Eosinophilia - Knowledge (XXG)

384:. These genes code for dysfunctional protein products capable of enhancing proliferation and/or survival of their parent cells which, in consequence, become an evolving and constantly growing clone of eosinophils. These mutations are recognized by the World Health Association as causing distinct entities differing from idiopathic hypereosinophilia and the idiopathic hypereosinophilic syndrome. Presence of these clones may be associated with tissue injury but in any case suggests specific therapy be directed at reducing the size and suppressing the growth of the eosinophil clone. More recently, mutations in other genes have been described as causing a similar type of clonal hypereosinophilia but have not yet been recognized as entities distinct from idiopathic hypereosinophilia and the idiopathic hyperesoniphilic syndrome. These include gene mutations in 582:) is a disorder characterized by an increase in eosinophil blood counts above 1,500/μL, as detected on at least 2 separate examinations. The disorder cannot be associated with eosinophil-based tissue damage or a primary or secondary cause of eosinophilia. That is, it is a diagnosis of exclusion and has no known cause. Over time, this disorder can resolve into a primary hypereosinophilia, typically clonal hypereosinophilia, chronic eosinphilic leukemia, or an eosinophilia associated with another hematological leukemia. The disorder may also become associated with tissue or organ damage and therefore be diagnosed as the hypereosinophilic syndrome. Idiopathic hypereosinophilia is treated by observation to detect development of the cited more serious disorders. 1479:. Less commonly, almost any other organ or tissue except joints and brain may be beleaguered by the inflammatory disorder. About 1/3 of cases exhibit eosinophilia or, rarely, hypereosinophilia. This increase in blood eosinophil count is often associated with abnormal T-lymphocyte clones (e.g. increased numbers of CD4 negative, CD7 positive T cells, CD3 negative, CD4 positive T cells, or CD3 positive, CD4 negative, CD8 negative T cells) and is thought to be secondary to these immunological disturbances. The disorder often exhibits are recurrent-relapsing course and is highly responsive to 123:(CBC), but diagnostic procedures directed at the underlying cause vary depending on the suspected condition(s). An absolute eosinophil count is not generally needed if the CBC shows marked eosinophilia. The location of the causal factor can be used to classify eosinophilia into two general types: extrinsic, in which the factor lies outside the eosinophil cell lineage; and intrinsic eosinophilia, which denotes etiologies within the eosinophil cell line. Specific treatments are dictated by the causative condition, though in 43: 597:

The World Health Organization restrict this diagnosis to cases which have no well-defined cause. That is, all cases of secondary (i.e. reactive) eosinophilia (including lymphocyte-variant hypereosinophilia) and primary hypereosinophilia (including chronic eosinophilic leukemia (NOS), clonal eosinophilia, and hypereosinophilia associated with hematological malignancies) are excluded from this diagnosis.

915:(DRESS) syndrome. Drug- induced hepatitis marked by immunoallergic pathology, which has much bidirectional crossover with DRESS syndrome, is typically accompanied by some severity of eosinophilia. While virtually any drug should be considered as a possible cause of these signs and symptoms, the following drugs and drug classes are some of the most frequently reported causes: 278:

between hypereosinophilia and eosinophilia is somewhat arbitrary. There are at least two different guidelines for classifying hypereosinophilia/eosinophilia into subtypes. The General Haematoloy and Haemato-oncology Task Forces for the British Committee for Standards in Haematology classifies these disorders into

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The idiopathic hypereosinophilic syndrome is a disorder characterized by hypereosiophilia that is associated with eosinophil-based tissue or organ damage. While almost any organ or tissue may be damaged, the lung, skin, heart, blood vessels, sinuses, kidneys, and brain are the most commonly affected.

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Certain malignancies cause a secondary eosinophilia or, less commonly, hypereosinophilia. These increases in blood eosinophils appear due to the release of stimulatory cytokines or invasion of the bone marrow and thereby irritation of resident eosinophils or their precursors. Malignancies associated

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for interleukin 3 or colony stimulating factor 2. This suggests that the primary defect in familial eosinophilia is not a mutation in one of these genes but rather in another gene within this chromosome area. Clinical manifestations and tissue destruction related to the eosinophilia in this disorder

1700:, contain granules (or sacs) filled with digestive enzymes and cytotoxic proteins which under normal conditions are used to destroy parasites but in eosinophilia these agents can damage healthy tissues. In addition to these agents, the granules in eosinophils also contain inflammatory molecules and 1205:

production by tumor cells, especially IL-5 or IL-3. This has also been shown to occur in Hodgkin lymphoma, in the form of IL-5 secreted by Reed-Sternberg cells. In primary cutaneous T cell lymphoma, blood and dermal eosinophilia are often seen. Lymphoma cells have also been shown to produce IL-5 in

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Based on their causes, hypereosinophilias can be sorted into subtypes. However, cases of eosinophilia, which exhibit eosinophil counts between 500 and 1,500/μL, may fit the clinical criteria for, and thus be regarded as falling into, one of these hypereosinophilia categories: the cutoff of 1,500/μL

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that destroy invading microbes, foreign tissue, and malignant cells. When overproduced and over-activated, which occurs in certain cases of hypereosinophilia and to a lesser extent eosinophilia, eosinophils may misdirect their reactive oxygen species and armamentarium of preformed molecules toward

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Hypereosinophilia may occur in the setting of damage to a single specific organ due to a massive infiltration by eosinophils. This disorder is sub-classified based on the organ involved and is not considered to be a form of primary hypereosinophilia, secondary hypereosinophilia, or the idiopathic

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must be absent. The latter diagnostic features include clonal cytogenetic abnormalities and molecular genetic abnormalities diagnostic for other forms of leukemia or the presence of myeloblast counts greater than 55% in bone marrow or 2% in blood. Chronic eosinophilic leukemia may transform into

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Angiolymphoid hyperplasia with eosinophilia is a disorder initially classified as a form of IgG4-related diseases but now considered a distinct entity. The disorder involves inflamed benign tumors of the vasculature in skin and, less commonly, other tissues. The tumors consist of histiocytoid

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alpha or beta. Patients displaying eosinophilia overexpress a gene encoding an eosinophil hematopoietin. A translocation between chromosomes 5 and 14 in patients with acute B lymphocytic leukemia resulted in the juxtaposition of the IL-3 gene and the immunoglobulin heavy-chain gene, causing

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stimulate circulating eosinophils to enter tissues and release tissue-injuring agents. These cytokines may be released by the diseased cells or the diseased cells may cause the release of these cytokines by non-diseased cells. Primary disorders associated with and known or presumed to cause

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Informally, blood eosinophil levels are often regarded as mildly elevated at counts of 500–1,500/μL, moderately elevated between 1,500 and 5,000/μL, and severely elevated when greater than 5,000/μL. Elevations in blood eosinophil counts can be transient, sustained, recurrent, or cyclical.

335:. The fundamental driver of these hypereosinophilic (or uncommonly eosinophilic) disorders is the mutation which increases the proliferation, survival, and further mutation of cells descendant from the originally mutated cell. There are several subtypes of primary hypereosinophilia. 110:

Eosinophils usually account for less than 7% of the circulating leukocytes. A marked increase in non-blood tissue eosinophil count noticed upon histopathologic examination is diagnostic for tissue eosinophilia. Several causes are known, with the most common being some form of

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hypereosinophilia/eosinophilia, disorders and also includes another subtype, organ-restricted hypereosinophilias, a disorder in which eosinophil-mediated tissue damage is restricted to one organ and is often but not always associated with increased blood eosinophil counts.

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positive immunophenotype may occur during the disorders progression to lymphoma. Reports on treatment of the disorder are rare. In on study of 16 lymphocyte-variant hypereosinophilia patients with the aberrant CD3 negative, CD41 positive immunophenotype, good responds to

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the Idiopathic hypereosinophilic syndrome. In the latter classification, secondary hypereosinophilia/eosinophilia is not viewed as a true disorder of eosinophils. Here these two classifications are merged and expanded to include the many forms of secondary, i.e. reactive

1077:(NSAIDs), some antipsychotics such as risperidone, and certain antibiotics. Phenibut, an analogue of the neurotransmitter GABA, has also been implicated in high doses. The reaction which has been shown to be T-cell mediated may also cause eosinophilia-myalgia syndrome. 426:-inducing disorder in the eosinophil cell lineage that causes eosinophil blood counts greater than 1,500/μL. The most recent (2017) World health organization criteria specifically excludes from this disorder hypereosinophilia/eosinophilia associated with 1363:. The disorder is clonal with regard to the production of abnormal T-cell lymphocytes not eosinophils which appear phenotypically normal. The phenotypically aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of 1704:

which can recruit more eosinophils and other inflammatory cells to the area and hence amplify and perpetuate the damage. This process is generally accepted to be the major inflammatory process in the pathophysiology of atopic or allergic asthma.

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is most likely to provoke eosinophilia, though any other cancer can cause the condition. Solid epithelial cell tumors have been shown to cause both tissue and blood eosinophilia, with some reports indicating that this may be mediated by

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function tests, and serologic tests for parasitic and connective tissue diseases. The stool is often examined for traces of parasites (i.e. eggs, larvae, etc.) though a negative test does not rule out parasitic infection; for example,

959:. These drugs may cause severely toxic reactions such as the DRESS syndrome. Other drugs and drug classes often reported to cause increased blood eosinophil levels accompanied by less severe (e.g. non-DRESS syndrome) symptoms include 1717:(CBC). However, in some cases, a more accurate absolute eosinophil count may be needed. Medical history is taken, with emphasis on travel, allergies and drug use. Specific test for causative conditions are performed, often including 1528:

of a large artery dislodge, travel downstream in the blood, and clog smaller arteries. This results in obstructive damage to multiple organs and tissues. Affected tissues exhibit acute inflammation involving eosinophils,

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Valent P, Klion AD, Horny HP, Roufosse F, Gotlib J, Weller PF, Hellmann A, Metzgeroth G, Leiferman KM, Arock M, Butterfield JH, Sperr WR, Sotlar K, Vandenberghe P, Haferlach T, Simon HU, Reiter A, Gleich GJ (2012).

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Primary hypereosinophilia is due to the development of a clone of eosinophils, i.e. a group of genetically identical eosinophils derived from a significantly mutated ancestor cell. The clone may prove to be benign,

1429:. Similar to lymphocyte-variant hypereosinophilia, the increased levels of blood eosinophils in Gleich's syndrome is thought to be secondary to the secretion of eosinophil-stimulating cytokines by a T cell clones. 1206:

these disorders. Other types of lymphoid malignancies have been associated with eosinophilia, as in lymphoblastic leukemia with a translocation between chromosomes 5 and 14 or alterations in the genes which encode

1569:, low levels of these hormones allow increased eosinophil proliferation and survival. This leads to increases in blood eosinophil levels, typically eosinophilia and, less commonly, hypereosinophilia. 1229:

diseases are inborn errors in the immune system due to defective genes. Certain of these disorders are sometimes or often associated with hypereosinophilia. The list of such disorders includes

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can be diagnostic for allergic causes, as the eosinophilia should resolve with suppression of the immune over-response. Neoplastic disorders are diagnosed through the usual methods, such as

485:) cell counts in the bone marrow and peripheral blood must be less than 20% and the chromosomal alterations (inv(16)(p13.1q22)) and t(16;16)(p13;q22) as well as other features diagnostic of 3097:

Fathi AT, Dec GW, Richter JM, et al. (February 2014). "Case records of the Massachusetts General Hospital. Case 7-2014. A 27-year-old man with diarrhea, fatigue, and eosinophilia".

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Manti S, Leonardi S, Salpietro A, Del Campo G, Salpietro C, Cuppari C (2017). "A systematic review of food protein-induced enterocolitis syndrome from the last 40 years".

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Beeken WL, Northwood I, Beliveau C, Baigent G, Gump D (1987). "Eosinophils of human colonic mucosa: C3b and Fc gamma receptor expression and phagocytic capabilities".

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Eosinophilia and comparatively fewer cases of hypereosinophilia are associated with the following known diseases that are known or thought to have an allergic basis:

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are common causes of hypereosinophilia and eosinophilia in areas endemic to these parasites. Helminths infections causing increased blood eosinophil counts include:

2530:"Chronic eosinophilic leukemia – not otherwise specified has a poor prognosis with unresponsiveness to conventional treatment and high risk of acute transformation" 146:

Eosinophil counts in human blood normally range between 100 and 500 per/μL. Maintenance of these levels results from a balance between production of eosinophils by

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Angelis, M; Yu, M; Takanishi, D; Hasaniya, NW; Brown, MR (December 1996). "Eosinophilia as a marker of adrenal insufficiency in the surgical intensive care unit".

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Certain types of food allergy disorders may also be associated with eosinophilia or, less commonly, hypereosinophilia. Allergic eosinophilic esophagitis and the

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Carruthers MN, Park S, Slack GW, Dalal BI, Skinnider BF, Schaeffer DF, Dutz JP, Law JK, Donnellan F, Marquez V, Seidman M, Wong PC, Mattman A, Chen LY (2017).

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is a sustained elevation in this count above 1.5 × 10/L (i.e. 1,500/μL) that is also associated with evidence of eosinophil-based tissue injury.

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to migrate from the blood and localize in affected tissues. Accumulation of eosinophils in tissues can be significantly damaging. Eosinophils, like other

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gene). More than 30 other primary immunodeficiency diseases are sometimes associated with modest increases in eosinophil counts, i.e. eosinophilia. The

3963: 1379:. Accumulation of partial deletions in the short arm of chromosome 6, the long arm of chromosome 10, or the acquirement of an extra chromosome (i.e. 526:

family studies localize the gene responsible for it to chromosome 5 at position q31–q33, between markers D5S642 and D5S816. This region contains a

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are less likely to have efficacy in this variant of hypereosinophilia than in many cases of clonal eosinophilia or chronic eosinophilic leukemia.

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Gotlib J (2014). "World Health Organization-defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management".

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Clonal hypereosinophilia is hypereosinophilia caused by a pre-malignant or malignant clone of eosinophils that bear mutations in genes for

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Klion AD, Law MA, Riemenschneider W, McMaster ML, Brown MR, Horne M, Karp B, Robinson M, Sachdev V, Tucker E, Turner M, Nutman TB (2004).

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Butt NM, Lambert J, Ali S, Beer PA, Cross NC, Duncombe A, Ewing J, Harrison CN, Knapper S, McLornan D, Mead AJ, Radia D, Bain BJ (2017).

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the disorder in each individual case typically is limited to the affected organ. Examples of organ-restricted hypereosinophilia include

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Montgomery ND, Dunphy CH, Mooberry M, Laramore A, Foster MC, Park SI, Fedoriw YD (2013). "Diagnostic complexities of eosinophilia".

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endothelial cells prominently infiltrated by lymphocytes and eosinophils and is associated with hypereosinophilia or eosinophilia.

165:(usually less than 8%), have a half-life in the circulation of only 8–18 hours, but persist in tissues for at least several weeks. 1782:

may be used. However, immune suppression, the mechanism of action of corticosteroids, can be fatal in patients with parasitosis.

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Treatment is directed toward the underlying cause. However, in primary eosinophilia, or if the eosinophil count must be lowered,

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which includes three genes whose protein products function in regulating the development and proliferation of eosinophils viz.,

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Secondary (or reactive) eosinophilias are non-clonal increases in blood eosinophil levels caused by an underlying disease. The

450: 1997: 1316: 1288: 1054:, also associated with hypereosinophilia, appears due to trace contaminants in certain commercial batches of the amino acid, 817: 2892:

Nunes MC, Guimarães Júnior MH, Diamantino AC, Gelape CL, Ferrari TC (2017). "Cardiac manifestations of parasitic diseases".

196:, and the killing of tumor cells. In conducting these functions, eosinophils produce and release on demand a range of toxic 3055:"The Importance of Quality Specifications in Safety Assessments of Amino Acids: The Cases of l-Tryptophan and l-Citrulline" 4285: 4245: 4191: 4042: 446: 417: 310: 257: 2796:"World Health Organization-defined eosinophilic disorders: 2015 update on diagnosis, risk stratification, and management" 2257:"World Health Organization-defined eosinophilic disorders: 2017 update on diagnosis, risk stratification, and management" 1256: 1130:. Some hematological malignancies are likewise associated with secondary rises in blood eosinophil counts; these include 1980: 1963: 1928: 1923: 1885: 1880: 1603: 798: 778: 454: 1684:

Harm resulting from untreated eosinophilia potentially varies with cause. During an allergic reaction, the release of

837: 662: 542: 249: 1421:, which may be a form of lymphocyte-variant hypereosinophilia, involves hypereosinophilia, elevated blood levels of 4295: 4137: 825: 591: 486: 237: 104: 306:(i.e. high eosinophil blood counts caused by mutations in the eosinophil cell line of one of these three genes), ' 1619: 1159: 1123: 291: 193: 2651:"Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes" 1634:. Other examples of organ-restricted hepereosinophilia include those involving the heart, kidney, liver, colon, 3840: 1958: 1953: 1849: 1599: 1595: 1476: 1220: 1151: 1143: 873: 849: 438: 427: 368: 344: 3919: 3690: 3437:

Oxford Respiratory Medicine Library: Asthma, 2nd ed., ed. Graeme P. Currie and John. F. W. Baker, OUP, 2012.

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is associated with hypereosinophilia/eosinophilia and systemic symptoms due to one or more contaminants in

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Szczawinska-Poplonyk A, Kycler Z, Pietrucha B, Heropolitanska-Pliszka E, Breborowicz A, Gerreth K (2011).

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is associated with hypereosinophilia or eosinophilia due to mutations in any one of the following genes:

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Allergic reactions to drugs are a common cause of eosinophilia, with manifestations ranging from diffuse

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normal tissues. This can result in serious damage to such organs as the lung, heart, kidneys, and brain.

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Curtis C, Ogbogu PU (2015). "Evaluation and Differential Diagnosis of Persistent Marked Eosinophilia".

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levels that reach ranges diagnostic of eosinophilia or, far more commonly, hypereosinophilia. It is an

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A wide range of drugs are known to cause hypereosinophilia or eosinophilia accompanied by an array of

3356:"Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review" 1968: 1906: 1868: 1858: 1803: 1747: 1714: 1521: 1515: 1438: 1418: 1413: 1185: 833: 813: 546: 189: 120: 3829: 3274:"IgG4-related disease and lymphocyte-variant hypereosinophilic syndrome: A comparative case series" 3223:"The hyperimmunoglobulin E syndrome--clinical manifestation diversity in primary immune deficiency" 2086: 1992: 1895: 1863: 1754:. In cases of idiopathic eosinophilia, the patient is followed for complications. A brief trial of 1726: 1036: 889: 821: 794: 667: 562: 550: 508: 404: 245: 42: 1367:

which in studied cases appears due to their excess production of interleukin 5, interleukin 3, or

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Roufosse F (2013). "L4. Eosinophils: how they contribute to endothelial damage and dysfunction".

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and biopsy for the leukemias, MRI/CT to look for solid tumors, and tests for serum LDH and other

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Idiopathic hypereosinophilia (also termed hypereosinophilia of undetermined significance, i.e. HE

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Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007). "Table 12-6".

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Ho MH, Wong WH, Chang C (2014). "Clinical spectrum of food allergies: a comprehensive review".

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Prakash Babu S, Chen YK, Bonne-Annee S, Yang J, Maric I, Myers TG, Nutman TB, Klion AD (2017).

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and serotonin mediated release of eosinophil granules occur, complement complex (C5-C6-C7),

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the eosinophils associated with the disorder have not been shown to be clonal in nature;

4123: 3753: 3728: 3380: 3355: 3249: 3222: 3198: 3171: 2727: 2702: 2675: 2650: 2462: 2437: 2378: 2353: 2172:(18th ed.). Whitehouse Station, New Jersey: Merck Research Laboratories. pp. 2003: 1933: 1834: 1730: 1674: 1464: 1460: 1448: 1393: 1368: 1320: 1197: 1099: 1087: 1066: 1016: 972: 770: 766: 749: 736: 713: 694: 609:

of the hypereosinophilia in these diseases is thought to be the release of one or more

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Lymphocyte-variant hypereosinophilia is a disorder attributed to the expansion of a

4128: 4112: 4021: 3991: 3004: 2514: 2438:"A Player and Coordinator: The Versatile Roles of Eosinophils in the Immune System" 1456: 1452: 1328: 1283: 1055: 1047: 960: 774: 728: 606: 530: 523: 229: 136: 3891: 3845: 2905: 2771: 2754: 17: 4200: 4187: 4094: 4032: 1735: 1718: 1697: 1670: 1542: 1397: 1202: 1095: 1070: 1032: 996: 988: 964: 940: 928: 916: 841: 758: 701: 678: 630: 381: 201: 169: 147: 116: 3667: 3650: 3031: 2845:"Recent advances in pathogenesis and management of hypereosinophilic syndromes" 2666: 2620: 2603: 2103: 4233: 4172: 4142: 4065: 4003: 3897: 3856: 3819: 3626: 3609: 3536: 3519: 3416: 3331: 3314: 3188: 3134:"Peripheral eosinophilia in a case of adenocarcinoma lung: A rare association" 2988: 2953: 2414: 2369: 1875: 1839: 1814:

can cause eosinophilia. Diseases that feature eosinophilia as a sign include:

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Transient, fluctuating hypereosinophilia occurs in 60–80% of individuals with

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drugs were uniform but 16 ultimately required corticosteroid-sparing agents.

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overproduction production of IL-3, leading to blood and tissue eosinophilia.

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Chronic eosinophilic leukemia, not otherwise specified (i.e. CEL, NOS), is a

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Eosinophils in the peripheral blood of a patient with idiopathic eosinophilia

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and the emigration of circulating eosinophils out of the blood through post-

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precursor cells, i.e. CFU-Eos, to proliferate and mature into eosinophils;

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into tissues. Eosinophils represent a small percentage of peripheral blood

3504: 3371: 3071: 3054: 2317: 4147: 3999: 3987: 3744: 2578:"EOS eosinophilia, familial [Homo sapiens (human)] – Gene – NCBI" 2577: 1701: 1534: 1472: 1401: 1356: 1189: 1020: 744: 610: 527: 423: 213: 3649:

Séguéla PE, Iriart X, Acar P, Montaudon M, Roudaut R, Thambo JB (2015).

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Oketch-Rabah HA, Roe AL, Gurley BJ, Griffiths JC, Giancaspro GI (2016).

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a reason for the increase in blood eosinophils has not been determined;

3729:"Epidemiologic, clinical, and diagnostic aspects of coccidioidomycosis" 3651:"Eosinophilic cardiac disease: Molecular, clinical and imaging aspects" 2161: 1818: 1647: 1426: 1380: 924: 908: 709: 185: 151: 132: 3787: 3560:

Eosinophilic Granulomatosis with Polyangiitis (Churg–Strauss Syndrome)

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are the most common cause. A parasitic infection of nearly any bodily

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Hypereosiophilia or eosinophilia may be associated with the following

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Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of

3814: 3799: 1824: 1795: 1305: 1251: 1193: 865: 762: 558: 357: 351: 158: 3916: 2703:"Dysregulation of interleukin 5 expression in familial eosinophilia" 1661:-mediated eosinophil production is induced by compounds released by 1681:, and histamine (though this has a narrow range of concentration). 282:

Primary, i.e. caused by abnormalities in the eosinophil cell line;

3867: 1371:. The disorder is usually indolent but infrequently progresses to 1297: 1293: 1246: 1235: 363: 181: 96: 2528:

Helbig G, Soja A, Bartkowska-Chrobok A, Kyrcz-Krzemień S (2012).

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promote release of bone marrow eosinophils into the circulation,

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compared to other congenital and acquired eosinophilic diseases.

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acute eosinophilic or other types of acute myelogenous leukemia.

2202:"Guideline for the investigation and management of eosinophilia" 1388: 1337: 1333: 1311: 1301: 1273: 1241: 1184:(Hodgkin's disease) often elicits severe eosinophilia; however, 899:

are commonly associated with increased blood eosinophil levels.

554: 398: 392: 386: 377: 373: 3959: 2590: 1977:(Valley fever), a fungal disease prominent in the US Southwest. 911:. Rarely, these reactions are severe causing, for example, the 511:

characterized by the presence of sustained elevations in blood

216:) and they also release on demand a preformed armamentarium of 2000:, an immune disorder characterized by high levels of serum IgE 1590:

organ damage has not been shown to be due to eosinophils; and

1545:. The cause for this hypereosinophilic response is not known. 1422: 782: 1798:

diseases are the most common causes, especially those of the

1383:) 7) in T-cells or the proliferation of lymphocytes with the 481:

fusion genes. For this diagnosis, immature eosinophil (e.g.

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are uncommon: familial eosinophilia typically has a benign

172:; they function to neutralize invading microbes, primarily 3172:"Primary immunodeficiencies associated with eosinophilia" 3132:

Takhar, Rajendra; Motilal, Bunkar; Savita, Arya (2015).

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and stress-induced suppression of adrenal gland function

457:, clonal eosinophilias involving gene rearrangements of 286:

Secondary, i.e. caused by non-eosinophil disorders; and

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on American Academy of Allergy, Asthma & Immunology

1524:. In this disorder, cholesterol crystals located in an 1359:-producing, aberrant population of a particular T-cell 1067:

drug reactions with eosinophilia and systemic symptoms

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Eosinophils are one form of terminally differentiated

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Saubolle MA, McKellar PP, Sussland D (January 2007).

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drug reaction with eosinophilia and systemic symptoms

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is an elevation in an individual's circulating blood

3777: 1565:, inhibit eosinophil proliferation and survival. In 4276: 4232: 4223: 4169: 4162: 4109: 4102: 4093: 4062: 4055: 4018: 4011: 3998: 3877: 3781: 3610:"Blood and Bone Marrow Evaluation for Eosinophilia" 3576:Arlettaz L, Abdou M, Pardon F, Dayer E (2012). "". 3520:"Blood and Bone Marrow Evaluation for Eosinophilia" 2591:

OMIM Entry - % 131400 - EOSINOPHILIA, FAMILIAL

2160:Beers, Mark; Porter, Robert; Jones, Thomas (2006). 642:hypereosinophilia or eosinophilia are given below. 54: 35: 3696:American College of Allergy, Asthma and Immunology 2165: 1192:produce less marked eosinophilia. Of solid tumor 127:eosinophilia, the disease may be controlled with 2097:(6). New York: Elsevier: 1291–300, quiz 1301–2. 615:granulocyte macrophage colony stimulating factor 3614:Archives of Pathology & Laboratory Medicine 3603: 3601: 3599: 3524:Archives of Pathology & Laboratory Medicine 3405:Archives of Pathology & Laboratory Medicine 3319:Archives of Pathology & Laboratory Medicine 3165: 3163: 3161: 2942:Immunology and Allergy Clinics of North America 2935: 2933: 2931: 2748: 2746: 2696: 2694: 2643: 2641: 2639: 2347: 1341:, or, more rarely, one of several other genes. 402:and chromosomal translocations that create the 3138:The Journal of Association of Chest Physicians 2655:The Journal of Allergy and Clinical Immunology 2345: 2343: 2341: 2339: 2337: 2335: 2333: 2331: 2329: 2327: 2250: 2248: 2246: 2244: 2242: 2240: 2195: 2193: 1317:mutations in the hymperimmoglobulin E syndrome 27:Excess number of eosinophil cells in the blood 3971: 3354:Zhang J, Zhang HY, Chen SZ, Huang JY (2016). 3315:"Angiolymphoid hyperplasia with eosinophilia" 1939:Eosinophilic granulomatosis with polyangiitis 1669:, including eosinophil chemotactic factor of 806:eosinophilic granulomatosis with polyangiitis 431:fusion gene-positive chronic myeloid leukemia 8: 3461: 3459: 3457: 3455: 3453: 3451: 3449: 3447: 3445: 3443: 2977:Clinical Reviews in Allergy & Immunology 1239:gene), CD3gamma chain deficiency (defective 260:). These agents serve to orchestrate robust 3493:Journal of the American College of Surgeons 2604:"Familial eosinophilia: a benign disorder?" 2085:Simon, Dagmar; HU Simon (16 January 2007). 1501:Angiolymphoid hyperplasia with eosinophilia 1495:Angiolymphoid hyperplasia with eosinophilia 1176:myelodysplastic–myeloproliferative syndrome 897:food protein-induced enterocolitis syndrome 4229: 4166: 4106: 4099: 4059: 4015: 4008: 3978: 3964: 3956: 3778: 3092: 3090: 3020:Annals of Allergy, Asthma & Immunology 2091:Journal of Allergy and Clinical Immunology 469:, and chromosome translocations that form 41: 32: 3917:Hypereosinophilic Syndrome research in UK 3752: 3666: 3625: 3535: 3379: 3330: 3289: 3248: 3238: 3197: 3187: 3149: 3070: 2860: 2811: 2770: 2726: 2674: 2619: 2545: 2461: 2377: 2272: 2220: 2168:The Merck Manual of Diagnosis and Therapy 2102: 3470:(8th ed.). Philadelphia: Saunders. 3176:Allergy, Asthma, and Clinical Immunology 2155: 2153: 2151: 2149: 1208:platelet-derived growth factor receptors 2843:Roufosse F, Cogan E, Goldman M (2004). 2298:Clinical Immunology and Immunopathology 2147: 2145: 2143: 2141: 2139: 2137: 2135: 2133: 2131: 2129: 2080: 2078: 2076: 2074: 2072: 2070: 2068: 2066: 2064: 2062: 2034: 1279:autoimmune lymphoproliferative syndrome 886:allergic bronchopulmonary aspergillosis 882:aspirin-exacerbated respiratory disease 4268:Neutrophil-specific granule deficiency 1989:Idiopathic hypereosinophilic syndrome. 1365:bone marrow eosinophil-precursor cells 888:, chronic eosinophilic pneumonia, and 561:, of these genes or within the common 3360:Experimental and Therapeutic Medicine 2755:"Myeloid neoplasms with eosinophilia" 2436:Long H, Liao W, Wang L, Lu Q (2016). 1632:eosinophilic ulcer of the oral mucosa 119:. Diagnosis of eosinophilia is via a 7: 4291:Neutrophil immunodeficiency syndrome 2442:Transfusion Medicine and Hemotherapy 1912:Lymphocyte-variant hypereosinophilia 1578:hypereosinophilic syndrome because: 1425:antibodies, and clonal expansion of 1351:Lymphocyte-variant hypereosinophilia 1345:Lymphocyte-variant hypereosinophilia 1075:nonsteroidal anti-inflammatory drugs 586:Idiopathic hypereosiophilic syndrome 3655:Archives of Cardiovascular Diseases 1573:Organ-restricted hypereosinophilias 412:Chronic eosinophilic leukemia (NOS) 4321:Monocyte and granulocyte disorders 1806:systems. In the developing world, 545:. However, no functional sequence 150:eosinophil precursor cells termed 25: 3227:Orphanet Journal of Rare Diseases 1692:causes vasodilation which allows 1215:Primary immunodeficiency diseases 1172:T-lymphoblastic leukemia/lymphoma 4184:Granulocytopenia/agranulocytosis 3944:Hypereosinophilic Syndrome (HES) 2862:10.1111/j.1398-9995.2004.00465.x 1447:-related disease is a condition 294:classifies these disorders into 3278:European Journal of Haematology 2352:Kovalszki A, Weller PF (2016). 1168:chronic myelomonocytic leukemia 706:tropical pulmonary eosinophilia 451:chronic myelomonocytic leukemia 290:Idiopathic, cause unknown. The 95:count above 1.5 × 10/ 2800:American Journal of Hematology 2534:American Journal of Hematology 2487:American Journal of Hematology 2261:American Journal of Hematology 2209:British Journal of Haematology 1998:Hyperimmunoglobulin E syndrome 1289:hyperimmunoglobulin E syndrome 818:progressive systemic sclerosis 777:); and viral infections, e.g. 765:infections (e.g. disseminated 1: 4286:Chronic granulomatous disease 4246:Leukocyte adhesion deficiency 4192:Severe congenital neutropenia 4043:Chronic granulomatous disease 1065:, to severe life-threatening 1052:eosinophilia–myalgia syndrome 447:chronic neutrophilic leukemia 418:Chronic eosinophilic leukemia 311:Chronic eosinophilic leukemia 258:eosinophil-derived neurotoxin 3711:Eosinophilic Gastroenteritis 2906:10.1136/heartjnl-2016-309870 2772:10.1182/blood-2016-10-695973 2310:10.1016/0090-1229(87)90138-3 1981:Human immunodeficiency virus 1964:Eosinophilic gastroenteritis 1929:Systemic lupus erythematosus 1924:Systemic autoimmune diseases 1886:Chronic myelogenous leukemia 1881:Acute lymphoblastic leukemia 1604:eosinophilic gastroenteritis 1327:characterized by skin rash, 799:systemic lupus erythematosus 779:Human T-lymphotropic virus 1 574:Idiopathic hypereosinophilia 455:chronic myelogenous leukemia 240:), and toxic proteins (e.g. 75:is a condition in which the 3170:Navabi B, Upton JE (2016). 2753:Reiter A, Gotlib J (2017). 1178:-associated eosinophilias. 1086:with these effects include 838:inflammatory bowel diseases 663:Angiostrongylus cantonensis 601:Secondary hypereosinophilia 543:colony stimulating factor 2 250:eosinophil cationic protein 188:. They also participate in 139:) unless it is idiopathic. 4337: 4296:Myeloperoxidase deficiency 4138:Hypereosinophilic syndrome 3950:Hypereosinophilic syndrome 3935:Hypereosinophilic Syndrome 3929:Hypereosinophilic Syndrome 3691:"Eosinophilic Esophagitis" 3668:10.1016/j.acvd.2015.01.006 3518:Boyer, DF (October 2016). 3032:10.1016/j.anai.2017.02.005 2667:10.1016/j.jaci.2012.02.019 2621:10.1182/blood-2003-11-3850 2104:10.1016/j.jaci.2007.02.010 1513: 1498: 1487:as first-line therapy and 1459:(i.e. inflammation of the 1436: 1411: 1348: 1218: 826:thromboangiitis obliterans 592:Hypereosinophilic syndrome 589: 497: 487:acute myelogenous leukemia 415: 342: 238:platelet activating factor 180:but also certain types of 105:hypereosinophilic syndrome 3627:10.5858/arpa.2016-0223-RA 3537:10.5858/arpa.2016-0223-RA 3417:10.5858/arpa.2011-0597-RA 3332:10.5858/arpa.2013-0334-RS 3313:Guo R, Gavino AC (2015). 3189:10.1186/s13223-016-0130-4 2989:10.1007/s12016-012-8339-6 2954:10.1016/j.iac.2015.04.001 2415:10.1016/j.lpm.2013.01.005 2370:10.1016/j.pop.2016.07.010 1620:eosinophilic folliculitis 1160:essential thrombocythemia 1144:myelodysplastic syndromes 1069:(DRESS). Drugs that has, 322:Primary hypereosinophilia 292:World Health Organization 194:Graft-versus-host disease 49: 40: 4263:Chédiak–Higashi syndrome 4225:Disorder of phagocytosis 3151:10.4103/2320-8775.158859 3059:The Journal of Nutrition 2087:"Eosinophilic Disorders" 2046:"Eosinophilic Disorders" 1986:Interstitial nephropathy 1959:Eosinophilic esophagitis 1954:Eosinophilic myocarditis 1850:Dermatitis herpetiformis 1746:or low white blood cell 1600:eosinophilic esophagitis 1596:eosinophilic myocarditis 1491:as second-line therapy. 1477:retroperitoneal fibrosis 1443:IgG4-related disease or 1407: 1325:immunodeficiency disease 1257:Wiskott–Aldrich syndrome 1221:Primary immunodeficiency 1152:chronic myeloid leukemia 874:eosinophilic esophagitis 850:dermatitis herpetiformis 439:essential thrombocytosis 369:chromosome translocation 345:Clonal hypereosinophilia 339:Clonal hypereosinophilia 228:, lipid mediators (e.g. 131:. Eosinophilia is not a 3468:Robbins Basic Pathology 1628:eosinophilic vasculitis 1624:eosinophilic cellulitis 1170:, and certain cases of 198:reactive oxygen species 3240:10.1186/1750-1172-6-76 3111:10.1056/NEJMcpc1302331 2023:Acidophile (histology) 1944:Eosinophilic fasciitis 1840:Allergic skin diseases 1760:bone marrow aspiration 1616:eosinophilic fasciitis 1612:eosinophilic pneumonia 1526:atherosclerotic plaque 1455:, lymphadentitis, and 1249:deficiency (defective 1140:acute myeloid leukemia 802:eosinophilic fasciitis 683:visceral larva migrans 266:inflammatory responses 3578:Revue Médicale Suisse 3372:10.3892/etm.2016.3349 3072:10.3945/jn.115.227280 2009:Familial eosinophilia 1948:Eosinophilic myositis 1917:Systemic mastocytosis 1891:Eosinophilic leukemia 1608:eosinophilic cystitis 1567:adrenal insufficiency 1549:Adrenal insufficiency 1522:cholesterol embolisms 1475:, respectively) plus 1323:is a severe combined 1148:systemic mastocytosis 549:are found within the 547:genetic polymorphisms 505:Familial eosinophilia 500:Familial eosinophilia 494:Familial eosinophilia 443:primary myelofibrosis 367:or, alternatively, a 254:eosinophil peroxidase 3745:10.1128/JCM.02230-06 1993:Congenital disorders 1969:Cholesterol embolism 1907:non-Hodgkin lymphoma 1864:Parasitic infections 1859:IgG4-related disease 1790:Eosinophilia can be 1748:alkaline phosphatase 1715:complete blood count 1516:Cholesterol embolism 1510:Cholesterol embolism 1439:IgG4-related disease 1433:IgG4-related disease 1186:non-Hodgkin lymphoma 834:IgG4-related disease 814:rheumatoid arthritis 755:Dientamoeba fragilis 190:transplant rejection 121:complete blood count 3065:(12): 2643S–2651S. 2409:(4 Pt 2): 503–507. 1896:Clonal eosinophilia 1037:hydrochlorothiazide 795:autoimmune diseases 789:Autoimmune diseases 668:Hookworm infections 509:congenital disorder 246:major basic protein 117:parasitic infection 4196:Cyclic neutropenia 3922:2018-08-05 at the 3878:External resources 3733:J. Clin. Microbiol 3699:. 16 January 2015. 1975:Coccidioidomycosis 1752:myeloproliferation 1742:. Elevated serum B 1063:maculopapular rash 1044:toxic oil syndrome 846:bullous pemphigoid 519:disorder in which 517:autosomal dominant 242:metalloproteinases 61:Infectious disease 4308: 4307: 4304: 4303: 4278:Respiratory burst 4219: 4218: 4215: 4214: 4158: 4157: 4089: 4088: 4085: 4084: 4051: 4050: 3912: 3911: 3608:Boyer DF (2016). 3477:978-1-4160-2973-1 3291:10.1111/ejh.12842 2813:10.1002/ajh.24196 2806:(11): 1077–1089. 2794:Gotlib J (2015). 2719:10.1111/all.13146 2661:(3): 607–612.e9. 2614:(11): 4050–4055. 2547:10.1002/ajh.23193 2499:10.1002/ajh.23664 2454:10.1159/000445215 2274:10.1002/ajh.24880 2267:(11): 1243–1259. 2255:Gotlib J (2017). 2222:10.1111/bjh.14488 1869:Addison's disease 1636:pulmonary pleurae 1445:Immunoglobulin G4 1419:Gleich's syndrome 1414:Gleich's syndrome 1408:Gleich's syndrome 1277:gene defect, and 1156:polycythemia vera 909:allergic symptoms 878:chronic sinusitis 870:atopic dermatitis 862:allergic rhinitis 856:Allergic diseases 747:infections, e.g. 435:polycythemia vera 371:that creates the 113:allergic reaction 89:Hypereosinophilia 70: 69: 30:Medical condition 18:Hypereosinophilia 16:(Redirected from 4328: 4230: 4177: 4167: 4117: 4107: 4100: 4070: 4060: 4026: 4016: 4009: 3980: 3973: 3966: 3957: 3779: 3767: 3766: 3756: 3724: 3718: 3707: 3701: 3700: 3687: 3681: 3680: 3670: 3646: 3640: 3639: 3629: 3605: 3594: 3593: 3573: 3567: 3556: 3550: 3549: 3539: 3515: 3509: 3508: 3488: 3482: 3481: 3463: 3438: 3435: 3429: 3428: 3400: 3394: 3393: 3383: 3366:(2): 1012–1018. 3351: 3345: 3344: 3334: 3310: 3304: 3303: 3293: 3269: 3263: 3262: 3252: 3242: 3218: 3212: 3211: 3201: 3191: 3167: 3156: 3155: 3153: 3129: 3123: 3122: 3094: 3085: 3084: 3074: 3050: 3044: 3043: 3015: 3009: 3008: 2972: 2966: 2965: 2937: 2926: 2925: 2889: 2883: 2882: 2864: 2840: 2834: 2833: 2815: 2791: 2785: 2784: 2774: 2750: 2741: 2740: 2730: 2713:(9): 1338–1345. 2698: 2689: 2688: 2678: 2645: 2634: 2633: 2623: 2599: 2593: 2588: 2582: 2581: 2574: 2568: 2567: 2549: 2525: 2519: 2518: 2482: 2476: 2475: 2465: 2433: 2427: 2426: 2398: 2392: 2391: 2381: 2349: 2322: 2321: 2293: 2287: 2286: 2276: 2252: 2235: 2234: 2224: 2206: 2197: 2188: 2187: 2171: 2157: 2124: 2123: 2121: 2119: 2106: 2082: 2057: 2056: 2054: 2053: 2048:. Merck & Co 2042: 1901:Hodgkin lymphoma 1713:Diagnosis is by 1557:secreted by the 1555:steroid hormones 1489:interferon gamma 1231:ZAP70 deficiency 1227:immunodeficiency 1182:Hodgkin lymphoma 1146:, many cases of 1136:T-cell lymphomas 890:Kimura's disease 830:Behçet's disease 822:Sjögren syndrome 676:strongyloidiasis 206:hypobromous acid 135:(rather, only a 86: 81:peripheral blood 45: 33: 21: 4336: 4335: 4331: 4330: 4329: 4327: 4326: 4325: 4311: 4310: 4309: 4300: 4272: 4211: 4170: 4154: 4110: 4081: 4063: 4047: 4019: 3994: 3984: 3931:on patient.info 3924:Wayback Machine 3913: 3908: 3907: 3873: 3872: 3790: 3776: 3771: 3770: 3726: 3725: 3721: 3708: 3704: 3689: 3688: 3684: 3648: 3647: 3643: 3607: 3606: 3597: 3575: 3574: 3570: 3557: 3553: 3517: 3516: 3512: 3490: 3489: 3485: 3478: 3465: 3464: 3441: 3436: 3432: 3402: 3401: 3397: 3353: 3352: 3348: 3312: 3311: 3307: 3271: 3270: 3266: 3220: 3219: 3215: 3169: 3168: 3159: 3131: 3130: 3126: 3099:N. Engl. J. Med 3096: 3095: 3088: 3052: 3051: 3047: 3017: 3016: 3012: 2974: 2973: 2969: 2939: 2938: 2929: 2891: 2890: 2886: 2842: 2841: 2837: 2793: 2792: 2788: 2752: 2751: 2744: 2700: 2699: 2692: 2647: 2646: 2637: 2601: 2600: 2596: 2589: 2585: 2576: 2575: 2571: 2527: 2526: 2522: 2484: 2483: 2479: 2435: 2434: 2430: 2403:Presse Médicale 2400: 2399: 2395: 2351: 2350: 2325: 2295: 2294: 2290: 2254: 2253: 2238: 2204: 2199: 2198: 2191: 2184: 2159: 2158: 2127: 2117: 2115: 2084: 2083: 2060: 2051: 2049: 2044: 2043: 2036: 2031: 2019: 1788: 1776:corticosteroids 1772: 1756:corticosteroids 1745: 1711: 1656: 1654:Pathophysiology 1575: 1563:glucocorticoids 1551: 1518: 1512: 1503: 1497: 1481:corticosteroids 1465:salivary glands 1461:lacrimal glands 1441: 1435: 1416: 1410: 1377:Sezary syndrome 1373:T-cell lymphoma 1353: 1347: 1223: 1217: 1174:-associated or 1132:Hodgkin disease 1110:cancers of the 1104:thyroid cancers 1083: 905: 858: 810:dermatomyositis 791: 741:fasciolopsiasis 725:schistosomiasis 687:Gnathostomiasis 648: 603: 594: 588: 581: 576: 521:genetic linkage 502: 496: 420: 414: 347: 341: 324: 275: 129:corticosteroids 87:10/L (500/μL). 84: 31: 28: 23: 22: 15: 12: 11: 5: 4334: 4332: 4324: 4323: 4313: 4312: 4306: 4305: 4302: 4301: 4299: 4298: 4293: 4288: 4282: 4280: 4274: 4273: 4271: 4270: 4265: 4260: 4259: 4258: 4253: 4242: 4240: 4227: 4221: 4220: 4217: 4216: 4213: 4212: 4210: 4209: 4203: 4198: 4180: 4178: 4164: 4160: 4159: 4156: 4155: 4153: 4152: 4151: 4150: 4145: 4140: 4131: 4124:granulocytosis 4120: 4118: 4104: 4097: 4091: 4090: 4087: 4086: 4083: 4082: 4080: 4079: 4073: 4071: 4057: 4053: 4052: 4049: 4048: 4046: 4045: 4040: 4035: 4029: 4027: 4013: 4006: 3996: 3995: 3985: 3983: 3982: 3975: 3968: 3960: 3954: 3953: 3952:on Mayo Clinic 3947: 3941: 3932: 3926: 3910: 3909: 3906: 3905: 3894: 3882: 3881: 3879: 3875: 3874: 3871: 3870: 3859: 3848: 3837: 3822: 3807: 3791: 3786: 3785: 3783: 3782:Classification 3775: 3774:External links 3772: 3769: 3768: 3719: 3702: 3682: 3641: 3620:(10): 1060–7. 3595: 3584:(337): 854–8. 3568: 3551: 3530:(10): 1060–7. 3510: 3483: 3476: 3439: 3430: 3411:(2): 259–269. 3395: 3346: 3325:(5): 683–686. 3305: 3284:(4): 378–387. 3264: 3213: 3157: 3124: 3086: 3045: 3026:(4): 411–418. 3010: 2983:(3): 225–240. 2967: 2948:(3): 387–402. 2927: 2900:(9): 651–658. 2884: 2855:(7): 673–689. 2835: 2786: 2765:(6): 704–714. 2742: 2690: 2635: 2594: 2583: 2569: 2540:(6): 643–645. 2520: 2493:(3): 325–337. 2477: 2428: 2393: 2364:(4): 607–617. 2354:"Eosinophilia" 2323: 2304:(3): 289–300. 2288: 2236: 2215:(4): 553–572. 2189: 2182: 2125: 2058: 2033: 2032: 2030: 2027: 2026: 2025: 2018: 2015: 2014: 2013: 2012: 2011: 2006: 2004:Omenn syndrome 2001: 1990: 1987: 1984: 1978: 1972: 1966: 1961: 1956: 1951: 1950: 1949: 1946: 1941: 1936: 1934:Kimura disease 1931: 1921: 1920: 1919: 1914: 1909: 1905:Some forms of 1903: 1898: 1893: 1888: 1883: 1874:Some forms of 1872: 1866: 1861: 1856: 1855: 1854: 1853: 1852: 1847: 1837: 1835:Drug allergies 1832: 1827: 1787: 1786:List of causes 1784: 1771: 1768: 1743: 1710: 1707: 1675:leukotriene B4 1655: 1652: 1642:, fat tissue, 1574: 1571: 1550: 1547: 1514:Main article: 1511: 1508: 1499:Main article: 1496: 1493: 1449:dacryoadenitis 1437:Main article: 1434: 1431: 1412:Main article: 1409: 1406: 1394:corticosteroid 1369:interleukin 13 1349:Main article: 1346: 1343: 1321:Omenn syndrome 1219:Main article: 1216: 1213: 1198:ovarian cancer 1082: 1079: 1017:ACE inhibitors 973:nitrofurantoin 921:cephalosporins 904: 901: 857: 854: 790: 787: 771:cryptococcosis 767:histoplasmosis 750:Isospora belli 737:paragonimiasis 714:onchocerciasis 695:echinococcosis 647: 644: 602: 599: 590:Main article: 587: 584: 579: 575: 572: 498:Main article: 495: 492: 416:Main article: 413: 410: 343:Main article: 340: 337: 323: 320: 300:PDGFRA, PDGFRB 274: 273:Classification 271: 234:prostaglandins 226:growth factors 68: 67: 58: 52: 51: 47: 46: 38: 37: 29: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 4333: 4322: 4319: 4318: 4316: 4297: 4294: 4292: 4289: 4287: 4284: 4283: 4281: 4279: 4275: 4269: 4266: 4264: 4261: 4257: 4254: 4252: 4249: 4248: 4247: 4244: 4243: 4241: 4239: 4238:degranulation 4235: 4231: 4228: 4226: 4222: 4207: 4204: 4202: 4199: 4197: 4193: 4189: 4185: 4182: 4181: 4179: 4176: 4174: 4168: 4165: 4161: 4149: 4146: 4144: 4141: 4139: 4135: 4132: 4130: 4127: 4126: 4125: 4122: 4121: 4119: 4116: 4114: 4108: 4105: 4101: 4098: 4096: 4092: 4078: 4077:Monocytopenia 4075: 4074: 4072: 4069: 4067: 4061: 4058: 4054: 4044: 4041: 4039: 4038:Histiocytosis 4036: 4034: 4031: 4030: 4028: 4025: 4023: 4017: 4014: 4010: 4007: 4005: 4001: 3997: 3993: 3989: 3981: 3976: 3974: 3969: 3967: 3962: 3961: 3958: 3951: 3948: 3945: 3942: 3940: 3936: 3933: 3930: 3927: 3925: 3921: 3918: 3915: 3914: 3904: 3900: 3899: 3895: 3893: 3889: 3888: 3884: 3883: 3880: 3876: 3869: 3865: 3864: 3860: 3858: 3854: 3853: 3849: 3847: 3843: 3842: 3838: 3836: 3832: 3831: 3827: 3823: 3821: 3817: 3816: 3812: 3808: 3806: 3802: 3801: 3797: 3793: 3792: 3789: 3784: 3780: 3773: 3764: 3760: 3755: 3750: 3746: 3742: 3738: 3734: 3730: 3723: 3720: 3717: 3713: 3712: 3706: 3703: 3698: 3697: 3692: 3686: 3683: 3678: 3674: 3669: 3664: 3661:(4): 258–68. 3660: 3656: 3652: 3645: 3642: 3637: 3633: 3628: 3623: 3619: 3615: 3611: 3604: 3602: 3600: 3596: 3591: 3587: 3583: 3580:(in French). 3579: 3572: 3569: 3566: 3562: 3561: 3555: 3552: 3547: 3543: 3538: 3533: 3529: 3525: 3521: 3514: 3511: 3506: 3502: 3499:(6): 589–96. 3498: 3494: 3487: 3484: 3479: 3473: 3469: 3462: 3460: 3458: 3456: 3454: 3452: 3450: 3448: 3446: 3444: 3440: 3434: 3431: 3426: 3422: 3418: 3414: 3410: 3406: 3399: 3396: 3391: 3387: 3382: 3377: 3373: 3369: 3365: 3361: 3357: 3350: 3347: 3342: 3338: 3333: 3328: 3324: 3320: 3316: 3309: 3306: 3301: 3297: 3292: 3287: 3283: 3279: 3275: 3268: 3265: 3260: 3256: 3251: 3246: 3241: 3236: 3232: 3228: 3224: 3217: 3214: 3209: 3205: 3200: 3195: 3190: 3185: 3181: 3177: 3173: 3166: 3164: 3162: 3158: 3152: 3147: 3143: 3139: 3135: 3128: 3125: 3120: 3116: 3112: 3108: 3105:(9): 861–72. 3104: 3100: 3093: 3091: 3087: 3082: 3078: 3073: 3068: 3064: 3060: 3056: 3049: 3046: 3041: 3037: 3033: 3029: 3025: 3021: 3014: 3011: 3006: 3002: 2998: 2994: 2990: 2986: 2982: 2978: 2971: 2968: 2963: 2959: 2955: 2951: 2947: 2943: 2936: 2934: 2932: 2928: 2923: 2919: 2915: 2911: 2907: 2903: 2899: 2895: 2888: 2885: 2880: 2876: 2872: 2868: 2863: 2858: 2854: 2850: 2846: 2839: 2836: 2831: 2827: 2823: 2819: 2814: 2809: 2805: 2801: 2797: 2790: 2787: 2782: 2778: 2773: 2768: 2764: 2760: 2756: 2749: 2747: 2743: 2738: 2734: 2729: 2724: 2720: 2716: 2712: 2708: 2704: 2697: 2695: 2691: 2686: 2682: 2677: 2672: 2668: 2664: 2660: 2656: 2652: 2644: 2642: 2640: 2636: 2631: 2627: 2622: 2617: 2613: 2609: 2605: 2598: 2595: 2592: 2587: 2584: 2579: 2573: 2570: 2565: 2561: 2557: 2553: 2548: 2543: 2539: 2535: 2531: 2524: 2521: 2516: 2512: 2508: 2504: 2500: 2496: 2492: 2488: 2481: 2478: 2473: 2469: 2464: 2459: 2455: 2451: 2448:(2): 96–108. 2447: 2443: 2439: 2432: 2429: 2424: 2420: 2416: 2412: 2408: 2404: 2397: 2394: 2389: 2385: 2380: 2375: 2371: 2367: 2363: 2359: 2355: 2348: 2346: 2344: 2342: 2340: 2338: 2336: 2334: 2332: 2330: 2328: 2324: 2319: 2315: 2311: 2307: 2303: 2299: 2292: 2289: 2284: 2280: 2275: 2270: 2266: 2262: 2258: 2251: 2249: 2247: 2245: 2243: 2241: 2237: 2232: 2228: 2223: 2218: 2214: 2210: 2203: 2196: 2194: 2190: 2185: 2183:0-911910-18-2 2179: 2175: 2170: 2169: 2163: 2156: 2154: 2152: 2150: 2148: 2146: 2144: 2142: 2140: 2138: 2136: 2134: 2132: 2130: 2126: 2114: 2110: 2105: 2100: 2096: 2092: 2088: 2081: 2079: 2077: 2075: 2073: 2071: 2069: 2067: 2065: 2063: 2059: 2047: 2041: 2039: 2035: 2028: 2024: 2021: 2020: 2016: 2010: 2007: 2005: 2002: 1999: 1996: 1995: 1994: 1991: 1988: 1985: 1982: 1979: 1976: 1973: 1971:(transiently) 1970: 1967: 1965: 1962: 1960: 1957: 1955: 1952: 1947: 1945: 1942: 1940: 1937: 1935: 1932: 1930: 1927: 1926: 1925: 1922: 1918: 1915: 1913: 1910: 1908: 1904: 1902: 1899: 1897: 1894: 1892: 1889: 1887: 1884: 1882: 1879: 1878: 1877: 1873: 1870: 1867: 1865: 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1280: 1276: 1275: 1270: 1266: 1265:IPEX syndrome 1262: 1258: 1254: 1253: 1248: 1244: 1243: 1238: 1237: 1232: 1228: 1222: 1214: 1212: 1209: 1204: 1199: 1195: 1191: 1187: 1183: 1179: 1177: 1173: 1169: 1165: 1164:myelofibrosis 1161: 1157: 1153: 1149: 1145: 1141: 1137: 1133: 1129: 1125: 1121: 1117: 1113: 1109: 1108:squamous cell 1106:, as well as 1105: 1101: 1097: 1093: 1089: 1080: 1078: 1076: 1072: 1068: 1064: 1059: 1057: 1053: 1049: 1045: 1040: 1038: 1034: 1030: 1026: 1022: 1018: 1014: 1010: 1006: 1002: 1001:amitriptyline 998: 994: 990: 986: 985:phenobarbital 982: 981:carbamazepine 978: 977:metronidazole 974: 970: 966: 962: 958: 954: 950: 946: 945:valproic acid 942: 938: 934: 933:carbamazepine 930: 926: 922: 918: 914: 910: 902: 900: 898: 893: 891: 887: 883: 879: 875: 871: 867: 863: 855: 853: 851: 847: 843: 839: 835: 831: 827: 823: 819: 815: 811: 807: 803: 800: 796: 788: 786: 784: 780: 776: 772: 768: 764: 760: 756: 752: 751: 746: 742: 738: 734: 733:clonorchiasis 730: 726: 722: 719: 715: 711: 707: 703: 700: 696: 692: 691:cysticercosis 688: 684: 680: 677: 673: 669: 665: 664: 659: 656: 652: 645: 643: 640: 636: 632: 628: 624: 623:interleukin 5 620: 619:interleukin 3 616: 612: 608: 600: 598: 593: 585: 583: 573: 571: 569: 564: 563:gene enhancer 560: 556: 552: 548: 544: 540: 539:interleukin 5 536: 535:interleukin 3 532: 529: 525: 522: 518: 514: 510: 506: 501: 493: 491: 488: 484: 480: 476: 472: 468: 464: 460: 456: 452: 448: 444: 440: 436: 432: 430: 425: 419: 411: 409: 408:fusion gene. 407: 406: 401: 400: 395: 394: 389: 388: 383: 380: 379: 375: 370: 366: 365: 360: 359: 354: 353: 346: 338: 336: 334: 331:, or overtly 330: 329:pre-malignant 321: 319: 316: 312: 309: 305: 301: 297: 293: 289: 285: 281: 272: 270: 267: 263: 259: 255: 251: 247: 243: 239: 235: 231: 227: 223: 219: 215: 211: 207: 203: 199: 195: 191: 187: 183: 179: 175: 171: 166: 164: 160: 157: 153: 149: 144: 140: 138: 134: 130: 126: 122: 118: 114: 108: 106: 102: 98: 94: 90: 82: 79:count in the 78: 74: 66: 62: 59: 57: 53: 48: 44: 39: 34: 19: 4171: 4134:Eosinophilia 4133: 4129:Neutrophilia 4111: 4095:Granulocytes 4064: 4020: 3992:granulocytes 3986:Diseases of 3903:Eosinophilia 3896: 3885: 3861: 3850: 3839: 3824: 3809: 3794: 3739:(1): 26–30. 3736: 3732: 3722: 3709: 3705: 3694: 3685: 3658: 3654: 3644: 3617: 3613: 3581: 3577: 3571: 3558: 3554: 3527: 3523: 3513: 3496: 3492: 3486: 3467: 3433: 3408: 3404: 3398: 3363: 3359: 3349: 3322: 3318: 3308: 3281: 3277: 3267: 3230: 3226: 3216: 3179: 3175: 3141: 3137: 3127: 3102: 3098: 3062: 3058: 3048: 3023: 3019: 3013: 2980: 2976: 2970: 2945: 2941: 2897: 2893: 2887: 2852: 2848: 2838: 2803: 2799: 2789: 2762: 2758: 2710: 2706: 2658: 2654: 2611: 2607: 2597: 2586: 2572: 2537: 2533: 2523: 2490: 2486: 2480: 2445: 2441: 2431: 2406: 2402: 2396: 2361: 2358:Primary Care 2357: 2301: 2297: 2291: 2264: 2260: 2212: 2208: 2167: 2116:. Retrieved 2094: 2090: 2050:. Retrieved 1789: 1773: 1712: 1698:granulocytes 1683: 1657: 1591: 1587: 1583: 1579: 1576: 1552: 1543:plasma cells 1519: 1504: 1457:pancreatitis 1453:sialadenitis 1442: 1417: 1354: 1332: 1310: 1292: 1284:Fas receptor 1282: 1272: 1268: 1260: 1250: 1240: 1234: 1233:(defective 1224: 1180: 1128:nasopharyrnx 1084: 1081:Malignancies 1060: 1056:L-tryptophan 1048:rapeseed oil 1041: 961:tetracyclins 929:sulfonamides 906: 894: 859: 792: 775:coccidioides 754: 748: 729:fascioliasis 717: 698: 661: 654: 649: 638: 634: 626: 607:pathogenesis 604: 595: 577: 531:gene cluster 524:gene mapping 504: 503: 478: 474: 470: 466: 462: 458: 428: 421: 403: 397: 391: 385: 372: 362: 356: 350: 348: 325: 314: 307: 303: 299: 295: 287: 283: 279: 276: 230:leukotrienes 170:granulocytes 167: 145: 141: 109: 99:(i.e. 1,500/ 88: 73:Eosinophilia 72: 71: 36:Eosinophilia 4201:Eosinopenia 4188:Neutropenia 4033:Monocytosis 4004:macrophages 1800:respiratory 1738:requires a 1736:trichinosis 1719:chest x-ray 1694:eosinophils 1671:anaphylaxis 1553:A class of 1539:lymphocytes 1531:neutrophils 1469:lymph nodes 1398:Hydroxyurea 1329:slenomegaly 1281:(defective 1267:(defective 1259:(defective 1203:interleukin 1071:allopurinol 1033:cyclosporin 997:desipramine 989:lamotrigine 965:doxycycline 941:lamotrigine 917:penicillins 842:sarcoidosis 759:sarcocystis 702:filarioidea 679:trichinosis 631:bone marrow 453:, atypical 382:fusion gene 202:hypobromite 148:bone marrow 4234:Chemotaxis 4143:Basophilia 3898:Patient UK 3852:DiseasesDB 2118:21 October 2052:2012-11-02 2029:References 1876:malignancy 1821:disorders 1792:idiopathic 1780:prednisone 1723:urinalysis 1690:mast cells 1667:mast cells 1644:myometrium 1640:peritoneum 1387:negative, 1134:, certain 1092:colorectal 1029:ranitidine 1025:nevirapine 1013:diclofenac 1005:fluoxetine 949:nevirapine 672:ascariasis 646:Infections 513:eosinophil 507:is a rare 483:myeloblast 405:ETV6-ACSL6 222:chemokines 210:superoxide 178:helminthes 163:leucocytes 125:idiopathic 93:eosinophil 77:eosinophil 65:hematology 4206:Basopenia 4000:Monocytes 3988:monocytes 3939:eMedicine 3887:eMedicine 3868:419455006 3863:SNOMED CT 3716:eMedicine 3565:eMedicine 3144:(2): 60. 2922:206974794 2174:1093–1096 1983:infection 1845:Pemphigus 1830:Hay fever 1808:parasites 1770:Treatment 1709:Diagnosis 1702:cytokines 1686:histamine 1663:basophils 1535:monocytes 1485:rituximab 1361:phenotype 1194:neoplasms 1009:piroxicam 993:valproate 969:linezolid 957:ibuprofen 953:efavirenz 937:phenytoin 812:, severe 745:protozoan 658:nematodes 651:Helminths 611:cytokines 568:phenotype 475:ETV6-JAK2 471:PCM1-JAK2 333:malignant 218:cytokines 174:parasites 156:capillary 83:exceeds 5 56:Specialty 4315:Category 4148:Bandemia 4113:-cytosis 4022:-cytosis 3920:Archived 3763:17108067 3677:25858537 3636:27684977 3590:22594010 3546:27684977 3425:23368869 3390:27446313 3341:25927152 3300:28005278 3259:22085750 3208:27222657 3119:24571759 3081:27934657 3040:28390583 2997:23229594 2962:26209891 2914:28285268 2879:23451016 2871:15180753 2830:42668440 2822:26486351 2781:28028030 2737:28226398 2685:22460074 2630:14988154 2564:30277072 2556:22473587 2507:24577808 2472:27226792 2423:23453213 2388:27866580 2283:29044676 2231:28112388 2162:"Ch. 11" 2113:17399779 2017:See also 1819:Allergic 1778:such as 1473:pancreas 1402:imatinib 1357:cytokine 1225:Primary 1190:leukemia 1050:and the 1021:abacavir 660:, (e.g. 625:) that: 551:promoter 528:cytokine 479:BCR-JAK2 429:BCR-ABL1 424:leukemia 214:peroxide 133:disorder 3892:med/685 3846:D004802 3754:1828958 3505:8957461 3381:4950912 3250:3226432 3199:4878059 3005:5421783 2849:Allergy 2728:5546948 2707:Allergy 2676:4091810 2515:8464735 2463:4872051 2379:5293177 2318:2953511 1648:synovia 1427:T cells 1381:trisomy 1271:gene), 1263:gene), 1255:gene), 1245:gene), 1100:bladder 1088:gastric 925:dapsone 773:), and 723:, e.g. 710:loiasis 704:, e.g. 559:introns 186:viruses 159:venules 152:CFU-Eos 103:). 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