159:(ABC Australia). He has served on a range of national science, expert panel and professional society committees. He held the role of Biotechnology Program Director for almost a decade and was a founding executive member and advisor to the Sydney Emerging Infectious Disease and Biosecurity Institute. He has collaborated with a range of industry partners in the biotechnology and analytical science sector.
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Mass
Spectrometry Research Resource at MIT before leading his own research laboratories in the United States and Australia over the past 25 years. During this time, he has developed new proteotyping approaches to study viruses, viral proteins, and protein structures and interactions more generally to
65:
A major focus of his research is to arrest the impact of infectious disease causing viruses. For some 25 years, he has led the development of new mass spectrometry, bioinformatics and computer-aided approaches to characterise respiratory viruses and is an international leader in this field. He has
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Conference on
Proteomics in 2003 and the largest biennial Australian mass spectrometry conference in 2009 after serving on the Executive MS Committee for 7 years (2002-2005 & 2007-2009). He has been active in promoting the importance of research in his field and the
154:
and its pioneers for which he received the Moran award from the
Australian Academy of Science in 2006. His activities have been highlighted in scientific journals in the analytical sciences, scientific web resources, and in the media including interviews with the
36:
and other molecular approaches in the life and medical sciences. Downard has over 35 years of experience in the field and has written 150 lead-author scientific peer-reviewed journal publications, and two books including a textbook for the
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319:
Lun, Aaron T.; Swaminathan, Kavya; Wong, Jason W.; Downard, Kevin M. (April 2013). "Mass trees: a new phylogenetic approach and algorithm to chart evolutionary history with mass spectrometry".
864:
Kiselar, Janna G.; Downard, Kevin M. (1999). "Direct
Identification of Protein Epitopes by Mass Spectrometry without Immobilization of Antibody and Isolation of Antibody−Peptide Complexes".
389:
Akand, Elma H.; Downard, Kevin M. (2018). "Identification of
Epistatic Mutations and Insights into the Evolution of the Influenza Virus Using a Mass-Based Protein Phylogenetic Approach".
907:
Downard, Kevin M. (2016). "Indirect study of non-covalent protein complexes by MALDI mass spectrometry: Origins, advantages, and applications of the "intensity-fading" approach"".
102:
advance the application of MS in biology and medicine. In recent years, he has developed a new mass (i.e. numbers) based molecular phylogenetics approach (referred to as "
74:, to help arrest the impact of infectious diseases on human health. His laboratory has led Australia's response to the SARS-CoV2 virus with mass spectrometry since 2020.
354:
Akand, Elma H.; Downard, Kevin M. (2017). "Mutational
Analysis Employing a Phylogenetic Mass Tree Approach in a Study of the Evolution of the Influenza Virus".
950:
Maleknia, Simin D.; Downard, Kevin M. (March 2014). "Advances in
Radical Probe Mass Spectrometry for Protein Footprinting in Chemical Biology Applications".
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Downard, Kevin M.; Biemann, Klaus (1994). "The effect of charge state and the localization of charge on the collision-induced dissociation of peptide ions".
114:
142:
118:
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Morrissey, Bethny; Downard, Kevin M. (April 2006). "A proteomics approach to survey the antigenicity of the influenza virus by mass spectrometry".
125:
experiments, in the same year, employing radicals to study protein structures and was the first to apply the technique to study protein complexes.
241:
Schwahn, Alexander B.; Wong, Jason W. H.; Downard, Kevin M. (May 2009). "Subtyping of the
Influenza Virus by High Resolution Mass Spectrometry".
97:
and investigated subtleties of tandem mass spectra to help advance this application He remained at MIT as the
Assistant Director of the former
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Downard, Kevin M. (2006). "Ions of the interactome: The role of MS in the study of protein interactions in proteomics and structural biology".
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and other respiratory biopathogens, including SARS CoV-2, and has identified and investigated the molecular basis of new antiviral
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Müller, P.; Downard, KM. (2015). "Catechins
Inhibit Influenza Neuraminidase and its Molecular Basis with Mass Spectrometry".
424:
Nyugen, An P.; Downard, Kevin M. (2013). "Proteotyping of the Parainfluenza Virus with High-Resolution Mass Spectrometry".
138:
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His laboratory was the first to demonstrate the preservation (in 1999) of large macromolecular complexes on conventional
151:
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Downard, Kevin (2022). "Building Australia's first mass spectrometer: Recognising the achievements of J. Roger Bird".
38:
692:
Downard, Kevin M. (2013). "Proteotyping for the rapid identification of influenza virus and other biopathogens".
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1999) and British (2016) mass spectrometry societies. He has received four international fellowships from the
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1111:
1001:
Downard, Kevin (2007). "Historical Account: Francis William Aston: the man behind the mass spectrograph".
50:
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and the first book to be published on the role of mass spectrometry in the study of protein interactions.
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Downard, Kevin M. (2020). "Darwin's Tree of Life is Numbered. Resolving the Origins of Species by Mass".
133:
Downard has been internationally recognised for his research having received awards from both American (
461:"Detection, Mapping and Proteotyping of SARS CoV-2 Coronavirus with High Resolution Mass Spectrometry"
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ANZSMS 22: 22nd Biennial Mass Spectrometry Conference in Australia and New Zealand, Sydney, Australia
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developed approaches to type, subtype, study the lineage, antigenicity, and evolution of the
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scientist whose research specialises in the improving responses to
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where he received the inaugural Donald Stranks fellowship.
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Downard held a post-doctoral fellowship from 1991 at the
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Downard Research Laboratory WWW Site : keVChem.com
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Expert - Kevin Downard | Australian Academy of Science
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Journal of the American Society for Mass Spectrometry
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Academic staff of the University of New South Wales
208:Downard, Kevin M. (2007). Downard, Kevin M (ed.).
89:. He led the laboratory's early implementation of
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49:Downard was awarded his Ph.D. degree from the
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115:Matrix-assisted laser desorption/ionization
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210:Mass Spectrometry of Protein Interactions
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145:. He convened and chaired the second Sir
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1003:European Journal of Mass Spectrometry
212:. Hoboken, N.J.: Wiley-Interscience.
177:Mass Spectrometry A Foundation Course
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508:Griffin, JH.; Downard, KM. (2021).
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121:by others. He also co-developed
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175:Downard, Kevin M. (2004).
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1092:ORCID ID Kevin Downard
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