114:, oxidative drugs and unstable hemoglobins. People receiving large quantities of oxidative drugs such as dapsone or sulfasalazine are more prone to have degmacytes. The underlying cause of degmacytes is a result of the splenic macrophages removing Heinz bodies from the membrane of red blood cells, which results in a "bitten" appearance of the cell.
70:
77:
Degmacytes usually appear smaller, denser, and more contracted than a normal red blood cell due to the bites. The appearance of the "bites" in red blood cells may vary in number, smoothness, and size. These cells can also exhibit other peripheral effects.
934:
126:
to analyze the red blood cells in the blood. The degmacyte look similar to a "bitten apple", which is their defining feature. However, bite cells may be difficult to distinguish from
130:, a fragmented red blood cell, due to the similarity in shape. Confirming the presence of degmacytes in patients likely indicates a form of red blood cell oxidant injury or
42:
with one or more semicircular portions removed from the cell margin, known as "bites". These "bites" result from the mechanical removal of denatured hemoglobin during
94:
is maintained, and when this ruptures, the resulting bite cells have horn-like projections. Blister cells appear as red blood cells containing a peripherally located
547:
55:
146:
combined with oxidative stress or other trigger, such as fava beans and certain antimalarial or sulfa drugs. Patients may attempt to decrease exposure to
513:
486:
459:
432:
405:
369:
249:
62:. Bite cells can contain more than one "bite." The "bites" in degmacytes are smaller than the missing red blood cell fragments seen in
157:
As there are currently no means of reversing red blood cell damage and the formation of degmacytes, treatment options are limited to
540:
106:
Bite cells are caused by G6PD deficiency, NADPH deficiency, thalassemia, glutathione synthase deficiency, and other red-cell
503:
476:
821:
533:
154:. If one is not G6PD deficient, lessening the use of oxidative triggers may help prevent the formation of degmacytes.
858:
846:
683:
629:
883:
878:
641:
449:
359:
239:
54:
into the splenic sinuses. Bite cells are known to be a result from processes of oxidative hemolysis, such as
422:
111:
780:
732:
893:
737:
888:
816:
742:
673:
267:"Contrasting splenic mechanisms in the blood clearance of red blood cells and colloidal particles"
265:
Klausner, MA; Hirsch, LJ; Leblond, PF; Chamberlain, JK; Klemperer, MR; Segel, GB (December 1975).
706:
158:
873:
868:
509:
482:
455:
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365:
337:
329:
288:
245:
213:
147:
395:
799:
721:
319:
278:
205:
151:
143:
863:
826:
606:
565:
39:
928:
711:
636:
209:
170:
51:
851:
701:
590:
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580:
361:
Hematopathology E-Book: A Volume in the Series: Foundations in
Diagnostic Pathology
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59:
838:
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266:
127:
123:
107:
63:
58:, in which uncontrolled oxidative stress causes hemoglobin to denature and form
808:
775:
757:
655:
333:
650:
131:
91:
47:
17:
341:
196:
Yoo, D; Lessin, LS (1992). "Drug-associated 'bite cell' Hemolytic anemia".
292:
217:
909:
785:
619:
394:
Tkachuk, Douglas C.; Hirschmann, Jan V.; Wintrobe, Maxwell Myer (2007).
324:
307:
95:
69:
43:
525:
451:
The ABC of CBC: Interpretation of
Complete Blood Count and Histograms
475:
Aster, Jon C.; Pozdnyakova, Olga; Kutok, Jeffery L. (2012-05-07).
68:
529:
502:
Handin, Robert I.; Lux, Samuel E.; Stossel, Thomas P. (2003).
389:
387:
385:
383:
381:
122:
The diagnosis of degmacytes is performed by using a
902:
837:
807:
798:
768:
720:
694:
599:
573:
564:
935:Abnormal clinical and laboratory findings for RBCs
50:attempt to migrate through endothelial slits from
400:. Lippincott Williams & Wilkins. p. 30.
312:International Journal of Laboratory Hematology
541:
8:
505:Blood: Principles and Practice of Hematology
56:Glucose-6-phosphate dehydrogenase deficiency
804:
570:
548:
534:
526:
323:
282:
142:Bite cells are primarily formed due to a
397:Wintrobe's Atlas of Clinical Hematology
185:
40:abnormally shaped mature red blood cell
27:Abnormally shaped mature red blood cell
508:. Lippincott Williams & Wilkins.
244:. Lippincott Williams & Wilkins.
191:
189:
7:
353:
351:
233:
231:
229:
227:
478:Hematopathology E-Book: High-Yield
25:
421:Cherry, Daniel A. (2011-02-25).
198:The American Journal of Medicine
424:Bone Marrow: A Practical Manual
238:Anderson, Shauna (2013-01-24).
241:Anderson's Atlas of Hematology
1:
448:Lokwani, D. P. (2013-05-30).
176:(dêgma): “to bite” + -cyte.
481:. Elsevier Health Sciences.
364:. Elsevier Health Sciences.
210:10.1016/0002-9343(92)90071-I
358:Hsi, Eric D. (2017-09-19).
308:"Red blood cell morphology"
284:10.1182/blood.V46.6.965.965
951:
847:Hypersegmented neutrophil
754:Hemoglobin precipitation
684:Hereditary stomatocytosis
630:Hereditary elliptocytosis
150:, which can then lead to
879:Critical green inclusion
670:Sickle cell/drepanocyte
642:Hereditary spherocytosis
138:Treatment and Prevention
611:Membrane abnormalities
112:pentose phosphate shunt
781:Red cell agglutination
124:peripheral blood smear
74:
72:
884:Alder–Reilly anomaly
738:Basophilic stippling
859:Pelger–Huët anomaly
817:Reactive lymphocyte
743:Pappenheimer bodies
674:Sickle cell disease
152:hemolytic disorders
707:Hypochromic anemia
454:. JP Medical Ltd.
325:10.1111/ijlh.12082
159:blood transfusions
90:, an outer rim of
75:
922:
921:
918:
917:
874:Toxic vacuolation
869:Toxic granulation
800:White blood cells
794:
793:
733:Howell–Jolly body
515:978-0-7817-1993-3
488:978-1-4557-3758-1
461:978-93-5025-788-3
434:978-1-4987-1296-5
407:978-0-7817-7023-1
371:978-0-323-51231-2
306:Ford, J. (2013).
251:978-1-4698-2636-3
16:(Redirected from
942:
889:Jordans' anomaly
805:
722:Inclusion bodies
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566:Red blood cells
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144:G6PD deficiency
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5:
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827:Russell bodies
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772:
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766:
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729:Developmental
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609:
607:Poikilocytosis
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583:
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521:
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494:
487:
467:
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347:
318:(3): 351–357.
298:
257:
250:
223:
184:
183:
181:
178:
166:
163:
139:
136:
119:
116:
110:involving the
103:
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83:
80:
46:filtration as
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24:
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10:
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3:
2:
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713:
712:Polychromasia
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531:
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427:. CRC Press.
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277:(6): 965–76.
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171:Ancient Greek
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155:
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137:
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133:
129:
125:
117:
115:
113:
109:
108:enzymopathies
101:
99:
97:
93:
89:
88:blister cells
81:
79:
71:
67:
65:
61:
57:
53:
52:splenic cords
49:
45:
41:
37:
33:
19:
864:Döhle bodies
852:Arneth count
839:Granulocytes
702:Anisochromia
680:Stomatocyte
665:
591:Microcytosis
586:Macrocytosis
581:Anisocytosis
504:
497:
477:
470:
450:
443:
423:
416:
396:
360:
315:
311:
301:
274:
270:
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240:
204:(3): 243–8.
201:
197:
173:
168:
156:
141:
128:helmet cells
121:
105:
85:
82:Blister cell
76:
64:schistocytes
60:Heinz bodies
35:
31:
29:
18:Blister cell
822:Smudge cell
809:Lymphocytes
748:Cabot rings
661:Schistocyte
625:Elliptocyte
615:Acanthocyte
894:Left shift
776:Haemoconia
758:Heinz body
656:Echinocyte
637:Spherocyte
557:Blood film
180:References
73:BITE CELLS
666:Degmacyte
651:Dacrocyte
334:1751-553X
165:Etymology
132:hemolysis
118:Diagnosis
92:cytoplasm
48:red cells
36:bite cell
32:degmacyte
929:Category
910:Auer rod
786:Rouleaux
620:Codocyte
559:findings
342:23480230
293:1203539
218:1546722
148:hypoxia
96:vacuole
44:splenic
695:Colour
512:
485:
458:
431:
404:
368:
340:
332:
291:
248:
216:
102:Causes
38:is an
903:Other
769:Other
600:Shape
271:Blood
174:δῆγμα
169:From
574:Size
510:ISBN
483:ISBN
456:ISBN
429:ISBN
402:ISBN
366:ISBN
338:PMID
330:ISSN
289:PMID
246:ISBN
214:PMID
320:doi
279:doi
206:doi
86:In
34:or
931::
380:^
350:^
336:.
328:.
316:35
314:.
310:.
287:.
275:46
273:.
269:.
226:^
212:.
202:92
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188:^
161:.
134:.
98:.
66:.
30:A
549:e
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535:v
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491:.
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410:.
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344:.
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295:.
281::
254:.
220:.
208::
20:)
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