025:
2024:
2019:
2014:
2008:
2006:
1993:
1987:
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1966:
1959:
1951:
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1941:
1939:
1938:
1927:
1922:
1917:
1905:
1902:
1901:
1899:
1898:
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1883:
1881:Contrast media
1878:
1872:
1870:
1858:
1857:
1855:
1854:
1849:
1843:
1841:
1834:sensory organs
1830:
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1711:
1706:
1701:
1696:
1691:
1686:
1681:
1679:Antipsychotics
1676:
1671:
1666:
1661:
1656:
1651:
1649:Antiaddictives
1646:
1641:
1636:
1635:
1634:
1629:
1619:
1613:
1611:
1604:nervous system
1595:
1594:
1592:
1591:
1586:
1581:
1576:
1574:Antirheumatics
1571:
1570:
1569:
1559:
1553:
1551:
1530:
1529:
1527:
1526:
1525:
1524:
1519:
1508:
1506:
1493:
1492:
1490:
1489:
1488:
1487:
1482:
1480:Antineoplastic
1477:
1472:
1467:
1456:
1454:
1441:
1440:
1438:
1437:
1432:
1427:
1426:
1425:
1420:
1415:
1413:Antiprotozoals
1408:Antiparasitics
1405:
1400:
1395:
1388:Antibacterials
1384:Antimicrobials
1380:
1378:
1354:
1353:
1351:
1350:
1341:
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1255:
1254:
1249:
1247:Antipsoriatics
1244:
1239:
1234:
1228:
1226:
1215:
1214:
1212:
1211:
1210:
1209:
1204:
1199:
1189:
1188:
1187:
1182:
1177:
1175:ACE inhibitors
1165:
1160:
1155:
1150:
1145:
1140:
1139:
1138:
1133:
1128:
1114:
1112:
1103:cardiovascular
1099:
1098:
1096:
1095:
1094:
1093:
1088:
1083:
1073:
1072:
1071:
1066:
1064:Anticoagulants
1061:
1050:
1048:
1035:
1034:
1032:
1031:
1026:
1021:
1016:
1011:
1002:
997:
992:
991:
990:
985:
980:
976:
965:
963:
947:
946:
940:
938:
937:
930:
923:
915:
907:
906:
893:
880:
829:
810:(5): 291–297.
790:
739:
714:
669:(5): 620–628.
649:
620:(4): 956–968.
600:
553:
501:
476:
457:(8): 597–599.
441:
432:
423:
387:
350:(8): 800–801.
329:
328:
326:
323:
322:
321:
314:
311:
310:
309:
306:Bempedoic acid
303:
292:
289:
284:
279:
264:
261:
260:
259:
254:
248:
243:
240:Red yeast rice
237:
232:
227:
222:
216:
209:
201:
198:
197:
196:
190:
168:
158:
152:
146:
128:
118:
115:rhabdomyolysis
102:
99:
87:evidence-based
58:
55:
51:hyperlipidemia
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2746:
2735:
2732:
2731:
2729:
2710:
2708:
2705:
2704:
2702:
2699:
2696:
2693:
2691:
2688:
2687:
2683:
2677:
2674:
2672:
2669:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2604:
2603:
2601:
2597:
2591:
2588:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2542:
2540:
2536:
2526:
2523:
2522:
2520:
2517:
2513:
2509:
2505:
2499:
2496:
2494:
2491:
2489:
2486:
2484:
2481:
2480:
2478:
2475:
2471:
2467:
2461:
2458:
2456:
2453:
2451:
2448:
2446:
2443:
2441:
2438:
2437:
2435:
2432:
2428:
2424:
2414:
2411:
2410:
2408:
2404:
2398:
2395:
2393:
2390:
2388:
2385:
2383:
2380:
2378:
2375:
2373:
2370:
2368:
2365:
2363:
2360:
2358:
2355:
2353:
2350:
2348:
2345:
2343:
2340:
2338:
2335:
2333:
2330:
2329:
2327:
2325:
2321:
2318:
2315:
2314:PPAR agonists
2311:
2308:
2306:
2305:Blood vessels
2302:
2292:
2289:
2287:
2284:
2283:
2281:
2278:
2277:Thyromimetics
2274:
2268:
2265:
2264:
2262:
2259:
2255:
2251:
2245:
2242:
2240:
2237:
2235:
2232:
2231:
2229:
2226:
2222:
2218:
2212:
2209:
2207:
2204:
2202:
2199:
2197:
2194:
2192:
2189:
2187:
2184:
2183:
2181:
2178:
2174:
2169:
2163:
2160:
2158:
2155:
2153:
2150:
2148:
2145:
2143:
2140:
2138:
2135:
2133:
2130:
2128:
2125:
2123:
2120:
2119:
2117:
2114:
2110:
2106:
2102:
2099:
2097:
2093:
2083:
2079:
2075:
2074:Soluble fiber
2072:
2070:
2067:
2065:
2064:Colestyramine
2062:
2060:
2057:
2055:
2052:
2050:
2047:
2046:
2044:
2041:
2037:
2033:
2029:
2023:
2020:
2018:
2015:
2013:
2010:
2009:
2007:
2005:
2001:
1997:
1994:
1992:
1988:
1983:
1979:
1972:
1967:
1965:
1960:
1958:
1953:
1952:
1949:
1937:
1932:
1928:
1926:
1923:
1921:
1918:
1916:
1907:
1906:
1903:
1897:
1894:
1892:
1889:
1887:
1884:
1882:
1879:
1877:
1874:
1873:
1871:
1868:
1864:
1859:
1853:
1850:
1848:
1845:
1844:
1842:
1839:
1835:
1831:
1825:
1818:
1816:
1813:
1811:
1808:
1806:
1805:Decongestants
1803:
1802:
1800:
1797:
1793:
1787:
1781:
1778:
1776:
1773:
1771:
1768:
1766:
1763:
1761:
1758:
1756:
1753:
1751:
1748:
1746:
1743:
1741:
1737:
1734:
1730:
1727:
1725:
1724:Dissociatives
1722:
1720:
1717:
1716:
1715:
1714:Hallucinogens
1712:
1710:
1707:
1705:
1702:
1700:
1697:
1695:
1692:
1690:
1687:
1685:
1682:
1680:
1677:
1675:
1672:
1670:
1667:
1665:
1662:
1660:
1657:
1655:
1652:
1650:
1647:
1645:
1642:
1640:
1637:
1633:
1630:
1628:
1625:
1624:
1623:
1620:
1618:
1615:
1614:
1612:
1609:
1605:
1600:
1596:
1590:
1587:
1585:
1582:
1580:
1577:
1575:
1572:
1568:
1565:
1564:
1563:
1560:
1558:
1555:
1554:
1552:
1549:
1545:
1539:
1535:
1531:
1523:
1520:
1518:
1515:
1514:
1513:
1510:
1509:
1507:
1504:
1498:
1494:
1486:
1483:
1481:
1478:
1476:
1473:
1471:
1468:
1466:
1463:
1462:
1461:
1458:
1457:
1455:
1452:
1446:
1442:
1436:
1433:
1431:
1428:
1424:
1421:
1419:
1418:Anthelmintics
1416:
1414:
1411:
1410:
1409:
1406:
1404:
1401:
1399:
1396:
1393:
1389:
1385:
1382:
1381:
1379:
1376:
1372:
1368:
1364:
1359:
1355:
1349:
1345:
1342:
1340:
1337:
1333:
1330:
1328:
1325:
1324:
1323:
1320:
1318:
1315:
1314:
1312:
1309:
1305:
1299:
1293:
1290:
1288:
1285:
1283:
1280:
1278:
1275:
1274:
1272:
1269:
1265:
1262:genitourinary
1259:
1253:
1250:
1248:
1245:
1243:
1242:Antipruritics
1240:
1238:
1235:
1233:
1230:
1229:
1227:
1224:
1220:
1216:
1208:
1205:
1203:
1200:
1198:
1195:
1194:
1193:
1190:
1186:
1183:
1181:
1178:
1176:
1173:
1172:
1171:
1170:
1166:
1164:
1161:
1159:
1158:Beta blockers
1156:
1154:
1151:
1149:
1146:
1144:
1141:
1137:
1134:
1132:
1129:
1127:
1124:
1123:
1122:
1121:
1116:
1115:
1113:
1110:
1106:
1100:
1092:
1089:
1087:
1084:
1082:
1079:
1078:
1077:
1074:
1070:
1067:
1065:
1062:
1060:
1059:Antiplatelets
1057:
1056:
1055:
1052:
1051:
1049:
1046:
1040:
1036:
1030:
1027:
1025:
1022:
1020:
1017:
1015:
1012:
1010:
1006:
1003:
1001:
998:
996:
993:
989:
986:
984:
977:
975:
972:
971:
970:
967:
966:
964:
961:
957:
952:
948:
944:
936:
931:
929:
924:
922:
917:
916:
913:
903:
897:
894:
890:
884:
881:
876:
872:
867:
862:
857:
852:
848:
844:
840:
833:
830:
825:
821:
817:
813:
809:
805:
801:
794:
791:
786:
782:
777:
772:
767:
762:
758:
754:
750:
743:
740:
728:
724:
718:
715:
710:
706:
702:
698:
694:
690:
685:
680:
676:
672:
668:
664:
660:
653:
650:
645:
641:
636:
631:
627:
623:
619:
615:
611:
604:
601:
596:
592:
588:
584:
580:
576:
572:
568:
564:
557:
554:
549:
545:
540:
535:
530:
525:
521:
517:
513:
505:
502:
490:
486:
480:
477:
472:
468:
464:
460:
456:
452:
445:
442:
436:
433:
427:
424:
411:
410:
406:
401:
397:
391:
388:
383:
379:
374:
369:
365:
361:
357:
353:
349:
345:
341:
334:
331:
324:
320:
317:
316:
312:
307:
304:
301:
297:
293:
290:
288:
287:ApoA-1 Milano
285:
283:
280:
277:
273:
270:
269:
268:
262:
258:
255:
252:
249:
247:
244:
241:
238:
236:
233:
231:
228:
226:
223:
220:
217:
213:
210:
207:
204:
203:
199:
194:
191:
188:
184:
180:
176:
172:
169:
166:
162:
159:
156:
153:
150:
147:
144:
140:
136:
135:hyperglycemia
132:
129:
126:
122:
119:
116:
112:
108:
105:
104:
100:
98:
96:
92:
88:
84:
80:
76:
72:
68:
64:
56:
54:
52:
48:
44:
40:
36:
32:
19:
2676:Volanesorsen
2538:Combinations
2510:inhibitors (
2352:Clinofibrate
2347:Ciprofibrate
2256:inhibitors (
2223:inhibitors (
2206:Nicofuranose
2157:Rosuvastatin
2147:Pitavastatin
2127:Cerivastatin
2122:Atorvastatin
1719:Psychedelics
1689:Aphrodisiacs
1363:infestations
1339:Sex hormones
1292:Sex hormones
1237:Cicatrizants
1167:
1153:Vasodilators
1120:antianginals
1117:
969:stomach acid
968:
896:
883:
846:
842:
832:
807:
803:
793:
756:
752:
742:
730:. Retrieved
726:
717:
684:11585/827471
666:
662:
652:
617:
613:
603:
573:(5): 683–5.
570:
566:
556:
519:
515:
504:
493:. Retrieved
491:. 2018-05-01
488:
479:
454:
450:
444:
435:
426:
414:, retrieved
403:
390:
347:
343:
333:
319:ATC code C10
266:
257:Flaxseed oil
212:Phytosterols
139:liver damage
60:
42:
38:
34:
30:
29:
2697:from market
2656:Policosanol
2631:Lapaquistat
2611:Azacosterol
2488:Bococizumab
2460:Torcetrapib
2455:Obicetrapib
2450:Evacetrapib
2445:Dalcetrapib
2440:Anacetrapib
2392:Ronifibrate
2387:Pemafibrate
2377:Gemfibrozil
2372:Fenofibrate
2337:Bezafibrate
2244:Mitratapide
2234:Dirlotapide
2162:Simvastatin
2152:Pravastatin
2132:Fluvastatin
2082:glucomannan
2049:Colesevelam
1852:Otologicals
1824:antagonists
1790:respiratory
1765:Orexigenics
1760:Neurotoxins
1709:Euphoriants
1699:Entactogens
1694:Depressants
1684:Anxiolytics
1622:Anesthetics
1398:Antifungals
995:Antiemetics
983:antagonists
276:Anacetrapib
200:Alternative
101:Established
2671:Triparanol
2646:Mipomersen
2626:Darapladib
2621:Benfluorex
2616:Azalanstat
2525:Evinacumab
2498:Inclisiran
2493:Evolocumab
2483:Alirocumab
2397:Simfibrate
2367:Etofibrate
2362:Clofibride
2357:Clofibrate
2291:Resmetirom
2239:Lomitapide
2201:Niceritrol
2142:Mevastatin
2137:Lovastatin
2059:Colestipol
2054:Colestilan
2017:Hyzetimibe
1775:Stimulants
1755:Nootropics
1729:Deliriants
1704:Entheogens
1639:Anorectics
1617:Analgesics
1470:Alkylating
1403:Antivirals
1358:infections
1232:Emollients
1086:Coagulants
956:metabolism
495:2021-02-02
325:References
296:mipomersen
251:L-arginine
230:Pycnogenol
215:ezetimibe.
183:Inclisiran
179:Evolocumab
167:inhibitor.
161:Lomitapide
77:, and the
2707:Phase III
2695:Withdrawn
2382:Nafenopin
2069:Colextran
2022:SCH-48461
2012:Ezetimibe
1925:ATC codes
1891:Dressings
1876:Antidotes
1740:Sedatives
1736:Hypnotics
1445:malignant
1302:endocrine
1148:Diuretics
1081:Platelets
1041:and blood
1000:Laxatives
759:(1): 29.
709:231803755
693:0735-1097
522:(1): 11.
364:0098-7484
235:Berberine
155:Ezetimibe
2728:Category
2666:Tiadenol
2661:Probucol
2641:Meglutol
2413:GW501516
2324:Fibrates
2186:Acipimox
2078:psyllium
2076:such as
1991:GI tract
1770:Serenics
1435:Vaccines
1202:Fibrates
1024:Vitamins
974:Antacids
875:22305169
824:19555809
785:24495344
727:Casetext
701:33538260
644:29228784
587:15926873
548:22390677
471:71032494
416:20 April
382:30715135
313:See also
263:Research
206:Lecithin
193:Probucol
143:acipimox
121:Fibrates
111:myopathy
2508:ANGPTL3
2105:Statins
1627:General
1534:muscles
1503:L03–L04
1499:disease
1451:L01–L02
1447:disease
1197:Statins
866:3307491
776:3929136
732:21 June
635:5871262
595:1708378
539:3310777
373:6679800
225:Choline
219:Omega-3
187:statins
107:Statins
57:Classes
2690:WHO-EM
2406:Others
2279:(VLDL)
2196:Niacin
2036:resins
2004:NPC1L1
1934:
1913:
1861:other
1792:system
1544:joints
1497:immune
1304:system
1264:system
1105:system
873:
863:
822:
783:
773:
707:
699:
691:
642:
632:
593:
585:
546:
536:
469:
380:
370:
362:
131:Niacin
93:&
83:kidney
2599:Other
2316:(LDL)
2096:Liver
1915:Drugs
1632:Local
1599:brain
1538:bones
1039:blood
849:: 8.
705:S2CID
591:S2CID
489:NCCIH
467:S2CID
171:PCSK9
163:is a
79:liver
41:, or
2225:VLDL
2221:MTTP
2175:and
2080:and
1542:and
1219:skin
871:PMID
820:PMID
781:PMID
734:2019
697:PMID
689:ISSN
640:PMID
583:PMID
544:PMID
418:2015
378:PMID
360:ISSN
344:JAMA
113:and
81:and
2516:HDL
2512:LDL
2474:LDL
2431:HDL
2258:LDL
2177:LDL
2173:HDL
2113:LDL
2040:LDL
1982:C10
1863:ATC
1601:and
1360:and
861:PMC
851:doi
812:doi
771:PMC
761:doi
679:hdl
671:doi
630:PMC
622:doi
575:doi
534:PMC
524:doi
459:doi
368:PMC
352:doi
348:321
302:.).
2730::
2703::
2111:,
2002:,
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2034:/
1984:)
1980:(
1970:e
1963:t
1956:v
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1838:S
1836:(
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1820:H
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1221:(
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