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mesothelioma cases. In contrast, only 14% of metastatic adenocarcinomas were positive for CK5/6. Cytokeratin 5/6 also stains reactive mesothelium, which limits its specificity. Overall, CK5/6, along with other markers like calretinin and thrombomodulin, demonstrates high sensitivity for epithelioid mesothelioma, making it a valuable tool in diagnostic pathology.
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Cytokeratin 5/6 (CK5/6) is a biomarker that has emerged as a valuable tool in distinguishing epithelioid pleural mesothelioma from metastatic adenocarcinoma. In a study comparing its effectiveness with other markers, CK5/6 showed high sensitivity, staining positively in 92% of epithelioid pleural
220:"Value of the Mesothelium-Associated Antibodies Thrombomodulin, Cytokeratin 5/6, Calretinin, and CD44H in Distinguishing Epithelioid Pleural Mesothelioma from Adenocarcinoma Metastatic to the Pleura"
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and CK5/6 staining could be used in concert to distinguish between the diagnosis of papilloma (Cyclin D1 < 4.20%, CK 5/6 positive) or papillary carcinoma (Cyclin D1 > 37.00%, CK 5/6 negative).
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Until recently the diagnostic method predominantly depended on identifying antibodies' responses that are positive for adenocarcinoma and negative for mesothelioma.
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Cury, P M; Butcher, D N; Fisher, C; Corrin, B; Nicholson, A G (2000-02-01).
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89:(UDH) and papillary lesions (having a mosaic-like pattern) from
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Wang, Yu; Zhu, Jin-fu; Liu, Ying-ying; Han, Gui-ping (2013).
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Immunohistochemistry with cytokeratin 5/6 antibodies in
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318:Recombinant Antibodies
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405:Immunohistochemistry
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