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Ogata et al. found significant correlations among the CrB score, the concentration of sputum ECP and %FEV1.0 (p less than 0.001). The CrB score on the day of clinical appraisal significantly correlated with the number 6f days of treatment needed for remission. These results were in keeping with the
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Ogata, Hidetsugu; Motojima, Shinji; Fukuda, Takeshi; Makino, Sohei (1990). "急性喘息発作時におけるCreola Bodyと喀痰中Eosinophil
Cationic Proteinの関係およびその臨床的意義" [Creola bodies and the eosinophil cationic protein in sputum in acute asthmatic attacks with respect to their clinical significance].
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hypothesis that eosinophils cause desquamation of respiratory epithelial cells resulting in prolongation of asthmatic attacks. Observation of CrB seemed to be useful as a marker of duration of asthmatic attacks.
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activity concluding that "epithelial damage is associated with a locally enhanced chemotactic signal for and activity of neutrophils, but not eosinophils, during acute exacerbations of paediatric asthma."
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Yoshihara et al. reported 60% of pediatric asthmatic patients demonstrating acute symptoms were found to have creola bodies in their sputum. These patients had increased levels of
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mucosa of a patient with asthma. Other common findings in the sputum of asthma patients include
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Yoshihara, S.; Yamada, Y.; Abe, T.; Linden, A.; Arisaka, O. (2006).
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Yamada, Yumi; Yoshihara, Shigemi; Arisaka, Osamu (2004).
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