2736:
270:
antibodies arising from gevokizumab. XOMA received an approximately $ 16 million upfront payment, and
Novartis repaid in its entirety the approximately €12 million of debt owed by XOMA to Les Laboratoires Servier. XOMA is eligible to receive up to $ 438 million in development, regulatory and commercial milestones plus tiered high-single to mid-double-digit royalties on net sales of gevokizumab.
2679:
269:
On August 25, 2017, XOMA Corporation licensed the global commercial rights to gevokizumab to
Novartis. Under the license agreement, Novartis will have worldwide rights to gevokizumab, and will be solely responsible for the development and commercialization of antibodies and products containing
266:(IL-1 beta), a pro-inflammatory cytokine, and downmodulates the cellular signaling events that produce inflammation. IL-1 beta has been implicated in cardiovascular conditions, lung cancer, and auto-inflammatory diseases.
1419:
2818:
354:
78:
238:
2784:
2720:
1412:
347:
34:
1405:
2803:
2777:
2713:
2617:
1884:
340:
2621:
2607:
2567:
1363:
2636:
2813:
2541:
2770:
2706:
1489:
2808:
1335:
2502:
2481:
1345:
135:
289:"Gevokizumab in the Treatment of Autoimmune Non-necrotizing Anterior Scleritis: Results of a Phase I/II Clinical Trial"
1380:
929:
2460:
2420:
2399:
2343:
2311:
2270:
2228:
2182:
2101:
2075:
2019:
1978:
1952:
1926:
1580:
1368:
2035:
1895:
1875:
1854:
1773:
1712:
1656:
1610:
1534:
1439:
441:
363:
1545:
2657:
2440:
1428:
645:
1570:
2750:
2686:
2431:
1989:
1784:
1560:
1454:
259:
99:
44:
27:
2301:
2296:
2281:
2193:
2172:
1621:
1555:
1514:
1458:
1431:
830:
789:
629:
421:
287:
Knickelbein JE, Tucker WR, Bhatt N, Armbrust K, Valent D, Obiyor D, et al. (December 2016).
263:
2162:
2030:
1937:
1916:
1667:
1636:
1631:
1575:
1494:
2208:
1641:
1469:
1464:
1814:
1799:
1763:
1733:
1479:
721:
391:
332:
318:
66:
2754:
2690:
262:, developed by XOMA Corporation, with allosteric modulating properties. Gevokizumab binds to
108:
2652:
711:
701:
308:
300:
180:
2128:
2124:
2120:
144:
2747:
2444:
1129:
905:
2743:
2642:
2632:
2627:
2613:
2599:
2589:
2584:
2531:
2513:
2492:
2471:
2450:
2436:
2410:
2354:
2322:
2286:
2249:
2244:
2239:
2203:
2198:
2112:
2091:
2045:
1994:
1963:
1942:
1677:
1646:
1374:
313:
288:
2797:
2384:
2040:
1906:
1865:
1789:
1723:
1672:
1626:
1565:
1450:
1284:
1085:
1030:
955:
915:
835:
729:
375:
367:
2558:
2379:
2065:
2060:
2055:
1804:
1743:
1702:
1274:
1259:
1239:
1229:
1208:
1124:
1065:
1050:
1020:
1000:
995:
970:
950:
945:
940:
890:
880:
870:
820:
815:
810:
739:
624:
608:
511:
501:
496:
471:
411:
1397:
2389:
2369:
2332:
2167:
2157:
2009:
2004:
1839:
1809:
1748:
1590:
1550:
1504:
1340:
1330:
1269:
1254:
1234:
1213:
1198:
1183:
1178:
1173:
1148:
1101:
1080:
1075:
1070:
1060:
1055:
1040:
1015:
1005:
985:
965:
960:
925:
920:
910:
900:
895:
865:
855:
825:
779:
774:
764:
749:
734:
706:
691:
676:
671:
666:
634:
577:
572:
562:
542:
521:
516:
486:
406:
2735:
2678:
2374:
2364:
2259:
2152:
2147:
1968:
1829:
1819:
1753:
1687:
1600:
1595:
1524:
1300:
1279:
1264:
1249:
1193:
1188:
1168:
1163:
1134:
1108:
1045:
1025:
1010:
990:
980:
935:
885:
875:
850:
845:
840:
805:
800:
769:
754:
696:
686:
681:
661:
598:
593:
582:
552:
547:
491:
466:
451:
436:
431:
401:
304:
219:
119:
1844:
1834:
1824:
1697:
1203:
1035:
860:
759:
744:
603:
567:
557:
531:
526:
506:
481:
476:
461:
456:
426:
396:
49:
20:
322:
1484:
613:
536:
446:
416:
2603:
2086:
1090:
975:
61:
2218:
1315:
164:
2525:
2521:
2517:
2136:
2132:
2116:
53:
155:
1401:
336:
2593:
2758:
2694:
245:
2577:
2557:
2550:
2501:
2480:
2459:
2419:
2398:
2342:
2310:
2269:
2227:
2181:
2100:
2074:
2018:
1977:
1951:
1925:
1894:
1874:
1853:
1772:
1711:
1655:
1609:
1533:
1438:
1323:
1313:
1293:
1222:
1156:
1147:
1116:
788:
720:
654:
383:
374:
218:
179:
174:
154:
134:
118:
98:
93:
77:
72:
60:
43:
33:
26:
107:
2819:Antineoplastic and immunomodulating drug stubs
2778:
2714:
1413:
348:
8:
19:
2785:
2771:
2721:
2707:
2554:
1420:
1406:
1398:
1320:
1153:
380:
355:
341:
333:
312:
143:
2585:Interleukin 14 (taxilin alpha, HMW-BCGF)
279:
1883:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
18:
7:
2732:
2730:
2675:
2673:
163:
2757:. You can help Knowledge (XXG) by
2693:. You can help Knowledge (XXG) by
14:
293:American Journal of Ophthalmology
2734:
2677:
197:
191:
2411:Interleukin 27 (interleukin 30)
2804:Drugs not assigned an ATC code
209:
203:
185:
1:
1761:Antisense oligonucleotides:
2835:
2729:
2672:
175:Chemical and physical data
2814:Monoclonal antibody stubs
1358:
305:10.1016/j.ajo.2016.09.017
235:
2451:Interleukin-29 (IFN-λ1)
1596:Daclizumab (dacliximab)
1581:Tucotuzumab celmoleukin
2689:–related article is a
2432:Interferon λ4 (IFN-λ4)
1525:Rilonacept (IL-1 Trap)
2809:Monoclonal antibodies
2355:Interleukin 23 (SGRF)
2036:Cintredekin besudotox
1964:Interleukin 11 (AGIF)
1943:Interleukin 10 (CSIF)
442:Camidanlumab tesirine
364:Monoclonal antibodies
1429:Interleukin receptor
1117:Chimeric + humanized
646:Nivolumab/relatlimab
2687:monoclonal antibody
1561:Denileukin diftitox
260:monoclonal antibody
258:is an experimental
28:Monoclonal antibody
23:
16:Monoclonal antibody
2133:E (interleukin 25)
1385:Never to phase III
831:Certolizumab pegol
798:Immunosuppressive:
264:interleukin-1 beta
2766:
2765:
2702:
2701:
2670:
2669:
2666:
2665:
2635:(signals through
2616:(signals through
2602:(signals through
2592:(signals through
2216:Binding proteins:
1546:Adargileukin alfa
1395:
1394:
1354:
1353:
1309:
1308:
1143:
1142:
1098:Immune activation
590:Immune activation
392:Immunosuppression
253:
252:
2826:
2787:
2780:
2773:
2748:immunomodulatory
2738:
2731:
2723:
2716:
2709:
2681:
2674:
2658:Efineptakin alfa
2653:Efavaleukin alfa
2555:
1522:Decoy receptors:
1422:
1415:
1408:
1399:
1321:
1154:
712:Zolimomab aritox
702:Telimomab aritox
381:
357:
350:
343:
334:
327:
326:
316:
284:
249:
248:
241:
230:
228:
211:
205:
199:
193:
187:
167:
147:
111:
24:
22:
2834:
2833:
2829:
2828:
2827:
2825:
2824:
2823:
2794:
2793:
2792:
2791:
2728:
2727:
2671:
2662:
2573:
2546:
2497:
2476:
2455:
2415:
2394:
2338:
2335:(against IL-22)
2306:
2265:
2262:(against IL-20)
2223:
2177:
2096:
2070:
2014:
1973:
1947:
1921:
1890:
1870:
1849:
1768:
1707:
1651:
1605:
1529:
1434:
1426:
1396:
1391:
1390:
1375:Clinical trials
1350:
1305:
1289:
1218:
1139:
1130:Rozanolixizumab
1118:
1112:
1104:
1093:
906:Lulizumab pegol
784:
716:
650:
370:
361:
331:
330:
286:
285:
281:
276:
244:
242:
239:(what is this?)
236:
226:
224:
214:
208:
202:
196:
190:
170:
150:
130:
114:
89:
17:
12:
11:
5:
2832:
2830:
2822:
2821:
2816:
2811:
2806:
2796:
2795:
2790:
2789:
2782:
2775:
2767:
2764:
2763:
2744:antineoplastic
2739:
2726:
2725:
2718:
2711:
2703:
2700:
2699:
2682:
2668:
2667:
2664:
2663:
2661:
2660:
2655:
2646:
2645:
2643:Interleukin 35
2640:
2633:Interleukin 34
2630:
2628:Interleukin 32
2625:
2614:Interleukin 26
2611:
2600:Interleukin 24
2597:
2590:Interleukin 16
2587:
2581:
2579:
2575:
2574:
2572:
2571:
2563:
2561:
2552:
2548:
2547:
2545:
2544:
2535:
2534:
2532:Interleukin 38
2529:
2514:Interleukin 36
2507:
2505:
2499:
2498:
2496:
2495:
2493:Interleukin 33
2486:
2484:
2478:
2477:
2475:
2474:
2472:Interleukin 31
2465:
2463:
2457:
2456:
2454:
2453:
2448:
2437:Interleukin 28
2434:
2425:
2423:
2417:
2416:
2414:
2413:
2404:
2402:
2396:
2395:
2393:
2392:
2387:
2382:
2377:
2372:
2367:
2358:
2357:
2348:
2346:
2340:
2339:
2337:
2336:
2326:
2325:
2323:Interleukin 22
2316:
2314:
2308:
2307:
2305:
2304:
2299:
2290:
2289:
2287:Interleukin 21
2284:
2275:
2273:
2267:
2266:
2264:
2263:
2253:
2252:
2250:Interleukin 24
2247:
2245:Interleukin 20
2242:
2240:Interleukin 19
2233:
2231:
2225:
2224:
2222:
2221:
2212:
2211:
2206:
2204:Interleukin 37
2201:
2199:Interleukin 18
2196:
2187:
2185:
2179:
2178:
2176:
2175:
2170:
2165:
2160:
2155:
2150:
2141:
2140:
2113:Interleukin 17
2106:
2104:
2098:
2097:
2095:
2094:
2092:Interleukin 15
2089:
2080:
2078:
2072:
2071:
2069:
2068:
2063:
2058:
2049:
2048:
2046:Interleukin 13
2043:
2038:
2033:
2024:
2022:
2016:
2015:
2013:
2012:
2007:
1998:
1997:
1995:Interleukin 12
1992:
1983:
1981:
1975:
1974:
1972:
1971:
1966:
1957:
1955:
1949:
1948:
1946:
1945:
1940:
1931:
1929:
1923:
1922:
1920:
1919:
1910:
1909:
1900:
1898:
1892:
1891:
1889:
1888:
1880:
1878:
1872:
1871:
1869:
1868:
1859:
1857:
1851:
1850:
1848:
1847:
1842:
1837:
1832:
1827:
1822:
1817:
1812:
1807:
1802:
1793:
1792:
1787:
1778:
1776:
1770:
1769:
1767:
1766:
1757:
1756:
1751:
1746:
1737:
1736:
1727:
1726:
1717:
1715:
1709:
1708:
1706:
1705:
1700:
1691:
1690:
1681:
1680:
1678:Interleukin 13
1675:
1670:
1661:
1659:
1653:
1652:
1650:
1649:
1647:Promegapoietin
1644:
1639:
1634:
1629:
1624:
1615:
1613:
1607:
1606:
1604:
1603:
1598:
1593:
1584:
1583:
1578:
1573:
1571:Pegaldesleukin
1568:
1563:
1558:
1553:
1548:
1539:
1537:
1531:
1530:
1528:
1527:
1518:
1517:
1512:
1507:
1498:
1497:
1492:
1487:
1482:
1473:
1472:
1467:
1462:
1444:
1442:
1436:
1435:
1427:
1425:
1424:
1417:
1410:
1402:
1393:
1392:
1389:
1388:
1387:
1386:
1383:
1372:
1366:
1360:
1359:
1356:
1355:
1352:
1351:
1349:
1348:
1343:
1338:
1333:
1327:
1325:
1318:
1311:
1310:
1307:
1306:
1304:
1303:
1297:
1295:
1291:
1290:
1288:
1287:
1282:
1277:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1237:
1232:
1226:
1224:
1220:
1219:
1217:
1216:
1211:
1206:
1201:
1196:
1191:
1186:
1181:
1176:
1171:
1166:
1160:
1158:
1151:
1145:
1144:
1141:
1140:
1138:
1137:
1132:
1127:
1121:
1119:
1114:
1113:
1095:
1094:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
930:+hyaluronidase
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
794:
792:
786:
785:
783:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
726:
724:
718:
717:
715:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
658:
656:
652:
651:
649:
648:
638:
637:
632:
627:
617:
616:
611:
606:
601:
596:
586:
585:
580:
575:
570:
565:
560:
555:
550:
545:
540:
534:
529:
524:
519:
514:
509:
504:
499:
494:
489:
484:
479:
474:
469:
464:
459:
454:
449:
444:
439:
434:
429:
424:
419:
414:
409:
404:
399:
387:
385:
378:
372:
371:
362:
360:
359:
352:
345:
337:
329:
328:
278:
277:
275:
272:
251:
250:
233:
232:
222:
216:
215:
212:
206:
200:
194:
188:
183:
177:
176:
172:
171:
169:
168:
160:
158:
152:
151:
149:
148:
140:
138:
132:
131:
129:
128:
124:
122:
116:
115:
113:
112:
104:
102:
96:
95:
91:
90:
88:
87:
83:
81:
75:
74:
70:
69:
67:Interleukin 1β
64:
58:
57:
47:
41:
40:
39:Whole antibody
37:
31:
30:
15:
13:
10:
9:
6:
4:
3:
2:
2831:
2820:
2817:
2815:
2812:
2810:
2807:
2805:
2802:
2801:
2799:
2788:
2783:
2781:
2776:
2774:
2769:
2768:
2762:
2760:
2756:
2753:article is a
2752:
2749:
2745:
2740:
2737:
2733:
2724:
2719:
2717:
2712:
2710:
2705:
2704:
2698:
2696:
2692:
2688:
2683:
2680:
2676:
2659:
2656:
2654:
2651:
2648:
2647:
2644:
2641:
2638:
2634:
2631:
2629:
2626:
2623:
2619:
2615:
2612:
2609:
2605:
2601:
2598:
2595:
2591:
2588:
2586:
2583:
2582:
2580:
2576:
2569:
2565:
2564:
2562:
2560:
2556:
2553:
2549:
2543:
2540:
2537:
2536:
2533:
2530:
2527:
2523:
2519:
2515:
2512:
2509:
2508:
2506:
2504:
2500:
2494:
2491:
2488:
2487:
2485:
2483:
2479:
2473:
2470:
2467:
2466:
2464:
2462:
2458:
2452:
2449:
2446:
2442:
2438:
2435:
2433:
2430:
2427:
2426:
2424:
2422:
2418:
2412:
2409:
2406:
2405:
2403:
2401:
2397:
2391:
2388:
2386:
2385:Tildrakizumab
2383:
2381:
2378:
2376:
2373:
2371:
2368:
2366:
2363:
2360:
2359:
2356:
2353:
2350:
2349:
2347:
2345:
2341:
2334:
2331:
2328:
2327:
2324:
2321:
2318:
2317:
2315:
2313:
2309:
2303:
2300:
2298:
2295:
2292:
2291:
2288:
2285:
2283:
2280:
2277:
2276:
2274:
2272:
2268:
2261:
2258:
2255:
2254:
2251:
2248:
2246:
2243:
2241:
2238:
2235:
2234:
2232:
2230:
2226:
2220:
2217:
2214:
2213:
2210:
2207:
2205:
2202:
2200:
2197:
2195:
2192:
2189:
2188:
2186:
2184:
2180:
2174:
2171:
2169:
2166:
2164:
2161:
2159:
2156:
2154:
2151:
2149:
2146:
2143:
2142:
2138:
2134:
2130:
2126:
2122:
2118:
2114:
2111:
2108:
2107:
2105:
2103:
2099:
2093:
2090:
2088:
2085:
2082:
2081:
2079:
2077:
2073:
2067:
2064:
2062:
2059:
2057:
2054:
2051:
2050:
2047:
2044:
2042:
2041:Interleukin 4
2039:
2037:
2034:
2032:
2029:
2026:
2025:
2023:
2021:
2017:
2011:
2008:
2006:
2003:
2000:
1999:
1996:
1993:
1991:
1990:Edodekin alfa
1988:
1985:
1984:
1982:
1980:
1976:
1970:
1967:
1965:
1962:
1959:
1958:
1956:
1954:
1950:
1944:
1941:
1939:
1936:
1933:
1932:
1930:
1928:
1924:
1918:
1915:
1912:
1911:
1908:
1907:Interleukin 9
1905:
1902:
1901:
1899:
1897:
1893:
1886:
1882:
1881:
1879:
1877:
1873:
1867:
1866:Interleukin 7
1864:
1861:
1860:
1858:
1856:
1852:
1846:
1843:
1841:
1838:
1836:
1833:
1831:
1828:
1826:
1823:
1821:
1818:
1816:
1813:
1811:
1808:
1806:
1803:
1801:
1798:
1795:
1794:
1791:
1790:Interleukin 6
1788:
1786:
1785:Atexakin alfa
1783:
1780:
1779:
1777:
1775:
1771:
1765:
1762:
1759:
1758:
1755:
1752:
1750:
1747:
1745:
1742:
1739:
1738:
1735:
1732:
1729:
1728:
1725:
1724:Interleukin 5
1722:
1719:
1718:
1716:
1714:
1710:
1704:
1701:
1699:
1696:
1693:
1692:
1689:
1686:
1683:
1682:
1679:
1676:
1674:
1673:Interleukin 4
1671:
1669:
1666:
1663:
1662:
1660:
1658:
1654:
1648:
1645:
1643:
1640:
1638:
1635:
1633:
1630:
1628:
1627:Interleukin 3
1625:
1623:
1620:
1617:
1616:
1614:
1612:
1608:
1602:
1599:
1597:
1594:
1592:
1589:
1586:
1585:
1582:
1579:
1577:
1574:
1572:
1569:
1567:
1566:Interleukin 2
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1541:
1540:
1538:
1536:
1532:
1526:
1523:
1520:
1519:
1516:
1513:
1511:
1508:
1506:
1503:
1500:
1499:
1496:
1493:
1491:
1488:
1486:
1483:
1481:
1478:
1475:
1474:
1471:
1468:
1466:
1463:
1460:
1456:
1452:
1451:Interleukin 1
1449:
1446:
1445:
1443:
1441:
1437:
1433:
1430:
1423:
1418:
1416:
1411:
1409:
1404:
1403:
1400:
1384:
1382:
1379:
1378:
1376:
1373:
1370:
1367:
1365:
1362:
1361:
1357:
1347:
1344:
1342:
1339:
1337:
1334:
1332:
1329:
1328:
1326:
1322:
1319:
1317:
1314:Inflammatory
1312:
1302:
1299:
1298:
1296:
1292:
1286:
1285:Tildrakizumab
1283:
1281:
1278:
1276:
1273:
1271:
1268:
1266:
1263:
1261:
1258:
1256:
1253:
1251:
1248:
1246:
1243:
1241:
1238:
1236:
1233:
1231:
1228:
1227:
1225:
1221:
1215:
1212:
1210:
1207:
1205:
1202:
1200:
1197:
1195:
1192:
1190:
1187:
1185:
1182:
1180:
1177:
1175:
1172:
1170:
1167:
1165:
1162:
1161:
1159:
1155:
1152:
1150:
1146:
1136:
1133:
1131:
1128:
1126:
1123:
1122:
1120:
1115:
1111:
1110:
1107:
1103:
1099:
1092:
1089:
1087:
1086:Vobarilizumab
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1031:Spartalizumab
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
956:Pembrolizumab
954:
952:
949:
947:
944:
942:
939:
937:
934:
931:
927:
924:
922:
919:
917:
916:Mogamulizumab
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
836:Crizanlizumab
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
796:
795:
793:
791:
787:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
730:Andecaliximab
728:
727:
725:
723:
719:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
659:
657:
653:
647:
643:
640:
639:
636:
633:
631:
628:
626:
622:
619:
618:
615:
612:
610:
607:
605:
602:
600:
597:
595:
591:
588:
587:
584:
581:
579:
576:
574:
571:
569:
566:
564:
561:
559:
556:
554:
551:
549:
546:
544:
541:
538:
535:
533:
530:
528:
525:
523:
520:
518:
515:
513:
510:
508:
505:
503:
500:
498:
495:
493:
490:
488:
485:
483:
480:
478:
475:
473:
470:
468:
465:
463:
460:
458:
455:
453:
450:
448:
445:
443:
440:
438:
435:
433:
430:
428:
425:
423:
420:
418:
415:
413:
410:
408:
405:
403:
400:
398:
394:
393:
389:
388:
386:
382:
379:
377:
376:Immune system
373:
369:
368:immune system
365:
358:
353:
351:
346:
344:
339:
338:
335:
324:
320:
315:
310:
306:
302:
298:
294:
290:
283:
280:
273:
271:
267:
265:
261:
257:
247:
240:
234:
223:
221:
217:
184:
182:
178:
173:
166:
162:
161:
159:
157:
153:
146:
142:
141:
139:
137:
133:
126:
125:
123:
121:
117:
110:
106:
105:
103:
101:
97:
92:
85:
84:
82:
80:
76:
73:Clinical data
71:
68:
65:
63:
59:
55:
51:
48:
46:
42:
38:
36:
32:
29:
25:
2759:expanding it
2741:
2695:expanding it
2684:
2649:
2637:M-CSFR/CSF1R
2624:heterodimer)
2610:heterodimer)
2539:Antagonists:
2538:
2510:
2489:
2468:
2428:
2407:
2380:Risankizumab
2361:
2351:
2329:
2319:
2302:NNC0114-0006
2297:NNC0114-0005
2293:
2278:
2256:
2236:
2215:
2190:
2144:
2109:
2083:
2066:Tralokinumab
2061:Lebrikizumab
2056:Anrukinzumab
2052:
2027:
2001:
1986:
1960:
1934:
1913:
1903:
1862:
1805:Clazakizumab
1796:
1781:
1760:
1744:Benralizumab
1740:
1731:Antagonists:
1730:
1720:
1703:Pascolizumab
1694:
1685:Antagonists:
1684:
1664:
1618:
1587:
1542:
1521:
1509:
1501:
1477:Antagonists:
1476:
1447:
1275:Risankizumab
1260:Lebrikizumab
1244:
1240:Clazakizumab
1230:Anrukinzumab
1209:Tralokinumab
1125:Otelixizumab
1105:
1097:
1096:
1066:Tregalizumab
1051:Tislelizumab
1021:Satralizumab
1001:Rontalizumab
996:Retifanlimab
971:Plozalizumab
951:Pateclizumab
946:Pascolizumab
941:Ozoralizumab
891:Lampalizumab
881:Inebilizumab
871:Fontolizumab
821:Camrelizumab
816:Benralizumab
811:Atezolizumab
797:
740:Clenoliximab
641:
625:Bertilimumab
620:
609:Tremelimumab
589:
512:Mavrilimumab
502:Lirentelimab
497:Lerdelimumab
472:Fresolimumab
412:Atorolimumab
390:
296:
292:
282:
268:
255:
254:
243:
237:
109:1129435-60-4
2390:Ustekinumab
2370:Briakinumab
2362:Antibodies:
2333:Fezakinumab
2330:Antibodies:
2294:Antibodies:
2282:Denenicokin
2257:Antibodies:
2194:Iboctadekin
2173:Vunakizumab
2168:Secukinumab
2158:Perakizumab
2145:Antibodies:
2053:Antibodies:
2010:Ustekinumab
2005:Briakinumab
2002:Antibodies:
1914:Antibodies:
1840:Tocilizumab
1810:Elsilimomab
1797:Antibodies:
1749:Mepolizumab
1741:Antibodies:
1695:Antibodies:
1622:Daniplestim
1591:Basiliximab
1588:Antibodies:
1556:Celmoleukin
1551:Aldesleukin
1515:Lutikizumab
1510:Gevokizumab
1505:Canakinumab
1502:Antibodies:
1371:from market
1341:Lemalesomab
1336:Fanolesomab
1331:Besilesomab
1270:Perakizumab
1255:Mirikizumab
1245:Gevokizumab
1235:Bimekizumab
1214:Ustekinumab
1199:Secukinumab
1184:Fezakinumab
1179:Canakinumab
1174:Briakinumab
1149:Interleukin
1102:Dostarlimab
1081:Visilizumab
1076:Vedolizumab
1071:Vatelizumab
1061:Toralizumab
1056:Tocilizumab
1041:Teclistamab
1016:Samalizumab
1006:Rovelizumab
986:Ravulizumab
966:Pidilizumab
961:Pexelizumab
926:Ocrelizumab
921:Natalizumab
911:Mepolizumab
901:Ligelizumab
896:Letolizumab
866:Etrolizumab
856:Epratuzumab
826:Cedelizumab
780:Vapaliximab
775:Teneliximab
765:Lumiliximab
750:Gomiliximab
735:Basiliximab
707:Vepalimomab
692:Nerelimomab
677:Gavilimomab
672:Faralimomab
667:Elsilimomab
642:Combination
635:Zanolimumab
630:Ontamalimab
578:Ulocuplumab
573:Tezepelumab
563:Sifalimumab
543:Pamrevlumab
522:Morolimumab
517:Metelimumab
487:Lanadelumab
422:Avdoralimab
407:Anifrolumab
299:: 104–110.
256:Gevokizumab
231: g·mol
94:Identifiers
21:Gevokizumab
2798:Categories
2445:B (IFN-λ3)
2441:A (IFN-λ2)
2375:Guselkumab
2365:Brazikumab
2260:Fletikumab
2163:Remtolumab
2153:Ixekizumab
2148:Brodalumab
2031:Binetrakin
1969:Oprelvekin
1938:Ilodecakin
1917:Enokizumab
1830:Siltuximab
1820:Olokizumab
1754:Reslizumab
1688:Pitrakinra
1668:Binetrakin
1637:Milodistim
1632:Leridistim
1601:Inolimomab
1576:Teceleukin
1495:Isunakinra
1432:modulators
1301:Lokivetmab
1294:Veterinary
1280:Spesolimab
1265:Olokizumab
1250:Ixekizumab
1194:Guselkumab
1189:Fletikumab
1169:Brazikumab
1164:Bermekimab
1135:Sutimlimab
1109:Ibalizumab
1046:Teplizumab
1026:Siplizumab
1011:Ruplizumab
991:Reslizumab
981:Quilizumab
936:Omalizumab
886:Itolizumab
876:Frexalimab
851:Efalizumab
846:Eculizumab
841:Daclizumab
806:Aselizumab
801:Apolizumab
770:Priliximab
755:Infliximab
697:Odulimomab
687:Maslimomab
682:Inolimomab
662:Afelimomab
599:Durvalumab
594:Ipilimumab
583:Varlilumab
553:Relatlimab
548:Placulumab
492:Lenzilumab
467:Emapalumab
452:Cemiplimab
437:Brodalumab
432:Bleselumab
402:Adalimumab
274:References
220:Molar mass
145:QX3JU54GYQ
120:ChemSpider
100:CAS Number
2650:Unsorted:
2511:Agonists:
2490:Agonists:
2469:Agonists:
2429:Agonists:
2408:Agonists:
2352:Agonists:
2320:Agonists:
2279:Agonists:
2237:Agonists:
2209:Tadekinig
2191:Agonists:
2110:Agonists:
2084:Agonists:
2028:Agonists:
1987:Agonists:
1961:Agonists:
1935:Agonists:
1904:Agonists:
1863:Agonists:
1845:Levilimab
1835:Sirukumab
1825:Sarilumab
1782:Agonists:
1721:Agonists:
1698:Dupilumab
1665:Agonists:
1642:Muplestim
1619:Agonists:
1543:Agonists:
1470:Pifonakin
1465:Mobenakin
1448:Agonists:
1381:Phase III
1369:Withdrawn
1346:Sulesomab
1223:Humanized
1204:Sirukumab
1036:Talizumab
861:Erlizumab
790:Humanized
760:Keliximab
745:Galiximab
604:Nivolumab
568:Tabalumab
558:Sarilumab
532:Oleclumab
527:Namilumab
507:Lirilumab
482:Ianalumab
477:Golimumab
462:Eldelumab
457:Dupilumab
427:Belimumab
397:Abrilumab
50:Humanized
2604:IL-22Rα1
2570:instead.
1887:instead.
1815:mAb 1339
1800:ARGX-109
1764:TPI ASM8
1734:YM-90709
1485:Anakinra
1480:AF-12198
722:Chimeric
614:Urelumab
537:Oxelumab
447:Carlumab
417:Avelumab
366:for the
323:27663070
246:(verify)
79:ATC code
2622:IL-10Rβ
2618:IL-20Rα
2608:IL-20Rβ
2542:IL-36RA
2087:ALT-803
1316:lesions
1091:TGN1412
976:PRO 140
314:5121021
181:Formula
2578:Others
2551:Others
2503:IL1RL2
2482:IL1RL1
2219:IL18BP
1490:IL-1RA
1364:WHO-EM
1106:Other:
321:
311:
165:D09911
62:Target
52:(from
45:Source
2742:This
2685:This
2461:IL-31
2421:IL-28
2400:IL-27
2344:IL-23
2312:IL-22
2271:IL-21
2229:IL-20
2183:IL-18
2102:IL-17
2076:IL-15
2020:IL-13
1979:IL-12
1953:IL-11
1927:IL-10
1324:Mouse
1157:Human
655:Mouse
621:Other
384:Human
54:mouse
2755:stub
2751:drug
2691:stub
2568:here
2566:See
1896:IL-9
1885:here
1876:IL-8
1855:IL-7
1774:IL-6
1713:IL-5
1657:IL-4
1611:IL-3
1535:IL-2
1440:IL-1
319:PMID
207:2010
201:1710
195:9962
189:6442
156:KEGG
136:UNII
127:None
86:None
35:Type
2746:or
2594:CD4
2559:JAK
309:PMC
301:doi
297:172
229:.64
227:193
225:145
2800::
2524:,
2520:,
2443:,
2135:,
2131:,
2127:,
2123:,
2119:,
1457:,
1377::
1100::
644::
623::
592::
395::
317:.
307:.
295:.
291:.
213:52
2786:e
2779:t
2772:v
2761:.
2722:e
2715:t
2708:v
2697:.
2639:)
2620:/
2606:/
2596:)
2528:)
2526:γ
2522:β
2518:α
2516:(
2447:)
2439:(
2139:)
2137:F
2129:D
2125:C
2121:B
2117:A
2115:(
1461:)
1459:β
1455:α
1453:(
1421:e
1414:t
1407:v
932:)
928:(
539:§
356:e
349:t
342:v
325:.
303::
210:S
204:O
198:N
192:H
186:C
56:)
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