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As a small research house, Cephalon initially avoided involving itself in activities that would require maintaining a sales staff, managing clinical trials, and shepherding new drugs through the Food and Drug
Administration (FDA) approval process. With no product to sell, Cephalon's only asset was
835:
noted in
February 2010, "Cephalon... exercised its option to acquire Ception Therapeutics, following receipt of positive data from a clinical study in adults with eosinophilic asthma." Commenting on this, Frank Baldino Jr., CEO of Cephalon, said, "The acquisition of Ception is consistent with our
981:
filed suit against
Cephalon, stating that it had made "illegal deals with generic drug companies to delay generic competition to Provigil", an accusation that Cephalon has reportedly disputed. In September 2008, Cephalon paid $ 425 million to the federal government to settle four whistleblower
598:(FDA) approval process. With no product to sell, Cephalon's only asset was its scientific expertise. That expertise proved sufficient to attract investors, and the company managed to fund its operations through research grants and contracts with larger pharmaceutical firms.
579:. Baldino served as Cephalon's chairman and chief executive officer, until his death in December 2010. The company's name comes from the adjective "cephalic" meaning "related to the head or brain", as it was established primarily to pursue treatments for
806:
and other small molecules, Cephalon licensed other compounds, purchased other products, and acquired entire companies, in the latter case, including CIMA Labs, Anesta, and
Laboratoire Lafon. It was from Lafon that Cephalon obtained the rights to
602:
Cephalon was first included in the
Fortune 1000 list of U.S. companies based upon annual revenues for 2006. Sales revenues reached $ 2.8 billion in 2010, ranking Cephalon among the leading biopharmaceutical companies in the world at that time.
830:
In
February 2009, Cephalon acquired the Australian biotechnology firm, Arana Therapeutics, which brought Cephalon its lead biologic candidate, ART621, a candidate for inflammatory diseases, and biologics for the treatment of cancers. Then, as
937:
Longtime chief financial officer J. Kevin Buchi succeeded
Baldino as CEO in 2011. Members of the board included: venture capitalist William Egan, former COR Therapeutics CEO Vaughan Kailian, prominent healthcare economist Dr.
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its scientific expertise. That expertise proved sufficient to attract investors, and the company managed to fund its operations through research grants and contracts with larger pharmaceutical firms.
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Thereafter, the company developed and commercialized products for the treatment of sleep disorders, pain, addiction and cancer, establishing the "wake franchise" on the basis of
Provigil (
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In 1999 Cephalon settled a lawsuit for $ 17 million in which it had faced claims that
Baldino and other company executives had overstated the potential for a drug aimed at treating
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Cephalon initially avoided involving itself in activities that would require maintaining a sales staff, managing clinical trials, and shepherding new drugs through the
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245:. The reason given is: it is missing a statement of closure, from source, on Teva acquisition, as well as an update on its activities since acquisition in 2011.
942:, former SmithKline Beecham executive Dr. Martyn Greenacre, former Harvard physician and Glaxo USA head Dr. Charles Sanders and former Ambassador Kevin Moley.
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965:. European operations were based near Paris, France. After the acquisition of Arana, Research and Development operations continued in Sydney, Australia.
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1415:"Cephalon Pays $ 425M to Settle Whistleblower Off-label Marketing Case: Whistleblower Bruce Boise–Cephalon opioid lollipops lawsuit"
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lawsuits and a criminal charge alleging
Cephalon had marketed Actiq, Gabitril and Provigil for “off-label” (unapproved) uses.
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At the time of Baldino's death in 2010, the company he had co-founded in 1987 was best known for the alertness drug
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strategy to diversify into biologics and provides us with an important phase three asset for further development."
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1206:"טבע רוכשת את Cephalon תמורת 6.8 מיליארד דולר [Teva acquires Cephalon for $ 6.8 billion]"
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Please help update this article to reflect recent events or newly available information.
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Please help update this article to reflect recent events or newly available information.
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1290:"Cephalon agrees to acquire ChemGenex: Potential leukemia drug key to $ 230M purchase"
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announced it would acquire Cephalon. The deal was completed on October 11, 2011.
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cited. Unsourced or poorly sourced material may be challenged and removed.
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Writer, By Christopher K. Hepp, Inquirer Staff (December 23, 2010).
815:, for the treatment of excessive daytime sleepiness associated with
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1149:"Frank Baldino Jr., Founder of Pharmaceutical Company, Dies at 57"
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Select products that Cephalon manufactured and marketed included:
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19:
For information about the head portion in arthropod anatomy, see
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827:. Sales of Provigil reached nearly one billion dollars in 2008.
802:-enantiomer of modafinil. In addition to conducting research on
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Defunct pharmaceutical companies of the United States
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957:and manufacturing and other operations in suburban
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97:. Unsourced material may be challenged and removed.
1515:List of companies based in the Philadelphia area
3013:Pharmaceutical companies disestablished in 2011
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3018:Biotechnology companies disestablished in 2011
2210:Pharmaceutical companies of the United States
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290:. Consider transferring direct quotations to
8:
3008:Biotechnology companies of the United States
2978:Pharmaceutical companies established in 1987
1420:. Washington, D.C.: Phillips & Cohen LLP
1356:"Cephalon's CEO Dies While on Medical Leave"
1339:: CS1 maint: multiple names: authors list (
1174:Funding Universe Staff (November 30, 2015).
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783:, toward the development of a treatment for
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3003:Biotechnology companies established in 1987
2993:Health care companies based in Pennsylvania
1024:. Unsourced material may be challenged and
905:. Unsourced material may be challenged and
855:, a therapeutic agent for a drug-resistant
652:Learn how and when to remove these messages
614:Product development and acquisition history
60:Learn how and when to remove these messages
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1413:Phillips and Cohen Staff (July 8, 2019) .
1263:"Cephalon To Acquire Ception Therapeutics"
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1044:Learn how and when to remove this message
977:(Lou Gehrig's disease). In addition, the
925:Learn how and when to remove this message
811:, which it marketed under the trade name
759:Learn how and when to remove this message
705:Learn how and when to remove this message
379:Learn how and when to remove this message
361:Learn how and when to remove this message
216:Learn how and when to remove this message
157:Learn how and when to remove this message
1235:"Teva Completes Acquisition of Cephalon"
953:, and had research operations in nearby
2998:Companies formerly listed on the Nasdaq
2988:Defunct companies based in Pennsylvania
1316:"Cephalon names J. Kevin Buchi new CEO"
1125:
3028:2011 disestablishments in Pennsylvania
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945:The company was headquartered west of
847:, and the seizure disorder medication
571:co-founded in 1987 by pharmacologist
7:
1022:adding citations to reliable sources
903:adding citations to reliable sources
687:adding citations to reliable sources
95:adding citations to reliable sources
3023:1987 establishments in Pennsylvania
1389:"Westlaw Sign In | Thomson Reuters"
1354:Gryta, Thomas (December 17, 2010).
182:This section called "Legal issues"
2488:Pharmaceutical Product Development
1288:Bennett, Simeon (March 29, 2011),
1261:Staff Writer (February 24, 2010).
1146:Meier, Barry (December 21, 2010).
16:American biopharmaceutical company
14:
1233:FiecrePharma (October 11, 2011).
633:This section has multiple issues.
41:This article has multiple issues.
2957:List of pharmaceutical companies
1627:Other notable Philadelphia-based
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1882:Susquehanna International Group
674:needs additional citations for
641:or discuss these issues on the
198:check for citation inaccuracies
82:needs additional citations for
49:or discuss these issues on the
1500:Philadelphia-area corporations
608:Teva Pharmaceutical Industries
538:Teva Pharmaceutical Industries
1:
3033:2011 mergers and acquisitions
2364:Institute for OneWorld Health
2026:Notable Delaware Valley-based
1946:Notable Delaware Valley-based
1827:Crozer Keystone Health System
1822:Christiana Care Health System
975:amyotrophic lateral sclerosis
785:amyotrophic lateral sclerosis
336:secondary or tertiary sources
2583:West Pharmaceutical Services
596:Food and Drug Administration
2041:Cerberus Capital Management
1932:W. L. Gore & Associates
1729:Morgan, Lewis & Bockius
443:; 37 years ago
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2389:McNeil Consumer Healthcare
1719:Drinker Biddle & Reath
1690:Notable Philadelphia-based
1666:Philadelphia Media Network
1204:Teva Staff (May 1, 2011).
1176:"History of Cephalon, Inc"
777:insulin-like growth factor
581:neurodegenerative diseases
18:
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2895:Smith, Kline & French
2446:Northwest Biotherapeutics
2431:Merrimack Pharmaceuticals
1957:Aberdeen Asset Management
1692:professional partnerships
1599:Universal Health Services
1511:
1393:signon.thomsonreuters.com
825:shift work sleep disorder
730:This section needs to be
343:primary research articles
281:overly lengthy quotations
241:This article needs to be
21:Cephalon (arthropod head)
2028:division headquarters of
979:Federal Trade Commission
867:Management and locations
779:, in collaboration with
328:This scientific article
288:summarize the quotations
2109:(Johnson & Johnson)
1797:Brandywine Realty Trust
1755:Valley-based businesses
1656:Independence Blue Cross
1573:(rank in the 2017 list)
1533:(rank in the 2017 list)
2820:Leiner Health Products
2264:Amneal Pharmaceuticals
1912:Vishay Intertechnology
1852:Liberty Property Trust
1753:Other notable Delaware
959:Minneapolis, Minnesota
600:
2374:Johnson & Johnson
2051:Johnson & Johnson
2002:Shire Pharmaceuticals
1449:(Teva Pharmaceutical)
511:, seizure medication
2668:Jazz Pharmaceuticals
2658:Horizon Therapeutics
2528:Sarepta Therapeutics
2503:Proteon Therapeutics
2498:Procter & Gamble
2411:Melinta Therapeutics
2304:Bristol Myers Squibb
2012:Teva Pharmaceuticals
1997:Siemens Healthineers
1977:Delaware Investments
1807:Carpenter Technology
1646:Day & Zimmermann
1018:improve this section
963:Salt Lake City, Utah
951:Frazer, Pennsylvania
899:improve this section
683:improve this article
479:Frazer, Pennsylvania
91:improve this article
2875:Repros Therapeutics
2790:Forest Laboratories
2775:Cutter Laboratories
2493:Prasco Laboratories
2234:Acorda Therapeutics
2224:Abbott Laboratories
2107:McNeil Laboratories
1360:Wall Street Journal
1180:FundingUniverse.com
588:fundinguniverse.com
526:(December 31, 2010)
520:Number of employees
395:
2835:Miles Laboratories
2825:Martek Biosciences
2648:Endo International
2568:Ventria Bioscience
2334:Danco Laboratories
1950:foreign businesses
1948:US headquarters of
1867:Rita's Italian Ice
1857:Penn Entertainment
1744:White and Williams
1154:The New York Times
1064:(fentanyl citrate)
863:therapeutic area.
781:Chiron Corporation
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2780:DNAPrint Genomics
2269:Avax Technologies
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1762:Actua Corporation
1617:Burlington Stores
1593:Lincoln Financial
1581:AmerisourceBergen
1070:(cyclobenzaprine)
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804:kinase inhibitors
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573:Frank Baldino, Jr
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2416:Melior Discovery
2401:Kinetic Concepts
2344:Galena Biopharma
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2101:Sherwin-Williams
1927:Wilmington Trust
1681:Urban Outfitters
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2426:Merck & Co.
2384:Janssen Biotech
2354:Gilead Sciences
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2117:Hewlett-Packard
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1792:Bentley Systems
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2720:Allergan, Inc.
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2700:(Canada, 2010)
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1088:(armodafinil)
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1034:February 2020
1027:
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1008:
1003:This section
1001:
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940:Gail Wilensky
929:
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915:February 2020
908:
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884:This section
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794:) and later,
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742:February 2020
733:
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695:February 2020
688:
684:
678:
677:
672:This section
670:
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465:Michael Lewis
463:
462:Frank Baldino
460:
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428:Biotechnology
426:
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351:February 2020
344:
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304:February 2020
297:
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277:This article
275:
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253:February 2020
244:
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147:February 2020
139:
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108: –
107:
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102:Find sources:
96:
92:
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80:This article
78:
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69:
68:
63:
61:
54:
53:
48:
47:
42:
37:
28:
27:
22:
2754:
2678:Mallinckrodt
2563:Upsher-Smith
2394:Ortho-McNeil
2163:Tasty Baking
2147:Dow Chemical
2077:GSI Commerce
1842:EPAM Systems
1811:
1782:Aqua America
1772:AlliedBarton
1724:Duane Morris
1676:Radian Group
1524:Philadelphia
1513:
1424:February 10,
1422:. Retrieved
1408:
1398:February 21,
1396:. Retrieved
1392:
1383:
1371:. Retrieved
1359:
1349:
1323:. Retrieved
1320:inquirer.com
1319:
1309:
1298:, retrieved
1293:
1283:
1273:February 10,
1271:. Retrieved
1267:the original
1241:. Retrieved
1228:
1218:February 10,
1216:. Retrieved
1212:
1199:
1190:
1185:November 30,
1183:. Retrieved
1179:
1169:
1159:November 21,
1157:. Retrieved
1153:
1102:bendamustine
1055:
1040:
1031:
1016:Please help
1004:
972:
969:Legal issues
955:West Chester
947:Philadelphia
944:
936:
921:
912:
897:Please help
885:
838:
833:infogrok.com
832:
829:
799:
789:
770:
755:
739:
731:
701:
692:
681:Please help
676:verification
673:
649:
642:
636:
635:Please help
632:
605:
601:
593:
587:
586:As noted by
585:
561:
560:
474:Headquarters
399:Company type
390:
375:
357:
348:
329:
301:
286:Please help
278:
250:
242:
212:
203:
188:that do not
184:may contain
183:
153:
144:
134:
127:
120:
113:
101:
89:Please help
84:verification
81:
57:
50:
44:
43:Please help
40:
2870:Parke-Davis
2553:Trevena Inc
2421:Mentholatum
2229:AbbVie Inc.
1967:AstraZeneca
1862:Penn Mutual
1568:Fortune 500
1528:Fortune 500
1094:(modafinil)
1082:(tiagabine)
821:sleep apnea
419:: CEPH
2972:Categories
2930:ViroPharma
2830:Massengill
2558:Ultragenyx
2289:Bioverativ
2097:MAB Paints
1907:ViroPharma
1837:DuckDuckGo
1739:Saul Ewing
1704:Blank Rome
1629:businesses
1213:Teva.co.il
1120:References
1076:(fentanyl)
817:narcolepsy
638:improve it
487:Key people
403:Subsidiary
296:Wikisource
117:newspapers
106:"Cephalon"
46:improve it
2880:Qualitest
2750:CancerVax
2533:Sheffield
2523:RespireRx
2518:Regeneron
2369:Intercept
2349:Genentech
2339:Eli Lilly
2324:CytoSport
2314:Ceragenix
1937:WSFS Bank
1636:Amoroso's
1368:0099-9660
1300:March 30,
1243:March 11,
1005:does not
886:does not
859:, in the
809:modafinil
792:modafinil
644:talk page
551:.cephalon
411:Traded as
332:citations
292:Wikiquote
279:contains
186:citations
52:talk page
2760:CoTherix
2755:Cephalon
2638:Covidien
2628:Allergan
2618:Alkermes
2538:Spectrum
2406:McKesson
2299:Biovista
2279:BioCryst
2087:Hercules
2047:Centocor
1887:Vanguard
1817:Chemours
1812:Cephalon
1802:Boscov's
1787:Asplundh
1661:Pep Boys
1641:Chemtura
1335:cite web
1108:Trisenox
1092:Provigil
1080:Gabitril
986:Products
861:oncology
857:leukemia
849:Gabitril
841:Provigil
813:Provigil
513:Gabitril
505:Provigil
500:Products
424:Industry
192:the text
2915:Trubion
2765:Covance
2745:Bradley
2694:, 2013)
2692:Ireland
2688:Perrigo
2684:, 2013)
2682:Ireland
2674:, 2012)
2672:Ireland
2664:, 2014)
2662:Ireland
2654:, 2014)
2652:Ireland
2644:, 2007)
2642:Ireland
2634:, 2015)
2632:Ireland
2624:, 2011)
2622:Ireland
2614:, 2013)
2612:Ireland
2608:Actavis
2578:Viatris
2476:Hospira
2466:Ovation
2461:Organon
2456:NovaBay
2441:Moderna
2379:Ethicon
2309:Century
2294:Biovest
2254:Alnylam
2249:Alexion
2239:Advaxis
2217:Current
2153:SunGard
2113:Neoware
2091:Ashland
2061:Conseco
2017:TD Bank
1847:EnerSys
1714:Dechert
1566:-based
1547:Aramark
1541:Comcast
1526:-based
1098:Treanda
1086:Nuvigil
1074:Fentora
1026:removed
1011:sources
907:removed
892:sources
796:Nuvigil
732:updated
569:company
544:Website
456:Founder
446: (
438:Founded
243:updated
196:Please
131:scholar
2940:Zonite
2920:Upjohn
2855:Nuvelo
2850:Nereus
2845:Naurex
2770:Cubist
2740:Biolex
2725:Amylin
2592:Former
2573:Vertex
2481:Searle
2471:Pfizer
2284:Biogen
2274:Baxter
2127:Exelon
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