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Poeschla's laboratory is interested in how viruses interact with, use, or evade cellular proteins as they replicate, as well as innate immunity, and viral emergence. Early work determined how FIV, the feline HIV-like virus, carries out its life cycle. It also established FIV-based lentiviral vectors.
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Subsequent research included contributions to identifying the role of a cellular protein (LEDGF) in the chromosomal attachment and integration step of HIV, and investigations of other cellular factors that regulate the HIV life cycle. More recent studies have further concerned cellular innate immune
803:
Painter, Meghan M.; Morrison, James H.; Zoecklein, Laurie J.; Rinkoski, Tommy A.; Watzlawik, Jens O.; Papke, Louisa M.; Warrington, Arthur E.; Bieber, Allan J.; Matchett, William E.; Poeschla, Eric M.; Rodriguez, Moses (2015).
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125:, where he also holds the Tim Gill Endowed Chair in HIV Research and has helped direct the institutional response to the COVID-19 pandemic. Poeschla was elected to the
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Meehan, Anne M.; Saenz, Dyana T.; Guevera, Rebekah; Morrison, James H.; Peretz, Mary; Fadel, Hind J.; Hamada, Masakazu; van
Deursen, Jan; Poeschla, Eric M. (2014).
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461:"HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products"
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Llano, Manuel; Saenz, Dyana T.; Meehan, Anne; Wongthida, Phonphimon; Peretz, Mary; Walker, William H.; Teo, Wulin; Poeschla, Eric M. (2006-10-20).
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Miller, Caitlin M.; Barrett, Bradley S.; Chen, Jianfang; Morrison, James H.; Radomile, Caleb; Santiago, Mario L.; Poeschla, Eric M. (2020-04-16).
83:
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Fadel, Hind J.; Morrison, James H.; Saenz, Dyana T.; Fuchs, James R.; Kvaratskhelia, Mamuka; Ekker, Stephen C.; Poeschla, Eric M. (2014-09-01).
634:"Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation"
632:
Morrison, James H.; Guevara, Rebekah B.; Marcano, Adriana C.; Saenz, Dyana T.; Fadel, Hind J.; Rogstad, Daniel K.; Poeschla, Eric M. (2014).
748:"Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation"
341:"CXCR4 is required by a nonprimate lentivirus: heterologous expression of feline immunodeficiency virus in human, rodent, and feline cells"
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defenses to other RNA viruses as well. The laboratory uses picornavirus RNA polymerase-transgenic mouse models to investigate
518:"TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism"
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Bankers, Laura; Miller, Caitlin; Liu, Guoqi; Thongkittidilok, Chommanart; Morrison, James; Poeschla, Eric M. (2020-05-15).
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In 2020, a restriction to primate lentiviruses (HIV and related simian viruses) was reported in cells of large bats.
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Morrison, James H.; Miller, Caitlin; Bankers, Laura; Crameri, Gary; Wang, Lin-Fa; Poeschla, Eric M. (2020-09-15).
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in 1999, where he was
Professor of Molecular Medicine and directed research focused on the HIV life cycle.
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Since 2014, Poeschla has been
Professor of Medicine and Chief of the Infectious Diseases Division at the
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286:"Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors"
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School of
Medicine in 1988, which was followed by a year of tropical medicine training in
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691:"Systemic Expression of a Viral RdRP Protects against Retrovirus Infection and Disease"
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865:"A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat"
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110:. After infectious disease fellowship and post-doctoral training in virology at the
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is an
American infectious disease physician, virologist, and innate immunologist.
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575:"A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection"
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Kumar, Swati; Morrison, James H.; Dingli, David; Poeschla, Eric (2018-08-15).
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806:"Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity"
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in 1985 and completed his residency in internal medicine at the
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This article about a biologist from the United States is a
220:"Poeschla named head of Division of Infectious Diseases"
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Poeschla, E. M.; Wong-Staal, F.; Looney, D. J. (1998).
398:"An essential role for LEDGF/p75 in HIV integration"
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98:Poeschla was the project physician for the 1990
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222:. University of Colorado. August 21, 2014
123:University of Colorado School of Medicine
339:Poeschla, E. M.; Looney, D. J. (1998).
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84:University of California, San Francisco
34:University of California, San Francisco
1002:University of Colorado Denver faculty
244:. University of Colorado Denver. 2014
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129:(AAP) in 2016. He lives in Denver.
112:University of California, San Diego
945:. You can help Knowledge (XXG) by
127:Association of American Physicians
114:School of Medicine, he joined the
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199:Lost City of the Maya Documentary
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357:10.1128/JVI.72.8.6858-6866.1998
116:Mayo Clinic College of Medicine
1007:Yale School of Medicine alumni
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57:University of Colorado Denver
823:10.1371/journal.ppat.1005311
592:10.1371/journal.ppat.1003969
264:"Eric M Poeschla's research"
78:Poeschla graduated from the
174:"Kundiawa General Hospital"
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144:Interferon-stimulated gene
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1017:American biologist stubs
764:10.4049/jimmunol.1901421
422:10.1126/science.1132319
80:Yale School of Medicine
32:Yale School of Medicine
881:10.1128/mBio.01854-20
752:Journal of Immunology
100:Vanderbilt University
68:Eric Murnane Poeschla
23:Eric Murnane Poeschla
997:HIV/AIDS researchers
707:10.1128/JVI.00071-20
650:10.1128/JVI.03814-13
534:10.1128/JVI.01397-14
477:10.1128/JVI.00001-18
242:"Eric Poeschla, M.D"
695:Journal of Virology
638:Journal of Virology
522:Journal of Virology
465:Journal of Virology
414:2006Sci...314..461L
345:Journal of Virology
328:– via Pubmed.
16:HIV/AIDS researcher
302:10.1038/nm0398-354
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108:Guatemala
104:Dos Pilas
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