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Congenital sensorineural deafness in cats

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The established link between deafness and blue eyes is found in the link between deafness, blue eyes and solid white coats. However, it is a common misconception that all white cats with blue eyes are deaf. It is possible to have a cat with a naturally white coat without this gene, as an extreme form
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which suppresses pigmentation and hearing. The cat would have an underlying coat colour and pattern, but when the dominant white gene is present, that pattern will not be expressed, and the cat will be deaf. A cat that is homozygous (WW) or heterozygous (Ww) for this gene will have a white coat
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was found to have degenerated in the first few weeks after birth; however, even during these weeks no brain stem responses could be evoked by auditory stimuli, suggesting that these animals had never experienced any auditory sensations. It was found that some months after the organ of Corti had
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David, Victor A.; Menotti-Raymond, Marilyn; Wallace, Andrea Coots; Roelke, Melody; Kehler, James; Leighty, Robert; Eizirik, Eduardo; Hannah, Steven S.; Nelson, George; Schäffer, Alejandro A.; Connelly, Catherine J. (1 October 2014).
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MARKAKIS, MARIOS N.; SOEDRING, VIBEKE E.; DANTZER, VIBEKE; CHRISTENSEN, KNUD; ANISTOROAEI, RAZVAN (1 August 2014). "Association of MITF gene with hearing and pigmentation phenotype in Hedlund white American mink (Neovison vison)".
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Complete Guide to Cats, "17 to 20 percent of white cats with non-blue eyes are deaf; 40 percent of "odd-eyed" white cats with one blue eye are deaf; and 65 to 85 percent of blue-eyed white cats are deaf."
70:, to explain correlated variation. Deafness can occur in white cats with yellow, green or blue irises, although it is mostly likely in white cats with blue irises. In white cats with mixed-coloured eyes ( 194:(physical appearance). Therefore, not all solid white cats with one or two blue eyes are deaf. It is not advisable to breed from deaf white cats, as this would pass the trait along. BAER-testing ( 795:
Lee, Youl-Nam; Brandal, Stephanie; Noel, Pierre; Wentzel, Erik; Mendell, Joshua T.; McDevitt, Michael A.; Kapur, Reuben; Carter, Melody; Metcalfe, Dean D.; Takemoto, Clifford M. (31 March 2011).
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This engraving depicts two cats on a wall, with a dog jumping and barking below them. The white-spotted cat hisses at the dog, the solid-white deaf cat dozes unaware of the barking.
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Furthermore, there are multiple different genes responsible for blue (incl. odd) eyes, and several of these genes are not linked to masking, white coats or deafness (e.g., "
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Bosher, SK; Hallpike, CS (13 April 1965). "Observations on the histological features, development and pathogenesis of the inner ear degeneration of the deaf white cat".
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Heid, S; Hartmann, R; Klinke, R (January 1998). "A model for prelingual deafness, the congenitally deaf white cat—population statistics and degenerative changes".
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has congenital sensorineural deafness. His condition leads to his death as he fails to hear his mother's warning of the appearance of a predator.
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cell development, such a disruption would lead to this presentation in cats as well. Waardenburg syndrome type 2A (caused by a mutation in
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Hamadah, Issam; Chisti, Muzamil; Haider, Mansoor; Al Dosssari, Haya; Alhumaidan, Rawan; Meyer, Brian F.; Wakil, Salma M. (13 July 2019).
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Omenn, Gilbert S.; McKusick, Victor A.; Gorlin, Robert J. (1979). "The association of Waardenburg syndrome and Hirschsprung megacolon".
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despite the underlying pattern/colour. A cat that lacks this dominant masking gene (ww) will exhibit a coat colour/pattern.
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and mice, and they all display at least patchy white depigmentation and some degeneration of the cochlea and
1991: 1955: 1802: 208: 1960: 683:"Endogenous Retrovirus Insertion in the KIT Oncogene Determines White and White spotting in Domestic Cats" 2040: 2001: 1907: 1872: 1372: 1255: 1240: 967: 797:"KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation" 1599: 1494: 1392: 1215: 279: 247: 107: 2050: 1965: 1847: 1694: 1479: 1449: 1230: 1180: 45: 1917: 1822: 1614: 1524: 1439: 1405: 1387: 1108: 603: 498: 303: 449:
ASPCA Complete Guide to Cats: Everything You Need to Know About Choosing and Caring for Your Pet
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mutations have also led to patchy depigmentation and different coloured irises in humans, and
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In one 1997 study of white cats, 72% of the animals were found to be totally deaf. The entire
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Although few studies have been done to link this to genes known to be involved in human
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A major gene that causes a cat to have a white coat is a dominant masking gene, an
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or Ojos Azules cats are not linked to deafness. Deafness depends on the cat's
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Domesticated cats with blue eyes and white coats are often completely deaf.
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High rates of congenital deafness in white cats with light-coloured eyes
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expression, the gene involved in human Waardenburg syndrome type 2A.
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Proceedings of the Royal Society B: Biological Sciences
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Harper Children's. p. 79-81. 518:American Journal of Medical Genetics 198:) is used to test deafness in cats. 1368:Governing Council of the Cat Fancy 196:Brainstem Auditory Evoked Response 14: 1828:Congenital sensorineural deafness 1383:The International Cat Association 1338:American Cat Fanciers Association 942:. Harper Children's. p. 94. 38:Congenital sensorineural deafness 2015: 2014: 1363:FĂ©dĂ©ration Internationale FĂ©line 48:caused by a degeneration of the 627:Frontiers in Veterinary Science 452:. Chronicle Books. p. 71. 190:(genetic make-up), and not its 938:Hunter, Erin (17 March 2015). 913:Hunter, Erin (17 March 2015). 1: 487:10.1016/S0378-5955(97)00182-2 207:The character Snowkit in the 158:Non-deaf blue-eyed white cats 813:10.1182/blood-2010-07-293548 687:G3: Genes, Genomes, Genetics 40:occurs commonly in domestic 1997:List of longest-living cats 1878:Lower urinary tract disease 1858:Hypertrophic cardiomyopathy 1378:Southern Africa Cat Council 150:has been found to increase 44:with a white coat. It is a 2067: 1353:Cat Aficionado Association 852:Strain, George M. (2011). 756:10.1016/j.jdcr.2019.01.021 621:Strain, George M. (2015). 2010: 1833:Feline corneal sequestrum 1358:Cat Fanciers' Association 855:Deafness in Dogs and Cats 583:10067/1211550151162165141 574:10.1007/s12041-014-0370-3 368:On the Origins of Species 128:, as in deaf white cats. 1348:Canadian Cat Association 887:Hartwell, Sarah (2023). 640:10.3389/fvets.2015.00029 67:On the Origin of Species 1992:List of individual cats 530:10.1002/ajmg.1320030302 1868:Infectious peritonitis 1863:Immunodeficiency virus 292:10.1098/rspb.1965.0030 34: 26: 1933:Viral rhinotracheitis 1908:Tritrichomonas foetus 1373:New Zealand Cat Fancy 1241:Cats in ancient Egypt 699:10.1534/g3.114.013425 446:Richards, J. 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J 180:Ojos Azules 2051:Hair color 2035:Categories 1888:Giardiasis 1741:Highlander 1640:Ragamuffin 1580:Maine Coon 1560:Khao Manee 1540:German Rex 1430:Abyssinian 1330:Registries 1313:Ship's cat 1298:Bodega cat 1054:Calico cat 999:Felinology 403:3 December 254:References 238:Pleiotropy 56:Occurrence 1951:Australia 1913:Roundworm 1848:Heartworm 1805:disorders 1765:Landraces 1751:Serengeti 1700:Tonkinese 1670:Singapura 1630:Pixie-bob 1625:Peterbald 1545:Himalayan 1510:Devon Rex 1485:Chartreux 1406:full list 1268:Feral cat 1251:fictional 1211:Cat cafĂ©s 1196:Human–cat 1087:Declawing 1059:Tabby cat 1049:Black cat 1017:Dwarf cat 821:0006-4971 764:2352-5126 707:2160-1836 649:2297-1769 592:0973-7731 538:1096-8628 365:(1909) . 192:phenotype 50:inner ear 2046:Deafness 2020:Category 1903:Ringworm 1843:Coccidia 1746:Savannah 1675:Snowshoe 1665:Siberian 1590:Munchkin 1555:Javanese 1475:Burmilla 1445:Balinese 1423:domestic 1320:Zoonosis 1303:Farm cat 1256:Internet 1236:Cat show 1226:Cat meat 1166:Kneading 1142:valerian 1132:Catfight 1119:Behavior 1032:Squitten 1012:Genetics 839:21273305 782:31341943 725:25085922 667:26664958 608:16725018 600:25189243 503:38262220 349:20808581 308:36675534 300:14285813 222:See also 188:genotype 102:Genetics 1985:Related 1736:Chausie 1660:Siamese 1635:Ragdoll 1620:Persian 1515:Donskoy 1470:Burmese 1288:Pet cat 1007:Anatomy 830:3072881 773:6630042 716:4199695 658:4672198 495:9472739 340:2871368 280:Bibcode 243:Van cat 172:Siamese 126:saccule 91:cochlea 89:in the 1956:Canada 1898:Rabies 1818:Asthma 1788:Sokoke 1783:Kellas 1778:Cyprus 1773:Aegean 1731:Bengal 1724:Hybrid 1705:Toyger 1685:Sphynx 1680:Somali 1605:Ocicat 1535:Foldex 1505:Cymric 1465:Bombay 1460:Birman 1402:Breeds 1278:Lolcat 1186:Senses 1137:Catnip 1102:senior 1074:Health 1022:Kitten 946:  921:  870:  837:  827:  819:  780:  770:  762:  723:  713:  705:  665:  655:  647:  633:: 29. 606:  598:  590:  546:484594 544:  536:  501:  493:  456:  375:  347:  337:  306:  298:  133:allele 1961:Japan 1575:Lykoi 1565:Korat 1421:Fully 1082:Aging 801:Blood 604:S2CID 499:S2CID 304:S2CID 211:book 122:minks 79:ASPCA 1923:Tick 1838:Flea 1813:Acne 1690:Thai 1585:Manx 1159:Purr 1154:Meow 1092:Diet 944:ISBN 919:ISBN 900:2023 868:ISBN 835:PMID 817:ISSN 778:PMID 760:ISSN 721:PMID 703:ISSN 663:PMID 645:ISSN 596:PMID 588:ISSN 542:PMID 534:ISSN 491:PMID 454:ISBN 433:2013 405:2016 373:ISBN 345:PMID 296:PMID 152:MITF 117:MITF 42:cats 1793:Van 825:PMC 809:doi 805:117 768:PMC 752:doi 711:PMC 695:doi 653:PMC 635:doi 578:hdl 570:doi 526:doi 483:doi 479:115 335:PMC 288:doi 276:162 163:of 148:KIT 144:KIT 138:KIT 135:of 2037:: 891:. 866:. 864:68 858:. 833:. 823:. 815:. 803:. 799:. 776:. 766:. 758:. 746:. 742:. 719:. 709:. 701:. 689:. 685:. 661:. 651:. 643:. 629:. 625:. 602:. 594:. 586:. 576:. 566:93 564:. 540:. 532:. 520:. 497:. 489:. 477:. 424:. 413:^ 395:. 343:. 331:51 329:. 325:. 302:. 294:. 286:. 274:. 262:^ 178:, 174:" 1414:) 1410:( 1408:) 1404:( 983:e 976:t 969:v 952:. 927:. 902:. 876:. 841:. 811:: 784:. 754:: 748:5 727:. 697:: 691:4 669:. 637:: 631:2 610:. 580:: 572:: 548:. 528:: 522:3 505:. 485:: 462:. 435:. 407:. 381:. 351:. 310:. 290:: 282::

Index



cats
congenital deafness
inner ear
Charles Darwin
On the Origin of Species
odd-eyed cats
ASPCA
organ of Corti
cochlea
spiral ganglion
Waardenburg syndrome
neural crest
MITF
minks
saccule
allele
KIT
white spotting
Siamese
colourpoint-gene
Ojos Azules
Foreign White
genotype
phenotype
Brainstem Auditory Evoked Response
Warriors series
A Dangerous Path
Cat coat genetics

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