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pneumonia (H1N1) to uninfected controls during autopsy; there was a significantly greater density of intussusceptive angiogenic features in the lungs of patients who had died from Covid-19 as compared to influenza A and the control group. The degree of intussusceptive angiogenic features in the lungs
90:
is considered the opposite of intussusceptive angiogenesis. During coalescent angiogenesis capillaries fuse and form larger vessels to increase blood flow and circulation. Several other modes of angiogenesis have been described, such as sprouting angiogenesis, vessel co-option and vessel elongation.
41:
is created. By intussusception a new blood vessel is created by splitting of an existing blood vessel in two. Intussusception occurs in normal development as well as in pathologic conditions involving wound healing, tissue regeneration, inflammation as colitis or myocarditis, lung fibrosis, and
483:
Ackermann, Maximilian; Stark, Helge; Neubert, Lavinia; Schubert, Stephanie; Borchert, Paul; Linz, Friedemann; Wagner, Willi L.; Stiller, Wolfram; Wielpütz, Mark; Hoefer, Anne; Haverich, Axel; Mentzer, Steven J.; Shah, Harshit R.; Welte, Tobias; Kuehnel, Mark; Jonigk, Danny (March 2020).
108:
from the Covid-19 patients were also found to be greater as the length of hospitalization increased (which was not seen in the influenza or control groups). This suggests that increased or enhanced intussusceptive angiogenesis is seen in Covid-19 and may play a role in pathogenesis.
775:
Ackermann, Maximilian; Verleden, Stijn E.; Kuehnel, Mark; Haverich, Axel; Welte, Tobias; Laenger, Florian; Vanstapel, Arno; Werlein, Christopher; Stark, Helge; Tzankov, Alexandar; Li, William W.; Li, Vincent W.; Mentzer, Steven J.; Jonigk, Danny (21 May 2020).
867:
Ackermann, Maximilian; Verleden, Stijn E.; Kuehnel, Mark; Haverich, Axel; Welte, Tobias; Laenger, Florian; Vanstapel, Arno; Werlein, Christopher; Stark, Helge; Tzankov, Alexandar; Li, William W.; Li, Vincent W.; Mentzer, Steven J.; Jonigk, Danny (2020-07-09).
568:
Ackermann, Maximilian; Morse, Brent A.; Delventhal, Vera; Carvajal, Irvith M.; Konerding, Moritz A. (23 August 2012). "Anti-VEGFR2 and anti-IGF-1R-Adnectins inhibit Ewing's sarcoma A673-xenograft growth and normalize tumor vascular architecture".
74:
for growth of the vessel lumen. Finally, the core is fleshed out with no alterations to the basic structure. Intussusception is important because it is a reorganization of existing cells. It allows a vast increase in the number of
286:
Erba, Paolo; Ogawa, Rei; Ackermann, Maximilian; Adini, Avner; Miele, Lino F.; Dastouri, Pouya; Helm, Doug; Mentzer, Steven J.; D’Amato, Robert J.; Murphy, George F.; Konerding, Moritz A.; Orgill, Dennis P. (February 2011).
57:
junctions are reorganized and the vessel bilayer is perforated to allow growth factors and cells to penetrate into the lumen. Third, a core is formed between the two new vessels at the zone of contact that is filled with
83:. This is especially important in embryonic development as there are not enough resources to create a rich microvasculature with new cells every time a new vessel develops.
53:
to split a single vessel in two. There are four phases of intussusceptive angiogenesis. First, the two opposing capillary walls establish a zone of contact. Second, the
237:
De
Spiegelaere, Ward; Casteleyn, Christophe; Van den Broeck, Wim; Plendl, Johanna; Bahramsoltani, Mahtab; Simoens, Paul; Djonov, Valentin; Cornillie, Pieter (2012).
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Nitzsche, Bianca; Rong, Wen Wei; Goede, Andrean; Hoffmann, Björn; Scarpa, Fabio; Kuebler, Wolfgang M.; Secomb, Timothy W.; Pries, Axel R. (February 2022).
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Konerding, Moritz A.; Turhan, Aslihan; Ravnic, Dino J.; Lin, Miao; Fuchs, Christine; Secomb, Timothy W.; Tsuda, Akira; Mentzer, Steven J. (May 2010).
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Ackermann, Maximilian; Wagner, Willi L.; Rellecke, Philipp; Akhyari, Payam; Boeken, Udo; Reinecke, Petra (21 March 2020).
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Ackermann, Maximilian; Tsuda, Akira; Secomb, Timothy W.; Mentzer, Steven J.; Konerding, Moritz A. (May 2013).
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Mentzer SJ, Konerding MA. Intussusceptive angiogenesis: Expansion and remodeling of microvascular networks
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71:
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Ribatti, Domenico; Djonov, Valentin (March 2012). "Intussusceptive microvascular growth in tumors".
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184:"Intussusceptive angiogenesis and its role in vascular morphogenesis, patterning, and remodeling"
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387:"Intussusceptive remodeling of vascular branch angles in chemically-induced murine colitis"
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Intussusception was first observed in neonatal rats. In this type of vessel formation, the
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614:"Coalescent angiogenesis-evidence for a novel concept of vascular network maturation"
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486:"Morphomolecular motifs of pulmonary neoangiogenesis in interstitial lung diseases"
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127:"Intussusceptive angiogenesis: its role in embryonic vascular network formation"
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The
Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
870:"Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19"
778:"Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19"
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671:"On coalescent angiogenesis and the remarkable flexibility of blood vessels"
239:"Intussusceptive Angiogenesis: A Biologically Relevant Form of Angiogenesis"
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338:"Inflammation-Induced Intussusceptive Angiogenesis in Murine Colitis"
289:"Angiogenesis in Wounds Treated by Microdeformational Wound Therapy"
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Makanya, Andrew N.; Hlushchuk, Ruslan; Djonov, Valentin G. (2009).
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Djonov, V.; Schmid, M.; Tschanz, S. A.; Burri, P. H. (2000-02-18).
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In a small study comparing the lungs of patients who had died from
728:"Pathological angiogenesis: mechanisms and therapeutic strategies"
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436:"Parvovirus B19-induced angiogenesis in fulminant myocarditis"
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Pezzella, Francesco; Kerbel, Robert S. (February 2022).
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Vascular remodeling by intussusceptive angiogenesis
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21:Intussusception (disambiguation)
874:New England Journal of Medicine
859:, Djonov V, Baum O, Burri PH.,
853:. Angiogenesis 2014;17:499-509.
782:New England Journal of Medicine
1:
547:10.1016/j.canlet.2011.10.040
490:European Respiratory Journal
305:10.1097/SLA.0b013e31820563a8
243:Journal of Vascular Research
103:to those that had died from
37:, the process whereby a new
27:Intussusceptive angiogenesis
1093:Cardiovascular system stubs
503:10.1183/13993003.00933-2019
66:. These cells begin laying
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403:10.1016/j.mvr.2013.02.002
200:10.1007/s10456-009-9129-5
863:, 2003 Oct;314(1):107-17
861:Cell and Tissue Research
144:10.1161/01.res.86.3.286
88:coalescent angiogenesis
42:tumors amongst others.
832:Panta Rhei Study Group
440:European Heart Journal
391:Microvascular Research
49:wall extends into the
31:splitting angiogenesis
1035:cardiovascular system
920:Das HIMALAYA- Projekt
886:10.1056/NEJMoa2015432
795:10.1056/NEJMoa2015432
131:Circulation Research
72:extracellular matrix
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112:References
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