42:
96:(AQP5), a water channel protein, in human individuals with primary focal hyperhidrosis. AQP5 has been identified as a candidate gene in many hyperhidrosis studies. Using a family that had members with primary focal hyperhidrosis, researchers found that there was no connection between primary focal hyperhidrosis and AQP5. There was also no significant connection between the gene 14q11.2-q13 locus, which was linked to primary palmar hyperhidrosis, and primary focal hyperhidrosis in this family.
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was significantly higher in a patient group in comparison to the control group. In 2011, using a control group (individuals without primary focal hyperhidrosis) and a patient group (individuals with primary focal hyperhidrosis) researchers found that there was no difference between the number of
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of all the participants in the study. Not every member of the pedigree exhibited forms of hyperhidrosis, which allowed the researchers to track the patterns of inheritance. The findings in this study indicated that primary focal hyperhidrosis is typically an hereditary disorder.
266:
Solish N, Bertucci V, Dansereau A, Hong HC, Lynde C, Lupin M, et al. (2007). "A Comprehensive
Approach to the Recognition, Diagnosis, and Severity-Based Treatment of Focal Hyperhidrosis: Recommendations of the Canadian Hyperhidrosis Advisory Committee".
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Typical regions of excessive sweating include the hand palms, underarms, the sole of the foot, and sometimes groin, face, and scalp. Indeed, profuse sweating is present mostly in the underarms, followed by the feet, palms and facial region.
65:
localized in certain body regions (particularly palms, feet and underarms). Studies suggest that this condition, affecting between 1% and 3% of the US population, seems to have a genetic predisposition in about two thirds of those affected.
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different between individuals with and without primary focal hyperhidrosis. The discrepancies between the studies above call on further studies to confirm or deny the role of AQP5, and the role of other proteins, in hyperhidrosis.
190:), laser-assisted removal of the sweat glands (underarms), other local procedures such as liposuction and curettage of the sweat glands (underarms), medications of the anticholinergic type that are taken by mouth, and
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Gresz V, Kwon T, Gong H, Agre P, Steward M, King L, et al. (2004). "Immunolocalization of AQP-5 in rat parotid and submandibular salivary glands after stimulation of inhibition of secretion in vivo".
161:
The
Canadian Hyperhidrosis Advisory Committee has published a comprehensive set of guidelines which outlines key aspects of treatment related to this condition. Topical hyperhidrosis gels containing
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Higashimoto I, Yoshiura KI, Hirakawa N, Higashimoto K, Soejima H, Totoki T, et al. (2006). "Primary palmar hyperhidrosis locus maps to 14q11.2-q13".
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Del Sorbo F, Brancati F, De Joanna G, Valente E, Lauria G, Albanese A (2011). "Primary focal hyperhidrosis in a new family not linked to known loci".
440:
Du G, Min M, Yang J, Chen J, Tu Y (2016). "Overexpression of AQP5 Was
Detected in Axillary Sweat Glands of Primary Focal Hyperhidrosis Patients".
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Beyond looking at the genes and individual proteins that play a role in primary focal hyperhidrosis, researchers have looked at the patterns of
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Kaufmann H, Saadia D, Polin C, Hague S, Singleton A, Singleton A (2003). "Primary hyperhidrosis--evidence for autosomal dominant inheritance".
77:, as it has a significant impact on the quality of life, affecting the individual socially, psychologically, emotionally and professionally.
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Brown AL, Gordon J, Hill S (August 2014). "Hyperhidrosis: review of recent advances and new therapeutic options for primary hyperhidrosis".
132:. 21 patients in this study reported a positive family history of hyperhidrosis (62%). Researchers were able to uncover this by creating
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for this trait. In a 2003 study, using multiple families, researchers found that primary focal hyperhidrosis was not a
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Swartling C, Brismar K, Aquilonius SM, Naver H, Rystedt A, Rosell K (2011). "Hyperhidros - det "tysta" handikappet".
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89:, referring to excess sweating on the palms of the hands and feet, maps to the gene locus 14q11.2-q13.
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86:
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172:(whose main active ingredients usually are aluminum or zirconium salts) treatment options include:
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124:, since male-to-male transmission was seen in multiple families. Instead evidence supported an
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Walling HW (2011). "Clinical differentiation of primary from secondary hyperhidrosis".
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Based on previous research using mice and rats, researchers looked towards the role of
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surgery for sweating of the hands or head that can't be controlled by other means.
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180:) injections (underarms, hands, feet, and other localized areas), electromagnetic/
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Jacob C (March 2013). "Treatment of hyperhidrosis with microwave technology".
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Evidence demonstrates that a positive family history is also present (see the
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McConaghy JR, Fosselman D (June 2018). "Hyperhidrosis: Management
Options".
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American
Journal of Physiology. Gastrointestinal and Liver Physiology
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is approved for the treatment of primary axillary hyperhidrosis.
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751:(Press release). Botanix Pharmaceuticals. 20 June 2024.
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are usually first choice treatments for this condition.
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630:Clinical, Cosmetic and Investigational Dermatology
128:pattern of inheritance with an incomplete disease
528:"Focal hyperhidrosis: diagnosis and management"
591:Journal of the American Academy of Dermatology
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99:The expression of the AQP5 protein and AQP5
85:In 2006, researchers uncovered that primary
312:American Journal of Medical Genetics Part A
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677:Seminars in Cutaneous Medicine and Surgery
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16:Excessive sweating in certain body regions
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624:Stashak AB, Brewer JD (29 October 2014).
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176:(hands, feet), onabotulinumtoxinA (
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108:. This indicates that there is nothing
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532:Canadian Medical Association Journal
485:Clinical Autonomic Research Journal
574:: CS1 maint: overridden setting (
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755:from the original on 20 June 2024
749:"FDA Approves Sofdra topical gel"
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281:10.1111/j.1524-4725.2007.33192.x
61:characterized by an excessive
1:
707:Current Opinion in Pediatrics
626:"Management of hyperhidrosis"
163:aluminum chloride hexahydrate
719:10.1097/mop.0000000000000108
104:sweat coils in the axillary
73:is sometimes referred to as
526:Haider A, Solish N (2005).
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603:10.1016/j.jaad.2010.03.013
186:of underarm sweat glands (
497:10.1007/s10286-003-0082-x
39:
368:10.1152/ajpgi.00480.2003
182:microwave energy
168:In addition to topical
55:primary hyperhidrosis
35:primary hyperhidrosis
862:Cutaneous conditions
544:10.1503/cmaj.1040708
324:10.1002/ajmg.a.31127
269:Dermatologic Surgery
87:palmar hyperhidrosis
643:10.2147/CCID.S53119
198:Sofpironium bromide
75:The Silent Handicap
51:Focal hyperhidrosis
27:Focal hyperhidrosis
126:autosomal dominant
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411:10.1159/000334936
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252:(47): 2428–2432.
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225:(11): 729–734.
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275:(8): 908–923.
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248:(in Swedish).
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442:Dermatology
399:Dermatology
184:thermolysis
94:aquaporin 5
32:Other names
683:(1): 2–8.
636:: 285–99.
204:References
157:Treatments
130:penetrance
141:Diagnosis
134:pedigrees
856:Category
846:Medicine
753:Archived
735:33641836
727:24905102
689:24049923
662:25378942
611:21334095
562:15632408
513:27224801
505:12720093
462:26930592
427:33908389
419:22237135
384:10012101
376:14988067
340:43382712
332:16470694
289:17661933
231:30215934
151:Genetics
118:heredity
81:Genetics
63:sweating
759:20 June
653:4218921
470:1160454
297:3791845
188:miraDry
153:part).
59:disease
57:, is a
832:Portal
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69:Focal
803:Xxx.x
731:S2CID
509:S2CID
466:S2CID
423:S2CID
380:S2CID
336:S2CID
293:S2CID
178:Botox
813:9-CM
761:2024
723:PMID
685:PMID
658:PMID
607:PMID
576:link
558:PMID
501:PMID
458:PMID
415:PMID
372:PMID
328:PMID
316:140A
285:PMID
227:PMID
101:mRNA
818:xxx
809:ICD
794:ICD
715:doi
648:PMC
638:doi
599:doi
548:PMC
540:doi
536:172
493:doi
450:doi
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407:doi
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364:doi
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320:doi
277:doi
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