112:, IT support, analytical support, etc.) many companies choose to outsource this function to a company that specializes in this arena. It is important to work with a company that has significant experience in compound management due to the complexity of tracking not only inventory data, but also compound location, storage conditions, and compound integrity. This experience also is of paramount importance when knowing how to appropriately deal with the wide array of materials handled including, solids, liquids, volatile materials, sticky solids, oils, and gums as well as hazardous, flammable, hygroscopic and toxic compounds.
57:
monitored for shelf life, quantity, purity and other parameters, and its banked location. In some companies, the compounds can also include biological compounds, such as purified proteins or nucleic acids. The management of these chemical libraries, including renewal of outdated chemicals, databases containing the information, robotics often involved in fetching chemicals, and quality control of the storage environment is called
Compound Management or Compound Control. Compound Management is often a significant expense, as well as career for one or more individuals who manage a
124:
Subsequently the service allows re-evaluation of compounds that may have decomposed during long term storage. The purification services complement the analytical services by allowing cost effective, environmentally friendly recovery of partially degraded reactive intermediates and HTS compounds at a fraction of the cost of synthesizing or purchasing these materials.
56:
The chemical libraries in larger pharmaceutical companies are a critical part of the discovery process. These chemicals are stored in environmentally controlled conditions in small or large containers, often labeled with codes that pass back into a database. Each chemical in the storage bank must be
95:
management. The manager must also be acutely aware of safety standards in the handling and storing of radioactive, volatile, flammable and unstable compounds. Often, in large pharmaceutical companies, the chemical and biological compounds contained in compound libraries can number in the millions,
115:
Customers can specify not only the quantity of material but also the exact vial and cap or plate for their specific application. The service provides enormous savings from a time perspective as researchers do not spend their valuable time on weighing hundreds of compounds or getting them into the
123:
component of the company allows rapid validation that compounds are the correct material at the desired purity. While controlled storage conditions minimize degradation, customers may use this service to validate that the material they sent to outsourcing partner originally was correct and pure.
116:
correct format for their assay. It also dramatically reduces disposal costs since the exact amount of material required can be ordered rather than needing to order e.g. 100 g of material when only 0.1 g is needed for the experiment.
132:
There are several conferences related to compound management. The best known is
Compound Management & Integrity although many chemistry and pharmaceutical conferences include talks or specific sections on the topic.
304:
72:'s Chemical Genomics Center have released a paper showing the necessity of a highly automated, reliable and parallel compound management platform, in order to serve over 200,000 different compounds.
68:. There are great challenges to be faced in the necessity of compound management, which are being surmounted by concerted efforts in the public and private domain. In 2008, authors at the
64:
There are many books and journal articles devoted entirely or in part to compound management. It has become a critical technological component for high-throughput screening and
312:
37:
depends on methods by which many different chemicals are assayed for their activity. These chemicals are stored as physical quantities in a
75:
In short, Compound
Management requires inventory control of small molecules and biologics needed for assays and experiments, especially in
220:
69:
108:
Because of the significant expenses and infrastructure required for accurate compound management (space requirements,
50:
186:
150:
Archer JR (December 2004). "History, evolution, and trends in compound management for high throughput screening".
76:
46:
28:
332:
236:
Wedin R (January–February 1999). "Taming the monster haystack: The challenge of compound management".
120:
42:
23:
refers to the systematic collection, storage, retrieval, and quality control of small molecule
286:
216:
167:
65:
24:
276:
268:
159:
58:
38:
31:
and other research activities to identify hits that can be developed into candidate drugs.
281:
256:
97:
96:
making compound management and compound control important contributors to research and
34:
20:
326:
255:
Yasgar A, Shinn P, Jadhav A, Auld D, Michael S, Zheng W, et al. (April 2008).
272:
41:
or libraries which are often assembled from both outside vendors and internal
80:
290:
171:
163:
109:
92:
84:
88:
257:"Compound Management for Quantitative High-Throughput Screening"
45:efforts. These chemical libraries are used in
8:
305:"Compound Management & Integrity 2009"
280:
211:Handen JS (2005). "Compound Management".
152:Assay and Drug Development Technologies
142:
7:
213:Industrialization of Drug Discovery
187:"Compound management comes of age"
14:
1:
70:National Institutes of Health
79:. It utilizes knowledge of
349:
273:10.1016/j.jala.2007.12.004
51:drug discovery hit to lead
77:high-throughput screening
47:high-throughput screening
29:high-throughput screening
185:Yates I (March 2003).
164:10.1089/adt.2004.2.675
309:Chemistry Conferences
238:Modern Drug Discovery
315:on 25 December 2008.
121:analytical chemistry
119:The high throughput
61:at a research site.
17:Compound management
43:chemical synthesis
25:chemical compounds
194:Drug Discov World
66:chemical genomics
340:
317:
316:
311:. Archived from
301:
295:
294:
284:
252:
246:
245:
233:
227:
226:
208:
202:
201:
191:
182:
176:
175:
147:
59:chemical library
39:chemical library
19:in the field of
348:
347:
343:
342:
341:
339:
338:
337:
323:
322:
321:
320:
303:
302:
298:
254:
253:
249:
235:
234:
230:
223:
210:
209:
205:
189:
184:
183:
179:
149:
148:
144:
139:
130:
106:
12:
11:
5:
346:
344:
336:
335:
333:Drug discovery
325:
324:
319:
318:
296:
247:
228:
221:
203:
177:
158:(6): 675–681.
141:
140:
138:
135:
129:
126:
105:
102:
98:drug discovery
35:Drug discovery
21:drug discovery
13:
10:
9:
6:
4:
3:
2:
345:
334:
331:
330:
328:
314:
310:
306:
300:
297:
292:
288:
283:
278:
274:
270:
266:
262:
258:
251:
248:
243:
239:
232:
229:
224:
222:9780824723910
218:
215:. CRC Press.
214:
207:
204:
199:
195:
188:
181:
178:
173:
169:
165:
161:
157:
153:
146:
143:
136:
134:
127:
125:
122:
117:
113:
111:
103:
101:
99:
94:
90:
86:
82:
78:
73:
71:
67:
62:
60:
54:
52:
48:
44:
40:
36:
32:
30:
26:
22:
18:
313:the original
308:
299:
267:(2): 79–89.
264:
260:
250:
241:
237:
231:
212:
206:
197:
193:
180:
155:
151:
145:
131:
118:
114:
107:
74:
63:
55:
33:
16:
15:
128:Conferences
104:Outsourcing
137:References
81:chemistry
53:process.
327:Category
291:18496600
244:: 47–53.
200:: 35–42.
172:15674025
110:robotics
93:database
85:robotics
27:used in
282:2390859
89:biology
49:in the
289:
279:
219:
170:
91:, and
190:(PDF)
287:PMID
261:Jala
217:ISBN
168:PMID
277:PMC
269:doi
160:doi
329::
307:.
285:.
275:.
265:13
263:.
259:.
240:.
196:.
192:.
166:.
154:.
100:.
87:,
83:,
293:.
271::
242:2
225:.
198:2
174:.
162::
156:2
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.