Knowledge (XXG)

Individual participant data

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In an IPD meta-analysis, patient-level data from multiple studies or settings are combined to address a certain research question. IPD meta-analyses tend to be common for large-scale and international projects, and they are less limited than aggregate data (AD) meta-analyses in terms of the
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Taichman, Darren B.; Backus, Joyce; Baethge, Christopher; Bauchner, Howard; de Leeuw, Peter W.; Drazen, Jeffrey M.; Fletcher, John; Frizelle, Frank A.; Groves, Trish; Haileamlak, Abraham; James, Astrid; Laine, Christine; Peiperl, Larry; Pinborg, Anja; Sahni, Peush; Wu, Sinan (2016).
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availability and quality of data they can use. Due to the high level of precision and consistency this approach allows for (which in turn makes it easier for researchers to minimize
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Debray, Thomas P. A.; Riley, Richard D.; Rovers, Maroeska M.; Reitsma, Johannes B.; Moons, Karel G. M.; Group, Cochrane IPD Meta-analysis Methods (2015-10-13).
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Tierney, Jayne F.; Pignon, Jean-Pierre; Gueffyier, Francois; Clarke, Mike; Askie, Lisa; Vale, Claire L.; Burdett, Sarah (November 2015).
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Tierney, Jayne F.; Vale, Claire; Riley, Richard; Smith, Catrin Tudur; Stewart, Lesley; Clarke, Mike; Rovers, Maroeska (2015-07-21).
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Over the past few decades, meta-analyses conducted with IPD (also known as IPD meta-analyses) have become increasingly popular.
493: 318:"Individual Participant Data (IPD) Meta-analyses of Diagnostic and Prognostic Modeling Studies: Guidance on Their Use" 524: 486: 443: 519: 369: 254:"Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use" 458: 38:(ICMJE) has stated that sharing of deidentified individual participant data is an ethical obligation. 97:"Sharing Clinical Trial Data: A Proposal From the International Committee of Medical Journal Editors" 154:"How individual participant data meta-analyses have influenced trial design, conduct, and analysis" 418: 357: 339: 293: 275: 234: 203:"Systematic review of methods for individual patient data meta- analysis with binary outcomes" 183: 134: 116: 470: 408: 347: 329: 283: 265: 224: 214: 173: 165: 124: 108: 381: 352: 317: 288: 253: 229: 202: 178: 153: 129: 96: 513: 48: 28: 169: 397:"Meta-analysis of individual participant data: rationale, conduct, and reporting" 334: 270: 27:) is raw data from individual participants, and is often used in the context of 466: 343: 279: 120: 219: 422: 361: 297: 238: 187: 138: 413: 396: 112: 201:
Thomas, Doneal; Radji, Sanyath; Benedetti, Andrea (19 June 2014).
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Riley, R. D.; Lambert, P. C.; Abo-Zaid, G. (5 February 2010).
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to evaluate the predictive performance of prognostic models
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to evaluate the safety or efficacy of medical interventions
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Individual participant data meta-analysis information
70:to develop multivariable prediction models (rules) 67:to evaluate the association of prognostic markers 36:International Committee of Medical Journal Editors 494: 8: 64:to evaluate the accuracy of diagnostic tests 501: 487: 412: 351: 333: 287: 269: 228: 218: 177: 128: 61:to identify modifiers of treatment effect 54:Common aims for an IPD meta-analysis are 86: 377: 367: 7: 455: 453: 311: 309: 307: 473:. You can help Knowledge (XXG) by 14: 457: 207:BMC Medical Research Methodology 158:Journal of Clinical Epidemiology 170:10.1016/j.jclinepi.2015.05.024 1: 335:10.1371/journal.pmed.1001886 271:10.1371/journal.pmed.1001855 101:Annals of Internal Medicine 17:Individual participant data 541: 452: 220:10.1186/1471-2288-14-79 21:individual patient data 469:-related article is a 23:, often abbreviated 380:has generic name ( 482: 481: 407:(feb05 1): c221. 164:(11): 1325–1335. 42:IPD meta-analysis 532: 525:Statistics stubs 503: 496: 489: 461: 454: 427: 426: 416: 414:10.1136/bmj.c221 392: 386: 385: 379: 375: 373: 365: 355: 337: 328:(10): e1001886. 313: 302: 301: 291: 273: 249: 243: 242: 232: 222: 198: 192: 191: 181: 149: 143: 142: 132: 113:10.7326/M15-2928 91: 540: 539: 535: 534: 533: 531: 530: 529: 510: 509: 508: 507: 450: 436: 431: 430: 394: 393: 389: 376: 366: 315: 314: 305: 264:(7): e1001855. 251: 250: 246: 200: 199: 195: 151: 150: 146: 93: 92: 88: 83: 44: 19:(also known as 12: 11: 5: 538: 536: 528: 527: 522: 512: 511: 506: 505: 498: 491: 483: 480: 479: 462: 448: 447: 435: 434:External links 432: 429: 428: 387: 303: 244: 193: 144: 107:(7): 127–128. 85: 84: 82: 79: 75: 74: 71: 68: 65: 62: 59: 43: 40: 13: 10: 9: 6: 4: 3: 2: 537: 526: 523: 521: 520:Meta-analysis 518: 517: 515: 504: 499: 497: 492: 490: 485: 484: 478: 476: 472: 468: 463: 460: 456: 451: 445: 441: 438: 437: 433: 424: 420: 415: 410: 406: 402: 398: 391: 388: 383: 371: 363: 359: 354: 349: 345: 341: 336: 331: 327: 323: 322:PLOS Medicine 319: 312: 310: 308: 304: 299: 295: 290: 285: 281: 277: 272: 267: 263: 259: 258:PLOS Medicine 255: 248: 245: 240: 236: 231: 226: 221: 216: 212: 208: 204: 197: 194: 189: 185: 180: 175: 171: 167: 163: 159: 155: 148: 145: 140: 136: 131: 126: 122: 118: 114: 110: 106: 102: 98: 90: 87: 80: 78: 72: 69: 66: 63: 60: 57: 56: 55: 52: 50: 49:heterogeneity 41: 39: 37: 32: 30: 29:meta-analysis 26: 22: 18: 475:expanding it 464: 449: 404: 400: 390: 378:|last6= 370:cite journal 325: 321: 261: 257: 247: 210: 206: 196: 161: 157: 147: 104: 100: 89: 76: 53: 45: 33: 24: 20: 16: 15: 514:Categories 467:statistics 81:References 344:1549-1676 280:1549-1676 213:(1): 79. 121:0003-4819 444:Cochrane 423:20139215 362:26461078 298:26196287 239:24943877 188:26186982 139:26830980 446:website 442:at the 353:4603958 289:4510878 230:4074845 179:4635379 130:4799536 421:  360:  350:  342:  296:  286:  278:  237:  227:  186:  176:  137:  127:  119:  465:This 471:stub 419:PMID 382:help 358:PMID 340:ISSN 294:PMID 276:ISSN 235:PMID 184:PMID 135:PMID 117:ISSN 34:The 409:doi 405:340 401:BMJ 348:PMC 330:doi 284:PMC 266:doi 225:PMC 215:doi 174:PMC 166:doi 125:PMC 109:doi 105:164 25:IPD 516:: 417:. 403:. 399:. 374:: 372:}} 368:{{ 356:. 346:. 338:. 326:12 324:. 320:. 306:^ 292:. 282:. 274:. 262:12 260:. 256:. 233:. 223:. 211:14 209:. 205:. 182:. 172:. 162:68 160:. 156:. 133:. 123:. 115:. 103:. 99:. 31:. 502:e 495:t 488:v 477:. 425:. 411:: 384:) 364:. 332:: 300:. 268:: 241:. 217:: 190:. 168:: 141:. 111::

Index

meta-analysis
International Committee of Medical Journal Editors
heterogeneity
"Sharing Clinical Trial Data: A Proposal From the International Committee of Medical Journal Editors"
doi
10.7326/M15-2928
ISSN
0003-4819
PMC
4799536
PMID
26830980
"How individual participant data meta-analyses have influenced trial design, conduct, and analysis"
doi
10.1016/j.jclinepi.2015.05.024
PMC
4635379
PMID
26186982
"Systematic review of methods for individual patient data meta- analysis with binary outcomes"
doi
10.1186/1471-2288-14-79
PMC
4074845
PMID
24943877
"Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use"
doi
10.1371/journal.pmed.1001855
ISSN

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