53:
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149:(Tensilon), as it only worsens the paralysis caused by cholinergic crisis but strengthens the muscle response in the case of myasthenia gravis. (Edrophonium is a cholinesterase inhibitor, hence increases the concentration of acetylcholine present).
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458:, the main breathing muscle), works by acetylcholine activating nicotinic acetylcholine receptors and leading to muscle contraction. Atropine
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470:), so atropine will not improve the muscle strength and ability to breathe in someone with cholinergic crisis. Such a patient will require
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medication in order to prevent side effects. Flaccid paralysis resulting from cholinergic crisis can be distinguished from
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can be thought of as a subset of cholinergic crisis, as it also involves excessive parasympathetic stimulation.
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As a result of cholinergic crisis, the muscles stop responding to the high synaptic levels of ACh, leading to
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570:"A Comparative Toxidrome Analysis of Human Organophosphate and Nerve Agent Poisonings Using Social Media"
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64:. The reason given is: It will be more useful to expand this article for medical students..
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Please help update this article to reflect recent events or newly available information.
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Schep LJ, Slaughter RJ, Beasley DM (September 2009). "Nicotinic plant poisoning".
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The neuromuscular junction, where the brain communicates with muscles (like the
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Last Minute
Emergency Medicine : A Concise Review for the Specialty Boards
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Contamination with - or excessive exposure to - certain chemicals including:
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466:(a different receptor class than the nicotinic receptors at the
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Some elements of the cholinergic crisis can be reversed with
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constriction of the pupils of the eye via stimulation of the
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Cholinergic toxicity, cholinergic poisoning, SLUDGE syndrome
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Current
Therapy of Trauma and Surgical Critical Care E-Book
122:. Other symptoms include increased sweating, salivation,
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This crisis may be masked by the concomitant use of
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drug is given to reverse surgical muscle paralysis.
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32:
352:who take too high a dose of medications such as
695:, Treasure Island (FL): StatPearls Publishing,
118:, and other signs and symptoms reminiscent of
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687:Lott, Erica L.; Jones, Elizabeth B. (2024),
102:, which normally breaks down acetylcholine.
95:(ACh), as a result of the inactivity of the
407:. Unsourced material may be challenged and
348:In medicine, this is seen in patients with
250:Cholinergic crisis, sometimes known by the
29:
593:
427:Learn how and when to remove this message
623:. McGraw Hill Professional. p. 12.
513:. Elsevier Health Sciences. p. 31.
617:Wagner MJ, Promes SB (1 January 2007).
507:Asensio JA, Trunkey DD (Apr 20, 2015).
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478:until the crisis resolves on its own.
544:Lehne's Pharmacology for Nursing Care
7:
405:adding citations to reliable sources
188:internal sphincter muscle of urethra
241:acetylcholine receptor stimulation)
574:Clinical and Translational Science
464:muscarinic acetylcholine receptors
333:-containing members of the genera
25:
278:mesis), can be a consequence of:
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51:
568:Reddy DS, Colman E (May 2017).
1:
304:organophosphorus insecticides
274:astrointestinal distress and
226:pupillary constrictor muscles
547:. Elsevier Health Sciences.
472:neuromuscular blocking drugs
360:, when too high a dose of a
87:is an over-stimulation at a
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658:10.1080/15563650903252186
354:cholinesterase inhibitors
210:gastrointestinal problems
202:Gastrointestinal distress
190:, and contraction of the
120:organophosphate poisoning
60:This article needs to be
541:Burchum J (2014-12-02).
362:cholinesterase inhibitor
139:cholinesterase inhibitor
130:(constricted pupils).
145:by the use of the drug
689:"Cholinergic Toxicity"
476:mechanical ventilation
468:neuromuscular junction
126:secretions along with
106:Symptoms and diagnosis
89:neuromuscular junction
325:Ingestion of certain
208:tone changes causing
176:: stimulation of the
167:: stimulation of the
160:stimulation include:
736:Parasympathomimetics
441:antimuscarinic drugs
401:improve this section
356:, or seen following
212:, including cramping
186:: relaxation of the
91:due to an excess of
18:Cholinergic toxicity
741:Medicinal chemistry
646:Clinical Toxicology
358:general anaesthesia
254:"SLUDGE syndrome" (
116:respiratory failure
329:(particularly the
318:nicotine poisoning
85:cholinergic crisis
33:Cholinergic crisis
746:Medical mnemonics
731:Neurotransmitters
630:978-0-07-150975-6
586:10.1111/cts.12435
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350:myasthenia gravis
233:: stimulation of
143:myasthenia gravis
112:flaccid paralysis
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27:Medical condition
16:(Redirected from
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327:poisonous fungi
298:Novichok agents
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235:skeletal muscle
178:lacrimal glands
169:salivary glands
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580:(3): 225–230.
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652:(8): 771–81.
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72:February 2024
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524:. Retrieved
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399:Please help
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286:nerve agents
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267:
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262:acrimation,
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231:Muscle spasm
152:Some of the
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132:
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84:
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69:
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270:efecation,
258:alivation,
174:Lacrimation
158:cholinergic
147:edrophonium
137:along with
38:Other names
726:Toxicology
720:Categories
706:2024-02-01
693:StatPearls
494:References
266:rination,
218:: Vomiting
197:Defecation
165:Salivation
526:2 October
456:diaphragm
388:does not
369:Treatment
342:Clitocybe
331:muscarine
308:parathion
288:, (e.g.,
239:nicotinic
184:Urination
180:(tearing)
124:bronchial
701:30969605
674:28312730
666:19778187
604:28238224
482:See also
445:atropine
312:aldicarb
252:mnemonic
237:(due to
154:symptoms
135:atropine
595:5421825
462:blocks
409:removed
394:sources
336:Inocybe
306:(e.g.,
62:updated
699:
672:
664:
627:
602:
592:
551:
517:
222:Miosis
216:Emesis
204::
128:miosis
100:enzyme
670:S2CID
443:like
290:sarin
246:Cause
697:PMID
662:PMID
625:ISBN
600:PMID
549:ISBN
528:2017
515:ISBN
474:and
460:only
392:any
390:cite
339:and
97:AChE
654:doi
590:PMC
582:doi
447:or
403:by
722::
691:,
668:.
660:.
650:47
648:.
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588:.
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294:VX
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424:(
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415:(
411:.
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314:)
276:E
272:G
268:D
264:U
260:L
256:S
74:)
70:(
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