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Gangrene

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369: 760: 832:, from 1795 on Director of the Medical Bureau of the Batavian Republic, and inspector-general of the French Imperial Military Health-Service in 1811, became a leading expert in the fight against hospital-gangrene and its prevention. He wrote a treatise on gangrene in 1814 in which he meticulously analyzed and explained the causes of this dreadful disease, which he was convinced was contagious. He completed his entry with a thorough evaluation of all possible and well experienced sanitary regulations. His work was very well received and was instrumental in convincing most later authors that gangrene was a contagious disease. 502:, for example), which cause tissue to swell and emit a foul odor. Wet gangrene usually develops rapidly due to blockage of venous (mainly) or arterial blood flow. The affected part is saturated with stagnant blood, which promotes the rapid growth of bacteria. The toxic products formed by bacteria are absorbed, causing systemic manifestation of sepsis and finally death. The affected part is edematous, soft, putrid, rotten, and dark. 475: 47: 2260: 562:. These environmental bacteria may enter the muscle through a wound and subsequently proliferate in necrotic tissue and secrete powerful toxins that destroy nearby tissue, generating gas at the same time. A gas composition of 5.9% hydrogen, 3.4% carbon dioxide, 74.5% nitrogen, and 16.1% oxygen was reported in one clinical case. 666:
and antibiotics. Since gangrene is associated with periodic pain caused by too little blood flow, pain management is important so patients can continue doing exercises that promote circulation. Pain management medications can include opioids and opioid-like analgesics. Since gangrene is a result of
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is a rare infection that spreads deep into the body along tissue planes. It is categorized into four subtypes, with the first two being the most common. Type 1 requires an infection with an anaerobe and a species in the Enterobacteriaceae family, while type 2 is characterized by infection with
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Gerhard-Herman, MD; Gornik, HL; Barrett, C; Barshes, NR; Corriere, MA; Drachman, DE; Fleisher, LA; Fowkes, FG; Hamburg, NM; Kinlay, S; Lookstein, R; Misra, S; Mureebe, L; Olin, JW; Patel, RA; Regensteiner, JG; Schanzer, A; Shishehbor, MH; Stewart, KJ; Treat-Jacobson, D; Walsh, ME (2017).
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Dead tissue alone does not require debridement, and in some cases, such as dry gangrene, the affected part falls off (autoamputates), making surgical removal unnecessary. Waiting for autoamputation, however, may cause health complications as well as decreased quality of life.
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to prevent or arrest necrotic spread, as some species of maggots consume only dead flesh, leaving nearby living tissue unaffected. This practice largely died out after the introduction of antibiotics to the range of treatments for wounds. In recent times, however,
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is a risk factor for peripheral vascular disease, thus for dry gangrene, but also a risk factor for wet gangrene, particularly in patients with poorly controlled blood sugar levels, as elevated serum glucose creates a favorable environment for bacterial infection.
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are often a critical component of its treatment. The life-threatening nature of gangrene requires treatment with intravenous antibiotics in an inpatient setting. Antibiotics alone are not effective because they may not penetrate infected tissues sufficiently.
541:, or various nonclostridial species. Infection spreads rapidly as the gases produced by the bacteria expand and infiltrate healthy tissue in the vicinity. Because of its ability to quickly spread to surrounding tissues, gas gangrene should be treated as a 431:
and bacteria fail to survive. The affected part is dry, shrunken, and dark reddish-black. The line of separation usually brings about complete separation, with eventual falling off of the gangrenous tissue if it is not removed surgically, a process called
2149:"Verhandeling ter beantwoording der vrage: Kan de gesteldheid en zamenstelling van den dampkring, welke onmiddelijk tot de Hospitaal-versterving (Gangraena NosocomialisZ) aanleiding geeft, door Natuur- of Scheikundige middelen worden ontdekt?" 2330: 2303: 2288: 226:. Symptoms may include a change in skin color to red or black, numbness, swelling, pain, skin breakdown, and coolness. The feet and hands are most commonly affected. If the gangrene is caused by an infectious agent, it may present with a 1360:
Aiello A, Anichini R, Brocco E, Caravaggi C, Chiavetta A, Cioni R, Da Ros R, De Feo ME, Ferraresi R, Florio F, Gargiulo M, Galzerano G, Gandini R, Giurato L, Graziani L, Mancini L, Manzi M, Modugno P, Setacci C, Uccioli L (2014).
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to hinder the spread of the associated infection. The extent of surgical debridement needed depends on the extent of the gangrene and may be limited to the removal of a finger, toe, or ear, but in severe cases may involve a
1405:"2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines" 3035: 455:(via vascular bypass or angioplasty). However, once gangrene has developed, the affected tissues are not salvageable. Because dry gangrene is not accompanied by infection, it is not as 696:
Surgical removal of all dead tissue, however, is the mainstay of treatment for gangrene. Often, gangrene is associated with underlying infection, thus the gangrenous tissue must be
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solutions on infected wounds to reduce the incidence and virulence of "poisoned miasma". Copies of his book were issued to Union surgeons to encourage the use of his methods.
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treatment is used to treat gas gangrene. It increases pressure and oxygen content to allow blood to carry more oxygen to inhibit anaerobic organism growth and reproduction.
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Liu R, Li L, Yang M, Boden G, Yang G (2013). "Systematic review of the effectiveness of hyperbaric oxygenation therapy in the management of chronic diabetic foot ulcers".
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as gas gangrene or wet gangrene, both of which have a risk of sepsis. Over time, dry gangrene may develop into wet gangrene if an infection develops in the dead tissues.
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An illustration showing four different stages of gangrene, including one (Fig. 4 top right) caused by an obstacle to the return of the venous blood due to heart disease.
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Ischemic disease of the legs is the most common reason for amputations. In about a quarter of these cases, the other side requires amputation in the next three years.
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was 45%. Goldsmith's method, which he applied to over 330 cases, yielded a mortality under 3%." Goldsmith advocated the use of debridement and topical and injected
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during the American Civil War, meticulously studied hospital gangrene and developed a revolutionary treatment regimen. The cumulative Civil War hospital gangrene
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Because of the high mortality associated with infected gangrene (about 80% without treatment and 20% with treatment), an emergency salvage amputation, such as a
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Symptoms may include a change in skin color to red or black, numbness, pain, skin breakdown, and coolness. The feet and hands are most commonly involved.
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is used only when referring to a limb or to the gut (in other locations, this same type of necrosis is called an infarction, such as
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After the gangrene is treated with debridement and antibiotics, the underlying cause can be treated. In the case of gangrene due to
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Korzon-Burakowska, A; Dziemidok, P (December 2011). "Diabetic foot-the need for comprehensive multidisciplinary approach".
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Teun van Heiningen, "Sebald Justinus Brugmans' strijd tegen de hospitaalversterving", Leiden University,
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to treat any infection, and efforts to address the underlying cause. Surgical efforts may include
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Levenson, RB; Singh, AK; Novelline, RA (March–April 2008). "Fournier gangrene: role of imaging".
1617: 1516: 840: 808: 663: 290: 82: 4066: 4051: 3973: 3653: 3364: 2977: 2400: 2360: 2185: 2135: 2065: 2042:"A systematic review of maggot debridement therapy for chronically infected wounds and ulcers" 1983: 1948: 1910: 1875: 1834: 1791: 1754: 1748: 1652: 1609: 1568: 1508: 1457: 1434: 1384: 1342: 1324: 1259: 1232: 1209: 1182: 1130: 829: 672: 601: 542: 462: 452: 178: 62: 2297: 1817:
Warkentin, TE (August 2010). "Agents for the treatment of heparin-induced thrombocytopenia".
592:, a Gram-positive cocci bacteria, and thus is also known as hemolytic streptococcal gangrene. 4010: 3931: 3745: 3713: 2897: 2763: 2649: 2513: 2175: 2148: 2055: 1975: 1940: 1865: 1826: 1783: 1636: 1601: 1558: 1550: 1498: 1490: 1424: 1416: 1374: 1332: 1314: 1172: 1164: 1120: 1112: 630: 552:-producing clostridial species, which are mostly found in soil, and other anaerobes such as 527:
Gas gangrene is a bacterial infection that produces gas within tissues. It can be caused by
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died of gangrene in his leg on 1 September 1715, four days prior to his 77th birthday.
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is a gangrene of the face most often found in Africa, Southeast Asia and South America.
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Shi, Eric; Shofler, David (2014). "Maggot debridement therapy: A systematic review".
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Medications may include pain management, medications that promote circulation in the
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contracted gangrene in January 1687 when, while conducting a performance of his
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Wet, or infected, gangrene is characterized by thriving bacteria and has a poor
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is a type of necrotizing fasciitis that usually affects the genitals and groin.
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Change in skin color to red or black, numbness, pain, skin breakdown, coolness
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Based on symptom, With medical imaging used to identify the underlying cause.
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Gas gangrene can cause necrosis, gas production, and sepsis. Progression to
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Yang, Z; Hu, J; Qu, Y; Sun, F; Leng, X; Li, H; Zhan, S (3 December 2015).
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Angioplasty should be considered if severe blockage in lower leg vessels (
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Liddell & Scott's Lexicon, Oxford University Press, 1963 edition
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Private Milton E. Wallen lies in bed with a gangrenous amputated arm
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Gangrene is caused by a critically insufficient blood supply (e.g.,
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has regained some credibility and is sometimes employed with great
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Puvanendran, Rukshini; Chan Meng Huey, Jason; Pasupathy, Shanker.
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Vayvada, H; Demirdover, C; Menderes, A; Karaca, C (August 2013).
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rather than gangrene are present, the process can be treated by
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Sun, Xinjuan; Jiang, Kechun; Chen, Jingan; et al. (2014).
1854:"Evidence-based antibiotic therapy of diabetic foot infections" 835:
John M. Trombold wrote: "Middleton Goldsmith, a surgeon in the
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Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
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Treatment varies based on the severity and type of gangrene.
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may be useful. How commonly the condition occurs is unknown.
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Exercises such as walking and massage therapy may be tried.
1101:"Management of lower extremity peripheral arterial disease" 815:, which eventually led to his death in March of that year. 332:
Treatment may involve surgery to remove the dead tissue,
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Type of tissue death by infection or lack of blood supply
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Sivapathasundharam, B.; Rajendran, Arya (30 June 2012).
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Journal of Cardiopulmonary Rehabilitation and Prevention
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have successfully altered gangrene and ulcer prognosis.
1911:"Angioplasty and stent placement – peripheral arteries" 1258:(7th ed.). Elsevier Health Sciences. p. 124. 2212:
A report on hospital gangrene, erysipelas and pyaemia
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Sakurai, J.; Nagahama, M.; Oda, M. (November 2004). "
2270: 348:. Efforts to treat the underlying cause may include 3845: 3765: 3744: 3635: 3582: 3443: 3434: 3425: 3378: 3234: 3225: 3193: 3168: 3152: 3099: 3069: 3060: 3051: 2931: 2856: 2627: 2529: 2491: 2386: 2274: 1590:alpha-toxin: characterization and mode of action". 205: 195: 187: 177: 133: 107: 91: 81: 61: 36: 31: 683:. As infection is often associated with gangrene, 1202:Annals of Agricultural and Environmental Medicine 1696:"For Clinicians: Type II Necrotizing Fasciitis" 1099:Gardner, AW; Afaq, A (November–December 2008). 54:Dry gangrene affecting the toes as a result of 778:were commonly used to treat chronic wounds or 3029: 2605: 2465: 1639:, Wu MH (December 1995). "Gas composition in 1008: 1006: 1004: 1002: 8: 2047:International Journal of Infectious Diseases 1819:Hematology/Oncology Clinics of North America 1539:"Type of incision for below knee amputation" 975: 973: 971: 969: 967: 965: 907: 905: 903: 901: 899: 897: 895: 2151:. J. van der Heij – via Google Books. 1645:Journal of the Formosan Medical Association 1543:The Cochrane Database of Systematic Reviews 1157:The Cochrane Database of Systematic Reviews 1043: 1041: 1039: 1037: 1035: 864: 4021:Recurrent toxin-mediated perineal erythema 3440: 3431: 3307:Mycobacterium avium–intracellulare complex 3231: 3066: 3057: 3036: 3022: 3014: 2612: 2598: 2590: 2472: 2458: 2450: 2271: 2147:Brugmans, Sebald Justinus (May 24, 1814). 2002:"Product Classification: Maggots, Medical" 1532: 1530: 1255:Underwood's Pathology: A Clinical Approach 1146: 1144: 45: 28: 3116:Cutaneous group B streptococcal infection 2179: 2059: 1869: 1753:. Elsevier Health Sciences. p. 333. 1562: 1502: 1428: 1378: 1336: 1318: 1176: 1153:"Interventions for treating gas gangrene" 1124: 938: 936: 934: 1229:Gangrene Management: Today and Tomorrow 891: 2090:. Utah Symphony Orchestra. August 2010 607:Venous limb gangrene may be caused by 447:. If ischemia is detected early, when 439:Dry gangrene is the result of chronic 388:) or infection. It is associated with 3340:Rapid growing mycobacterium infection 1296: 1294: 1292: 1290: 1288: 1286: 1284: 1282: 791:in cases of chronic tissue necrosis. 7: 3519:Human granulocytotropic anaplasmosis 3081:Staphylococcal scalded skin syndrome 2109:Laurenson, John (21 November 2015). 1968:British Journal of Community Nursing 1675:The Lecturio Medical Concept Library 548:Gas gangrene is caused by bacterial 3969:Chronic undermining burrowing ulcer 2084:"Music Trivia – The Death of Lully" 1750:Shafer's Textbook of Oral Pathology 1537:Tisi, PV; Than, MM (8 April 2014). 2923:Fluorescence in situ hybridization 1894:Amputations of the Lower Extremity 14: 3927:Superficial pustular folliculitis 3524:Human monocytotropic ehrlichiosis 1301:Al Wahbi, Abdullah (2018-06-01). 3335:Primary inoculation tuberculosis 2891:Oral and maxillofacial pathology 2258: 2111:"The strange death of Louis XIV" 1495:10.1111/j.1742-481x.2012.01006.x 609:Heparin-induced thrombocytopenia 419:). Dry gangrene is often due to 3833:Gram-negative toe web infection 3409:Group JK corynebacterium sepsis 511:below- or above-knee amputation 392:and long-term tobacco smoking. 299:Group B streptococcal infection 3574:Ehrlichiosis ewingii infection 3396:Cutaneous diphtheria infection 3350:Tuberculosis cutis orificialis 3261:Borderline tuberculoid leprosy 3251:Borderline lepromatous leprosy 1980:10.12968/bjcn.2014.19.Sup12.S6 1555:10.1002/14651858.CD003749.pub3 1169:10.1002/14651858.CD010577.pub2 633:may result in gangrene of the 622:may result in gangrene of the 1: 3598:Primary gonococcal dermatitis 3544:Flinders Island spotted fever 1871:10.1016/s0928-8244(99)00143-1 859:of gangrene derives from the 4062:Symptoms and signs: Vascular 3986:Blistering distal dactylitis 3514:Rocky Mountain spotted fever 3402:Arcanobacterium haemolyticum 3355:Tuberculosis verrucosa cutis 3139:Chronic recurrent erysipelas 2010:Food and Drug Administration 1945:10.1016/j.mayocp.2012.10.021 1858:FEMS Immunol. Med. Microbiol 1726:national library of medicine 1421:10.1161/CIR.0000000000000471 1380:10.1016/j.numecd.2013.12.007 1117:10.1097/HCR.0b013e31818c3b96 874: 4006:Blastomycosis-like pyoderma 3627:Chromobacteriosis infection 3539:Mediterranean spotted fever 2061:10.1016/j.ijid.2014.03.1397 1852:Lipsky BA (December 1999). 1635:Chi CH, Chen KW, Huang JJ, 1483:International Wound Journal 386:peripheral vascular disease 243:peripheral arterial disease 191:Depends on underlying cause 144:peripheral arterial disease 4095: 4026:Tick-borne lymphadenopathy 3828:Gram-negative folliculitis 2181:10.1177/000313481107700924 878:(γάγγραινα), which means " 520: 400:Dry gangrene is a form of 305:. It can be classified as 18: 4057:Health effects of tobacco 3330:Papulonecrotic tuberculid 3315:Mycobacterium haemophilum 2136:URN:NBN:NL:UI:10-1-112565 2024:"FDA CDRH 510(k) summary" 1831:10.1016/j.hoc.2010.05.009 1367:Nutr Metab Cardiovasc Dis 739:Hyperbaric oxygen therapy 478:Wet gangrene of the foot. 421:peripheral artery disease 358:hyperbaric oxygen therapy 56:peripheral artery disease 53: 44: 21:Gangrene (disambiguation) 3823:Lymphogranuloma venereum 3529:Flea-borne spotted fever 3502:Rickettsia aeschlimannii 3496:American tick bite fever 3206:Erysipeloid of Rosenbach 3121:Streptococcal intertrigo 1643:septicum gas gangrene". 826:Sebald Justinus Brugmans 3954:Trichomycosis axillaris 3491:African tick bite fever 3466:North Asian tick typhus 3386:Cutaneous actinomycosis 2998:Microbiological culture 2628:Principles of pathology 1722:"Necrotizing fasciitis" 1593:Journal of Biochemistry 1588:Clostridium perfringens 493:Clostridium perfringens 3666:Haemophilus influenzae 3610:Pasteurella hemolytica 3534:Japanese spotted fever 3486:Bacillary angiomatosis 3476:Flying squirrel typhus 3471:Queensland tick typhus 3360:Tuberculous cellulitis 3323:Mycobacterium kansasii 3045:Bacterial skin disease 865: 767: 714:critical limb ischemia 589:Streptococcus pyogenes 479: 373: 3981:Elephantiasis nostras 3959:Necrotizing fasciitis 3872:Hospital furunculosis 3554:Brill–Zinsser disease 3185:Dermatitis gangrenosa 2961:Diagnostic immunology 2786:Programmed cell death 2754:Liquefactive necrosis 2088:The Musician's Lounge 1452:Nather, Aziz (2013). 1252:Cross, Simon (2018). 1227:Smith, Tyler (2015). 762: 730:) leads to gangrene. 583:Necrotizing fasciitis 573:is often very rapid. 507:guillotine amputation 477: 417:myocardial infarction 371: 323:necrotizing fasciitis 295:meningococcal disease 237:Risk factors include 128:necrotizing fasciitis 4072:Causes of amputation 4016:Chronic lymphangitis 3685:Hot tub folliculitis 3674:Pseudomonal pyoderma 3301:Miliary tuberculosis 3291:Lichen scrofulosorum 3091:Toxic shock syndrome 2956:Medical microbiology 2951:Transfusion medicine 2908:Immunohistochemistry 2858:Anatomical pathology 2749:Coagulative necrosis 2267:at Wikimedia Commons 2162:Trombold JM (2011). 1788:10.1148/rg.282075048 1456:. World Scientific. 1320:10.2147/DMSO.S164199 1074:"Gangrene Diagnosis" 1049:"Gangrene Treatment" 745:Regenerative medical 423:, but can be due to 402:coagulative necrosis 356:. In certain cases, 224:lack of blood supply 19:For other uses, see 3905:Acute lymphadenitis 3898:Perianal cellulitis 3893:Pyogenic paronychia 3803:Chlamydia infection 3719:Granuloma inguinale 3693:Green nail syndrome 3689:Ecthyma gangrenosum 3564:Cat-scratch disease 3370:Tuberculoid leprosy 3281:Lepromatous leprosy 3128:Streptococcus iniae 2913:Electron microscopy 2881:Molecular pathology 2759:Gangrenous necrosis 2691:Cellular adaptation 2225:Watson, Dr. Scott. 913:"Gangrene Symptoms" 799:Jean-Baptiste Lully 749:stem-cell therapies 620:mesenteric ischemia 499:Bacillus fusiformis 425:acute limb ischemia 40:Gangrenous necrosis 3949:Pitted keratolysis 3860:Periapical abscess 3271:Erythema induratum 3256:Borderline leprosy 3246:Aquarium granuloma 2941:Clinical chemistry 2933:Clinical pathology 2918:Immunofluorescence 2886:Forensic pathology 2866:Surgical pathology 2774:Fibrinoid necrosis 2387:External resources 770:As early as 1028, 768: 664:circulatory system 480: 374: 364:Signs and symptoms 303:Raynaud's syndrome 291:radiation injuries 172:Raynaud's syndrome 68:Infectious disease 4039: 4038: 3974:Fournier gangrene 3841: 3840: 3740: 3739: 3681:hot-foot syndrome 3654:Vibrio vulnificus 3421: 3420: 3417: 3416: 3365:Tuberculous gumma 3221: 3220: 3011: 3010: 2978:Mass spectrometry 2587: 2586: 2447: 2446: 2263:Media related to 1760:978-81-312-3800-4 1606:10.1093/jb/mvh161 1454:The diabetic foot 1231:. Hayle Medical. 1080:. 13 October 2015 1020:. 13 October 2015 987:. 13 October 2015 981:"Gangrene Causes" 919:. 13 October 2015 830:Leyden University 673:antiplatelet drug 602:Fournier gangrene 543:medical emergency 463:Diabetes mellitus 453:revascularization 404:that develops in 319:internal gangrene 213: 212: 179:Diagnostic method 26:Medical condition 4084: 4011:Bullous impetigo 3932:Sycosis vulgaris 3746:Campylobacterota 3695: 3441: 3432: 3232: 3067: 3058: 3038: 3031: 3024: 3015: 2898:Gross processing 2764:Caseous necrosis 2614: 2607: 2600: 2591: 2474: 2467: 2460: 2451: 2272: 2262: 2246: 2243: 2237: 2236: 2234: 2233: 2222: 2216: 2208: 2202: 2201: 2183: 2159: 2153: 2152: 2144: 2138: 2132: 2126: 2125: 2123: 2121: 2106: 2100: 2099: 2097: 2095: 2080: 2074: 2073: 2063: 2037: 2031: 2030: 2028: 2020: 2014: 2013: 1998: 1992: 1991: 1963: 1957: 1956: 1928: 1922: 1921: 1919: 1917: 1907: 1901: 1890: 1884: 1883: 1873: 1849: 1843: 1842: 1814: 1808: 1807: 1771: 1765: 1764: 1744: 1738: 1737: 1735: 1733: 1717: 1711: 1710: 1708: 1707: 1692: 1686: 1685: 1683: 1681: 1667: 1661: 1660: 1632: 1626: 1625: 1583: 1577: 1576: 1566: 1534: 1525: 1524: 1506: 1474: 1468: 1467: 1449: 1443: 1442: 1432: 1399: 1393: 1392: 1382: 1357: 1351: 1350: 1340: 1322: 1298: 1277: 1276: 1274: 1272: 1249: 1243: 1242: 1224: 1218: 1217: 1197: 1191: 1190: 1180: 1163:(12): CD010577. 1148: 1139: 1138: 1128: 1096: 1090: 1089: 1087: 1085: 1070: 1064: 1063: 1061: 1059: 1045: 1030: 1029: 1027: 1025: 1010: 997: 996: 994: 992: 977: 960: 959: 957: 955: 940: 929: 928: 926: 924: 909: 877: 868: 796:Baroque composer 631:ischemic colitis 533:, most commonly 490:microorganisms ( 344:, or the use of 49: 29: 4094: 4093: 4087: 4086: 4085: 4083: 4082: 4081: 4077:Causes of death 4042: 4041: 4040: 4035: 3847: 3837: 3761: 3736: 3672: 3631: 3617:Meningococcemia 3578: 3549:Verruga peruana 3456:Epidemic typhus 3413: 3374: 3276:Histoid leprosy 3237: 3217: 3189: 3164: 3155:Corynebacterium 3148: 3095: 3047: 3042: 3012: 3007: 2966:Immunopathology 2946:Hematopathology 2927: 2852: 2623: 2618: 2588: 2583: 2525: 2519:Small intestine 2514:Large intestine 2487: 2478: 2448: 2443: 2442: 2427:article/2051157 2424:article/2028899 2382: 2381: 2283: 2255: 2250: 2249: 2244: 2240: 2231: 2229: 2224: 2223: 2219: 2209: 2205: 2161: 2160: 2156: 2146: 2145: 2141: 2133: 2129: 2119: 2117: 2108: 2107: 2103: 2093: 2091: 2082: 2081: 2077: 2039: 2038: 2034: 2026: 2022: 2021: 2017: 2000: 1999: 1995: 1965: 1964: 1960: 1933:Mayo Clin. Proc 1930: 1929: 1925: 1915: 1913: 1909: 1908: 1904: 1891: 1887: 1864:(3–4): 267–76. 1851: 1850: 1846: 1816: 1815: 1811: 1773: 1772: 1768: 1761: 1746: 1745: 1741: 1731: 1729: 1719: 1718: 1714: 1705: 1703: 1694: 1693: 1689: 1679: 1677: 1669: 1668: 1664: 1634: 1633: 1629: 1585: 1584: 1580: 1549:(4): CD003749. 1536: 1535: 1528: 1476: 1475: 1471: 1464: 1451: 1450: 1446: 1415:(12): e726–79. 1401: 1400: 1396: 1359: 1358: 1354: 1300: 1299: 1280: 1270: 1268: 1266: 1251: 1250: 1246: 1239: 1226: 1225: 1221: 1199: 1198: 1194: 1150: 1149: 1142: 1098: 1097: 1093: 1083: 1081: 1072: 1071: 1067: 1057: 1055: 1047: 1046: 1033: 1023: 1021: 1012: 1011: 1000: 990: 988: 979: 978: 963: 953: 951: 950:. 12 March 2014 942: 941: 932: 922: 920: 911: 910: 893: 888: 853: 828:, Professor at 757: 747:treatments and 736: 728:peroneal artery 703:limb amputation 694: 660: 652: 644: 635:large intestine 624:small intestine 579: 525: 519: 472: 449:ischemic wounds 398: 382: 366: 327:medical imaging 27: 24: 17: 12: 11: 5: 4092: 4091: 4088: 4080: 4079: 4074: 4069: 4064: 4059: 4054: 4044: 4043: 4037: 4036: 4034: 4033: 4031:Tropical ulcer 4028: 4023: 4018: 4013: 4008: 4003: 3998: 3993: 3988: 3983: 3978: 3977: 3976: 3971: 3961: 3956: 3951: 3946: 3941: 3936: 3935: 3934: 3929: 3918: 3917: 3912: 3910:Pilonidal cyst 3907: 3902: 3901: 3900: 3895: 3881: 3876: 3875: 3874: 3864: 3863: 3862: 3851: 3849: 3843: 3842: 3839: 3838: 3836: 3835: 3830: 3825: 3820: 3815: 3813:Rat-bite fever 3810: 3805: 3800: 3795: 3790: 3785: 3780: 3775: 3769: 3767: 3763: 3762: 3760: 3759: 3750: 3748: 3742: 3741: 3738: 3737: 3735: 3734: 3726: 3721: 3716: 3711: 3706: 3701: 3696: 3670: 3662: 3657: 3650: 3645: 3643:Pasteurellosis 3639: 3637: 3633: 3632: 3630: 3629: 3624: 3619: 3614: 3605: 3600: 3586: 3584: 3580: 3579: 3577: 3576: 3571: 3566: 3561: 3556: 3551: 3546: 3541: 3536: 3531: 3526: 3521: 3516: 3511: 3509:Rickettsialpox 3506: 3498: 3493: 3488: 3483: 3478: 3473: 3468: 3463: 3458: 3453: 3451:Endemic typhus 3447: 3445: 3438: 3436:Pseudomonadota 3429: 3423: 3422: 3419: 3418: 3415: 3414: 3412: 3411: 3406: 3398: 3393: 3388: 3382: 3380: 3376: 3375: 3373: 3372: 3367: 3362: 3357: 3352: 3347: 3342: 3337: 3332: 3327: 3319: 3311: 3303: 3298: 3296:Lupus vulgaris 3293: 3288: 3283: 3278: 3273: 3268: 3263: 3258: 3253: 3248: 3242: 3240: 3236:Mycobacterium- 3229: 3227:Actinomycetota 3223: 3222: 3219: 3218: 3216: 3215: 3208: 3203: 3197: 3195: 3191: 3190: 3188: 3187: 3182: 3176: 3174: 3166: 3165: 3160: 3158: 3150: 3149: 3147: 3146: 3141: 3132: 3123: 3118: 3113: 3107: 3105: 3097: 3096: 3094: 3093: 3088: 3083: 3077: 3075: 3072:Staphylococcus 3064: 3055: 3049: 3048: 3043: 3041: 3040: 3033: 3026: 3018: 3009: 3008: 3006: 3005: 3000: 2995: 2990: 2988:Flow cytometry 2985: 2983:Chromatography 2980: 2975: 2969: 2968: 2963: 2958: 2953: 2948: 2943: 2937: 2935: 2929: 2928: 2926: 2925: 2920: 2915: 2910: 2905: 2903:Histopathology 2900: 2894: 2893: 2888: 2883: 2878: 2873: 2868: 2862: 2860: 2854: 2853: 2851: 2850: 2845: 2844: 2843: 2838: 2829: 2817: 2811: 2810: 2805: 2800: 2795: 2794: 2793: 2783: 2782: 2781: 2776: 2771: 2766: 2761: 2756: 2751: 2741: 2739: 2733: 2732: 2731: 2730: 2725: 2715: 2710: 2705: 2700: 2695: 2693: 2687: 2686: 2681: 2676: 2671: 2670: 2669: 2659: 2658: 2657: 2652: 2647: 2642: 2631: 2629: 2625: 2624: 2619: 2617: 2616: 2609: 2602: 2594: 2585: 2584: 2582: 2581: 2576: 2575: 2574: 2569: 2564: 2559: 2551: 2550: 2549: 2544: 2535: 2533: 2527: 2526: 2524: 2523: 2522: 2521: 2516: 2511: 2506: 2497: 2495: 2489: 2488: 2479: 2477: 2476: 2469: 2462: 2454: 2445: 2444: 2441: 2440: 2429: 2421:article/438994 2418:article/214992 2415:article/782709 2412:article/217943 2403: 2391: 2390: 2388: 2384: 2383: 2380: 2379: 2368: 2357: 2346: 2327: 2300: 2284: 2279: 2278: 2276: 2275:Classification 2269: 2268: 2254: 2253:External links 2251: 2248: 2247: 2238: 2217: 2203: 2174:(9): 1138–43. 2154: 2139: 2127: 2101: 2075: 2032: 2015: 1993: 1958: 1923: 1902: 1885: 1844: 1809: 1766: 1759: 1739: 1712: 1687: 1671:"Gas Gangrene" 1662: 1651:(12): 757–59. 1627: 1578: 1526: 1469: 1463:978-9814417006 1462: 1444: 1394: 1352: 1278: 1264: 1244: 1238:978-1632412232 1237: 1219: 1192: 1140: 1091: 1065: 1031: 998: 961: 930: 890: 889: 887: 884: 852: 849: 785:maggot therapy 756: 753: 735: 732: 693: 690: 659: 656: 651: 648: 643: 640: 639: 638: 627: 616: 605: 599: 593: 578: 575: 558:and anaerobic 539:C. perfringens 521:Main article: 518: 515: 471: 468: 434:autoamputation 397: 394: 381: 378: 365: 362: 350:bypass surgery 346:maggot therapy 211: 210: 207: 203: 202: 199: 193: 192: 189: 185: 184: 181: 175: 174: 137: 131: 130: 109: 105: 104: 95: 89: 88: 85: 79: 78: 65: 59: 58: 51: 50: 42: 41: 38: 34: 33: 25: 15: 13: 10: 9: 6: 4: 3: 2: 4090: 4089: 4078: 4075: 4073: 4070: 4068: 4065: 4063: 4060: 4058: 4055: 4053: 4050: 4049: 4047: 4032: 4029: 4027: 4024: 4022: 4019: 4017: 4014: 4012: 4009: 4007: 4004: 4002: 3999: 3997: 3994: 3992: 3991:Botryomycosis 3989: 3987: 3984: 3982: 3979: 3975: 3972: 3970: 3967: 3966: 3965: 3962: 3960: 3957: 3955: 3952: 3950: 3947: 3945: 3942: 3940: 3937: 3933: 3930: 3928: 3925: 3924: 3923: 3920: 3919: 3916: 3913: 3911: 3908: 3906: 3903: 3899: 3896: 3894: 3890: 3887: 3886: 3885: 3882: 3880: 3877: 3873: 3870: 3869: 3868: 3867:Boil/furuncle 3865: 3861: 3858: 3857: 3856: 3853: 3852: 3850: 3844: 3834: 3831: 3829: 3826: 3824: 3821: 3819: 3816: 3814: 3811: 3809: 3808:Leptospirosis 3806: 3804: 3801: 3799: 3796: 3794: 3791: 3789: 3786: 3784: 3781: 3779: 3776: 3774: 3771: 3770: 3768: 3764: 3758: 3756: 3752: 3751: 3749: 3747: 3743: 3733: 3731: 3727: 3725: 3722: 3720: 3717: 3715: 3712: 3710: 3707: 3705: 3704:Salmonellosis 3702: 3700: 3697: 3694: 3690: 3686: 3682: 3680: 3675: 3671: 3669: 3667: 3663: 3661: 3660:Rhinoscleroma 3658: 3656: 3655: 3651: 3649: 3646: 3644: 3641: 3640: 3638: 3634: 3628: 3625: 3623: 3620: 3618: 3615: 3613: 3611: 3606: 3604: 3601: 3599: 3595: 3591: 3588: 3587: 3585: 3581: 3575: 3572: 3570: 3567: 3565: 3562: 3560: 3557: 3555: 3552: 3550: 3547: 3545: 3542: 3540: 3537: 3535: 3532: 3530: 3527: 3525: 3522: 3520: 3517: 3515: 3512: 3510: 3507: 3505: 3503: 3499: 3497: 3494: 3492: 3489: 3487: 3484: 3482: 3479: 3477: 3474: 3472: 3469: 3467: 3464: 3462: 3459: 3457: 3454: 3452: 3449: 3448: 3446: 3442: 3439: 3437: 3433: 3430: 3428: 3424: 3410: 3407: 3405: 3403: 3399: 3397: 3394: 3392: 3389: 3387: 3384: 3383: 3381: 3377: 3371: 3368: 3366: 3363: 3361: 3358: 3356: 3353: 3351: 3348: 3346: 3345:Scrofuloderma 3343: 3341: 3338: 3336: 3333: 3331: 3328: 3326: 3324: 3320: 3318: 3316: 3312: 3310: 3308: 3304: 3302: 3299: 3297: 3294: 3292: 3289: 3287: 3284: 3282: 3279: 3277: 3274: 3272: 3269: 3267: 3264: 3262: 3259: 3257: 3254: 3252: 3249: 3247: 3244: 3243: 3241: 3239: 3233: 3230: 3228: 3224: 3214: 3213: 3209: 3207: 3204: 3202: 3199: 3198: 3196: 3192: 3186: 3183: 3181: 3178: 3177: 3175: 3173: 3172: 3167: 3163: 3159: 3157: 3156: 3151: 3145: 3144:Scarlet fever 3142: 3140: 3136: 3133: 3131: 3129: 3124: 3122: 3119: 3117: 3114: 3112: 3109: 3108: 3106: 3104: 3103: 3102:Streptococcus 3098: 3092: 3089: 3087: 3084: 3082: 3079: 3078: 3076: 3074: 3073: 3068: 3065: 3063: 3059: 3056: 3054: 3050: 3046: 3039: 3034: 3032: 3027: 3025: 3020: 3019: 3016: 3004: 3001: 2999: 2996: 2994: 2991: 2989: 2986: 2984: 2981: 2979: 2976: 2974: 2971: 2970: 2967: 2964: 2962: 2959: 2957: 2954: 2952: 2949: 2947: 2944: 2942: 2939: 2938: 2936: 2934: 2930: 2924: 2921: 2919: 2916: 2914: 2911: 2909: 2906: 2904: 2901: 2899: 2896: 2895: 2892: 2889: 2887: 2884: 2882: 2879: 2877: 2874: 2872: 2871:Cytopathology 2869: 2867: 2864: 2863: 2861: 2859: 2855: 2849: 2846: 2842: 2839: 2837: 2833: 2830: 2828: 2825: 2824: 2823: 2822: 2818: 2816: 2815:Accumulations 2813: 2812: 2809: 2806: 2804: 2801: 2799: 2796: 2792: 2789: 2788: 2787: 2784: 2780: 2777: 2775: 2772: 2770: 2767: 2765: 2762: 2760: 2757: 2755: 2752: 2750: 2747: 2746: 2745: 2742: 2740: 2738: 2735: 2734: 2729: 2726: 2724: 2721: 2720: 2719: 2716: 2714: 2711: 2709: 2706: 2704: 2701: 2699: 2696: 2694: 2692: 2689: 2688: 2685: 2684:Wound healing 2682: 2680: 2677: 2675: 2672: 2668: 2665: 2664: 2663: 2660: 2656: 2653: 2651: 2648: 2646: 2643: 2641: 2638: 2637: 2636: 2633: 2632: 2630: 2626: 2622: 2615: 2610: 2608: 2603: 2601: 2596: 2595: 2592: 2580: 2577: 2573: 2570: 2568: 2565: 2563: 2560: 2558: 2555: 2554: 2552: 2548: 2545: 2543: 2540: 2539: 2537: 2536: 2534: 2532: 2528: 2520: 2517: 2515: 2512: 2510: 2507: 2505: 2502: 2501: 2499: 2498: 2496: 2494: 2490: 2486: 2482: 2475: 2470: 2468: 2463: 2461: 2456: 2455: 2452: 2439: 2435: 2434: 2430: 2428: 2425: 2422: 2419: 2416: 2413: 2409: 2408: 2404: 2402: 2398: 2397: 2393: 2392: 2389: 2385: 2378: 2374: 2373: 2369: 2367: 2363: 2362: 2358: 2356: 2352: 2351: 2347: 2345: 2341: 2337: 2336: 2332: 2328: 2326: 2322: 2318: 2314: 2310: 2309: 2305: 2301: 2299: 2295: 2294: 2290: 2286: 2285: 2282: 2277: 2273: 2266: 2261: 2257: 2256: 2252: 2242: 2239: 2228: 2221: 2218: 2214: 2213: 2207: 2204: 2199: 2195: 2191: 2187: 2182: 2177: 2173: 2169: 2165: 2158: 2155: 2150: 2143: 2140: 2137: 2131: 2128: 2116: 2115:The Spectator 2112: 2105: 2102: 2089: 2085: 2079: 2076: 2071: 2067: 2062: 2057: 2053: 2049: 2048: 2043: 2036: 2033: 2025: 2019: 2016: 2011: 2007: 2003: 1997: 1994: 1989: 1985: 1981: 1977: 1973: 1969: 1962: 1959: 1954: 1950: 1946: 1942: 1939:(2): 166–75. 1938: 1934: 1927: 1924: 1912: 1906: 1903: 1900: 1896: 1895: 1889: 1886: 1881: 1877: 1872: 1867: 1863: 1859: 1855: 1848: 1845: 1840: 1836: 1832: 1828: 1825:(4): 755–75. 1824: 1820: 1813: 1810: 1805: 1801: 1797: 1793: 1789: 1785: 1782:(2): 519–28. 1781: 1777: 1776:Radiographics 1770: 1767: 1762: 1756: 1752: 1751: 1743: 1740: 1727: 1723: 1716: 1713: 1701: 1697: 1691: 1688: 1676: 1672: 1666: 1663: 1658: 1654: 1650: 1646: 1642: 1638: 1631: 1628: 1623: 1619: 1615: 1611: 1607: 1603: 1600:(5): 569–74. 1599: 1595: 1594: 1589: 1582: 1579: 1574: 1570: 1565: 1560: 1556: 1552: 1548: 1544: 1540: 1533: 1531: 1527: 1522: 1518: 1514: 1510: 1505: 1500: 1496: 1492: 1489:(4): 466–72. 1488: 1484: 1480: 1473: 1470: 1465: 1459: 1455: 1448: 1445: 1440: 1436: 1431: 1426: 1422: 1418: 1414: 1410: 1406: 1398: 1395: 1390: 1386: 1381: 1376: 1373:(4): 355–69. 1372: 1368: 1364: 1356: 1353: 1348: 1344: 1339: 1334: 1330: 1326: 1321: 1316: 1312: 1308: 1304: 1297: 1295: 1293: 1291: 1289: 1287: 1285: 1283: 1279: 1267: 1265:9780702072109 1261: 1257: 1256: 1248: 1245: 1240: 1234: 1230: 1223: 1220: 1215: 1211: 1208:(2): 314–17. 1207: 1203: 1196: 1193: 1188: 1184: 1179: 1174: 1170: 1166: 1162: 1158: 1154: 1147: 1145: 1141: 1136: 1132: 1127: 1122: 1118: 1114: 1111:(6): 349–57. 1110: 1106: 1102: 1095: 1092: 1079: 1075: 1069: 1066: 1054: 1050: 1044: 1042: 1040: 1038: 1036: 1032: 1019: 1015: 1009: 1007: 1005: 1003: 999: 986: 982: 976: 974: 972: 970: 968: 966: 962: 949: 945: 939: 937: 935: 931: 918: 914: 908: 906: 904: 902: 900: 898: 896: 892: 885: 883: 882:of tissues". 881: 876: 872: 869:and from the 867: 862: 858: 850: 848: 846: 842: 838: 833: 831: 827: 823: 821: 816: 814: 810: 806: 805: 800: 797: 792: 790: 786: 781: 777: 773: 765: 761: 754: 752: 750: 746: 742: 740: 733: 731: 729: 725: 720: 717: 715: 710: 706: 704: 699: 691: 689: 686: 682: 681:fibrinolytics 678: 677:anticoagulant 674: 670: 665: 657: 655: 649: 647: 641: 636: 632: 628: 625: 621: 617: 614: 610: 606: 603: 600: 597: 594: 591: 590: 584: 581: 580: 576: 574: 572: 568: 563: 561: 557: 556: 551: 546: 544: 540: 536: 532: 531: 524: 516: 514: 512: 508: 503: 501: 500: 495: 494: 489: 485: 476: 469: 467: 464: 460: 458: 454: 450: 446: 442: 437: 435: 430: 426: 422: 418: 414: 410: 407: 403: 395: 393: 391: 387: 379: 377: 370: 363: 361: 359: 355: 351: 347: 343: 339: 335: 330: 328: 324: 320: 316: 312: 308: 304: 300: 296: 292: 288: 287:hypernatremia 284: 280: 276: 272: 268: 264: 260: 256: 252: 248: 244: 240: 235: 233: 229: 225: 221: 218:is a type of 217: 208: 204: 200: 198: 194: 190: 186: 182: 180: 176: 173: 169: 165: 161: 157: 153: 149: 145: 141: 138: 136: 132: 129: 125: 121: 117: 113: 110: 106: 103: 99: 96: 94: 93:Complications 90: 86: 84: 80: 77: 73: 69: 66: 64: 60: 57: 52: 48: 43: 39: 35: 30: 22: 3996:Malakoplakia 3963: 3922:Folliculitis 3846:Unspecified 3818:Lyme disease 3755:Helicobacter 3754: 3729: 3678: 3665: 3652: 3609: 3590:Gonococcemia 3501: 3481:Trench fever 3461:Scrub typhus 3401: 3322: 3314: 3306: 3266:Buruli ulcer 3235: 3210: 3180:Gas gangrene 3169: 3153: 3127: 3100: 3070: 2973:Enzyme assay 2819: 2814: 2803:Karyorrhexis 2779:Myocytolysis 2769:Fat necrosis 2758: 2674:Inflammation 2662:Hemodynamics 2655:Pathogenesis 2578: 2431: 2405: 2394: 2370: 2359: 2348: 2329: 2302: 2287: 2241: 2230:. 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Index

Gangrene (disambiguation)

peripheral artery disease
Specialty
Infectious disease
surgery
podiatry
Symptoms
Complications
Sepsis
amputation
Dry
wet
gas
internal
necrotizing fasciitis
Risk factors
Diabetes
peripheral arterial disease
smoking
major trauma
alcoholism
plague
HIV/AIDS
frostbite
Raynaud's syndrome
Diagnostic method
Prognosis
tissue death
lack of blood supply

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