Knowledge (XXG)

HIV-associated neurocognitive disorder

Source đź“ť

352:. Moreover, the results of some studies suggest loss of brain volume in cortical and subcortical regions even in asymptomatic HIV patients and patients who were on stable treatment. A recent longitudinal study of a small representative cohort of HIV-positive patients on stable medication regiments suggests that this cortical atrophy is progressive, and is in part related to nadir CD4. Cerebral brain volume is associated with factors related to duration of the disease and CD4 nadir; patients with a longer history of chronic HIV and higher CD4 nadir loss present with greater cerebral atrophy. CD4 lymphocyte counts have also been related to greater rates of brain tissue loss. Current factors, such as plasma HIV RNA, have been found to be associated with brain volumes as well, especially with regards to basal ganglia volume and total white matter. Loss of cortical grey matter oligodendrocytes and neurons might also contribute to the symptomatology. 327:(BBB) serves as a protective mechanism by preventing entry of foreign substances; disruption of the BBB by HIV contributes to the progression of infection. The virus is able to enter the brain through infected cells that pass through the BBB to replace the immune cells surrounding the blood supply in the brain. When infected, immune cells are able to better migrate into tissues compared to uninfected cells. Infected microglia add to the production of the virus. This activation of the microglia may contribute to the process of neuropathogenesis that spreads the infection to nearby cells. Other cells that can get infected include the astrocytes, which can trigger bystander cellular dysfunction and 512:(PFC) and left dorsolateral PFC. There was reduced connectivity between the left caudate and ventral PFC and between the left caudate and dorsolateral PFC compared to healthy controls. Additionally, there was hypoactivation of the left caudate in the HIV+ patients. In the control group, there was correlation between caudate activity and executive functioning as shown by performance on 199:. Studies have shown that patients exhibit cognitive deficits consistent with dysfunction of fronto-striatal circuits including associated parietal areas, the latter of which may account for observed deficits in visuospatial function. In addition to cognitive impairments, psychological dysfunction is also noted. For example, patients with HIV have higher rates of 81:. It is a syndrome of progressive deterioration of memory, cognition, behavior, and motor function in HIV-infected individuals during the late stages of the disease, when immunodeficiency is severe. HAND may include neurological disorders of various severity. HIV-associated neurocognitive disorders are associated with a metabolic 601:
Taken together, these observations suggest that the mechanism by which the virus can alter CNS development and induce pathology in the immature brain may depend upon the altered production of soluble bioactive compounds. Several potentially neurotoxic mediators have been identified in different model
214:
The diagnosis of HIV-associated neurocognitive impairment is made using clinical criteria after considering and ruling out other possible causes. The severity of neurocognitive impairment is associated with nadir CD4, suggesting that earlier treatment to prevent immunosuppression due to HIV may help
535:
Another area of impairment due to fronto-striatal dysfunction is in the area of emotion recognition. In a study of HIV+ patients and control adults by Clark et al. (2010), it was shown that HIV patients demonstrate impairments in the recognition of fearful facial expressions. The authors suggested
972:
Cysique LA, Maruff P, Brew BJ (December 2004). "Prevalence and pattern of neuropsychological impairment in human immunodeficiency virus-infected/acquired immunodeficiency syndrome (HIV/AIDS) patients across pre- and post-highly active antiretroviral therapy eras: a combined study of two cohorts".
507:
A study by Melrose et al. (2008) examined the integrity of the fronto-striatal circuitry that underlies executive functioning in HIV. Participants in the study were diagnosed with HIV three months to sixteen years before the study. Ten out of eleven patients were on antiretroviral medication and
643:
Gray F, Adle-Biassette H, Chretien F, Lorin de la Grandmaison G, Force G, Keohane C (2001). "Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-induced lesions of the brain, correlations with HIV-associated disorders and modifications according to
527:
The study by Melrose et al. (2008) also investigated parietal activation. It was found that anterior parietal activation in HIV+ patients was slightly anterior to that in control participants, which follows the idea that HIV causes a reorganization of the attention network leading to cognitive
210:
Without combination antiretroviral therapy, cognitive impairments increase with successive stages of HIV. HIV patients in early stages show mild difficulties in concentration and attention. In advanced cases of HIV-associated dementia, speech delay, motor dysfunction, and impaired thought and
578:
during organ development. In fact, within the developing CNS, cells are under the control of environmental factors that provide instructive signals to neural cell targets. By regulating the survival, differentiation and maintenance of specific functions of neuronal and glial precursors, these
182:
only exists when neurocognitive impairment in the patient is severe enough to interfere markedly with day-to-day function. That is, the patient is typically unable to work and may not be able to take care of themselves. Before this, the patient is said to have a mild neurocognitive disorder.
194:
impairments associated with HIV occur in the domains of attention, memory, verbal fluency, and visuospatial construction. Specifically for memory, the lowered activity of the hippocampus changes the basis for memory encoding and affects mechanisms such as long-term potentiation. Severity of
570:, whereas infected neurons have been rarely observed. The susceptibility to HIV-1 infection and replication in neuronal and glial cells is a function of cellular differentiation, and it is more likely in immature precursors than with differentiated cells. Several soluble signals, such as 410:. No single test is available to confirm the diagnosis, but the constellation of history, laboratory findings and examination can reliably establish the diagnosis when performed by experienced clinicians. The amount of virus in the brain does not correlate well with the degree of 539:
In identification tasks, administered by Clark et al. (2010), HIV+ patients and control participants were asked to identify different facial emotions and landscapes, with these picture categories matched for image complexity. HIV+ patients did worse than the control group on the
472:
Major intellectual incapacity - cannot follow news or personal events, cannot sustain complex conversation, considerable slowing of all output. And/or motor disability - cannot walk unassisted, requiring walker or personal support, usually with slowing and clumsiness of arms as
364:
Marked acquired impairment of at least two ability domains of cognitive function (e.g. memory, attention): typically, the impairment is in multiple domains, especially in learning, information processing and concentration/attention. The cognitive impairment is ascertained by
563:(CNS) is infected with HIV-1 weeks after primary infection, causing neuronal damage and cell death. Although neurological dysfunctions have been associated to HIV infection of the CNS, it is unclear how the pathogenesis of neurological disorders has been established. 2253: 2082: 2063: 160:+ T cell levels and high plasma viral loads. It is sometimes seen as the first sign of the onset of AIDS. Prevalence is between 10 and 24% in Western countries and has only been seen in 1–2% of India-based infections. With the advent of 531:
Overall, the study by Melrose et al. (2008) showed that HIV in the brain is associated with cognitive impairments. Damage to the fronto-striatal system may underlie cognitive problems including executive function and sequencing tasks.
227:; it is one of the few conditions caused directly by HIV itself. However, the cause of HAD can be difficult to discern because the central nervous system can be damaged by a number of other causes related to HIV infection: 385:
No evidence of another, pre-existing cause that could explain the dementia (e.g. another CNS infection, CNS neoplasm, cerebrovascular disease, pre-existing neurological disease, severe substance abuse compatible with CNS
303:
inhibits the stem cells in the brain from producing new nerve cells. In the neuronal cells, the HIV gp120 induces mitochondrial-death proteins like caspases, which may influence the upregulation of the death receptor
347:
regions. Neuroimaging studies of HIV patients indicate that significant volume reductions are apparent in the frontal white matter, whereas subcortically, hypertrophy is apparent in the basal ganglia, especially the
2248: 528:
impairments. Additionally, the anterior parietal activity showed a relationship with caudate functioning, which implicates a compensatory mechanism set forth when damage to the fronto-striatal system occurs.
594:, which are produced upon microglia/macrophages and astrocytes functional interactions, have been reported to mediate cell damage in primary neural cell cultures and neural cell lines with immature 2560: 782:
Satishchandra P, Nalini A, Gourie-Devi M, Khanna N, Santosh V, Ravi V, et al. (January 2000). "Profile of neurologic disorders associated with HIV/AIDS from Bangalore, south India (1989-96)".
355:
Changes in the brain may be ongoing but asymptomatic, that is with minimal interference in functioning, making it difficult to diagnose HIV-associated neurocognitive disorders in the early stages.
1068:
Olesen PJ, Schendan HE, Amick MM, Cronin-Golomb A (December 2007). "HIV infection affects parietal-dependent spatial cognition: evidence from mental rotation and hierarchical pattern perception".
524:
output nucleus). This dysfunction with the basal ganglia and PFC may explain the executive function and semantic event sequencing task impairments noted in HIV+ patients included in this study.
2524: 606:. Thus, it is likely that a complex interaction of several mediators may alter the function and survival of actively developing and maturing cells, responsible for the neurologic disorders. 3821: 4725: 2243: 41:
AIDS dementia complex (ADC), Brain AIDS, HIV dementia, HIV-associated dementia (HAD), HIV encephalopathy, mild neurocognitive disorder (MND), asymptomatic neurocognitive disorder (AND)
2615: 3211: 105:) are disabling cognitive impairment accompanied by motor dysfunction, speech problems and behavioral change. Cognitive impairment is characterised by mental slowness, trouble with 454:
Evidence of functional intellectual or motor impairment characteristic of HAD, but able to perform all but the more demanding aspects of work or ADL. Can walk without assistance.
3206: 2260: 1912:
Melrose RJ, Tinaz S, Castelo JM, Courtney MG, Stern CE (April 2008). "Compromised fronto-striatal functioning in HIV: an fMRI investigation of semantic event sequencing".
3244: 582:
In addition to the production of cytokines, HIV-1 infected mononuclear cells and astrocytes can produce a number of soluble mediators, including viral proteins such as
2721: 1895: 2194: 929:
Castelo JM, Sherman SJ, Courtney MG, Melrose RJ, Stern CE (June 2006). "Altered hippocampal-prefrontal activation in HIV patients during episodic memory encoding".
626:. 2nd Edition. Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103 USA: Lippincott Williams & Wilkins, 2012. Books@Ovid. Web. 03 December, 2020. 3835: 2595: 463:
Cannot work or maintain the more demanding aspects of daily life, but able to perform basic activities of self care. Ambulatory, but may require a single prop.
390:
While the progression of dysfunction is variable, it is regarded as a serious complication and untreated can progress to a fatal outcome. Diagnosis is made by
176:
is increasing. HAART may prevent or delay the onset of HAD in people with HIV infection, and may also improve mental function in people who already have HAD.
2467: 2286: 2236: 2184: 287:. The affected astrocytes, which normally nurture and protect neurons, also may now end up harming neurons. Astrocytes produce neurotoxic proteins such as 5197: 5153: 4256: 3501: 2580: 3332: 1162:"HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors" 627: 516:
testing. Further analysis of the pathways in the HIV+ group involving left caudate showed reduced functional connectivity between the left caudate and
3372: 1428:
Avison MJ, Nath A, Greene-Avison R, Schmitt FA, Greenberg RN, Berger JR (December 2004). "Neuroimaging correlates of HIV-associated BBB compromise".
544:
task but not on landscape identification. In the facial emotion task, fear recognition was significantly worse in the HIV than in the control group.
5012: 4629: 4442: 2394: 1568:"Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in the highly active antiretroviral therapy era" 445:, slowed extremity movements), but without impairment of work or capacity to perform activities of daily living (ADL). Gait and strength are normal. 4422: 555:
during pregnancy is the dominant mode of acquisition of HIV infection in children and has been associated with an increased risk of mortality and
51: 2136: 1982:
Le Doaré K, Bland R, Newell ML (November 2012). "Neurodevelopment in children born to HIV-infected mothers by infection and treatment status".
579:
extracellular signals can influence many steps of the CNS development and concur in controlling virus-cell interactions in the maturing brain.
3237: 2555: 1865: 752: 671: 3465: 2986: 161: 689:
Adle-Biassette H, Levy Y, Colombel M, Poron F, Natchev S, Keohane C, Gray F (June 1995). "Neuronal apoptosis in HIV infection in adults".
1514:"Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism" 809:
Wadia RS, Pujari SN, Kothari S, Udhar M, Kulkarni S, Bhagat S, Nanivadekar A (March 2001). "Neurological manifestations of HIV disease".
508:
none scored within the demented range on the HIV Dementia Scale. It was found that HIV+ patients showed less activity within the ventral
5209: 4357: 3522: 2674: 1616: 559:. Children with AIDS appear to have neurological diseases as a consequence of HIV-1 infection. In HIV-1 infected newborn and children, 4459: 4434: 4269: 3111: 2351: 733: 113:. Motor symptoms include a loss of fine motor control leading to clumsiness, poor balance and tremors. Behavioral changes may include 4963: 5245: 5065: 3841: 3367: 3324: 2534: 2424: 3756: 1850: 1346:"HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest" 207:, i.e., difficulty processing or recognizing one's own emotions. Patients also have more difficulty recognizing facial emotions. 5337: 4574: 4545: 4486: 3827: 3230: 2281: 4579: 4374: 4299: 482:
Nearly vegetative. Intellectual and social comprehension and responses are at a rudimentary level. Nearly or absolutely mute.
5017: 4988: 4249: 3426: 3412: 3014: 2276: 4758: 1385:
Thomas S, Mayer L, Sperber K (2009). "Mitochondria influence Fas expression in gp120-induced apoptosis of neuronal cells".
4476: 4452: 3076: 2590: 2570: 2301: 2189: 836:
Ellis R, Langford D, Masliah E (January 2007). "HIV and antiretroviral therapy in the brain: neuronal injury and repair".
1653:"Evidence for ongoing brain injury in human immunodeficiency virus-positive patients treated with antiretroviral therapy" 5519: 5421: 4958: 4491: 4336: 3631: 3625: 3536: 3530: 3420: 3189: 2462: 2450: 2331: 2291: 552: 339:
HIV is associated with pathological changes in mainly subcortical and fronto-striatal areas of the brain, including the
5479: 2657: 586:
and Tat, that can exert damaging effects on both developing and mature neural tissues. Moreover, molecules such as the
394:
who carefully rule out alternative diagnoses. This routinely requires a careful neurological examination, brain scans (
211:
behavior are observed. Specifically, lower motor speeds were found to correlate with hypertrophy of the right putamen.
4666: 4464: 3994: 3920: 3914: 3587: 2961: 2585: 2514: 2472: 2216: 2174: 628:
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=books1&NEWS=N&AN=01626619%2f2nd_Edition%2f2
5416: 4331: 2651: 2575: 2565: 2296: 2129: 587: 1254:"Putamen hypertrophy in nondemented patients with human immunodeficiency virus infection and cognitive compromise" 5426: 5395: 4773: 4656: 4242: 4051: 3658: 3125: 3093: 3081: 3034: 2610: 331:, further compromising the blood–brain barrier. The toxicity spreads through a gap junction-dependent mechanism. 200: 4550: 5474: 5390: 5385: 5082: 5045: 5037: 4855: 4824: 4565: 3760: 3672: 3577: 3407: 3380: 3352: 3285: 2966: 2816: 2689: 2377: 2336: 2097: 1295:"HIV-1 Tat Promotes Lysosomal Exocytosis in Astrocytes and Contributes to Astrocyte-mediated Tat Neurotoxicity" 556: 165: 1700:
Jernigan TL, Archibald SL, Fennema-Notestine C, Taylor MJ, Theilmann RJ, Julaton MD, et al. (June 2011).
324: 263:, indirectly. According to one theory, HIV either infects or activates cells that protect the brain, known as 5411: 4918: 4768: 4763: 4720: 4537: 3556: 3184: 3056: 2931: 2849: 2751: 2316: 2311: 224: 3750: 3346: 574:, have been described to modulate susceptibility and can further contribute in supporting virus latency or 275:
to self-destruct. The infected macrophages and microglia also appear to produce additional factors such as
5289: 4928: 4819: 4778: 4753: 4661: 3950: 3928: 3807: 3803: 3799: 3795: 3688: 3582: 3543: 2896: 2869: 2859: 2781: 2766: 2664: 2484: 2414: 2221: 2211: 560: 134: 5484: 5217: 5097: 5004: 4983: 3935: 3516: 3386: 3179: 3133: 3071: 3061: 2971: 2906: 2477: 2445: 2382: 2206: 2122: 1802:"Abnormalities in resting-state functional connectivity in early human immunodeficiency virus infection" 234: 3357: 299:. Tat is secreted and induces reactivity in astrocytes through increased GFAP expression. HIV protein 5309: 5222: 4978: 4798: 4399: 4379: 4199: 4031: 3666: 3495: 3148: 3066: 2981: 2956: 2941: 2879: 2831: 2811: 2736: 2731: 2716: 2457: 2389: 1160:
Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, Leblanc S, et al. (February 2011).
491: 1214:
Ances BM, Ellis RJ (February 2007). "Dementia and neurocognitive disorders due to HIV-1 infection".
5359: 5341: 5304: 5294: 5148: 5050: 5027: 4875: 4867: 4646: 4624: 4352: 3617: 3338: 3163: 3138: 3106: 3024: 2996: 2946: 2864: 2854: 2806: 2796: 2786: 2761: 2372: 2346: 2086: 1651:
Cardenas VA, Meyerhoff DJ, Studholme C, Kornak J, Rothlind J, Lampiris H, et al. (July 2009).
740: 407: 242: 196: 195:
impairment in different domains varies depending on whether or not a patient is being treated with
5232: 5022: 4619: 4471: 3720: 3476: 3153: 3143: 3051: 3046: 3019: 3006: 2991: 2976: 2926: 2889: 2874: 2826: 2821: 2801: 2771: 2746: 2706: 2698: 2630: 2625: 2494: 2419: 2321: 2007: 1937: 1889: 1453: 1410: 998: 954: 911: 861: 714: 513: 495: 3222: 1566:
Cohen RA, Harezlak J, Schifitto G, Hana G, Clark U, Gongvatana A, et al. (February 2010).
5524: 5514: 5268: 4793: 4783: 4715: 4641: 4525: 4184: 4135: 4116: 4097: 3887: 3883: 3879: 3875: 3792: 3697: 3401: 3279: 3101: 2951: 2921: 2901: 2884: 2791: 2756: 2741: 2726: 2711: 2489: 2399: 2356: 2226: 1999: 1964: 1929: 1861: 1831: 1782: 1731: 1682: 1597: 1543: 1494: 1445: 1402: 1367: 1326: 1275: 1231: 1191: 1139: 1085: 1050: 990: 946: 903: 853: 818: 791: 748: 706: 653: 575: 509: 169: 46: 1344:
Okamoto S, Kang YJ, Brechtel CW, Siviglia E, Russo R, Clemente A, et al. (August 2007).
5138: 5092: 5060: 4908: 4886: 4851: 4614: 4496: 4447: 4394: 4369: 4364: 4321: 4309: 4159: 3869: 3549: 3481: 3362: 3293: 3158: 2936: 2916: 2911: 2841: 2776: 2519: 1991: 1921: 1821: 1813: 1772: 1762: 1721: 1713: 1672: 1664: 1627: 1587: 1579: 1533: 1525: 1484: 1437: 1394: 1357: 1316: 1306: 1265: 1223: 1181: 1173: 1129: 1121: 1077: 1040: 1032: 982: 938: 895: 845: 698: 1036: 758: 5314: 5272: 5143: 5130: 5077: 5072: 5055: 4935: 4730: 4702: 4503: 4326: 4265: 4083: 4011: 4006: 3988: 3908: 3897: 3768: 3732: 3652: 3438: 3299: 2669: 2409: 2179: 541: 517: 403: 366: 5364: 566:
The main cells infected by HIV-1 in the nervous tissue are the microglia, astrocytes and
441:
Minimal symptoms of cognitive or motor dysfunction characteristic of HAD, or mild signs (
1871: 1615:
Nowak MR, Navia B, Harezlak J, Yiannoutsos C, Guttmann C, Singer E, et al. (2014).
5299: 5240: 5164: 4973: 4940: 4923: 4913: 3319: 2620: 2404: 1860:. Vol. 2 (6th ed.). Baltimore, MD: Williams and Wilkins. pp. 1644–1669. 1826: 1801: 1777: 1750: 1726: 1701: 1677: 1652: 1592: 1567: 1538: 1513: 1321: 1294: 1186: 1161: 1134: 1109: 1045: 1020: 942: 702: 414:, suggesting that secondary mechanisms are also important in the manifestation of HAD. 271:. These cells then produce toxins that can set off a series of reactions that instruct 146: 122: 82: 5508: 5333: 5284: 4602: 3314: 3309: 3257: 2600: 2509: 591: 521: 372:
Cognitive impairments identified in 1 interfere markedly with day-to-day functioning.
340: 292: 142: 110: 4234: 2091: 1941: 1751:"Untreated Patients Dying With AIDS Have Loss of Neocortical Neurons and Glia Cells" 1457: 1414: 958: 915: 865: 718: 5187: 4968: 4520: 4175: 4025: 3703: 3564: 2635: 2326: 2011: 1529: 1441: 1002: 442: 320: 305: 253: 1617:"Longitudinal Progression of Cortical Atrophy in HIV-Patients on Stable Treatment" 536:
that fronto-striatal abnormalities related to HIV may underlie these impairments.
382:, or if delirium is present, dementia was diagnosed when delirium was not present. 2102: 1081: 5172: 4903: 4634: 4384: 4215: 4164: 4152: 4147: 4140: 4128: 4123: 4102: 4072: 3974: 3813: 3725: 3708: 3643: 3304: 2539: 2440: 2231: 483: 430: 391: 344: 264: 204: 1362: 1345: 1270: 1253: 1021:"Neurocognitive correlates of alexithymia in asymptomatic individuals with HIV" 5489: 5182: 5087: 4788: 4513: 4508: 4304: 4065: 3849: 3606: 2499: 2341: 2169: 2076: 1925: 1717: 1668: 1583: 1398: 1177: 1125: 986: 603: 567: 487: 238: 173: 130: 94: 86: 1767: 156:
HAD typically occurs after years of HIV infection and is associated with low
5442: 5374: 5192: 4651: 4389: 4314: 4110: 4091: 4058: 4046: 4040: 4019: 3965: 3893: 3864: 3787: 3779: 3741: 3510: 3489: 3395: 3273: 3265: 3253: 2072: 1817: 1311: 595: 328: 296: 288: 284: 276: 268: 191: 90: 74: 55: 17: 2003: 1995: 1933: 1835: 1786: 1735: 1686: 1601: 1547: 1498: 1449: 1406: 1371: 1330: 1279: 1235: 1195: 1143: 1089: 1054: 994: 950: 907: 857: 822: 795: 657: 319:
enters the brain early on in the infection. It is thought that HIV uses a "
1968: 1227: 710: 5177: 4847: 4814: 4740: 4208: 3855: 3597: 3453: 2605: 2504: 2201: 2149: 1108:
Clark US, Cohen RA, Westbrook ML, Devlin KN, Tashima KT (November 2010).
602:
systems, including inflammatory cytokines, viral proteins and neurotoxic
571: 411: 379: 375:
Cognitive impairments identified in 1 are present for at least one month.
280: 179: 126: 118: 2055: 3961: 2529: 2025:
Ensoli F, Fiorelli V (2000). "HIV-1 Infection and the Developing CNS".
1955:
Calvelli TA, Rubinstein A (2010). "Pediatric HIV infection: a review".
1702:"Clinical factors related to brain structure in HIV: the CHARTER study" 747:(2nd ed.). London, UK: Oxford University Press. pp. 357–373. 399: 349: 272: 260: 138: 4895: 4710: 3570: 2645: 2067: 1800:
Wang X, Foryt P, Ochs R, Chung JH, Wu Y, Parrish T, Ragin AB (2011).
622:
Lynn, D. Joanne, Newton, Herbert B. and Rae-Grant, Alexander D. eds.
150: 114: 106: 899: 849: 883: 378:
Cognitive impairments identified in 1 do not meet the criteria for
4673: 4221: 3980: 3612: 2114: 583: 300: 1489: 1472: 259:
Many researchers believe that HIV damages the vital brain cells,
2679: 2640: 1252:
Castelo JM, Courtney MG, Melrose RJ, Stern CE (September 2007).
1110:"Facial emotion recognition impairments in individuals with HIV" 78: 5463: 5331: 5266: 5118: 4845: 4690: 4600: 4420: 4281: 4238: 3226: 2118: 3447: 2164: 2145: 395: 316: 283:
that can affect neurons as well as other brain cells known as
157: 71: 2561:
European and Developing Countries Clinical Trials Partnership
1851:"Psychiatric aspects of acquired immune deficiency syndrome." 85:
induced by HIV infection and fueled by immune activation of
1749:
Kaalund SS, Johansen A, Fabricius K, Pakkenberg B (2020).
1019:
Bogdanova Y, DĂ­az-Santos M, Cronin-Golomb A (April 2010).
369:, mental status examination or neuropsychological testing. 1512:
Eugenin EA, Clements JE, Zink MC, Berman JW (June 2011).
97:
of both host and viral origin. The essential features of
93:. These cells are actively infected with HIV and secrete 2244:
WHO disease staging system for HIV infection and disease
1624:
Conference on Retroviruses and Opportunistic Infections
1114:
Journal of the International Neuropsychological Society
3212:
List of HIV/AIDS cases and deaths registered by region
548:
Neurodevelopmental disorders associated with infection
811:
The Journal of the Association of Physicians of India
743:, Grant I, Everall I, Lipton SA, Swindells S (eds.). 2045: 882:
González-Scarano F, Martín-García J (January 2005).
121:
and diminished emotional responses and spontaneity.
5435: 5404: 5373: 5352: 5231: 5208: 5162: 5129: 5036: 5003: 4951: 4894: 4885: 4866: 4807: 4739: 4701: 4561: 4536: 4433: 4345: 4292: 4198: 4174: 4082: 4005: 3960: 3949: 3778: 3740: 3719: 3687: 3642: 3596: 3475: 3464: 3437: 3264: 3207:
List of countries by HIV/AIDS adult prevalence rate
3172: 3124: 3092: 3033: 3005: 2840: 2697: 2688: 2596:
President's Emergency Plan for AIDS Relief (PEPFAR)
2581:
Joint United Nations Programme on HIV/AIDS (UNAIDS)
2548: 2433: 2365: 2269: 2157: 2049: 45: 37: 32: 215:prevent HIV-associated neurocognitive disorders. 672:"HIV-Associated Dementia - Neurologic Disorders" 2195:National Addiction and HIV Data Archive Program 323:" mechanism to enter the brain. Normally, the 4250: 3238: 2130: 70:) are neurological disorders associated with 8: 1894:: CS1 maint: multiple names: authors list ( 1014: 1012: 223:HIV-associated dementia (HAD) is not a true 2287:Diffuse infiltrative lymphocytosis syndrome 1247: 1245: 5460: 5349: 5328: 5263: 5154:Other specified feeding or eating disorder 5126: 5115: 4891: 4863: 4842: 4698: 4687: 4597: 4430: 4417: 4289: 4278: 4257: 4243: 4235: 3957: 3737: 3502:Progressive multifocal leukoencephalopathy 3472: 3245: 3231: 3223: 3039: 2694: 2520:People With AIDS Self-Empowerment Movement 2137: 2123: 2115: 2046: 1907: 1905: 1856:. In Kaplan, H.I. and Sadock, B.J. (ed.). 1473:"The blood brain barrier in HIV infection" 877: 875: 125:, it is identified by the infiltration of 29: 3373:Extranodal NK/T-cell lymphoma, nasal type 1825: 1776: 1766: 1725: 1676: 1591: 1537: 1488: 1387:The International Journal of Neuroscience 1361: 1320: 1310: 1269: 1185: 1155: 1153: 1133: 1044: 5417:Disorganized (hebephrenic) schizophrenia 5013:Depersonalization-derealization disorder 1561: 1559: 1557: 1209: 1207: 1205: 1103: 1101: 1099: 732:Grant I, Sacktor H, McArthur J (2005). 691:Neuropathology and Applied Neurobiology 615: 64:HIV-associated neurocognitive disorders 33:HIV-associated neurocognitive disorders 1887: 1471:Berger JR, Avison M (September 2004). 1037:10.1016/j.neuropsychologia.2009.12.033 784:The Indian Journal of Medical Research 638: 636: 2556:Discredited HIV/AIDS origins theories 7: 1858:Comprehensive textbook of psychiatry 162:highly active antiretroviral therapy 5120:Physiological and physical behavior 3523:Subacute sclerosing panencephalitis 2675:The Freddie Mercury Tribute Concert 1299:The Journal of Biological Chemistry 5066:Psychogenic non-epileptic seizures 4460:Emotional and behavioral disorders 943:10.1212/01.wnl.0000218305.09183.70 703:10.1111/j.1365-2990.1995.tb01053.x 247:direct effects of HIV in the brain 25: 5246:Hypoactive sexual desire disorder 3842:Severe acute respiratory syndrome 3368:Follicular dendritic cell sarcoma 2261:Countries by AIDS prevalence rate 4546:X-linked intellectual disability 3828:Middle East respiratory syndrome 2722:Democratic Republic of the Congo 2282:AIDS-defining clinical condition 1849:Grant, I., Atkinson, J. (1995). 250:toxic effects of drug treatments 4375:Intermittent explosive disorder 4300:Ego-dystonic sexual orientation 884:"The neuropathogenesis of AIDS" 676:MSD Manual Professional Edition 624:5-Minute Neurology Consult, The 5018:Dissociative identity disorder 4283:Adult personality and behavior 3427:Adult T-cell leukemia/lymphoma 3413:Splenic marginal zone lymphoma 1530:10.1523/jneurosci.1460-11.2011 1442:10.1016/j.jneuroim.2004.08.025 734:"HIV neurocognitive disorders" 1: 2591:Misconceptions about HIV/AIDS 2571:International AIDS Conference 2525:HIV/AIDS in the porn industry 2468:Discrimination against people 1293:Fan Y, He JJ (October 2016). 5422:Pseudoneurotic schizophrenia 4959:Generalized anxiety disorder 4692:Neurological and symptomatic 4337:Sexual relationship disorder 3632:Tropical spastic paraparesis 3537:Lymphocytic choriomeningitis 2451:Catholic Church and HIV/AIDS 2332:HIV Drug Resistance Database 1626:. Boston, MA. Archived from 1082:10.1037/0735-7044.121.6.1163 838:Nature Reviews. Neuroscience 553:Mother-to-child transmission 5198:REM sleep behavior disorder 4667:Seasonal affective disorder 4465:Separation anxiety disorder 3995:Cytomegalovirus esophagitis 3915:Human parainfluenza viruses 3588:Ramsay Hunt syndrome type 2 2752:CĂ´te d'Ivoire (Ivory Coast) 2586:Media portrayal of HIV/AIDS 2515:List of HIV-positive people 1518:The Journal of Neuroscience 5541: 5465:Symptoms and uncategorized 4566:developmental disabilities 4332:Sexual maturation disorder 2652:Reports from the Holocaust 2576:International AIDS Society 2566:Elton John AIDS Foundation 1914:Behavioural Brain Research 1430:Journal of Neuroimmunology 1363:10.1016/j.stem.2007.07.010 1271:10.1001/archneur.64.9.1275 888:Nature Reviews. Immunology 588:platelet activating factor 5470: 5459: 5427:Simple-type schizophrenia 5396:Schizophreniform disorder 5348: 5327: 5280: 5262: 5125: 5114: 4862: 4841: 4774:Mild cognitive impairment 4759:Creutzfeldt–Jakob disease 4697: 4686: 4657:Major depressive disorder 4610: 4596: 4562:Psychological development 4429: 4416: 4288: 4277: 3659:Cytomegalovirus retinitis 3202: 3042: 2611:Treatment Action Campaign 2327:Tuberculosis co-infection 2190:disease progression rates 1926:10.1016/j.bbr.2007.11.021 1755:Frontiers in Neuroscience 1718:10.1007/s13365-011-0032-7 1669:10.1080/13550280902973960 1584:10.3109/13550280903552420 1399:10.1080/00207450802335537 1178:10.1007/s13365-010-0006-1 1126:10.1017/S1355617710001037 987:10.1080/13550280490521078 418:HAD stage characteristics 343:, deep white matter, and 5475:Impulse-control disorder 5391:Schizoaffective disorder 5386:Brief reactive psychosis 5083:Mass psychogenic illness 5046:Body dysmorphic disorder 4825:Post-concussion syndrome 4435:Emotional and behavioral 3761:Infectious mononucleosis 3578:Chandipura vesiculovirus 3408:Hepatocellular carcinoma 3353:Nasopharyngeal carcinoma 3286:Hepatocellular carcinoma 2337:Innate resistance to HIV 2307:Neurocognitive disorders 1957:Immunodeficiency Reviews 1768:10.3389/fnins.2019.01398 1706:Journal of Neurovirology 1657:Journal of Neurovirology 1572:Journal of Neurovirology 1166:Journal of Neurovirology 975:Journal of Neurovirology 231:opportunistic infections 5412:Childhood schizophrenia 4764:Frontotemporal dementia 4721:High-functioning autism 4538:Intellectual disability 3557:Encephalitis lethargica 3258:viral systemic diseases 2658:AIDS–Holocaust metaphor 2641:Gay Men's Health Crisis 2317:Opportunistic infection 1818:10.1089/brain.2011.0016 1477:Frontiers in Bioscience 1312:10.1074/jbc.M116.731836 1070:Behavioral Neuroscience 646:Clinical Neuropathology 225:opportunistic infection 168:of HAD has declined in 99:HIV-associated dementia 4929:Specific social phobia 4820:Organic brain syndrome 4662:Melancholic depression 4423:Childhood and learning 3929:Human orthopneumovirus 3583:Herpesviral meningitis 3544:Arbovirus encephalitis 2485:HIV-affected community 2425:HIV and homosexual men 1996:10.1542/peds.2012-0405 561:central nervous system 335:Brain regions affected 308:leading to apoptosis. 135:central nervous system 5485:Psychomotor agitation 5275:and substance-related 5218:Postpartum depression 5098:Somatization disorder 4984:Acute stress reaction 4749:AIDS dementia complex 3387:Merkel-cell carcinoma 2665:Silence=Death Project 2463:Criminal transmission 2383:Multiple sex partners 1258:Archives of Neurology 1228:10.1055/s-2006-956759 1216:Seminars in Neurology 745:The Neurology of AIDS 312:Direct effects of HIV 235:AIDS-related lymphoma 5480:KlĂĽver–Bucy syndrome 5310:Substance dependence 5223:Postpartum psychosis 4769:Huntington's disease 4551:Lujan–Fryns syndrome 4400:Personality disorder 4032:Adenovirus infection 3496:Human polyomavirus 2 3325:Oropharyngeal cancer 2987:United Arab Emirates 2458:Circumcision and HIV 2415:City of Hope Patient 2175:structure and genome 503:Neuroimaging studies 492:urinary incontinence 243:AIDS-related cancers 197:HAART or monotherapy 5520:Cognitive disorders 5360:Delusional disorder 5305:Stimulant psychosis 5295:Physical dependence 5149:Rumination syndrome 5051:Conversion disorder 5028:Psychogenic amnesia 4878:with depressed mood 4876:Adjustment disorder 4779:Parkinson's disease 4754:Alzheimer's disease 4647:Atypical depression 4483:Social functioning 4358:Munchausen syndrome 4353:Factitious disorder 3618:Post-polio syndrome 3254:Infectious diseases 2535:AIDS Memorial Quilt 2347:HIV-positive people 1305:(43): 22830–22840. 557:developmental delay 408:cerebrospinal fluid 359:Diagnostic criteria 325:blood–brain barrier 201:clinical depression 170:developed countries 145:, abnormalities of 123:Histopathologically 5379:schizophrenia-like 5023:Dissociative fugue 4472:Movement disorders 3751:Epstein–Barr virus 3721:Respiratory system 3358:Burkitt's lymphoma 3112:Dominican Republic 2495:HIV/AIDS denialism 2420:Women and HIV/AIDS 2410:The London Patient 2277:Signs and symptoms 2185:CDC classification 1806:Brain Connectivity 542:facial recognition 514:neuropsychological 496:fecal incontinence 429:Normal Mental and 52:Infectious disease 5502: 5501: 5498: 5497: 5455: 5454: 5451: 5450: 5323: 5322: 5258: 5257: 5254: 5253: 5110: 5109: 5106: 5105: 4999: 4998: 4837: 4836: 4833: 4832: 4794:Vascular dementia 4716:Asperger syndrome 4682: 4681: 4592: 4591: 4588: 4587: 4526:Tourette syndrome 4412: 4411: 4408: 4407: 4232: 4231: 4194: 4193: 3945: 3944: 3876:Influenza virus A 3793:Human coronavirus 3683: 3682: 3673:Herpes of the eye 3220: 3219: 3198: 3197: 3120: 3119: 2601:The SING Campaign 2490:HIV/AIDS activism 2478:Cost of treatment 2400:Timothy Ray Brown 2395:World AIDS Museum 2112: 2111: 1867:978-0-683-04532-1 754:978-0-19-852610-0 576:virus replication 510:prefrontal cortex 61: 60: 27:Medical condition 16:(Redirected from 5532: 5461: 5350: 5329: 5264: 5139:Anorexia nervosa 5127: 5116: 5093:Psychogenic pain 5061:Globus pharyngis 4909:Childhood phobia 4892: 4864: 4843: 4699: 4688: 4598: 4497:Selective mutism 4448:Conduct disorder 4431: 4418: 4395:Trichotillomania 4370:Gender dysphoria 4365:Fear of intimacy 4322:Sexual anhedonia 4290: 4279: 4266:Mental disorders 4259: 4252: 4245: 4236: 3958: 3953:digestive system 3870:Orthomyxoviridae 3836:SARS coronavirus 3822:MERS coronavirus 3738: 3550:Orthomyxoviridae 3473: 3439:Immune disorders 3363:Hodgkin lymphoma 3339:Kaposi's sarcoma 3247: 3240: 3233: 3224: 3190:Papua New Guinea 3040: 2695: 2139: 2132: 2125: 2116: 2047: 2035: 2034: 2022: 2016: 2015: 1979: 1973: 1972: 1952: 1946: 1945: 1909: 1900: 1899: 1893: 1885: 1883: 1882: 1876: 1870:. Archived from 1855: 1846: 1840: 1839: 1829: 1797: 1791: 1790: 1780: 1770: 1746: 1740: 1739: 1729: 1697: 1691: 1690: 1680: 1648: 1642: 1641: 1639: 1638: 1632: 1621: 1612: 1606: 1605: 1595: 1563: 1552: 1551: 1541: 1509: 1503: 1502: 1492: 1468: 1462: 1461: 1425: 1419: 1418: 1382: 1376: 1375: 1365: 1341: 1335: 1334: 1324: 1314: 1290: 1284: 1283: 1273: 1249: 1240: 1239: 1211: 1200: 1199: 1189: 1157: 1148: 1147: 1137: 1105: 1094: 1093: 1076:(6): 1163–1173. 1065: 1059: 1058: 1048: 1025:Neuropsychologia 1016: 1007: 1006: 969: 963: 962: 926: 920: 919: 879: 870: 869: 833: 827: 826: 806: 800: 799: 779: 773: 772: 770: 769: 763: 757:. Archived from 738: 729: 723: 722: 686: 680: 679: 668: 662: 661: 640: 631: 620: 406:to evaluate the 30: 21: 5540: 5539: 5535: 5534: 5533: 5531: 5530: 5529: 5505: 5504: 5503: 5494: 5466: 5447: 5431: 5400: 5378: 5369: 5344: 5319: 5276: 5273:substance abuse 5250: 5227: 5204: 5158: 5144:Bulimia nervosa 5121: 5102: 5078:Hypochondriasis 5073:False pregnancy 5056:Ganser syndrome 5038:Somatic symptom 5032: 4995: 4947: 4936:Specific phobia 4881: 4858: 4829: 4803: 4735: 4731:Savant syndrome 4703:Autism spectrum 4693: 4678: 4606: 4584: 4563: 4557: 4532: 4425: 4404: 4380:Dermatillomania 4341: 4327:Sexual anorexia 4284: 4273: 4263: 4233: 4228: 4190: 4170: 4078: 4052:Gastroenteritis 4010: 4007:Gastroenteritis 4001: 3989:Cytomegalovirus 3952: 3941: 3909:Paramyxoviridae 3898:Avian influenza 3774: 3769:Cytomegalovirus 3733:viral pneumonia 3731: 3728:nasopharyngitis 3727: 3724: 3715: 3679: 3653:Cytomegalovirus 3638: 3592: 3480: 3467: 3460: 3433: 3300:Cervical cancer 3260: 3251: 3221: 3216: 3194: 3168: 3116: 3088: 3029: 3001: 2947:Myanmar (Burma) 2836: 2684: 2670:Day Without Art 2616:The Global Fund 2544: 2473:Economic impact 2429: 2361: 2265: 2217:pathophysiology 2153: 2143: 2113: 2108: 2107: 2058: 2044: 2039: 2038: 2024: 2023: 2019: 1990:(5): e1326-44. 1981: 1980: 1976: 1954: 1953: 1949: 1911: 1910: 1903: 1886: 1880: 1878: 1874: 1868: 1853: 1848: 1847: 1843: 1799: 1798: 1794: 1748: 1747: 1743: 1699: 1698: 1694: 1650: 1649: 1645: 1636: 1634: 1630: 1619: 1614: 1613: 1609: 1565: 1564: 1555: 1524:(26): 9456–65. 1511: 1510: 1506: 1483:(1–3): 2680–5. 1470: 1469: 1465: 1427: 1426: 1422: 1384: 1383: 1379: 1343: 1342: 1338: 1292: 1291: 1287: 1251: 1250: 1243: 1213: 1212: 1203: 1159: 1158: 1151: 1107: 1106: 1097: 1067: 1066: 1062: 1031:(5): 1295–304. 1018: 1017: 1010: 971: 970: 966: 937:(11): 1688–95. 928: 927: 923: 900:10.1038/nri1527 881: 880: 873: 850:10.1038/nrn2040 835: 834: 830: 808: 807: 803: 781: 780: 776: 767: 765: 761: 755: 736: 731: 730: 726: 688: 687: 683: 670: 669: 665: 642: 641: 634: 621: 617: 612: 550: 518:globus pallidus 505: 420: 404:lumbar puncture 367:medical history 361: 337: 314: 221: 219:Pathophysiology 189: 172:, although its 28: 23: 22: 15: 12: 11: 5: 5538: 5536: 5528: 5527: 5522: 5517: 5507: 5506: 5500: 5499: 5496: 5495: 5493: 5492: 5487: 5482: 5477: 5471: 5468: 5467: 5464: 5457: 5456: 5453: 5452: 5449: 5448: 5446: 5445: 5439: 5437: 5433: 5432: 5430: 5429: 5424: 5419: 5414: 5408: 5406: 5402: 5401: 5399: 5398: 5393: 5388: 5382: 5380: 5371: 5370: 5368: 5367: 5362: 5356: 5354: 5346: 5345: 5332: 5325: 5324: 5321: 5320: 5318: 5317: 5312: 5307: 5302: 5300:Rebound effect 5297: 5292: 5287: 5281: 5278: 5277: 5267: 5260: 5259: 5256: 5255: 5252: 5251: 5249: 5248: 5243: 5241:Hypersexuality 5237: 5235: 5229: 5228: 5226: 5225: 5220: 5214: 5212: 5206: 5205: 5203: 5202: 5201: 5200: 5195: 5190: 5180: 5175: 5169: 5167: 5160: 5159: 5157: 5156: 5151: 5146: 5141: 5135: 5133: 5123: 5122: 5119: 5112: 5111: 5108: 5107: 5104: 5103: 5101: 5100: 5095: 5090: 5085: 5080: 5075: 5070: 5069: 5068: 5063: 5058: 5048: 5042: 5040: 5034: 5033: 5031: 5030: 5025: 5020: 5015: 5009: 5007: 5001: 5000: 4997: 4996: 4994: 4993: 4992: 4991: 4986: 4976: 4974:Panic disorder 4971: 4966: 4961: 4955: 4953: 4949: 4948: 4946: 4945: 4944: 4943: 4941:Claustrophobia 4933: 4932: 4931: 4926: 4924:Anthropophobia 4916: 4914:Social anxiety 4911: 4906: 4900: 4898: 4889: 4883: 4882: 4880: 4879: 4872: 4870: 4860: 4859: 4846: 4839: 4838: 4835: 4834: 4831: 4830: 4828: 4827: 4822: 4817: 4811: 4809: 4805: 4804: 4802: 4801: 4796: 4791: 4786: 4784:Pick's disease 4781: 4776: 4771: 4766: 4761: 4756: 4751: 4745: 4743: 4737: 4736: 4734: 4733: 4728: 4723: 4718: 4713: 4707: 4705: 4695: 4694: 4691: 4684: 4683: 4680: 4679: 4677: 4676: 4671: 4670: 4669: 4664: 4659: 4654: 4649: 4639: 4638: 4637: 4632: 4627: 4622: 4611: 4608: 4607: 4601: 4594: 4593: 4590: 4589: 4586: 4585: 4583: 4582: 4577: 4571: 4569: 4559: 4558: 4556: 4555: 4554: 4553: 4542: 4540: 4534: 4533: 4531: 4530: 4529: 4528: 4518: 4517: 4516: 4511: 4501: 4500: 4499: 4494: 4489: 4481: 4480: 4479: 4469: 4468: 4467: 4457: 4456: 4455: 4445: 4439: 4437: 4427: 4426: 4421: 4414: 4413: 4410: 4409: 4406: 4405: 4403: 4402: 4397: 4392: 4387: 4382: 4377: 4372: 4367: 4362: 4361: 4360: 4349: 4347: 4343: 4342: 4340: 4339: 4334: 4329: 4324: 4319: 4318: 4317: 4312: 4302: 4296: 4294: 4286: 4285: 4282: 4275: 4274: 4270:Classification 4264: 4262: 4261: 4254: 4247: 4239: 4230: 4229: 4227: 4226: 4225: 4224: 4212: 4204: 4202: 4196: 4195: 4192: 4191: 4189: 4188: 4180: 4178: 4172: 4171: 4169: 4168: 4156: 4144: 4132: 4120: 4113: 4107: 4106: 4094: 4088: 4086: 4080: 4079: 4077: 4076: 4069: 4062: 4055: 4043: 4037: 4036: 4035: 4034: 4022: 4016: 4014: 4003: 4002: 4000: 3999: 3998: 3997: 3985: 3984: 3983: 3970: 3968: 3955: 3947: 3946: 3943: 3942: 3940: 3939: 3932: 3925: 3924: 3923: 3903: 3902: 3901: 3900: 3861: 3860: 3859: 3858: 3846: 3845: 3844: 3832: 3831: 3830: 3818: 3817: 3816: 3784: 3782: 3776: 3775: 3773: 3772: 3765: 3764: 3763: 3746: 3744: 3735: 3717: 3716: 3714: 3713: 3712: 3711: 3706: 3693: 3691: 3689:Cardiovascular 3685: 3684: 3681: 3680: 3678: 3677: 3676: 3675: 3663: 3662: 3661: 3648: 3646: 3640: 3639: 3637: 3636: 3635: 3634: 3622: 3621: 3620: 3615: 3602: 3600: 3594: 3593: 3591: 3590: 3585: 3580: 3575: 3574: 3573: 3561: 3560: 3559: 3546: 3541: 3540: 3539: 3527: 3526: 3525: 3513: 3507: 3506: 3505: 3504: 3492: 3486: 3484: 3470: 3468:nervous system 3462: 3461: 3459: 3458: 3457: 3456: 3443: 3441: 3435: 3434: 3432: 3431: 3430: 3429: 3417: 3416: 3415: 3410: 3398: 3392: 3391: 3390: 3389: 3377: 3376: 3375: 3370: 3365: 3360: 3355: 3343: 3342: 3341: 3329: 3328: 3327: 3322: 3320:Vaginal cancer 3317: 3312: 3307: 3302: 3290: 3289: 3288: 3276: 3270: 3268: 3262: 3261: 3252: 3250: 3249: 3242: 3235: 3227: 3218: 3217: 3215: 3214: 3209: 3203: 3200: 3199: 3196: 3195: 3193: 3192: 3187: 3182: 3176: 3174: 3170: 3169: 3167: 3166: 3161: 3156: 3151: 3146: 3141: 3136: 3130: 3128: 3122: 3121: 3118: 3117: 3115: 3114: 3109: 3104: 3098: 3096: 3090: 3089: 3087: 3086: 3085: 3084: 3074: 3069: 3064: 3059: 3054: 3049: 3043: 3037: 3031: 3030: 3028: 3027: 3022: 3017: 3015:United Kingdom 3011: 3009: 3003: 3002: 3000: 2999: 2994: 2989: 2984: 2979: 2974: 2969: 2964: 2959: 2954: 2949: 2944: 2939: 2934: 2929: 2924: 2919: 2914: 2909: 2904: 2899: 2894: 2893: 2892: 2882: 2877: 2872: 2867: 2862: 2857: 2852: 2846: 2844: 2838: 2837: 2835: 2834: 2829: 2824: 2819: 2814: 2809: 2804: 2799: 2794: 2789: 2784: 2779: 2774: 2769: 2764: 2759: 2754: 2749: 2744: 2739: 2734: 2729: 2724: 2719: 2714: 2709: 2703: 2701: 2692: 2686: 2685: 2683: 2682: 2677: 2672: 2667: 2662: 2661: 2660: 2655: 2648: 2643: 2633: 2628: 2626:YAA/Youthforce 2623: 2621:World AIDS Day 2618: 2613: 2608: 2603: 2598: 2593: 2588: 2583: 2578: 2573: 2568: 2563: 2558: 2552: 2550: 2546: 2545: 2543: 2542: 2537: 2532: 2527: 2522: 2517: 2512: 2507: 2502: 2497: 2492: 2487: 2482: 2481: 2480: 2470: 2465: 2460: 2455: 2454: 2453: 2443: 2437: 2435: 2431: 2430: 2428: 2427: 2422: 2417: 2412: 2407: 2405:Berlin Patient 2402: 2397: 2392: 2387: 2386: 2385: 2375: 2369: 2367: 2363: 2362: 2360: 2359: 2354: 2349: 2344: 2339: 2334: 2329: 2324: 2322:Superinfection 2319: 2314: 2309: 2304: 2302:Cardiomyopathy 2299: 2294: 2289: 2284: 2279: 2273: 2271: 2267: 2266: 2264: 2263: 2258: 2257: 2256: 2254:Teens / Adults 2251: 2241: 2240: 2239: 2234: 2229: 2224: 2219: 2214: 2209: 2199: 2198: 2197: 2192: 2187: 2182: 2177: 2172: 2161: 2159: 2155: 2154: 2144: 2142: 2141: 2134: 2127: 2119: 2110: 2109: 2106: 2105: 2094: 2079: 2059: 2054: 2053: 2051: 2050:Classification 2043: 2042:External links 2040: 2037: 2036: 2017: 1974: 1947: 1901: 1866: 1841: 1792: 1741: 1692: 1643: 1607: 1553: 1504: 1463: 1436:(1–2): 140–6. 1420: 1377: 1350:Cell Stem Cell 1336: 1285: 1264:(9): 1275–80. 1241: 1201: 1149: 1120:(6): 1127–37. 1095: 1060: 1008: 964: 921: 871: 828: 801: 774: 753: 724: 681: 663: 632: 614: 613: 611: 608: 592:prostaglandins 549: 546: 504: 501: 500: 499: 474: 464: 455: 446: 443:snout response 433: 431:Motor Function 419: 416: 388: 387: 383: 376: 373: 370: 360: 357: 336: 333: 313: 310: 257: 256: 251: 248: 245: 232: 220: 217: 188: 185: 149:processes and 143:myelin sheaths 83:encephalopathy 59: 58: 49: 43: 42: 39: 35: 34: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 5537: 5526: 5523: 5521: 5518: 5516: 5513: 5512: 5510: 5491: 5488: 5486: 5483: 5481: 5478: 5476: 5473: 5472: 5469: 5462: 5458: 5444: 5441: 5440: 5438: 5434: 5428: 5425: 5423: 5420: 5418: 5415: 5413: 5410: 5409: 5407: 5405:Schizophrenia 5403: 5397: 5394: 5392: 5389: 5387: 5384: 5383: 5381: 5376: 5372: 5366: 5363: 5361: 5358: 5357: 5355: 5351: 5347: 5343: 5339: 5335: 5334:Schizophrenia 5330: 5326: 5316: 5313: 5311: 5308: 5306: 5303: 5301: 5298: 5296: 5293: 5291: 5288: 5286: 5285:Drug overdose 5283: 5282: 5279: 5274: 5270: 5265: 5261: 5247: 5244: 5242: 5239: 5238: 5236: 5234: 5233:Sexual desire 5230: 5224: 5221: 5219: 5216: 5215: 5213: 5211: 5207: 5199: 5196: 5194: 5191: 5189: 5186: 5185: 5184: 5181: 5179: 5176: 5174: 5171: 5170: 5168: 5166: 5161: 5155: 5152: 5150: 5147: 5145: 5142: 5140: 5137: 5136: 5134: 5132: 5128: 5124: 5117: 5113: 5099: 5096: 5094: 5091: 5089: 5086: 5084: 5081: 5079: 5076: 5074: 5071: 5067: 5064: 5062: 5059: 5057: 5054: 5053: 5052: 5049: 5047: 5044: 5043: 5041: 5039: 5035: 5029: 5026: 5024: 5021: 5019: 5016: 5014: 5011: 5010: 5008: 5006: 5002: 4990: 4987: 4985: 4982: 4981: 4980: 4977: 4975: 4972: 4970: 4967: 4965: 4962: 4960: 4957: 4956: 4954: 4950: 4942: 4939: 4938: 4937: 4934: 4930: 4927: 4925: 4922: 4921: 4920: 4919:Social phobia 4917: 4915: 4912: 4910: 4907: 4905: 4902: 4901: 4899: 4897: 4893: 4890: 4888: 4884: 4877: 4874: 4873: 4871: 4869: 4865: 4861: 4857: 4854:-related and 4853: 4849: 4844: 4840: 4826: 4823: 4821: 4818: 4816: 4813: 4812: 4810: 4806: 4800: 4797: 4795: 4792: 4790: 4787: 4785: 4782: 4780: 4777: 4775: 4772: 4770: 4767: 4765: 4762: 4760: 4757: 4755: 4752: 4750: 4747: 4746: 4744: 4742: 4738: 4732: 4729: 4727: 4724: 4722: 4719: 4717: 4714: 4712: 4709: 4708: 4706: 4704: 4700: 4696: 4689: 4685: 4675: 4672: 4668: 4665: 4663: 4660: 4658: 4655: 4653: 4650: 4648: 4645: 4644: 4643: 4640: 4636: 4633: 4631: 4628: 4626: 4623: 4621: 4618: 4617: 4616: 4613: 4612: 4609: 4604: 4599: 4595: 4581: 4578: 4576: 4573: 4572: 4570: 4567: 4560: 4552: 4549: 4548: 4547: 4544: 4543: 4541: 4539: 4535: 4527: 4524: 4523: 4522: 4519: 4515: 4512: 4510: 4507: 4506: 4505: 4502: 4498: 4495: 4493: 4490: 4488: 4485: 4484: 4482: 4478: 4475: 4474: 4473: 4470: 4466: 4463: 4462: 4461: 4458: 4454: 4451: 4450: 4449: 4446: 4444: 4441: 4440: 4438: 4436: 4432: 4428: 4424: 4419: 4415: 4401: 4398: 4396: 4393: 4391: 4388: 4386: 4383: 4381: 4378: 4376: 4373: 4371: 4368: 4366: 4363: 4359: 4356: 4355: 4354: 4351: 4350: 4348: 4344: 4338: 4335: 4333: 4330: 4328: 4325: 4323: 4320: 4316: 4313: 4311: 4308: 4307: 4306: 4303: 4301: 4298: 4297: 4295: 4291: 4287: 4280: 4276: 4271: 4267: 4260: 4255: 4253: 4248: 4246: 4241: 4240: 4237: 4223: 4220: 4219: 4218: 4217: 4213: 4211: 4210: 4206: 4205: 4203: 4201: 4197: 4187: 4186: 4182: 4181: 4179: 4177: 4173: 4166: 4162: 4161: 4157: 4154: 4150: 4149: 4145: 4142: 4138: 4137: 4133: 4130: 4126: 4125: 4121: 4119: 4118: 4114: 4112: 4109: 4108: 4104: 4100: 4099: 4095: 4093: 4090: 4089: 4087: 4085: 4081: 4075: 4074: 4070: 4068: 4067: 4063: 4061: 4060: 4056: 4053: 4049: 4048: 4044: 4042: 4039: 4038: 4033: 4030: 4029: 4028: 4027: 4023: 4021: 4018: 4017: 4015: 4013: 4008: 4004: 3996: 3993: 3992: 3991: 3990: 3986: 3982: 3979: 3978: 3977: 3976: 3972: 3971: 3969: 3967: 3963: 3959: 3956: 3954: 3948: 3938: 3937: 3933: 3931: 3930: 3926: 3922: 3921:Parainfluenza 3919: 3918: 3917: 3916: 3911: 3910: 3905: 3904: 3899: 3895: 3892: 3891: 3890: 3889: 3885: 3881: 3877: 3872: 3871: 3866: 3863: 3862: 3857: 3854: 3853: 3852: 3851: 3847: 3843: 3840: 3839: 3838: 3837: 3833: 3829: 3826: 3825: 3824: 3823: 3819: 3815: 3812: 3811: 3810: 3809: 3805: 3801: 3797: 3794: 3789: 3786: 3785: 3783: 3781: 3777: 3771: 3770: 3766: 3762: 3758: 3757:EBV infection 3755: 3754: 3753: 3752: 3748: 3747: 3745: 3743: 3739: 3736: 3734: 3729: 3722: 3718: 3710: 3707: 3705: 3702: 3701: 3700: 3699: 3695: 3694: 3692: 3690: 3686: 3674: 3671: 3670: 3669: 3668: 3664: 3660: 3657: 3656: 3655: 3654: 3650: 3649: 3647: 3645: 3641: 3633: 3630: 3629: 3628: 3627: 3623: 3619: 3616: 3614: 3613:Poliomyelitis 3611: 3610: 3609: 3608: 3604: 3603: 3601: 3599: 3595: 3589: 3586: 3584: 3581: 3579: 3576: 3572: 3569: 3568: 3567: 3566: 3562: 3558: 3555: 3554: 3552: 3551: 3547: 3545: 3542: 3538: 3535: 3534: 3533: 3532: 3528: 3524: 3521: 3520: 3519: 3518: 3514: 3512: 3509: 3508: 3503: 3500: 3499: 3498: 3497: 3493: 3491: 3488: 3487: 3485: 3483: 3478: 3474: 3471: 3469: 3463: 3455: 3452: 3451: 3450: 3449: 3445: 3444: 3442: 3440: 3436: 3428: 3425: 3424: 3423: 3422: 3418: 3414: 3411: 3409: 3406: 3405: 3404: 3403: 3399: 3397: 3394: 3393: 3388: 3385: 3384: 3383: 3382: 3378: 3374: 3371: 3369: 3366: 3364: 3361: 3359: 3356: 3354: 3351: 3350: 3349: 3348: 3344: 3340: 3337: 3336: 3335: 3334: 3330: 3326: 3323: 3321: 3318: 3316: 3315:Vulvar cancer 3313: 3311: 3310:Penile cancer 3308: 3306: 3303: 3301: 3298: 3297: 3296: 3295: 3291: 3287: 3284: 3283: 3282: 3281: 3277: 3275: 3272: 3271: 3269: 3267: 3263: 3259: 3255: 3248: 3243: 3241: 3236: 3234: 3229: 3228: 3225: 3213: 3210: 3208: 3205: 3204: 3201: 3191: 3188: 3186: 3183: 3181: 3178: 3177: 3175: 3171: 3165: 3162: 3160: 3157: 3155: 3152: 3150: 3147: 3145: 3142: 3140: 3137: 3135: 3132: 3131: 3129: 3127: 3126:South America 3123: 3113: 3110: 3108: 3105: 3103: 3100: 3099: 3097: 3095: 3091: 3083: 3082:New York City 3080: 3079: 3078: 3077:United States 3075: 3073: 3070: 3068: 3065: 3063: 3060: 3058: 3055: 3053: 3050: 3048: 3045: 3044: 3041: 3038: 3036: 3035:North America 3032: 3026: 3023: 3021: 3018: 3016: 3013: 3012: 3010: 3008: 3004: 2998: 2995: 2993: 2990: 2988: 2985: 2983: 2980: 2978: 2975: 2973: 2970: 2968: 2965: 2963: 2960: 2958: 2955: 2953: 2950: 2948: 2945: 2943: 2940: 2938: 2935: 2933: 2930: 2928: 2925: 2923: 2920: 2918: 2915: 2913: 2910: 2908: 2905: 2903: 2900: 2898: 2895: 2891: 2888: 2887: 2886: 2883: 2881: 2878: 2876: 2873: 2871: 2868: 2866: 2863: 2861: 2858: 2856: 2853: 2851: 2848: 2847: 2845: 2843: 2839: 2833: 2830: 2828: 2825: 2823: 2820: 2818: 2815: 2813: 2810: 2808: 2805: 2803: 2800: 2798: 2795: 2793: 2790: 2788: 2785: 2783: 2780: 2778: 2775: 2773: 2770: 2768: 2765: 2763: 2760: 2758: 2755: 2753: 2750: 2748: 2745: 2743: 2740: 2738: 2735: 2733: 2730: 2728: 2725: 2723: 2720: 2718: 2715: 2713: 2710: 2708: 2705: 2704: 2702: 2700: 2696: 2693: 2691: 2687: 2681: 2678: 2676: 2673: 2671: 2668: 2666: 2663: 2659: 2656: 2654: 2653: 2649: 2647: 2644: 2642: 2639: 2638: 2637: 2634: 2632: 2629: 2627: 2624: 2622: 2619: 2617: 2614: 2612: 2609: 2607: 2604: 2602: 2599: 2597: 2594: 2592: 2589: 2587: 2584: 2582: 2579: 2577: 2574: 2572: 2569: 2567: 2564: 2562: 2559: 2557: 2554: 2553: 2551: 2547: 2541: 2538: 2536: 2533: 2531: 2528: 2526: 2523: 2521: 2518: 2516: 2513: 2511: 2510:Sex education 2508: 2506: 2503: 2501: 2498: 2496: 2493: 2491: 2488: 2486: 2483: 2479: 2476: 2475: 2474: 2471: 2469: 2466: 2464: 2461: 2459: 2456: 2452: 2449: 2448: 2447: 2444: 2442: 2439: 2438: 2436: 2432: 2426: 2423: 2421: 2418: 2416: 2413: 2411: 2408: 2406: 2403: 2401: 2398: 2396: 2393: 2391: 2388: 2384: 2381: 2380: 2379: 2376: 2374: 2371: 2370: 2368: 2364: 2358: 2355: 2353: 2350: 2348: 2345: 2343: 2340: 2338: 2335: 2333: 2330: 2328: 2325: 2323: 2320: 2318: 2315: 2313: 2310: 2308: 2305: 2303: 2300: 2298: 2295: 2293: 2292:Lipodystrophy 2290: 2288: 2285: 2283: 2280: 2278: 2275: 2274: 2272: 2268: 2262: 2259: 2255: 2252: 2250: 2247: 2246: 2245: 2242: 2238: 2235: 2233: 2230: 2228: 2225: 2223: 2220: 2218: 2215: 2213: 2210: 2208: 2205: 2204: 2203: 2200: 2196: 2193: 2191: 2188: 2186: 2183: 2181: 2178: 2176: 2173: 2171: 2168: 2167: 2166: 2163: 2162: 2160: 2156: 2151: 2147: 2140: 2135: 2133: 2128: 2126: 2121: 2120: 2117: 2104: 2100: 2099: 2095: 2093: 2089: 2088: 2084: 2080: 2078: 2074: 2070: 2069: 2065: 2061: 2060: 2057: 2052: 2048: 2041: 2032: 2028: 2021: 2018: 2013: 2009: 2005: 2001: 1997: 1993: 1989: 1985: 1978: 1975: 1970: 1966: 1963:(2): 83–127. 1962: 1958: 1951: 1948: 1943: 1939: 1935: 1931: 1927: 1923: 1920:(2): 337–47. 1919: 1915: 1908: 1906: 1902: 1897: 1891: 1877:on 2009-02-25 1873: 1869: 1863: 1859: 1852: 1845: 1842: 1837: 1833: 1828: 1823: 1819: 1815: 1812:(3): 207–17. 1811: 1807: 1803: 1796: 1793: 1788: 1784: 1779: 1774: 1769: 1764: 1760: 1756: 1752: 1745: 1742: 1737: 1733: 1728: 1723: 1719: 1715: 1712:(3): 248–57. 1711: 1707: 1703: 1696: 1693: 1688: 1684: 1679: 1674: 1670: 1666: 1663:(4): 324–33. 1662: 1658: 1654: 1647: 1644: 1633:on 2016-03-04 1629: 1625: 1618: 1611: 1608: 1603: 1599: 1594: 1589: 1585: 1581: 1577: 1573: 1569: 1562: 1560: 1558: 1554: 1549: 1545: 1540: 1535: 1531: 1527: 1523: 1519: 1515: 1508: 1505: 1500: 1496: 1491: 1486: 1482: 1478: 1474: 1467: 1464: 1459: 1455: 1451: 1447: 1443: 1439: 1435: 1431: 1424: 1421: 1416: 1412: 1408: 1404: 1400: 1396: 1393:(2): 157–65. 1392: 1388: 1381: 1378: 1373: 1369: 1364: 1359: 1355: 1351: 1347: 1340: 1337: 1332: 1328: 1323: 1318: 1313: 1308: 1304: 1300: 1296: 1289: 1286: 1281: 1277: 1272: 1267: 1263: 1259: 1255: 1248: 1246: 1242: 1237: 1233: 1229: 1225: 1221: 1217: 1210: 1208: 1206: 1202: 1197: 1193: 1188: 1183: 1179: 1175: 1171: 1167: 1163: 1156: 1154: 1150: 1145: 1141: 1136: 1131: 1127: 1123: 1119: 1115: 1111: 1104: 1102: 1100: 1096: 1091: 1087: 1083: 1079: 1075: 1071: 1064: 1061: 1056: 1052: 1047: 1042: 1038: 1034: 1030: 1026: 1022: 1015: 1013: 1009: 1004: 1000: 996: 992: 988: 984: 980: 976: 968: 965: 960: 956: 952: 948: 944: 940: 936: 932: 925: 922: 917: 913: 909: 905: 901: 897: 893: 889: 885: 878: 876: 872: 867: 863: 859: 855: 851: 847: 843: 839: 832: 829: 824: 820: 816: 812: 805: 802: 797: 793: 789: 785: 778: 775: 764:on 2009-09-23 760: 756: 750: 746: 742: 735: 728: 725: 720: 716: 712: 708: 704: 700: 697:(3): 218–27. 696: 692: 685: 682: 677: 673: 667: 664: 659: 655: 652:(4): 146–55. 651: 647: 644:treatments". 639: 637: 633: 629: 625: 619: 616: 609: 607: 605: 599: 597: 593: 589: 585: 580: 577: 573: 569: 564: 562: 558: 554: 547: 545: 543: 537: 533: 529: 525: 523: 522:basal ganglia 519: 515: 511: 502: 497: 493: 489: 485: 481: 478: 475: 471: 468: 465: 462: 459: 456: 453: 450: 447: 444: 440: 439:(Subclinical) 437: 434: 432: 428: 425: 422: 421: 417: 415: 413: 409: 405: 401: 397: 393: 384: 381: 377: 374: 371: 368: 363: 362: 358: 356: 353: 351: 346: 342: 341:basal ganglia 334: 332: 330: 326: 322: 318: 311: 309: 307: 302: 298: 294: 290: 286: 282: 278: 274: 270: 266: 262: 255: 252: 249: 246: 244: 240: 236: 233: 230: 229: 228: 226: 218: 216: 212: 208: 206: 202: 198: 193: 186: 184: 181: 177: 175: 171: 167: 164:(HAART), the 163: 159: 154: 152: 148: 144: 140: 136: 132: 128: 124: 120: 116: 112: 111:concentration 108: 104: 100: 96: 92: 88: 84: 80: 76: 73: 69: 65: 57: 53: 50: 48: 44: 40: 36: 31: 19: 5365:Folie Ă  deux 5290:Intoxication 5271:substances, 5269:Psychoactive 5188:Night terror 5005:Dissociative 4969:Panic attack 4748: 4521:Tic disorder 4214: 4207: 4183: 4176:Pancreatitis 4158: 4146: 4134: 4122: 4115: 4096: 4071: 4064: 4057: 4045: 4024: 3987: 3973: 3934: 3927: 3913: 3907: 3874: 3868: 3848: 3834: 3820: 3791: 3767: 3749: 3704:Pericarditis 3696: 3665: 3651: 3624: 3605: 3563: 3548: 3529: 3515: 3494: 3477:Encephalitis 3446: 3419: 3400: 3379: 3345: 3331: 3292: 3278: 2977:Taiwan (ROC) 2967:Saudi Arabia 2817:South Africa 2650: 2636:Larry Kramer 2378:Epidemiology 2306: 2096: 2081: 2062: 2030: 2026: 2020: 1987: 1983: 1977: 1960: 1956: 1950: 1917: 1913: 1879:. Retrieved 1872:the original 1857: 1844: 1809: 1805: 1795: 1758: 1754: 1744: 1709: 1705: 1695: 1660: 1656: 1646: 1635:. Retrieved 1628:the original 1623: 1610: 1578:(1): 25–32. 1575: 1571: 1521: 1517: 1507: 1490:10.2741/1427 1480: 1476: 1466: 1433: 1429: 1423: 1390: 1386: 1380: 1356:(2): 230–6. 1353: 1349: 1339: 1302: 1298: 1288: 1261: 1257: 1222:(1): 86–92. 1219: 1215: 1169: 1165: 1117: 1113: 1073: 1069: 1063: 1028: 1024: 981:(6): 350–7. 978: 974: 967: 934: 930: 924: 894:(1): 69–81. 891: 887: 844:(1): 33–44. 841: 837: 831: 814: 810: 804: 787: 783: 777: 766:. Retrieved 759:the original 744: 741:Gendelman HE 727: 694: 690: 684: 675: 666: 649: 645: 623: 618: 600: 581: 565: 551: 538: 534: 530: 526: 506: 479: 476: 469: 466: 460: 457: 451: 448: 438: 435: 426: 423: 392:neurologists 389: 354: 338: 321:Trojan horse 315: 258: 254:malnutrition 222: 213: 209: 190: 187:Presentation 178: 155: 141:, pallor of 102: 98: 67: 63: 62: 18:HIV dementia 5338:schizotypal 5173:Hypersomnia 5163:Nonorganic 4904:Agoraphobia 4635:Cyclothymia 4630:Bipolar NOS 4605:(affective) 4477:Stereotypic 4385:Kleptomania 4073:Coronavirus 3814:Common cold 3726:acute viral 3709:Myocarditis 3553:(probable) 3305:Anal cancer 3185:New Zealand 3057:El Salvador 2962:Philippines 2932:North Korea 2885:China (PRC) 2850:Afghanistan 2540:Product Red 2441:AIDS orphan 2297:Nephropathy 2232:vaccination 1172:(1): 3–16. 604:metabolites 568:macrophages 484:Paraparetic 480:(End Stage) 345:hippocampal 265:macrophages 205:alexithymia 131:macrophages 95:neurotoxins 87:macrophages 38:Other names 5509:Categories 5490:Stereotypy 5353:Delusional 5342:delusional 5315:Withdrawal 5183:Parasomnia 5088:Nosophobia 4868:Adjustment 4856:somatoform 4789:Sundowning 4642:Depression 4625:Bipolar II 4514:Stuttering 4509:Cluttering 4305:Paraphilia 4200:Urogenital 4066:Astrovirus 4026:Adenovirus 3850:SARS-CoV-2 3607:Poliovirus 3482:meningitis 2897:East Timor 2870:Bangladesh 2860:Azerbaijan 2782:Mozambique 2767:Madagascar 2500:Red ribbon 2342:Serostatus 2270:Conditions 2222:prevention 2212:management 2170:Lentivirus 1984:Pediatrics 1881:2006-04-06 1637:2018-01-13 768:2006-04-06 610:References 590:(PAF) and 488:paraplegic 461:(Moderate) 285:astrocytes 277:chemokines 239:metastasis 174:prevalence 5443:Catatonia 5375:Psychosis 5210:Postnatal 5193:Nightmare 4799:Wandering 4652:Dysthymia 4620:Bipolar I 4575:Pervasive 4390:Pyromania 4315:Voyeurism 4310:Fetishism 4111:RNA virus 4092:DNA virus 4084:Hepatitis 4059:Norovirus 4047:Rotavirus 4041:RNA virus 4020:DNA virus 3966:Esophagus 3894:Influenza 3780:RNA virus 3742:DNA virus 3511:RNA virus 3490:DNA virus 3396:RNA virus 3274:DNA virus 3266:Oncovirus 3180:Australia 3134:Argentina 3094:Caribbean 3072:Nicaragua 3062:Guatemala 2972:Sri Lanka 2907:Indonesia 2690:Locations 2631:"Free Me" 2357:Pregnancy 2352:Nutrition 2207:diagnosis 2027:NeuroAids 1890:cite book 931:Neurology 817:: 343–8. 790:: 14–23. 596:phenotype 572:cytokines 436:Stage 0.5 386:disorder. 329:apoptosis 281:cytokines 269:microglia 241:of other 192:Cognitive 166:incidence 147:dendritic 133:into the 127:monocytes 109:and poor 91:microglia 75:infection 56:neurology 47:Specialty 5525:Dementia 5515:HIV/AIDS 5178:Insomnia 4848:Neurotic 4815:Delirium 4741:Dementia 4580:Specific 4209:BK virus 4012:diarrhea 3856:COVID-19 3598:Myelitis 3149:Colombia 3067:Honduras 2982:Thailand 2957:Pakistan 2942:Malaysia 2880:Cambodia 2832:Zimbabwe 2812:Tanzania 2737:Ethiopia 2732:Eswatini 2717:Botswana 2606:Solidays 2505:Safe sex 2446:Religion 2390:Timeline 2312:Pruritus 2249:Children 2227:research 2202:HIV/AIDS 2180:subtypes 2004:23118140 1942:17016258 1934:18242723 1836:22433049 1787:32009881 1761:: 1398. 1736:21544705 1687:19499454 1602:20113183 1548:21715610 1499:15358591 1458:10801232 1450:15579291 1415:25456692 1407:19125371 1372:18371353 1331:27609518 1280:17846265 1236:17226745 1196:21174240 1144:20961470 1090:18085869 1055:20036267 995:15765806 959:19876874 951:16769942 916:21564599 908:15630430 866:12936673 858:17180161 823:11291974 796:10793489 719:19576463 658:11495003 470:(Severe) 427:(Normal) 412:dementia 402:) and a 380:delirium 180:Dementia 151:neuronal 119:lethargy 4887:Anxiety 4726:PDD-NOS 4615:Bipolar 4268: ( 3962:Pharynx 3466:Central 3173:Oceania 3164:Uruguay 3139:Bolivia 3107:Jamaica 3025:Ukraine 2997:Vietnam 2865:Bahrain 2855:Armenia 2807:Senegal 2797:Nigeria 2787:Namibia 2762:Lesotho 2549:Culture 2530:HIV.gov 2373:History 2366:History 2103:D015526 2012:8096737 1969:2223063 1827:3621309 1778:6974793 1727:3702821 1678:2889153 1593:2995252 1539:3132881 1322:5077215 1187:3032197 1135:3070304 1046:2843804 1003:9718257 711:7477730 477:Stage 4 467:Stage 3 458:Stage 2 449:Stage 1 424:Stage 0 400:CT scan 350:putamen 273:neurons 261:neurons 139:gliosis 137:(CNS), 5131:Eating 4979:Stress 4896:Phobia 4852:stress 4711:Autism 4504:Speech 4293:Sexual 3626:HTLV-I 3571:Rabies 3421:HTLV-I 3154:Guyana 3144:Brazil 3052:Mexico 3047:Canada 3020:Russia 3007:Europe 2992:Turkey 2927:Jordan 2890:Yunnan 2875:Bhutan 2827:Zambia 2822:Uganda 2802:Rwanda 2772:Malawi 2747:Guinea 2707:Angola 2699:Africa 2646:ACT UP 2434:Social 2152:topics 2010:  2002:  1967:  1940:  1932:  1864:  1834:  1824:  1785:  1775:  1734:  1724:  1685:  1675:  1600:  1590:  1546:  1536:  1497:  1456:  1448:  1413:  1405:  1370:  1329:  1319:  1278:  1234:  1194:  1184:  1142:  1132:  1088:  1053:  1043:  1001:  993:  957:  949:  914:  906:  864:  856:  821:  794:  751:  717:  709:  656:  452:(Mild) 153:loss. 115:apathy 107:memory 5436:Other 5165:sleep 4952:Other 4808:Other 4674:Mania 4346:Other 4222:Mumps 3981:Mumps 3951:Human 3381:MCPyV 3102:Haiti 2952:Nepal 2922:Japan 2902:India 2792:Niger 2757:Kenya 2742:Ghana 2727:Egypt 2712:Benin 2077:F02.4 2008:S2CID 1938:S2CID 1875:(PDF) 1854:(PDF) 1631:(PDF) 1620:(PDF) 1454:S2CID 1411:S2CID 999:S2CID 955:S2CID 912:S2CID 862:S2CID 762:(PDF) 739:. In 737:(PDF) 715:S2CID 584:gp120 490:with 473:well. 301:gp120 5340:and 4989:PTSD 4603:Mood 4443:ADHD 3936:hMPV 3808:OC43 3804:HKU1 3800:NL63 3796:229E 3454:AIDS 3333:KSHV 3159:Peru 2937:Laos 2917:Iraq 2912:Iran 2842:Asia 2777:Mali 2680:Ayds 2237:PrEP 2150:AIDS 2098:MeSH 2087:9-CM 2033:(1). 2000:PMID 1965:PMID 1930:PMID 1896:link 1862:ISBN 1832:PMID 1783:PMID 1732:PMID 1683:PMID 1598:PMID 1544:PMID 1495:PMID 1446:PMID 1403:PMID 1368:PMID 1327:PMID 1276:PMID 1232:PMID 1192:PMID 1140:PMID 1086:PMID 1051:PMID 991:PMID 947:PMID 904:PMID 854:PMID 819:PMID 792:PMID 749:ISBN 707:PMID 654:PMID 494:and 295:and 279:and 267:and 203:and 129:and 89:and 79:AIDS 77:and 68:HAND 5377:and 4964:OCD 4492:RAD 4487:DAD 4453:ODD 4216:MuV 4185:CBV 4160:HEV 4148:HDV 4136:HCV 4124:HAV 4117:CBV 4098:HBV 3975:MuV 3906:V, 3698:CBV 3667:HSV 3644:Eye 3531:LCV 3517:MeV 3448:HIV 3402:HCV 3347:EBV 3294:HPV 3280:HBV 2165:HIV 2158:HIV 2146:HIV 2092:042 2083:ICD 2073:B22 2064:ICD 1992:doi 1988:130 1922:doi 1918:188 1822:PMC 1814:doi 1773:PMC 1763:doi 1722:PMC 1714:doi 1673:PMC 1665:doi 1588:PMC 1580:doi 1534:PMC 1526:doi 1485:doi 1438:doi 1434:157 1395:doi 1391:119 1358:doi 1317:PMC 1307:doi 1303:291 1266:doi 1224:doi 1182:PMC 1174:doi 1130:PMC 1122:doi 1078:doi 1074:121 1041:PMC 1033:doi 983:doi 939:doi 896:doi 846:doi 788:111 699:doi 486:or 398:or 396:MRI 317:HIV 306:Fas 297:Rev 293:Nef 289:Tat 237:or 158:CD4 103:HAD 72:HIV 5511:: 5336:, 4850:, 3912:: 3873:: 3867:, 3790:: 3788:IV 3565:RV 3256:– 2101:: 2090:: 2075:, 2071:: 2068:10 2029:. 2006:. 1998:. 1986:. 1959:. 1936:. 1928:. 1916:. 1904:^ 1892:}} 1888:{{ 1830:. 1820:. 1808:. 1804:. 1781:. 1771:. 1759:13 1757:. 1753:. 1730:. 1720:. 1710:17 1708:. 1704:. 1681:. 1671:. 1661:15 1659:. 1655:. 1622:. 1596:. 1586:. 1576:16 1574:. 1570:. 1556:^ 1542:. 1532:. 1522:31 1520:. 1516:. 1493:. 1479:. 1475:. 1452:. 1444:. 1432:. 1409:. 1401:. 1389:. 1366:. 1352:. 1348:. 1325:. 1315:. 1301:. 1297:. 1274:. 1262:64 1260:. 1256:. 1244:^ 1230:. 1220:27 1218:. 1204:^ 1190:. 1180:. 1170:17 1168:. 1164:. 1152:^ 1138:. 1128:. 1118:16 1116:. 1112:. 1098:^ 1084:. 1072:. 1049:. 1039:. 1029:48 1027:. 1023:. 1011:^ 997:. 989:. 979:10 977:. 953:. 945:. 935:66 933:. 910:. 902:. 890:. 886:. 874:^ 860:. 852:. 840:. 815:49 813:. 786:. 713:. 705:. 695:21 693:. 674:. 650:20 648:. 635:^ 598:. 291:, 117:, 54:, 4568:) 4564:( 4272:) 4258:e 4251:t 4244:v 4167:) 4165:E 4163:( 4155:) 4153:D 4151:( 4143:) 4141:C 4139:( 4131:) 4129:A 4127:( 4105:) 4103:B 4101:( 4054:) 4050:( 4009:/ 3964:/ 3896:/ 3888:D 3886:/ 3884:C 3882:/ 3880:B 3878:/ 3865:V 3806:/ 3802:/ 3798:/ 3759:/ 3730:/ 3723:/ 3479:/ 3246:e 3239:t 3232:v 2148:/ 2138:e 2131:t 2124:v 2085:- 2066:- 2056:D 2031:3 2014:. 1994:: 1971:. 1961:2 1944:. 1924:: 1898:) 1884:. 1838:. 1816:: 1810:1 1789:. 1765:: 1738:. 1716:: 1689:. 1667:: 1640:. 1604:. 1582:: 1550:. 1528:: 1501:. 1487:: 1481:9 1460:. 1440:: 1417:. 1397:: 1374:. 1360:: 1354:1 1333:. 1309:: 1282:. 1268:: 1238:. 1226:: 1198:. 1176:: 1146:. 1124:: 1092:. 1080:: 1057:. 1035:: 1005:. 985:: 961:. 941:: 918:. 898:: 892:5 868:. 848:: 842:8 825:. 798:. 771:. 721:. 701:: 678:. 660:. 630:. 520:( 498:. 101:( 66:( 20:)

Index

HIV dementia
Specialty
Infectious disease
neurology
HIV
infection
AIDS
encephalopathy
macrophages
microglia
neurotoxins
memory
concentration
apathy
lethargy
Histopathologically
monocytes
macrophages
central nervous system
gliosis
myelin sheaths
dendritic
neuronal
CD4
highly active antiretroviral therapy
incidence
developed countries
prevalence
Dementia
Cognitive

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.

↑