114:, or in order to realize the ideas of virtual screening and drug design are also called building blocks. To be practically useful for the modular drug or drug candidate assembly, the building blocks should be either mono-functionalised or possessing selectively chemically addressable functional groups, for example, orthogonally protected. Selection criteria applied to organic functionalized molecules to be included in the building block collections for medicinal chemistry are usually based on empirical rules aimed at
134:
collections prepared for fast and reliable construction of small-molecule sets of compounds (libraries) for biological screening became one of the major strategies for pharmaceutical industry involved in drug discovery; modular, usually one-step synthesis of compounds for biological screening from building blocks turned out to be in most cases faster and more reliable than multistep, even convergent syntheses of target compounds.
20:
169:
133:
The building block approach to drug discovery changed the landscape of chemical industry which supports medicinal chemistry. Major chemical suppliers for medicinal chemistry like
Maybridge, Chembridge, Enamine adjusted their business correspondingly. By the end of the 1990th the use of building block
322:
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V.S. Yarmolchuk; O.V. Shishkin; V.S. Starova; O.A. Zaporozhets; O. Kravchuk; S. Zozulya; I.V. Komarov; P.K. Mykhailiuk (2013). "Synthesis and
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Peptide Surrogates".
522:
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157:
properties, therefore, the fluorine-substituted building blocks in drug design increase the probability of finding drug leads. Other examples include natural and unnatural
287:
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211:
L. Zang; Y. Che; J.S. Moore (2008). "One-Dimensional Self-Assembly of Planar π-Conjugated
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487:
A. Kluczyk; T. Popek; T. Kiyota; P. de Macedo; P. Stefanowicz; C. Lazar; Y. Konishi (2002). "Drug
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110:
Organic functionalized molecules (reagents), carefully selected for the use in modular synthesis of novel drug candidates, in particular, by
98:. Of special interest for this purpose are the building blocks common to known biologically active compounds, in particular, known drugs, or
1058:
O.O. Grygorenko; D.S. Radchenko; D.M. Volochnyuk; A.A. Tolmachev; I.V. Komarov (2011). "Bicyclic
Conformationally Restricted Diamines".
600:
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535:
672:"Conformationally restricted monoprotected diamines as scaffolds for design of biologically active compounds and peptidomimetics"
1021:"Conformationally rigid cyclic α-amino acids in the design of peptidomimetics, peptide models and biologically active compounds"
248:"Dendrimers and other dendritic macromolecules: From building blocks to functional assemblies in nanoscience and nanotechnology"
102:. There are algorithms for de novo design of molecular architectures by assembly of drug-derived virtual building blocks.
34:
which is used to describe a virtual molecular fragment or a real chemical compound the molecules of which possess reactive
50:
complexes. Using building blocks ensures strict control of what a final compound or a (supra)molecular construct will be.
162:
149:-containing building blocks. Introduction of the fluorine into a molecule has been shown to be beneficial for its
670:
A.N. Shivanyuk; D.M. Volochnyuk; I.V. Komarov; K.G. Nazarenko; D.S. Radchenko; A. Kostyuk; A.A. Tomachev (2007).
806:"A MARKET GROWS, BLOCK BY BLOCK. Pharmaceutical building-block business attracts firms from ACROSS THE GLOBE".
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replacements of the molecular fragments in drug candidates could be made using analogous building blocks.
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Construction of complex molecular architectures is easily possible using simple building blocks
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G. Schneider; H.-J. Böhm (2002). "Virtual screening and fast automated docking methods".
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Typical examples of building block collections for medicinal chemistry are libraries of
94:, addressing the desire to have controllable molecular morphologies that interact with
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71:
19:
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libraries, collections of conformationally constrained bifunctionalized compounds and
38:. Building blocks are used for bottom-up modular assembly of molecular architectures:
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62:, the term defines either imaginable, virtual molecular fragments or chemical
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M Schlosser (2006). "CF3-Bearing Aromatic and Heterocyclic Building Blocks".
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and two building blocks BB1 and BB2 from which it could be synthesized
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I. Muegge (2003). "Selection criteria for drug-like compounds".
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Fluorine in Medicinal Chemistry and Chemical Biology
1095:"Organic chemistry: Molecular diversity by design"
197:Organic Building Blocks of the Chemical Industry
74:might be constructed or synthetically prepared.
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118:properties of the final drug candidates.
935:Angewandte Chemie International Edition
524:Angewandte Chemie International Edition
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54:Building blocks for medicinal chemistry
877:"Good Suppliers – And The Other Guys"
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862:"Building Blocks for Drug Discovery"
106:Chemical reagents as building blocks
82:Virtual building blocks are used in
200:. New York: John Wiley & Sons.
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137:There are online web-resources.
46:, organic molecular constructs,
1045:10.1070/rc2004v073n08abeh000912
1:
1006:10.1002/9781444312096.fmatter
912:10.1126/science.287.5460.1960
649:10.1016/S1359-6446(01)02091-8
848:"Building Blocks: Key Facts"
750:10.1016/j.drudis.2014.09.023
676:Chimica Oggi/Chemistry Today
252:J. Polym. Sci. A Polym. Chem
165:building block collections.
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875:Lowe, Derek (2010-03-18).
372:10.1016/j.addr.2003.10.047
820:10.1021/cen-v089n018.p016
395:J. Comput.-Aided Mol. Des
1025:Russian Chemical Reviews
1000:. Blackwell Publishing.
501:10.2174/0929867023368872
44:metal-organic frameworks
1093:S.L. Schreiber (2009).
415:10.1023/A:1008184403558
246:J.M.J. Fréchet (2003).
112:combinatorial chemistry
78:Virtual building blocks
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172:An anti-diabetic drug
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559:Nat. Rev. Drug Discov
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738:Drug Discovery Today
637:Drug Discovery Today
360:Adv. Drug Deliv. Rev
194:H.H. Szmant (1989).
126:Building blocks and
1111:2009Natur.457..153S
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898:(5460): 1960–1964.
814:(18): 16–18. 2011.
446:J. Chem. Inf. Model
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264:2003JPoSA..41.3713F
60:medicinal chemistry
273:10.1002/pola.10952
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163:diversity-oriented
96:biological targets
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996:I. Ojima (2009).
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181:References
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1060:Chem. Rev
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32:chemistry
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141:Examples
64:reagents
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