25:
170:
gene and its host (animal) genomes, and its non-essential status for viral reproduction, the v-Src gene is likely to have been acquired from a host genome and altered by subsequent mutations. These subsequent mutations are responsible for the oncogenic capabilities of the virus, as the normal (host)
521:
Feuerman, M. H.; Lee, W. T.; Pattengale, P. K.; Fan, H. (1988). "Comparison of three recombinant murine leukemia viruses carrying the v-src oncogene of avian sarcoma virus: Differences in in vitro transformation and in vivo pathogenicity".
133:
When a viral gene is introduced into the host cell and is sufficient to induce oncogenesis – the creation of cancerous cells – in the infected cell line, the gene is said to be a "viral transforming gene". When this type of gene is
207:(mice), the viral life cycle can also be responsible for oncogenesis through a Gag-v-Onc fusion protein called "Mo-MuLV(src)", which is a Gag-v-Src protein capable of inducing oncogenesis in living mice.
138:
to a protein, the protein is called a "transforming protein". Note that since the viral oncogenes originated from a host genome, the transformation event is different from
838:
833:
405:"Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src)"
890:
342:
1418:
1413:
1408:
1403:
1365:
1360:
1740:
1398:
1393:
869:
864:
859:
583:
2121:
1884:
387:
696:
326:
1854:
1788:
1015:
1482:
1150:
41:
154:
illustrates the dual role that the fusion protein plays in the viral and host cellular life cycle. For example, the viral gene
2001:
2255:
1475:
1470:
576:
2260:
2103:
2038:
1710:
1686:
1493:
1378:
1284:
1210:
1135:
1030:
914:
849:
769:
735:
686:
183:
and invasion pathways. These native pathways are disrupted in the presence of the mutant Src gene (v-Src) such that
779:
706:
671:
1661:
1465:
666:
2160:
2048:
1974:
1912:
1864:
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1343:
1104:
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990:
973:
823:
711:
646:
284:
569:
139:
113:
encodes proteins that constitute the matrix, capsid and nucleocapsid of the mature virus particles. Like in
813:
2059:
1944:
784:
242:
70:
2270:
2265:
2193:
2084:
1964:
1836:
1696:
200:
188:
172:
142:, which describes the process of introducing non-native genes to a host organism via a viral infection.
135:
106:
1995:
1933:
1620:
1064:
1055:
977:
924:
745:
636:
475:
416:
1666:
1060:
1050:
969:
280:
2188:
2065:
547:
217:
163:
155:
151:
89:. (In the case of a fusion with C-jun, the resulting "gag-jun" protein is known alternatively as
1640:
1388:
1327:
1092:
539:
503:
444:
383:
322:
232:
77:('onc'), a gene that plays a role in the development of a cancer. The name is also written as
1902:
1508:
1245:
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1230:
1225:
1220:
1199:
531:
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2132:
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1332:
403:
Smart JE, Oppermann H, Czernilofsky AP, Purchio AF, Erikson RL, Bishop JM (October 1981).
257:
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960:
880:
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66:
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176:
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1041:
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468:
Proceedings of the
National Academy of Sciences of the United States of America
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2143:
2138:
2079:
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1194:
1184:
1172:
945:
609:
429:
267:
247:
159:
102:
488:
158:(as in "sarcoma") is not necessary for viral reproduction, but does affect
543:
535:
507:
448:
725:
187:
becomes more likely for the infected host cells, since the v-Src gene is
74:
464:"Transduction of a cellular oncogene: The genesis of Rous sarcoma virus"
81:, with "v" indicating that the Onc sequence resides in a viral genome.
1985:
1923:
1671:
1610:
1503:
1001:
657:
204:
122:
110:
462:
Swanstrom, R.; Parker, R. C.; Varmus, H. E.; Bishop, J. M. (1983).
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1546:
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1516:
1123:
1118:
1113:
167:
86:
2108:
1939:
1551:
1536:
965:
701:
90:
85:
is a generic placeholder for a given specific oncogene, such as
565:
2169:
2165:
2148:
1294:
1145:
191:
into a functionally distinct version of its host counterpart.
114:
18:
121:
from the host cell's plasma membrane, where the fully formed
380:
Principles of
Virology, Vol. 2: Pathogenesis and Control
203:, a species of viruses capable of causing cancer in
2214:
2205:
2182:
2119:
2046:
2037:
2028:
1984:
1972:
1963:
1922:
1910:
1901:
1874:
1862:
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1826:
1814:
1805:
1778:
1766:
1757:
1730:
1718:
1709:
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1609:
1597:
1588:
1573:
1491:
1446:
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1376:
1341:
1326:
1311:
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1258:
1208:
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821:
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724:
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38:
Confusing, difficult for non-experts to understand.
314:
101:Gag genes are part of a general architecture for
368:, 3rd edition, Vol. 1, Molecular Biology, 2009
577:
343:"Oncogene Protein p65(gag-jun) - MeSH - NCBI"
8:
2211:
2202:
2043:
2034:
1981:
1969:
1919:
1907:
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1859:
1823:
1811:
1775:
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1323:
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956:
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614:
584:
570:
562:
291:http://www.ijbs.com/v06p0730.htm#headingA7
1741:Parainfluenza hemagglutinin-neuraminidase
497:
487:
438:
428:
283:at the U.S. National Library of Medicine
34:needs attention from an expert in Viruses
308:
306:
302:
150:The Gag-v-Onc fusion protein from the
125:leave the cell to infect other cells.
44:may be able to help recruit an expert.
1885:Respiratory syncytial virus G protein
7:
378:Flint, S. Jane (December 1, 2008).
14:
1789:Mumps hemagglutinin-neuraminidase
105:, viruses that replicate through
1151:Hepatitis B virus DNA polymerase
321:. USA: Oxford University Press.
117:, these proteins are needed for
23:
982:(non-enveloped circular ds-DNA)
162:. Due to evidence of conserved
16:Chimeric cancer-related protein
109:, where the gag region of the
1:
2002:Vesiculovirus matrix proteins
409:Proc. Natl. Acad. Sci. U.S.A
73:('gag') gene and that of an
2039:Structure and genome of HIV
1096:(circular partially ds-DNA)
36:. The specific problem is:
2287:
672:Herpesvirus glycoprotein B
667:HHV capsid portal protein
382:(3 ed.). ASM Press.
171:version of the Src gene,
524:Molecular Carcinogenesis
313:Lewin, Benjamin (1999).
285:Medical Subject Headings
65:is a general term for a
1662:Influenza hemagglutinin
430:10.1073/pnas.78.10.6013
281:gag-onc+Fusion+Proteins
201:murine leukemia viruses
115:HIV's replication cycle
2224:Gag-onc fusion protein
489:10.1073/pnas.80.9.2519
366:Principles of Virology
243:Bcr-abl fusion protein
71:group-specific antigen
63:gag-onc fusion protein
2194:murine leukemia virus
2085:Reverse transcriptase
1965:Indiana vesiculovirus
1837:Measles hemagglutinin
536:10.1002/mc.2940010112
195:murine leukemia virus
107:reverse transcription
925:Early 35 kDa protein
347:www.ncbi.nlm.nih.gov
2256:Viral protein class
480:1983PNAS...80.2519S
421:1981PNAS...78.6013S
199:In the case of the
175:promotes survival,
42:WikiProject Viruses
2261:Viral oncoproteins
2189:Rous sarcoma virus
218:Rous sarcoma virus
152:Rous sarcoma virus
146:Rous sarcoma virus
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2011:
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719:
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389:978-1-55581-480-9
233:Fusion transcript
59:
58:
2278:
2212:
2203:
2044:
2035:
1982:
1970:
1920:
1908:
1903:Zaire ebolavirus
1872:
1860:
1824:
1812:
1776:
1764:
1728:
1716:
1607:
1595:
1586:
1509:3C-like protease
1444:
1339:
1324:
1280:
1206:
1200:Duplornaviricota
1191:
1178:
1100:
1038:
998:
986:
957:
910:
819:
810:
765:
731:
654:
642:
633:
615:
586:
579:
572:
563:
556:
555:
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512:
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491:
474:(9): 2519–2523.
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2174:
2133:transactivators
2115:
2008:
1951:
1889:
1841:
1793:
1745:
1701:
1676:
1647:
1590:Influenza virus
1580:Negarnaviricota
1577:
1575:
1561:
1487:
1435:
1423:
1372:
1333:Kitrinoviricota
1330:
1315:
1313:
1299:
1271:
1250:
1197:
1182:
1155:
1129:
1095:
1083:
1070:
1020:
981:
963:
949:
943:
929:
895:
874:
843:
805:
804:(Duplodnaviria,
803:
802:circular ds-DNA
789:
750:
716:
676:
625:
619:
604:
590:
560:
559:
520:
519:
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401:
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364:
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258:Retrotransposon
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197:
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99:
55:
49:
46:
40:
28:
24:
17:
12:
11:
5:
2284:
2282:
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2268:
2263:
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2247:
2241:
2240:
2237:
2236:
2233:
2232:
2229:
2228:
2226:
2221:
2219:
2209:
2207:Fusion protein
2200:
2199:
2198:
2197:
2196:
2191:
2180:
2179:
2176:
2175:
2173:
2172:
2163:
2158:
2153:
2152:
2151:
2146:
2141:
2128:
2126:
2117:
2116:
2114:
2113:
2112:
2111:
2106:
2094:
2093:
2092:
2090:HIV-1 protease
2087:
2082:
2070:
2069:
2068:
2055:
2053:
2041:
2032:
2026:
2025:
2022:
2021:
2018:
2017:
2014:
2013:
2010:
2009:
2007:
2006:
2005:
2004:
1996:matrix protein
1991:
1989:
1979:
1967:
1961:
1960:
1957:
1956:
1953:
1952:
1950:
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1948:
1947:
1942:
1934:matrix protein
1929:
1927:
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1905:
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1887:
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1821:
1809:
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1791:
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1761:
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1744:
1743:
1737:
1735:
1725:
1713:
1707:
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1703:
1702:
1700:
1699:
1693:
1691:
1682:
1681:
1678:
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1675:
1674:
1669:
1664:
1658:
1656:
1649:
1648:
1646:
1645:
1644:
1643:
1635:viral envelope
1631:
1630:
1629:
1621:matrix protein
1616:
1614:
1604:
1592:
1583:
1576:negative-sense
1571:
1570:
1567:
1566:
1563:
1562:
1560:
1559:
1554:
1549:
1544:
1539:
1534:
1529:
1524:
1519:
1514:
1513:
1512:
1500:
1498:
1489:
1488:
1486:
1485:
1480:
1479:
1478:
1473:
1468:
1460:viral envelope
1455:
1453:
1441:
1429:
1428:
1425:
1424:
1422:
1421:
1416:
1411:
1406:
1401:
1396:
1391:
1385:
1383:
1374:
1373:
1371:
1370:
1369:
1368:
1363:
1355:viral envelope
1350:
1348:
1336:
1321:
1314:positive-sense
1309:
1308:
1305:
1304:
1301:
1300:
1298:
1297:
1291:
1289:
1277:
1256:
1255:
1252:
1251:
1249:
1248:
1243:
1238:
1233:
1228:
1223:
1217:
1215:
1203:
1188:
1175:
1169:
1168:
1165:
1164:
1161:
1160:
1157:
1156:
1154:
1153:
1148:
1142:
1140:
1131:
1130:
1128:
1127:
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1116:
1111:
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1097:
1089:
1088:
1085:
1084:
1082:
1081:
1075:
1072:
1071:
1069:
1068:
1058:
1053:
1047:
1045:
1035:
1026:
1025:
1022:
1021:
1019:
1018:
1013:
1007:
1005:
995:
983:
961:Polyomaviridae
954:
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867:
862:
856:
854:
845:
844:
842:
841:
836:
830:
828:
816:
807:
806:Varidnaviria?)
799:
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790:
788:
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762:
756:
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669:
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661:
651:
639:
637:Herpes simplex
630:
612:
606:
605:
593:Viral proteins
591:
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588:
581:
574:
566:
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557:
513:
454:
415:(10): 6013–7.
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328:978-0198792765
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275:External links
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223:Fusion protein
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69:formed from a
67:fusion protein
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1667:Neuraminidase
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984:
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952:
947:
940:
926:
923:
922:
920:
918:
916:
911:
908:
906:
905:Baculoviridae
902:
892:
889:
888:
886:
884:
882:
877:
871:
868:
866:
863:
861:
858:
857:
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840:
837:
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832:
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786:
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766:
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662:
659:
655:
652:
650:
648:
643:
640:
638:
634:
631:
628:
623:
622:Duplodnaviria
618:linear ds-DNA
616:
613:
611:
607:
602:
598:
594:
587:
582:
580:
575:
573:
568:
567:
564:
553:
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541:
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533:
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238:Chimeric gene
236:
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210:
208:
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202:
194:
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182:
181:proliferation
178:
174:
169:
165:
161:
157:
153:
145:
143:
141:
137:
128:
126:
124:
120:
119:viral budding
116:
112:
108:
104:
96:
94:
92:
88:
84:
80:
76:
72:
68:
64:
53:
43:
39:
35:
32:This article
30:
21:
20:
2271:Cell biology
2266:Biochemistry
2223:
2131:
2120:
2096:
2072:
2058:
2047:
1994:
1973:
1932:
1911:
1876:glycoprotein
1863:
1828:glycoprotein
1815:
1780:glycoprotein
1767:
1732:glycoprotein
1719:
1685:
1653:glycoprotein
1633:
1619:
1598:
1492:
1483:Nucleocapsid
1458:
1447:
1438:Pisuviricota
1377:
1353:
1342:
1283:
1274:Pisuviricota
1209:
1134:
1103:
1029:
989:
951:Monodnaviria
913:
879:
848:
822:
814:Epstein–Barr
768:
760:Adenoviridae
734:
685:
645:
627:Varidnaviria
530:(1): 57–66.
527:
523:
516:
471:
467:
457:
412:
408:
398:
379:
373:
365:
361:
350:. Retrieved
346:
337:
316:
198:
177:angiogenesis
166:between the
149:
140:transduction
132:
103:retroviruses
100:
82:
78:
62:
60:
47:
37:
33:
2216:oncoprotein
1328:Hepatitis C
1093:Hepatitis B
1079:Agnoprotein
1042:oncoprotein
1016:VP2 and VP3
228:Fusion gene
185:oncogenesis
2250:Categories
1641:M2 protein
1627:M1 protein
1433:SARS-CoV-2
352:2017-07-11
297:References
263:Retroposon
253:Retrovirus
189:translated
136:translated
97:Background
2183:Multiple
2080:Integrase
1318:Riboviria
1195:Rotavirus
1185:Riboviria
946:Riboviria
317:Genes VII
268:Integrase
248:Oncovirus
160:virulence
129:gag-v-onc
79:Gag-v-Onc
50:June 2013
1476:Membrane
1471:Envelope
1065:SV40 Tag
726:Vaccinia
552:24552816
211:See also
164:homology
75:oncogene
1807:Measles
1260:Rhinov.
707:ICP34.5
544:2855603
508:6302692
476:Bibcode
449:6273838
417:Bibcode
205:murines
123:virions
1986:capsid
1924:capsid
1672:HA-tag
1611:capsid
1574:ss-RNA
1504:ORF1ab
1312:ss-RNA
1272:etc. (
1181:ds-RNA
1002:capsid
870:EBNA-3
865:EBNA-2
860:EBNA-1
658:capsid
550:
542:
506:
499:393857
496:
447:
440:348967
437:
386:
325:
287:(MeSH)
111:genome
2122:VRAPs
2104:gp120
1759:Mumps
1557:ORF9b
1547:ORF7b
1542:ORF7a
1532:ORF3d
1527:ORF3c
1522:ORF3b
1517:ORF3a
1511:(NS5)
1466:Spike
1268:Hep A
1264:Polio
1124:HBeAg
1119:HBcAg
1114:HBsAg
978:HaPyV
974:MCPyV
942:other
881:ncRNA
839:LMP-2
834:LMP-1
712:ICP47
697:vmw65
597:early
548:S2CID
173:c-Src
168:v-Src
87:C-jun
2109:gp41
2049:VSPs
1975:VSPs
1945:VP24
1940:VP40
1913:VSPs
1865:VSPs
1817:VSPs
1769:VSPs
1721:VSPs
1687:VNPs
1600:VSPs
1552:ORF8
1537:ORF6
1494:VNPs
1449:VSPs
1419:NS5B
1414:NS5A
1409:NS4B
1404:NS4A
1379:VNPs
1344:VSPs
1285:VNPs
1246:NSP6
1241:NSP5
1236:NSP4
1231:NSP3
1226:NSP2
1221:NSP1
1211:VNPs
1136:VNPs
1105:VSPs
1061:LTag
1056:MTag
1051:STag
1031:VNPs
991:VSPs
970:MPyV
966:SV40
915:VNPs
891:EBER
850:VNPs
824:VSPs
770:VNPs
746:B13R
736:VNPs
702:ICP8
687:VNPs
647:VSPs
601:late
599:and
540:PMID
504:PMID
445:PMID
384:ISBN
323:ISBN
61:The
2170:Vpx
2168:or
2166:Vpu
2161:Vif
2156:Nef
2149:Vpr
2144:Rev
2139:Tat
2098:env
2074:pol
2066:p24
2060:gag
1855:RSV
1697:NS1
1399:NS3
1394:NS2
1295:VPg
1173:RNA
1146:HBx
1011:VP1
785:E1B
780:E1A
610:DNA
532:doi
494:PMC
484:doi
435:PMC
425:doi
156:Src
93:).
91:p65
83:Onc
2252::
2030:RT
1389:P7
1366:E2
1361:E1
1266:,
1262:,
976:,
972:,
968:,
546:.
538:.
526:.
502:.
492:.
482:.
472:80
470:.
466:.
443:.
433:.
423:.
413:78
411:.
407:.
345:.
305:^
179:,
2218::
2124::
2051::
1988::
1977::
1926::
1915::
1878::
1867::
1830::
1819::
1782::
1771::
1734::
1723::
1689::
1655::
1613::
1602::
1582:)
1578:(
1496::
1451::
1440:)
1436:(
1381::
1346::
1335:)
1331:(
1320:)
1316:(
1287::
1276:)
1270:,
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1198:(
1187:)
1183:(
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964:(
953:)
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629:)
624:,
620:(
603:)
595:(
585:e
578:t
571:v
554:.
534::
528:1
510:.
486::
478::
451:.
427::
419::
392:.
355:.
331:.
52:)
48:(
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