254:-based plastics are also used in these applications. While the individual components are not always perfectly safe as pharmaceutical additives and active substances per se, as bone cement the individual substances are either converted or fully enclosed in the cement matrix during the polymerization phase from the increase in viscosity to curing. From current knowledge, cured bone cement can now be classified as safe, as originally demonstrated during the early studies on compatibility with the body conducted in the 1950s.
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necessarily removed completely. However, if the implant has loosened for septic reasons, the cement must be fully removed to clear an infection. In the current state of knowledge it is easier to remove cement than to release a well-anchored cement-free prosthesis from the bone site. Ultimately it is important for the stability of the revised prosthesis to detect possible loosening of the initial implant early to be able to retain as much healthy bone as possible.
320:, can be added to the powder component. The active substances are released locally after implant placement of the new joint, i.e. in the immediate vicinity of the new prosthesis and have been confirmed to reduce the danger of infection. The antibiotics act against bacteria precisely at the site where they are required in the open wound without subjecting the body in general to unnecessarily high antibiotic levels. This makes bone cement a modern
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mechanical stability of the fixed prosthesis is weakened by a high proportion of active substance in the cement. The local active substance levels of industrially manufactured bone cements that are formed by the use of bone cements that contain active substances are approximate (assuming that there is no incompatibility) and are significantly below the clinical routine dosages for systemic single injections.
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changes over time from a runny liquid into a dough like state that can be safely applied and then finally hardens into solid hardened material. The set time can be tailored to help the physician safely apply the bone cement into the bone bed to either anchor metal or plastic prosthetic device to bone
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A prosthesis fixed with bone cement offers very high primary stability combined with fast remobilization of patients. The cemented-in prosthesis can be fully loaded very soon after the operation because the PMMA gets most of its strength within 24 hours. The necessary rehabilitation is comparatively
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procedures. The composition of these types of cement is mostly based on calcium phosphate and more recently magnesium phosphate. A novel biodegradable, non-exothermic, self-setting orthopedic cement composition based on amorphous magnesium phosphate (AMP) was developed. The occurrence of undesirable
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that delivers the required drugs directly to the surgical site. The important factor is not how much active substance is in the cement matrix but how much of the active substance is actually released locally. Too much active substance in the bone cement would actually be detrimental, because the
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Revision is the replacement of a prosthesis. This means that a prosthesis previously implanted in the body is removed and replaced by a new prosthesis. Compared to the initial operation revisions are often more complex and more difficult, because every revision involves the loss of healthy bone
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Today several million procedures of this type are conducted every year all over the world and more than half of them routinely use bone cements – and the proportion is increasing. Bone cement is considered a reliable anchorage material with its ease of use in clinical practice and particularly
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and plays the important role of an elastic zone. This is necessary because the human hip is acted on by approximately 10–12 times the body weight and therefore the bone cement must absorb the forces acting on the hips to ensure that the artificial implant remains in place over the long term.
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Unfortunately, it is not always possible to avoid revisions. There can also be different reasons for revisions and there is a distinction between septic or aseptic revision. If it is necessary to replace an implant without confirmation of an infection—for example, aseptic—the cement is not
558:
Havelin, L. I.; Espehaug, B.; Vollset, S. E.; Engesaeter, L. B. (1995). "The effect of the type of cement on early revision of
Charnley total hip prostheses. A review of eight thousand five hundred and seventy-nine primary arthroplasties from the Norwegian Arthroplasty Register".
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and water and excreted. Embolisms can always occur during anchorage of artificial joints when material is inserted into the previously cleared femoral canal. The result is intramedullary pressure increase, potentially driving fat into the circulation.
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If the patient is known to have any allergies to constituents of the bone cement, according to current knowledge bone cement should not be used to anchor the prosthesis. Anchorage without cement - cement-free implant placement - is the alternative.
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New bone cement formulations require characterization according to ASTM F451. This standard describes the test methods to assess cure rate, residual monomer, mechanical strength, benzoyl peroxide concentration, and heat evolution during cure.
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denaturation in the body. This low polymerization temperature is determined by the relatively thin cement coating, which should not exceed 5 mm, and the temperature dissipation via the large prosthesis surface and the flow of blood.
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What is referred to as bone cement implantation syndrome (BCIS) is described in the literature. For a long time it was believed that the incompletely converted monomer released from bone cement was the cause of circulation reactions and
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substance. Revision operations are also more expensive for a satisfactory result. The most important goal is therefore to avoid revisions by using a good surgical procedure and using products with good (long-term) results.
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simple for patients who have had a cemented-in prosthesis implanted. The joints can be loaded again very soon after the operation, but the use of crutches is still required for a reasonable period for safety reasons.
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Note 1: In situ self-curing can be the source of released reagents that can cause local and/or systemic toxicity as in the case of the monomer released from methacrylics-based bone cement used in orthopedic surgery.
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was used clinically for the first time in the 1940s in plastic surgery to close gaps in the skull. Comprehensive clinical tests of the compatibility of bone cements with the body were conducted before their use in
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registers for artificial joint replacements such as those in Sweden and Norway clearly demonstrate the advantages of cemented-in anchorage. A similar register for endoprosthesis was introduced in
Germany in 2010.
690:
Van Tol, Alexander
Franciscus; Tibballs, John E.; Roar Gjerdet, Nils; Ellison, Peter (2013). "Experimental investigation of the effect of surface roughness on bone-cement-implant shear bond strength".
160:) for more than half a century. Artificial joints (referred to as prostheses) are anchored with bone cement. The bone cement fills the free space between the prosthesis and the
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Note 2: In dentistry, polymer-based cements are also used as fillers of cavities. They are generally cured photochemically using UV radiation in contrast to bone cements.
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co-polymer beads and or amorphous powder, radio-opacifier, initiator) and a liquid (MMA monomer, stabilizer, inhibitor). The two components are mixed and a free
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free-radical polymerization process, which reaches temperatures of around 82–86 °C in the body, a temperature higher than the critical level for
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Vert, Michel; Doi, Yoshiharu; Hellwich, Karl-Heinz; Hess, Michael; Hodge, Philip; Kubisa, Przemyslaw; Rinaudo, Marguerite; Schué, François (2012).
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Bone cements are provided as two-component materials. Bone cements consist of a powder (i.e., pre-polymerized PMMA and or PMMA or
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646:
Evaluation of amorphous magnesium phosphate (AMP) based non-exothermic orthopedic cements, Biomed. Mater. 11 (2016) 055010,
177:. The excellent tissue compatibility of PMMA allowed bone cements to be used for anchorage of head prostheses in the 1950s.
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79:
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418:"Is there still a place for the cemented titanium femoral stem? 10,108 cases from the Norwegian Arthroplasty Register"
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Hallan, Geir; Espehaug, Birgitte; Furnes, Ove; Wangen, Helge; Høl, Paul J.; Ellison, Peter; Havelin, Leif I. (2012).
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Synthetic, self-curing organic or inorganic material used to fill up a cavity or to create a mechanical fixation.
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The individual components of the bone cement are also known in the area of dental filler materials.
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Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures
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Bone cement chemically is nothing more than
Plexiglas (i.e. polymethyl methacrylate or PMMA).
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356:"A portable negative pressure unit reduces bone cement fumes in a simulated operating room"
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Bone cement has proven particularly useful because specific active substances, e.g.
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exothermic reactions was avoided through using AMP as the solid precursor.
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Application note describing how to measure residual monomer in bone cement
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or used alone in the spine to treat osteoporotic compression fractures.
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if you can. Unsourced or poorly sourced material may be challenged and
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because of its proven long survival rate with cemented-in prostheses.
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279:. However, it is now known that this monomer (residual monomer) is
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when the initiator is mixed with the accelerator. The bone cement
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Vaishya, Raju; Chauhan, Mayank; Vaish, Abhishek (December 2013).
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More recently bone cement has been used in the spine in either
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Br. J. Anaesth. (2009) 102 (1): 12-22. doi: 10.1093/bja/aen328
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Journal of the
Mechanical Behavior of Biomedical Materials
474:. EPRD Deutsche Endoprothesenregister GmbH. Archived from
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354:Carroll, Gregory T.; Kirschman, David L. (2022).
670:"Standard Specification for Acrylic Bone Cement"
648:https://dx.doi.org/10.1088/1748-6041/11/5/055010
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270:Important information for the use of bone cement
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60:Please review the contents of the article and
735:A presentation on the rheology of bone cement
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603:Journal of Clinical Orthopaedics and Trauma
140:have been used very successfully to anchor
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283:by the respiratory chain and split into
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562:The Journal of Bone and Joint Surgery
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337:– use of bone cement to reduce pain
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472:Endoprothesenregister Deutschland
575:10.2106/00004623-199510000-00009
238:Bone cement heats up during the
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753:Orthopedic surgical procedures
62:add the appropriate references
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436:10.3109/17453674.2011.645194
706:10.1016/j.jmbbm.2013.08.005
47:reliable medical references
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616:10.1016/j.jcot.2013.11.005
507:Pure and Applied Chemistry
382:10.1038/s41598-022-16227-x
53:or relies too heavily on
520:10.1351/PAC-REC-10-12-04
224:radical polymerization
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322:drug delivery system
374:2022NatSR..1211890C
768:Medical treatments
361:Scientific Reports
569:(10): 1543–1550.
423:Acta Orthopaedica
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51:verification
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18:Bone cements
700:: 254–262.
482:22 February
335:Osteoplasty
318:antibiotics
281:metabolized
263:kyphoplasty
214:Composition
150:knee joints
45:needs more
747:Categories
541:2013-07-05
430:(1): 1–6.
342:References
240:exothermic
197:definition
146:hip joints
87:newspapers
763:Adhesives
300:Revisions
232:viscosity
714:24004958
634:26403875
528:98107080
454:22206445
400:35831355
329:See also
277:embolism
252:Acrylate
154:shoulder
625:3880950
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445:3278649
391:9279392
370:Bibcode
244:protein
228:monomer
175:surgery
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108:JSTOR
94:books
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630:PMID
579:PMID
484:2016
450:PMID
396:PMID
187:knee
185:and
170:PMMA
162:bone
156:and
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49:for
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620:PMC
612:doi
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516:doi
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432:doi
386:PMC
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261:or
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