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99:(CKD) patients on hemodialysis. Etelcalcetide is administered intravenously thrice weekly at the end of each dialysis session. Etelcalcetide binds to the CaSR on the parathyroid gland, which results in receptor activation and ultimately reduction in PTH.
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William G. Goodman, "Calcimimetic agents and secondary hyperparathyroidism: treatment and prevention"
76:(CaSR) on the parathyroid gland. As a result of the receptor "thinking" there is sufficient calcium,
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calcimimetics does not appear to affect the risk of early death. It does decrease the need for a
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177:"Calcimimetics for secondary hyperparathyroidism in chronic kidney disease patients"
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Ballinger, AE; Palmer, SC; Nistor, I; Craig, JC; Strippoli, GF (9 December 2014).
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that is expressed in various human organ tissues. Calcimimetics are used to treat
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80:(PTH) secretion will be reduced. Lower calcium levels will be seen as well.
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was the first calcimimetic to be approved. Cinacalcet mimics calcium at the
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Inc. announced that it had submitted a new drug application with the
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95:(formerly velcalcetide), for the treatment of SHPT in
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102:Calcimimetics can be used concomitantly with
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146:(on line). Last editorial review: 4/8/2004.
181:The Cochrane Database of Systematic Reviews
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89:United States Food and Drug Administration
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46:In the treatment of SHPT patients on
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303:Systemic hormonal preparation stubs
159:Nephrology Dialysis Transplantation
246:. You can help Knowledge (XXG) by
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113:. Common side effects include:
293:Systemic hormonal preparations
194:10.1002/14651858.CD006254.pub2
142:"Definition of calcimimetic",
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41:secondary hyperparathyroidism
70:parathyroid hormone receptor
54:but caused more issues with
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109:Calcimimetic use can have
27:that mimics the action of
74:calcium-sensing receptors
91:for a new calcimimetic,
56:low blood calcium levels
37:calcium-sensing receptor
97:chronic kidney disease
33:allosteric activation
240:hormonal preparation
161:(2002) 17: 204-207.
83:On August 25, 2015
78:parathyroid hormone
25:pharmaceutical drug
16:Pharmaceutical drug
298:Receptor agonists
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123:hypocalcemia
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287:Categories
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66:Cinacalcet
106:therapy.
104:vitamin D
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119:vomiting
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48:dialysis
43:(SHPT).
35:of the
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